The chiral recognition of racemicα-hydroxy/amino acids is an essential and challenging mission because enantiomers may profoundly differ in biological function,pharmacology and toxicity.Three stable,chiral 3D metal-c...The chiral recognition of racemicα-hydroxy/amino acids is an essential and challenging mission because enantiomers may profoundly differ in biological function,pharmacology and toxicity.Three stable,chiral 3D metal-carboxylate frameworks,namely[M2(bptc)(H_(2)O)(MeOH)]·3H_(2)O(bptc^(4-)=3,3’,5,5’-biphenyltetracarboxylate,M=Co,CoNi for 1-2,and[Ni_(2)(bptc)(MeOH)_(2)]·3H_(2)O for 3)have been successfully obtained by spontaneous resolution with an achiral ligand H_(4)bptc,and they crystallize in the chiral tetragonal space group I4_(1)22,and feature chiral four-fold helical metal chains as SBUs.In particular,the Co-MOF material could be used to rapidly and sensitively recognize racemicα-hydroxy/amino acids by the intensity change of circular dichroism signals.A large relative difference of 38.59%in circular dichroism signals for D/L-mandelic acid is achieved,which may be ascribed to the specific recognition sites(i.e.,groove of helical chains)and different bonding energies of D/L-isomers in the chiral microenvironment of the crystal structure.展开更多
基金support from 10000 Talents Plan,the Ministry of Education of China(Grant IRT1156)NSFC(Grant 21401119&20925101)is greatly appreciated.
文摘The chiral recognition of racemicα-hydroxy/amino acids is an essential and challenging mission because enantiomers may profoundly differ in biological function,pharmacology and toxicity.Three stable,chiral 3D metal-carboxylate frameworks,namely[M2(bptc)(H_(2)O)(MeOH)]·3H_(2)O(bptc^(4-)=3,3’,5,5’-biphenyltetracarboxylate,M=Co,CoNi for 1-2,and[Ni_(2)(bptc)(MeOH)_(2)]·3H_(2)O for 3)have been successfully obtained by spontaneous resolution with an achiral ligand H_(4)bptc,and they crystallize in the chiral tetragonal space group I4_(1)22,and feature chiral four-fold helical metal chains as SBUs.In particular,the Co-MOF material could be used to rapidly and sensitively recognize racemicα-hydroxy/amino acids by the intensity change of circular dichroism signals.A large relative difference of 38.59%in circular dichroism signals for D/L-mandelic acid is achieved,which may be ascribed to the specific recognition sites(i.e.,groove of helical chains)and different bonding energies of D/L-isomers in the chiral microenvironment of the crystal structure.
