AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge st...AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring ACP.This was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge tip.Using a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured ACP.For the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge tip.The bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was calculated.RESULTS:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge tips.Similarly,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly equal.The bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge tip.CONCLUSION:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.展开更多
THE name Zhen Huan has once again become a household name across China, On August 18, 2017, the author of the popular novel featuring Zhen＇s life in the imperial court in the Qing Dynasty （1644-1911）, now also a hi...THE name Zhen Huan has once again become a household name across China, On August 18, 2017, the author of the popular novel featuring Zhen＇s life in the imperial court in the Qing Dynasty （1644-1911）, now also a hit TV series, filed the first case tried by the first online court, Hangzhou Court of the Internet, in China - and the world,展开更多
The high-temperature mechanical properties of 95W-3.5Ni-1.5Fe and 95W-4.5Ni-0.5Co alloys were investigated in the temperature range of room temperature to1100℃. The yield strength and tensile strengths declined gradu...The high-temperature mechanical properties of 95W-3.5Ni-1.5Fe and 95W-4.5Ni-0.5Co alloys were investigated in the temperature range of room temperature to1100℃. The yield strength and tensile strengths declined gradually, and the ductility of both alloys increased as the testing temperature was increased to 300℃. All the three properties reached a plateau at temperatures between 300 and 500℃ in the case of 95W-3.5Ni-l.5Fe and at temperatures between 350 and 700℃ in the case of 95W-4.5Ni-0.5Co. Thereafter, the ductility as well as yield and tensile strengths decreased considerably.展开更多
Around half of the men who have sex with men(MSM)have never been tested for human immunodeficiency virus(HIV),even though the health authorities promoted a massive scale-up of HIV testing and counseling in health faci...Around half of the men who have sex with men(MSM)have never been tested for human immunodeficiency virus(HIV),even though the health authorities promoted a massive scale-up of HIV testing and counseling in health facilities[1].HIV self-testing has been recommended by the World Health Organization as a user-friendly,convenient,rapid,and accurate approach to access HIV testing[2].An internet-based provision of self-testing services may be critical to the rollout of HIV self-testing,but more research is needed.展开更多
Impact drop tests are routinely used to examine the dynamic performance of rockbolts.Numerous impact tests have been carried out in the past decades on independently designed,constructed and operated testing rigs.Each...Impact drop tests are routinely used to examine the dynamic performance of rockbolts.Numerous impact tests have been carried out in the past decades on independently designed,constructed and operated testing rigs.Each laboratory has developed testing procedures;thus,the results are often reported in different ways by various laboratories.The inconsistency in testing procedures and reporting formats presents a challenge when comparing results from different laboratories.A series of impact tests of identical rockbolts was carried out using the direct impact method(i.e.the mass free-fall method)on the rigs in four laboratories in different countries.The purpose of these tests was to investigate the level of consistency in the results from the four rigs.Each rig demonstrated a high level of repeatability,but differences existed between the various rigs.The differences would suggest that there is noticeable equipment-dependent bias when test results obtained from different laboratories are compared.It was also observed that the energy dissipated for the plastic displacement of the bolt was smaller than the impact energy in the tests.The average impact load(AIL)and the ultimate plastic displacement(D)of the bolt describe the ultimate dynamic performance of the bolt.In the case where the bolt does not rupture,the specific plastic energy(SPE)is an appropriate parameter in describing the impact performance of the bolt.Two other relevant parameters are the first peak load(FPL)and the initial stiffness(K)of the bolt sample.The information from this test series will guide the formulation of standardised testing procedures for dynamic impact tests of rockbolts.展开更多
Mother-to-child-transmission of human immunodeficiency virus(HIV) is a primary cause of pediatric infections with HIV. Many of these infections involve women who were not tested early enough in pregnancy, or who didno...Mother-to-child-transmission of human immunodeficiency virus(HIV) is a primary cause of pediatric infections with HIV. Many of these infections involve women who were not tested early enough in pregnancy, or who didnot receive prevention services. HIV testing of pregnant women is considered to be one of the key strategies for preventing mother-to-child-transmission of HIV, but HIV testing rates among pregnant women in various countries remain suboptimal. Understanding the factors relating to women's willingness to be tested for HIV during pregnancy is critical for developing strategies to increase HIV testing rates among pregnant women. Extensive research points to various factors relating to women's willingness to be tested for HIV during pregnancy, and various recommendations aimed at improving testing rates among pregnant women have been suggested based on the research. In light of the goals set by the United Nations to reduce the rate of infants infected with HIV, it is necessary to summarize what is currently known regarding factors related to women's willingness to be tested for HIV during pregnancy. The purpose of this review is therefore to examine factors related to women's willingness to be tested for HIV during pregnancy, and to summarize recommendations for practice and further research.展开更多
Data consisting of test performance records of 725 bulls was analysed to evaluate trends for growth and feed efficiency, and to determine environmental factors that influence growth of range performance tested bulls i...Data consisting of test performance records of 725 bulls was analysed to evaluate trends for growth and feed efficiency, and to determine environmental factors that influence growth of range performance tested bulls in the arid sweet bushveld of South Africa. Performance data were subjected to regression procedures to estimate parameters of the slope (β) and intercept (α) for average daily gain (ADG) and Kleiber ratio (KR). Mixed procedures were applied to test for sources of variation in ADG and KR. There was an increase of 3.481 g/day/year and 0.528 g/day/ year in ADG for Nguni and Bonsmara bulls, respectively. The ADG trends’ respective feed efficiency as reflected by KR was 0.093 and 0.059. Herd of origin and test-year were the sources of variation for ADG while the variation in KR was due to the herd of origin, test-year, start-age and start-weight. Results indicated a steady increase in ADG and KR for range performance tested bulls in the arid sweet bushveld.展开更多
Taking Ti-6Al-4V specimens into consideration, the coupled thermal-electrical finite element model has been developed in Abaqus/Explicit to simulate the heating process in Gleeble 3800 and to study the temperature his...Taking Ti-6Al-4V specimens into consideration, the coupled thermal-electrical finite element model has been developed in Abaqus/Explicit to simulate the heating process in Gleeble 3800 and to study the temperature history and distribution in the specimen. In order to verify the finite element （FE） results, thermal tests are carried out on Gleeble 3800 for a Ti-6Al-4V specimen with a slot to in the centre of the specimen. The effects of the specimen size, heating rate, and air convection on the temperature distribution over the specimen have been investigated. The conclusions can be drawn as： the temperature gradient of the specimen decreases as the specimen size, heating rate, and vacuuming decrease.展开更多
With the ever increasing popularity of international standardized English proficiency tests,the test takers' craze for them has nev er been greater.However,the issue of the inequity which comes from the legitimate...With the ever increasing popularity of international standardized English proficiency tests,the test takers' craze for them has nev er been greater.However,the issue of the inequity which comes from the legitimate knowledge which decides a test-taker's score hasn't been fully exposed.The theoretical study of this issue in this paper helps explore the legitimate knowledge tested in international English proficiency tests.By examining the legitimate knowledge in the sample tests of IELTS and TOEFL,the study reveals the underlying bias which constitutes a decent score for the test takers.In the end,the study proposes a more balanced assessment model for discussion.展开更多
Pengshui Miao and Tujia Autonomous County in Chongqing Municipality is located within the South China Karst,a vast area of mountains and geological formations cov-ering much of southwest China.Sweet potatoes,potatoes ...Pengshui Miao and Tujia Autonomous County in Chongqing Municipality is located within the South China Karst,a vast area of mountains and geological formations cov-ering much of southwest China.Sweet potatoes,potatoes and com are better suited to Pengshui's terrain and climate than other starch crops,and its innovative approach to the cultivation and processing of sweet potatoes received international recognition as means to alleviate poverty this month.展开更多
T he residual stray magnetic fields present in ferromagnetic casting slabs were investigated in this work,which result from the magnetic fields generated during the steel casting process.Existing optical detection met...T he residual stray magnetic fields present in ferromagnetic casting slabs were investigated in this work,which result from the magnetic fields generated during the steel casting process.Existing optical detection methods face challenges owing to surface oxide scales,and conventional high-precision magnetic sensors are ineffective at high temperatures.To overcome these limitations,a small coil sensor was employed to measure the residual magnetism strength in oscillation traces,using metal magnetic memory and electromagnetic induction methods,which can carry out detection without an external excitation source.Using this technology,the proposed scheme successfully detects defects at high tempe-ratures(up to 670℃)without a cooling device.The key findings include the ability to detect both surface and near-surface defects,such as cracks and oscillation marks,with an enhanced signal-to-noise ratio(SNR)of 7.2 dB after signal processing.The method’s practicality was validated in a steel mill environment,where testing on casting slabs effectively detected defects,providing a foundation for improving industrial quality control.The proposed detection scheme offers a significant advancement in nondestructive testing(NDT)for high-temperature applications,contributing to more efficient and accurate monitoring of ferromagnetic material integrity.展开更多
At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systema...At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater.展开更多
Cemented paste backfill(CPB)is a technology that achieves safe mining by filling the goaf with waste rocks,tailings,and other materials.It is an inevitable choice to deal with the development of deep and highly diffic...Cemented paste backfill(CPB)is a technology that achieves safe mining by filling the goaf with waste rocks,tailings,and other materials.It is an inevitable choice to deal with the development of deep and highly difficult mines and meet the requirements of environmental protection and safety regulations.It promotes the development of a circular economy in mines through the development of lowgrade resources and the resource utilization of waste,and extends the service life of mines.The mass concentration of solid content(abbreviated as“concentration”)is a critical parameter for CPB.However,discrepancies often arise between the on-site measurements and the pre-designed values due to factors such as groundwater inflow and segregation within the goaf,which cannot be evaluated after the solidification of CPB.This paper innovatively provides an in-situ non-destructive approach to identify the real concentration of CPB after curing for certain days using hyperspectral imaging(HSI)technology.Initially,the spectral variation patterns under different concentration conditions were investigated through hyperspectral scanning experiments on CPB samples.The results demonstrate that as the CPB concentration increases from 61wt%to 73wt%,the overall spectral reflectance gradually increases,with two distinct absorption peaks observed at 1407 and 1917 nm.Notably,the reflectance at 1407 nm exhibited a strong linear relationship with the concentration.Subsequently,the K-nearest neighbors(KNN)and support vector machine(SVM)algorithms were employed to classify and identify different concentrations.The study revealed that,with the KNN algorithm,the highest accuracy was achieved when K(number of nearest neighbors)was 1,although this resulted in overfitting.When K=3,the model displayed the optimal balance between accuracy and stability,with an accuracy of 95.03%.In the SVM algorithm,the highest accuracy of 98.24%was attained with parameters C(regularization parameter)=200 and Gamma(kernel coefficient)=10.A comparative analysis of precision,accuracy,and recall further highlighted that the SVM provided superior stability and precision for identifying CPB concentration.Thus,HSI technology offers an effective solution for the in-situ,non-destructive monitoring of CPB concentration,presenting a promising approach for optimizing and controlling CPB characteristic parameters.展开更多
BACKGROUND Familial adenomatous polyposis(FAP)is a disorder of autosomal dominant inheritance that is responsible for around 1%of colorectal cancer(CRC)cases.AIM To determine the mutation profile of FAP-specific to th...BACKGROUND Familial adenomatous polyposis(FAP)is a disorder of autosomal dominant inheritance that is responsible for around 1%of colorectal cancer(CRC)cases.AIM To determine the mutation profile of FAP-specific to the Hungarian population.METHODS This prospective single-center study enrolled patients with clinically suspected FAP or attenuated FAP(aFAP).Whole-exome next-generation sequencing was performed to detect variants of 50 FAP priority genes and 173 CRC predisposing genes or other CRC disease-associated genes.To identify larger deletions and insertions,a multiplex amplifiable probe hybridization technique was used.The identified genes were then classified according to the American College of Medical Genetics and Genomics guidelines.RESULTS A total of 26 index patients with clinically suspected FAP(n=21)and aFAP(n=5)were enrolled.APC gene alterations were confirmed in 92.31%of the cases(region 1B deletion,n=2;whole-gene deletion,n=4;frameshift mutation,n=2;nonsense mutation,n=5,and splice mutation,n=1),with the remaining two cases having CHEK2 and MSH3 gene alterations.According to pathogenicity,21 cases had pathogenic mutations,6 cases had likely pathogenic mutations,and 16 cases had variants of unknown significance(VUS).The most frequent of the latter were the POLE(n=5)and PIEZO1(n=4)gene variants.CONCLUSION Germline mutations in the APC gene were confirmed in more than 90%of Hungarian patients with clinically suspected FAP.Although the role of VUS genes is unclear,they are highly likely to play a role in the development of CRC.展开更多
ISO releases two standards for textiles.Recently,two international standards,ISO 8159:2025,Textiles-Morphology of fibres and yarns-Vocabulary,and ISO 17971:2025,Textiles-Smart textiles-Test method for determining the ...ISO releases two standards for textiles.Recently,two international standards,ISO 8159:2025,Textiles-Morphology of fibres and yarns-Vocabulary,and ISO 17971:2025,Textiles-Smart textiles-Test method for determining the screen-touch properties of fabrics,were officially released.They are of positive significance for eliminating technical ambiguities in exchanges on textile products and filling the gaps in international standards.展开更多
The etiopathogenesis of gastrointestinal diseases is varied in nature.Various etiogenic factors described are infective,inflammatory,viral,bacterial,parasitic,dietary and lifestyle change.Rare causative agents are imm...The etiopathogenesis of gastrointestinal diseases is varied in nature.Various etiogenic factors described are infective,inflammatory,viral,bacterial,parasitic,dietary and lifestyle change.Rare causative agents are immunological,and others associated as idiopathic,are undiagnosed by all possible means.Some of the rare diseases are congenital in nature,passing from the parent to the child.Many of the undiagnosed diseases are now being diagnosed as genetic and the genes have been implicated as a causative agent.There is a search for newer treatments for such diseases,which is called genomic medicine.Genomic medicine is an emerging medical discipline that involves the use of genomic information about an individual.This is used both for diagnostic as well as therapeutic decisions to improve the current health domain and pave the way for policymakers for its clinical use.In the developing era of precision medicine,genomics,epigenomics,environmental exposure,and other data would be used to more accurately guide individual diagnosis and treatment.Genomic medicine is already making an impact in the fields of oncology,pharmacology,rare,infectious and many undiagnosed diseases.It is beginning to fuel new approaches in certain medical specialties.Oncology is at the leading edge of incorporating genomics,as diagnostics for genetic and genomic markers are increasingly included in cancer screening,and to guide tailored treatment strategies.Genetics and genetic medicine have been reported to play a role in gastroenterology in several ways,including genetic testing(hereditary pancreatitis and hereditary gastrointestinal cancer syndromes).Genetic testing can also help subtype diseases,such as classifying pancreatitis as idiopathic or hereditary.Gene therapy is a promising approach for treating gastrointestinal diseases that are not effectively treated by conventional pharmaceuticals and surgeries.Gene therapy strategies include gene addition,gene editing,messenger RNA therapy,and gene silencing.Understanding genetic determinants,advances in genetics,have led to a better understanding of the genetic factors that contribute to human disease.Family-member risk stratification and genetic diagnosis can help identify family members who are at risk,which can lead to preventive treatments,lifestyle recommendations,and routine follow ups.Selecting target genes helps identify the gene targets associated with each gastrointestinal disease.Common gastrointestinal diseases associated with genetic abnormalities include-inflammatory bowel disease,gastroesophageal reflux disease,non-alcoholic fatty liver disease,and irritable bowel syndrome.With advancing tools and technology,research in the search of newer and individualized treatment,genes and genetic medicines are expected to play a significant role in human health and gastroenterology.展开更多
Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining...Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining technique that overcomes these issues by using impact to create strong bonds without melting the substrate materials.This study investigates the weldability of aluminum alloy Al-5754 with Al-7075 and MARS 380 steel,used in armouring solutions of defense systems,by the use of MPW.In this work,weldability windows are investigated by varying standoff distances between the coating material and its substrate(0.25-4.5 mm)and discharge energies(5-13 kJ)with both O-shape and U-shape inductors.Mechanical strength of the welded joints were assessed through single lap shear tests,identifying optimal welding parameters.Then,the velocity profiles of the flyer plates were measured using heterodyne velocimetry to understand the dynamics of the impact.Then,substructures assembled with the optimal welding conditions were subjected to ballistic testing using 7.62 mm×51 mm NATO and 9 mm×19 mm Parabellum munitions to evaluate the resilience of the welds under ballistic impact.The outcomes demonstrate that MPW effectively joins Al-5754 with both Al-7075 and MARS 380,producing robust welds capable of withstanding ballistic impacts under certain conditions.This research advances the application of MPW in lightweight ballistic protection of defense systems,contributing to the development of more resilient and lighter protective structures.展开更多
It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and er...It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.展开更多
Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analys...Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analyses to systematically examine the spatiotemporal patterns of runoff and its climatic driving mechanisms across Tajikistan,providing a scientific basis for sustainable water resource utilization and management in the study area.Results indicated that during 2000–2024,the annual runoff in Tajikistan exhibited statistically non-significant long-term trend(P=0.76),while displaying pronounced seasonal variability and strong spatial heterogeneity.Spring and summer average runoff primarily exhibited slight declining tendencies,while winter average runoff exhibited pronounced reduction in localized regions,such as the Syr Darya Basin,the Vakhsh River Basin,and the lower reaches of the Zeravshan River Basin.Precipitation emerged as the dominant positive driver of runoff,exhibiting moderate to strong positive correlations across over 78.00%of the country,whereas potential evapotranspiration consistently functioned as a negative driver.Rising temperatures exerted a dual competitive effect on runoff:in high-elevation,glacier-covered regions,rising temperatures temporarily increased runoff by accelerating glacier melt;however,at the national scale,the negative impact of rising temperature on runoff has played a slightly dominant role to a certain extent by enhancing evapotranspiration.Collectively,these results indicated that the present stability of runoff in Tajikistan is strongly dependent on the short-term compensatory effects of glacier melt and the risk of future runoff decline is likely to intensify as glacier reserves continue to diminish.This study provides a critical scientific evidence to inform sustainable water resource management in Tajikistan and underscores the need for glacier conservation and integrated water resource management strategies.展开更多
To investigate the strength degradation characteristics and microscopic damage mechanisms of moraine soil under hydro-thermo-mechanical coupling conditions,a series of X-ray Diffraction(XRD),standard triaxial testing,...To investigate the strength degradation characteristics and microscopic damage mechanisms of moraine soil under hydro-thermo-mechanical coupling conditions,a series of X-ray Diffraction(XRD),standard triaxial testing,Scanning Electron Microscopy(SEM),and Nuclear Magnetic Resonance(NMR)experiments were conducted.The mechanical property degradation laws and evolution characteristics of the microscopic pore structure of moraine soil under Freeze-Thaw(F-T)conditions were revealed.After F-T cycles,the stress-strain curves of moraine soil showed a strain-softening trend.In the early stage of F-T cycles(0–5 cycles),the shear strength and elastic modulus exhibited damage rate of approximately 10.33%±0.8%and 16.60%±1.2%,respectively.In the later stage(10–20 cycles),the strength parameters fluctuated slightly and tended to stabilize.The number of F-T cycles was negatively exponentially correlated with cohesion,while showing only slight fluctuation in the internal friction angle,thereby extending the Mohr-Coulomb strength criterion for moraine soil under F-T cycles.The NMR experiments quantitatively characterized the evolution of the internal pore structure of moraine soil under F-T cycles.As the number of F-T cycles increased,fine and micro pores gradually expanded and merged due to the frost-heaving effect during the water-ice phase transition,forming larger pores.The proportion of large and medium pores increased to 59.55%±2.1%(N=20),while that of fine and micro pores decreased to 40.45%±2.1%(N=20).The evolution of pore structure characteristics was essentially completed in the later stage of F-T cycles(10–20 cycles).This study provides a theoretical foundation and technical support for major engineering construction and disaster prevention in the Qinghai-Xizang Plateau.展开更多
文摘AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring ACP.This was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge tip.Using a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured ACP.For the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge tip.The bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was calculated.RESULTS:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge tips.Similarly,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly equal.The bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge tip.CONCLUSION:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.
文摘THE name Zhen Huan has once again become a household name across China, On August 18, 2017, the author of the popular novel featuring Zhen＇s life in the imperial court in the Qing Dynasty （1644-1911）, now also a hit TV series, filed the first case tried by the first online court, Hangzhou Court of the Internet, in China - and the world,
文摘The high-temperature mechanical properties of 95W-3.5Ni-1.5Fe and 95W-4.5Ni-0.5Co alloys were investigated in the temperature range of room temperature to1100℃. The yield strength and tensile strengths declined gradually, and the ductility of both alloys increased as the testing temperature was increased to 300℃. All the three properties reached a plateau at temperatures between 300 and 500℃ in the case of 95W-3.5Ni-l.5Fe and at temperatures between 350 and 700℃ in the case of 95W-4.5Ni-0.5Co. Thereafter, the ductility as well as yield and tensile strengths decreased considerably.
基金supported by the National Science and Technology Major Project Research of the 13th Five-Year[No.2018ZX10101001-001-003]National Natural Science Foundation of China[No.81872674]AIDS Healthcare Foundation(AHF)China program[No.2016-P-001]。
文摘Around half of the men who have sex with men(MSM)have never been tested for human immunodeficiency virus(HIV),even though the health authorities promoted a massive scale-up of HIV testing and counseling in health facilities[1].HIV self-testing has been recommended by the World Health Organization as a user-friendly,convenient,rapid,and accurate approach to access HIV testing[2].An internet-based provision of self-testing services may be critical to the rollout of HIV self-testing,but more research is needed.
文摘Impact drop tests are routinely used to examine the dynamic performance of rockbolts.Numerous impact tests have been carried out in the past decades on independently designed,constructed and operated testing rigs.Each laboratory has developed testing procedures;thus,the results are often reported in different ways by various laboratories.The inconsistency in testing procedures and reporting formats presents a challenge when comparing results from different laboratories.A series of impact tests of identical rockbolts was carried out using the direct impact method(i.e.the mass free-fall method)on the rigs in four laboratories in different countries.The purpose of these tests was to investigate the level of consistency in the results from the four rigs.Each rig demonstrated a high level of repeatability,but differences existed between the various rigs.The differences would suggest that there is noticeable equipment-dependent bias when test results obtained from different laboratories are compared.It was also observed that the energy dissipated for the plastic displacement of the bolt was smaller than the impact energy in the tests.The average impact load(AIL)and the ultimate plastic displacement(D)of the bolt describe the ultimate dynamic performance of the bolt.In the case where the bolt does not rupture,the specific plastic energy(SPE)is an appropriate parameter in describing the impact performance of the bolt.Two other relevant parameters are the first peak load(FPL)and the initial stiffness(K)of the bolt sample.The information from this test series will guide the formulation of standardised testing procedures for dynamic impact tests of rockbolts.
文摘Mother-to-child-transmission of human immunodeficiency virus(HIV) is a primary cause of pediatric infections with HIV. Many of these infections involve women who were not tested early enough in pregnancy, or who didnot receive prevention services. HIV testing of pregnant women is considered to be one of the key strategies for preventing mother-to-child-transmission of HIV, but HIV testing rates among pregnant women in various countries remain suboptimal. Understanding the factors relating to women's willingness to be tested for HIV during pregnancy is critical for developing strategies to increase HIV testing rates among pregnant women. Extensive research points to various factors relating to women's willingness to be tested for HIV during pregnancy, and various recommendations aimed at improving testing rates among pregnant women have been suggested based on the research. In light of the goals set by the United Nations to reduce the rate of infants infected with HIV, it is necessary to summarize what is currently known regarding factors related to women's willingness to be tested for HIV during pregnancy. The purpose of this review is therefore to examine factors related to women's willingness to be tested for HIV during pregnancy, and to summarize recommendations for practice and further research.
文摘Data consisting of test performance records of 725 bulls was analysed to evaluate trends for growth and feed efficiency, and to determine environmental factors that influence growth of range performance tested bulls in the arid sweet bushveld of South Africa. Performance data were subjected to regression procedures to estimate parameters of the slope (β) and intercept (α) for average daily gain (ADG) and Kleiber ratio (KR). Mixed procedures were applied to test for sources of variation in ADG and KR. There was an increase of 3.481 g/day/year and 0.528 g/day/ year in ADG for Nguni and Bonsmara bulls, respectively. The ADG trends’ respective feed efficiency as reflected by KR was 0.093 and 0.059. Herd of origin and test-year were the sources of variation for ADG while the variation in KR was due to the herd of origin, test-year, start-age and start-weight. Results indicated a steady increase in ADG and KR for range performance tested bulls in the arid sweet bushveld.
基金supported by the Fundamental Research Funds for the Central Universities of China under Grant No.A03007023801073
文摘Taking Ti-6Al-4V specimens into consideration, the coupled thermal-electrical finite element model has been developed in Abaqus/Explicit to simulate the heating process in Gleeble 3800 and to study the temperature history and distribution in the specimen. In order to verify the finite element （FE） results, thermal tests are carried out on Gleeble 3800 for a Ti-6Al-4V specimen with a slot to in the centre of the specimen. The effects of the specimen size, heating rate, and air convection on the temperature distribution over the specimen have been investigated. The conclusions can be drawn as： the temperature gradient of the specimen decreases as the specimen size, heating rate, and vacuuming decrease.
文摘With the ever increasing popularity of international standardized English proficiency tests,the test takers' craze for them has nev er been greater.However,the issue of the inequity which comes from the legitimate knowledge which decides a test-taker's score hasn't been fully exposed.The theoretical study of this issue in this paper helps explore the legitimate knowledge tested in international English proficiency tests.By examining the legitimate knowledge in the sample tests of IELTS and TOEFL,the study reveals the underlying bias which constitutes a decent score for the test takers.In the end,the study proposes a more balanced assessment model for discussion.
文摘Pengshui Miao and Tujia Autonomous County in Chongqing Municipality is located within the South China Karst,a vast area of mountains and geological formations cov-ering much of southwest China.Sweet potatoes,potatoes and com are better suited to Pengshui's terrain and climate than other starch crops,and its innovative approach to the cultivation and processing of sweet potatoes received international recognition as means to alleviate poverty this month.
文摘T he residual stray magnetic fields present in ferromagnetic casting slabs were investigated in this work,which result from the magnetic fields generated during the steel casting process.Existing optical detection methods face challenges owing to surface oxide scales,and conventional high-precision magnetic sensors are ineffective at high temperatures.To overcome these limitations,a small coil sensor was employed to measure the residual magnetism strength in oscillation traces,using metal magnetic memory and electromagnetic induction methods,which can carry out detection without an external excitation source.Using this technology,the proposed scheme successfully detects defects at high tempe-ratures(up to 670℃)without a cooling device.The key findings include the ability to detect both surface and near-surface defects,such as cracks and oscillation marks,with an enhanced signal-to-noise ratio(SNR)of 7.2 dB after signal processing.The method’s practicality was validated in a steel mill environment,where testing on casting slabs effectively detected defects,providing a foundation for improving industrial quality control.The proposed detection scheme offers a significant advancement in nondestructive testing(NDT)for high-temperature applications,contributing to more efficient and accurate monitoring of ferromagnetic material integrity.
基金supported by the National Natural Science Foundation of China(Project No.42307555).
文摘At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater.
基金funded by the National Natural Science Foundation of China(Nos.52474165 and 52522404)。
文摘Cemented paste backfill(CPB)is a technology that achieves safe mining by filling the goaf with waste rocks,tailings,and other materials.It is an inevitable choice to deal with the development of deep and highly difficult mines and meet the requirements of environmental protection and safety regulations.It promotes the development of a circular economy in mines through the development of lowgrade resources and the resource utilization of waste,and extends the service life of mines.The mass concentration of solid content(abbreviated as“concentration”)is a critical parameter for CPB.However,discrepancies often arise between the on-site measurements and the pre-designed values due to factors such as groundwater inflow and segregation within the goaf,which cannot be evaluated after the solidification of CPB.This paper innovatively provides an in-situ non-destructive approach to identify the real concentration of CPB after curing for certain days using hyperspectral imaging(HSI)technology.Initially,the spectral variation patterns under different concentration conditions were investigated through hyperspectral scanning experiments on CPB samples.The results demonstrate that as the CPB concentration increases from 61wt%to 73wt%,the overall spectral reflectance gradually increases,with two distinct absorption peaks observed at 1407 and 1917 nm.Notably,the reflectance at 1407 nm exhibited a strong linear relationship with the concentration.Subsequently,the K-nearest neighbors(KNN)and support vector machine(SVM)algorithms were employed to classify and identify different concentrations.The study revealed that,with the KNN algorithm,the highest accuracy was achieved when K(number of nearest neighbors)was 1,although this resulted in overfitting.When K=3,the model displayed the optimal balance between accuracy and stability,with an accuracy of 95.03%.In the SVM algorithm,the highest accuracy of 98.24%was attained with parameters C(regularization parameter)=200 and Gamma(kernel coefficient)=10.A comparative analysis of precision,accuracy,and recall further highlighted that the SVM provided superior stability and precision for identifying CPB concentration.Thus,HSI technology offers an effective solution for the in-situ,non-destructive monitoring of CPB concentration,presenting a promising approach for optimizing and controlling CPB characteristic parameters.
基金Supported by the Research Grants of the National Research,Development and Innovation Office,No.K125377,No.K134863 and No.K143549New National Excellence Program of the Ministry of Human Capacities,No.UNKP-20-5-SZTE-161,No.UNKP-22-3-SZTE-233,No.UNKP-23-5-SZTE-719,No.UNKP-22-4-SZTE-296 and No.UNKP-22-3-SZTE-278+1 种基金Janos Bolyai Research Grant,No.BO/00723/22the Géza Hetényi Research Grant by Albert Szent-Györgyi Medical School,University of Szeged.
文摘BACKGROUND Familial adenomatous polyposis(FAP)is a disorder of autosomal dominant inheritance that is responsible for around 1%of colorectal cancer(CRC)cases.AIM To determine the mutation profile of FAP-specific to the Hungarian population.METHODS This prospective single-center study enrolled patients with clinically suspected FAP or attenuated FAP(aFAP).Whole-exome next-generation sequencing was performed to detect variants of 50 FAP priority genes and 173 CRC predisposing genes or other CRC disease-associated genes.To identify larger deletions and insertions,a multiplex amplifiable probe hybridization technique was used.The identified genes were then classified according to the American College of Medical Genetics and Genomics guidelines.RESULTS A total of 26 index patients with clinically suspected FAP(n=21)and aFAP(n=5)were enrolled.APC gene alterations were confirmed in 92.31%of the cases(region 1B deletion,n=2;whole-gene deletion,n=4;frameshift mutation,n=2;nonsense mutation,n=5,and splice mutation,n=1),with the remaining two cases having CHEK2 and MSH3 gene alterations.According to pathogenicity,21 cases had pathogenic mutations,6 cases had likely pathogenic mutations,and 16 cases had variants of unknown significance(VUS).The most frequent of the latter were the POLE(n=5)and PIEZO1(n=4)gene variants.CONCLUSION Germline mutations in the APC gene were confirmed in more than 90%of Hungarian patients with clinically suspected FAP.Although the role of VUS genes is unclear,they are highly likely to play a role in the development of CRC.
文摘ISO releases two standards for textiles.Recently,two international standards,ISO 8159:2025,Textiles-Morphology of fibres and yarns-Vocabulary,and ISO 17971:2025,Textiles-Smart textiles-Test method for determining the screen-touch properties of fabrics,were officially released.They are of positive significance for eliminating technical ambiguities in exchanges on textile products and filling the gaps in international standards.
文摘The etiopathogenesis of gastrointestinal diseases is varied in nature.Various etiogenic factors described are infective,inflammatory,viral,bacterial,parasitic,dietary and lifestyle change.Rare causative agents are immunological,and others associated as idiopathic,are undiagnosed by all possible means.Some of the rare diseases are congenital in nature,passing from the parent to the child.Many of the undiagnosed diseases are now being diagnosed as genetic and the genes have been implicated as a causative agent.There is a search for newer treatments for such diseases,which is called genomic medicine.Genomic medicine is an emerging medical discipline that involves the use of genomic information about an individual.This is used both for diagnostic as well as therapeutic decisions to improve the current health domain and pave the way for policymakers for its clinical use.In the developing era of precision medicine,genomics,epigenomics,environmental exposure,and other data would be used to more accurately guide individual diagnosis and treatment.Genomic medicine is already making an impact in the fields of oncology,pharmacology,rare,infectious and many undiagnosed diseases.It is beginning to fuel new approaches in certain medical specialties.Oncology is at the leading edge of incorporating genomics,as diagnostics for genetic and genomic markers are increasingly included in cancer screening,and to guide tailored treatment strategies.Genetics and genetic medicine have been reported to play a role in gastroenterology in several ways,including genetic testing(hereditary pancreatitis and hereditary gastrointestinal cancer syndromes).Genetic testing can also help subtype diseases,such as classifying pancreatitis as idiopathic or hereditary.Gene therapy is a promising approach for treating gastrointestinal diseases that are not effectively treated by conventional pharmaceuticals and surgeries.Gene therapy strategies include gene addition,gene editing,messenger RNA therapy,and gene silencing.Understanding genetic determinants,advances in genetics,have led to a better understanding of the genetic factors that contribute to human disease.Family-member risk stratification and genetic diagnosis can help identify family members who are at risk,which can lead to preventive treatments,lifestyle recommendations,and routine follow ups.Selecting target genes helps identify the gene targets associated with each gastrointestinal disease.Common gastrointestinal diseases associated with genetic abnormalities include-inflammatory bowel disease,gastroesophageal reflux disease,non-alcoholic fatty liver disease,and irritable bowel syndrome.With advancing tools and technology,research in the search of newer and individualized treatment,genes and genetic medicines are expected to play a significant role in human health and gastroenterology.
基金funded on the one hand by Agence de l'Innovation de Défense(AID)grant reference number 2021650044on the other hand by Ecole Centrale de Nantes。
文摘Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining technique that overcomes these issues by using impact to create strong bonds without melting the substrate materials.This study investigates the weldability of aluminum alloy Al-5754 with Al-7075 and MARS 380 steel,used in armouring solutions of defense systems,by the use of MPW.In this work,weldability windows are investigated by varying standoff distances between the coating material and its substrate(0.25-4.5 mm)and discharge energies(5-13 kJ)with both O-shape and U-shape inductors.Mechanical strength of the welded joints were assessed through single lap shear tests,identifying optimal welding parameters.Then,the velocity profiles of the flyer plates were measured using heterodyne velocimetry to understand the dynamics of the impact.Then,substructures assembled with the optimal welding conditions were subjected to ballistic testing using 7.62 mm×51 mm NATO and 9 mm×19 mm Parabellum munitions to evaluate the resilience of the welds under ballistic impact.The outcomes demonstrate that MPW effectively joins Al-5754 with both Al-7075 and MARS 380,producing robust welds capable of withstanding ballistic impacts under certain conditions.This research advances the application of MPW in lightweight ballistic protection of defense systems,contributing to the development of more resilient and lighter protective structures.
文摘It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.
基金funded by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0720203)the National Key Research and Development Program of China(2023YFF0805603).
文摘Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analyses to systematically examine the spatiotemporal patterns of runoff and its climatic driving mechanisms across Tajikistan,providing a scientific basis for sustainable water resource utilization and management in the study area.Results indicated that during 2000–2024,the annual runoff in Tajikistan exhibited statistically non-significant long-term trend(P=0.76),while displaying pronounced seasonal variability and strong spatial heterogeneity.Spring and summer average runoff primarily exhibited slight declining tendencies,while winter average runoff exhibited pronounced reduction in localized regions,such as the Syr Darya Basin,the Vakhsh River Basin,and the lower reaches of the Zeravshan River Basin.Precipitation emerged as the dominant positive driver of runoff,exhibiting moderate to strong positive correlations across over 78.00%of the country,whereas potential evapotranspiration consistently functioned as a negative driver.Rising temperatures exerted a dual competitive effect on runoff:in high-elevation,glacier-covered regions,rising temperatures temporarily increased runoff by accelerating glacier melt;however,at the national scale,the negative impact of rising temperature on runoff has played a slightly dominant role to a certain extent by enhancing evapotranspiration.Collectively,these results indicated that the present stability of runoff in Tajikistan is strongly dependent on the short-term compensatory effects of glacier melt and the risk of future runoff decline is likely to intensify as glacier reserves continue to diminish.This study provides a critical scientific evidence to inform sustainable water resource management in Tajikistan and underscores the need for glacier conservation and integrated water resource management strategies.
基金support from the National Natural Science Foundation of China(Grant Nos.42107193,42077245)supported by the Sichuan Science and Technology Program(2025YFNH0008,2025YFNH0004)+1 种基金the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Independent Research Project(SKLGP2023Z006)the Everest Scientific Research Program 2.0:Research on mechanism and control of glacial lake outburst chain catastrophe in Qinghai-Xizang Plateau based on man-earth coordination perspective.
文摘To investigate the strength degradation characteristics and microscopic damage mechanisms of moraine soil under hydro-thermo-mechanical coupling conditions,a series of X-ray Diffraction(XRD),standard triaxial testing,Scanning Electron Microscopy(SEM),and Nuclear Magnetic Resonance(NMR)experiments were conducted.The mechanical property degradation laws and evolution characteristics of the microscopic pore structure of moraine soil under Freeze-Thaw(F-T)conditions were revealed.After F-T cycles,the stress-strain curves of moraine soil showed a strain-softening trend.In the early stage of F-T cycles(0–5 cycles),the shear strength and elastic modulus exhibited damage rate of approximately 10.33%±0.8%and 16.60%±1.2%,respectively.In the later stage(10–20 cycles),the strength parameters fluctuated slightly and tended to stabilize.The number of F-T cycles was negatively exponentially correlated with cohesion,while showing only slight fluctuation in the internal friction angle,thereby extending the Mohr-Coulomb strength criterion for moraine soil under F-T cycles.The NMR experiments quantitatively characterized the evolution of the internal pore structure of moraine soil under F-T cycles.As the number of F-T cycles increased,fine and micro pores gradually expanded and merged due to the frost-heaving effect during the water-ice phase transition,forming larger pores.The proportion of large and medium pores increased to 59.55%±2.1%(N=20),while that of fine and micro pores decreased to 40.45%±2.1%(N=20).The evolution of pore structure characteristics was essentially completed in the later stage of F-T cycles(10–20 cycles).This study provides a theoretical foundation and technical support for major engineering construction and disaster prevention in the Qinghai-Xizang Plateau.
