The common marmoset （Callithrix jacchus） has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test...The common marmoset （Callithrix jacchus） has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test methods are still limited in the field of marmoset research. The light-dark box is widely used for the evaluation of anxiety in rodents, but little is known about light-dark preference in marmosets. Here, we modified the light-dark test to study this behavior. The modified apparatus consisted of three compartments： one transparent open area and two closed opaque compartments. The closed compartments could be dark or light. We found that both adult and young marmosets liked to explore the open area, but the young animals showed more interest than adults. Furthermore, when one of the closed compartments was light and the other dark, the adult marmosets showed a preference for the dark compartment, but the young animals had no preference. These results suggest that the exploratory behavior and the light-dark preference in marmosets are age-dependent. Our study provides a new method to study exploration, anxiety, and fear in marmosets.展开更多
Background: The Box and Block clinical test is a validated and standardized scale for use in the clinical environment that allows the assessment of rough manipulative dexterity. Proposing virtual methods to carry out ...Background: The Box and Block clinical test is a validated and standardized scale for use in the clinical environment that allows the assessment of rough manipulative dexterity. Proposing virtual methods to carry out these assessments is an attempt to eliminate some of the subjectivity that the test may entail depending on the observer and the way in which the patient gives instructions. Applied to the assessment of skills after neurological pathologies, previous experiences in stroke patients have been found. So, this work was centered on the Spinal Cord Injury. Objective: To present the virtual application of the Box and Block scale, as well as details about its design and development for its manipulation based on Leap Motion Controller. Methodology: The relationship between the results obtained in the actual test and in the virtual application in healthy subjects and, mostly, patients with cervical spinal cord injury is analyzed, obtaining a high correlation index between both tests’ performance. Results: A high correlation index was obtained between both tests performance, the real and virtual version of the Box and Block Test. Conclusion: This virtual test can serve as an element to evaluate in the future the effectiveness of the RehabHand prototype based on virtual reality applications with a therapeutic and a rehabilitative sense that, manipulated from Leap Motion Controller, allow the improvement of the manipulative dexterity in patients with neurological diseases such as spinal cord injury.展开更多
A new security test for the substitution boxes （S-boxes） high-order bit independence criterion （HOBIC） test, is presented. Different from the previous security tests for S-boxes, the HOBIC test can be used to meas...A new security test for the substitution boxes （S-boxes） high-order bit independence criterion （HOBIC） test, is presented. Different from the previous security tests for S-boxes, the HOBIC test can be used to measure the strength of an S-box against attacks that keep some of its input bits constant. Test results over the S-boxes of Data Encryption Standard （DES） and Advanced Encryption Standard （AES） are given and some possible applications of the HOBIC test are analyzed. Meanwhile, the source code for a basic version of the HOBIC test is also provided, the implement process of which shows that it is very fast and efficient for practical applications .展开更多
In this paper, the test suite construction for GUI (Graphical User Interface) software may be executed centered on grey-box approach with the prior test design of window access controls for unit testing, including fro...In this paper, the test suite construction for GUI (Graphical User Interface) software may be executed centered on grey-box approach with the prior test design of window access controls for unit testing, including front-end method of white box and follow-up black box method for integration testing. Moreover, two key opinions are proposed for the test suite construction for GUI software, the first one is that the “Triple-step method” should be used for unit testing with the prior disposing of data boundary value testing of input controls, and another one is that the “Grey-box approach” should be applied in integration testing for GUI software with necessary testing preparation in the precondition. At the same time, the testing of baseline version and the incremental testing should be considered for the test case construction to coordinate with the whole evolution of software product today. Additionally, all our opinion and thought are verified and tested with a typical case of GUI software—PQMS (Product Quality Monitoring Software/System), and results indicate that these methods and specific disposing are practical and effective.展开更多
基金supported by the Youth Innovation Promotion Association of the Chinese Academy of Sciences and an SA-SIBS scholarshipthe National Basic Research Development Program (973 Program) of China (2011CBA00400)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020100)
文摘The common marmoset （Callithrix jacchus） has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test methods are still limited in the field of marmoset research. The light-dark box is widely used for the evaluation of anxiety in rodents, but little is known about light-dark preference in marmosets. Here, we modified the light-dark test to study this behavior. The modified apparatus consisted of three compartments： one transparent open area and two closed opaque compartments. The closed compartments could be dark or light. We found that both adult and young marmosets liked to explore the open area, but the young animals showed more interest than adults. Furthermore, when one of the closed compartments was light and the other dark, the adult marmosets showed a preference for the dark compartment, but the young animals had no preference. These results suggest that the exploratory behavior and the light-dark preference in marmosets are age-dependent. Our study provides a new method to study exploration, anxiety, and fear in marmosets.
文摘Background: The Box and Block clinical test is a validated and standardized scale for use in the clinical environment that allows the assessment of rough manipulative dexterity. Proposing virtual methods to carry out these assessments is an attempt to eliminate some of the subjectivity that the test may entail depending on the observer and the way in which the patient gives instructions. Applied to the assessment of skills after neurological pathologies, previous experiences in stroke patients have been found. So, this work was centered on the Spinal Cord Injury. Objective: To present the virtual application of the Box and Block scale, as well as details about its design and development for its manipulation based on Leap Motion Controller. Methodology: The relationship between the results obtained in the actual test and in the virtual application in healthy subjects and, mostly, patients with cervical spinal cord injury is analyzed, obtaining a high correlation index between both tests’ performance. Results: A high correlation index was obtained between both tests performance, the real and virtual version of the Box and Block Test. Conclusion: This virtual test can serve as an element to evaluate in the future the effectiveness of the RehabHand prototype based on virtual reality applications with a therapeutic and a rehabilitative sense that, manipulated from Leap Motion Controller, allow the improvement of the manipulative dexterity in patients with neurological diseases such as spinal cord injury.
基金Supported by the National Science Foundation of China (61072140)the Doctoral Program Foundation of Institutions of Higher Education of China (20100203110003)+1 种基金the 111 Project (B08038)the Fundamental Research Funds for the Central Universities ( JY10000901034)
文摘A new security test for the substitution boxes （S-boxes） high-order bit independence criterion （HOBIC） test, is presented. Different from the previous security tests for S-boxes, the HOBIC test can be used to measure the strength of an S-box against attacks that keep some of its input bits constant. Test results over the S-boxes of Data Encryption Standard （DES） and Advanced Encryption Standard （AES） are given and some possible applications of the HOBIC test are analyzed. Meanwhile, the source code for a basic version of the HOBIC test is also provided, the implement process of which shows that it is very fast and efficient for practical applications .
文摘In this paper, the test suite construction for GUI (Graphical User Interface) software may be executed centered on grey-box approach with the prior test design of window access controls for unit testing, including front-end method of white box and follow-up black box method for integration testing. Moreover, two key opinions are proposed for the test suite construction for GUI software, the first one is that the “Triple-step method” should be used for unit testing with the prior disposing of data boundary value testing of input controls, and another one is that the “Grey-box approach” should be applied in integration testing for GUI software with necessary testing preparation in the precondition. At the same time, the testing of baseline version and the incremental testing should be considered for the test case construction to coordinate with the whole evolution of software product today. Additionally, all our opinion and thought are verified and tested with a typical case of GUI software—PQMS (Product Quality Monitoring Software/System), and results indicate that these methods and specific disposing are practical and effective.
