Objective To investigate the factors resulting in spontaneous abortion after transferring frozen-thawing blastocysts.Methods A total of 108 cases transferring vitrified blastocysts were divided into two groups. aborti...Objective To investigate the factors resulting in spontaneous abortion after transferring frozen-thawing blastocysts.Methods A total of 108 cases transferring vitrified blastocysts were divided into two groups. abortion group （n=20） and ongoing group （n=88）. Cytogenetic analysis of apoblemas was performed in 12 cases of the abortion.Results The overall spontaneous abortion rate was 18.50%（20/108） and the early spontaneous rate was 16.67%（18/108）. A significant difference in maternal age was observed （abortion group： 33.3±4.0years, ongoing group： 31.0 ±3.6years, P=0.02）. No difference in other parameters was found. Cytogenetic analysis of apoblemas was obtained for 12 cases, and 2 specimens were contaminated. Seven often patients had abnormal karyotypes.Conclusion The underlying cause of spontaneous abortion after transferring frozenthawing blastoeysts appears to be abnormal karyotypes. Advancing maternal age seems to increase the risk of spontaneous abortion.展开更多
文摘Objective To investigate the factors resulting in spontaneous abortion after transferring frozen-thawing blastocysts.Methods A total of 108 cases transferring vitrified blastocysts were divided into two groups. abortion group （n=20） and ongoing group （n=88）. Cytogenetic analysis of apoblemas was performed in 12 cases of the abortion.Results The overall spontaneous abortion rate was 18.50%（20/108） and the early spontaneous rate was 16.67%（18/108）. A significant difference in maternal age was observed （abortion group： 33.3±4.0years, ongoing group： 31.0 ±3.6years, P=0.02）. No difference in other parameters was found. Cytogenetic analysis of apoblemas was obtained for 12 cases, and 2 specimens were contaminated. Seven often patients had abnormal karyotypes.Conclusion The underlying cause of spontaneous abortion after transferring frozenthawing blastoeysts appears to be abnormal karyotypes. Advancing maternal age seems to increase the risk of spontaneous abortion.
