Pulmonary dynamic ventilation dysfunction is a common feature of various lung diseases,including chronic obstructive pulmonary disease(COPD)[1],cystic fibrosis[2],and asthma[3].Regional assessment of ventilation dynam...Pulmonary dynamic ventilation dysfunction is a common feature of various lung diseases,including chronic obstructive pulmonary disease(COPD)[1],cystic fibrosis[2],and asthma[3].Regional assessment of ventilation dynamics offers substantial potential to enhance diagnostic accuracy and therapeutic monitoring in these conditions.Although current clinical evaluations primarily depend on global pulmonary function tests,emerging imaging modalities such as four-dimensional computed tomography(4D-CT)[4]and phase-resolved functional lung(PREFUL)imaging[5]enable temporal observation of structural and ventilation changes.展开更多
基金supported by the National key Research and Development Program of China(2023YFF0722200)the National Natural Science Foundation of China(82127802,82372150,82441015,and 82202119)+5 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDC0170000 and XDB0540000)Key Research Program of Frontier Sciences,CAS(ZDBS-LY-JSC004)Hubei Provincial Key Technology Foundation of China(2021ACA013)Major Program(JD)of Hubei Province(2023BAA021)Hubei Province Outstanding Youth Fund(2023AFA112,2022CFA050)the support from the Youth Innovation Promotion Association,CAS(2020330,2021330)。
文摘Pulmonary dynamic ventilation dysfunction is a common feature of various lung diseases,including chronic obstructive pulmonary disease(COPD)[1],cystic fibrosis[2],and asthma[3].Regional assessment of ventilation dynamics offers substantial potential to enhance diagnostic accuracy and therapeutic monitoring in these conditions.Although current clinical evaluations primarily depend on global pulmonary function tests,emerging imaging modalities such as four-dimensional computed tomography(4D-CT)[4]and phase-resolved functional lung(PREFUL)imaging[5]enable temporal observation of structural and ventilation changes.
