This work presents a systematic analysis of proton-induced total ionizing dose(TID)effects in 1.2 k V silicon carbide(SiC)power devices with various edge termination structures.Three edge terminations including ring-a...This work presents a systematic analysis of proton-induced total ionizing dose(TID)effects in 1.2 k V silicon carbide(SiC)power devices with various edge termination structures.Three edge terminations including ring-assisted junction termination extension(RA-JTE),multiple floating zone JTE(MFZ-JTE),and field limiting rings(FLR)were fabricated and irradiated with45 Me V protons at fluences ranging from 1×10^(12) to 1×10^(14) cm^(-2).Experimental results,supported by TCAD simulations,show that the RA-JTE structure maintained stable breakdown performance with less than 1%variation due to its effective electric field redistribution by multiple P+rings.In contrast,MFZ-JTE and FLR exhibit breakdown voltage shifts of 6.1%and 15.2%,respectively,under the highest fluence.These results demonstrate the superior radiation tolerance of the RA-JTE structure under TID conditions and provide practical design guidance for radiation-hardened Si C power devices in space and other highradiation environments.展开更多
In this paper,an improved error-rate sliding window decoder is proposed for spatially coupled low-density parity-check(SC-LDPC)codes.For the conventional sliding window decoder,the message retention mechanism causes u...In this paper,an improved error-rate sliding window decoder is proposed for spatially coupled low-density parity-check(SC-LDPC)codes.For the conventional sliding window decoder,the message retention mechanism causes unreliable messages along the edges of belief propagation(BP)decoding in the current window to be kept for subsequent window decoding.To improve the reliability of the retained messages during the window transition,a reliable termination method is embedded,where the retained messages undergo more reliable parity checks.Additionally,decoding failure is unavoidable and even causes error propagation when the number of errors exceeds the error-correcting capability of the window.To mitigate this problem,a channel value reuse mechanism is designed,where the received channel values are utilized to reinitialize the window.Furthermore,considering the complexity and performance of decoding,a feasible sliding optimized window decoding(SOWD)scheme is introduced.Finally,simulation results confirm the superior performance of the proposed SOWD scheme in both the waterfall and error floor regions.This work has great potential in the applications of wireless optical communication and fiber optic communication.展开更多
Mitochondria are semi-autonomous organelles present in eukaryotic cells,containing their own genome and transcriptional machinery.However,their functions are intricately linked to proteins encoded by the nuclear genom...Mitochondria are semi-autonomous organelles present in eukaryotic cells,containing their own genome and transcriptional machinery.However,their functions are intricately linked to proteins encoded by the nuclear genome.Mitochondrial transcription termination factors(mTERFs)are nucleic acid-binding proteins involved in RNA splicing and transcription termination within plant mitochondria and chloroplasts.Despite their recognized importance,the specific roles of mTERF proteins in maize remain largely unexplored.Here,we clone and functionally characterize the maize mTERF18 gene.Our findings reveal that mTERF18 mutations lead to severely undifferentiated embryos,resulting in abortive phenotypes.Early kernel exhibits abnormal basal endosperm transfer layer and a significant reduction in both starch and protein accumulation in mterf18.We identify the mTERF18 gene through mapping-based cloning and validate this gene through allelic tests.mTERF18 is widely expressed across various maize tissues and encodes a highly conserved mitochondrial protein.Transcriptome data reveal that mTERF18 mutations disrupt transcriptional termination of the nad6 gene,leading to undetectable levels of Nad6 protein and reduced complex I assembly and activity.Furthermore,transmission electron microscopy observation of mterf18 endosperm uncover severe mitochondrial defects.Collectively,these findings highlight the critical role of mTERF18 in mitochondrial gene transcription termination and its pivotal impact on maize kernel development.展开更多
目的探讨血清前Ⅲ型胶原氨基端肽(typeⅢprocollagen,PRO-C3)与高尔基体蛋白73(golgi protein 73,GP73)动态变化对人工肝治疗乙型肝炎慢加急性肝衰竭(hepatitis B virus-related acute-on-chronic liver failure,HBV-ACLF)患者短期预后...目的探讨血清前Ⅲ型胶原氨基端肽(typeⅢprocollagen,PRO-C3)与高尔基体蛋白73(golgi protein 73,GP73)动态变化对人工肝治疗乙型肝炎慢加急性肝衰竭(hepatitis B virus-related acute-on-chronic liver failure,HBV-ACLF)患者短期预后的评估价值。方法回顾性分析138例接受≥3次人工肝治疗的HBV-ACLF患者(生存组85例,死亡组53例)。检测基线及治疗2周后血清PRO-C3、GP73水平及常规肝肾功能指标,分析其与临床预后的相关性。血清PRO-C3采用罗氏cobas®分析仪(ECLIA法)检测;血清GP73采用ELISA法(北京热景生物试剂盒)检测。通过多因素Cox回归构建联合预测模型,并采用ROC曲线评估预测效能。结果对两组基线情况进行对比分析,结果显示,死亡组的总胆红素、肌酐、MELD水平均显著高于生存组(总胆红素535.5±118.7 vs 380.9±108.0μmol/L、肌酐96.6±29.6 vs 66.9±28.6μmol/L、MELD评分33.5±5.5 vs 20.7±4.3,均P<0.001);生存组PRO-C3与GP73降幅显著大于死亡组(P<0.001);多因素Cox回归显示,MELD评分为独立危险因素,PRO-C3降幅和GP73降幅为保护因素;联合动态指标(ΔPRO-C3%+ΔGP73%+MELD)的AUC达0.993,阴性预测值89.8%;按标志物降幅分组(良好/部分/无应答),3个月生存率分别为95.2%、65.5%、11.4%(P<0.001)。结论PRO-C3联合GP73的动态监测可精准评估人工肝治疗应答,其构建的预测模型对HBV-ACLF患者3个月预后具有显著的判别价值,尤其阴性预测效能突出。展开更多
To explore the best preparation process for terminal blend(TB)composite-modified asphalt and to filter its formulation with excellent performance,this study evaluates the performance of TB composite modified asphalt b...To explore the best preparation process for terminal blend(TB)composite-modified asphalt and to filter its formulation with excellent performance,this study evaluates the performance of TB composite modified asphalt by physical property index,microscopic morphology,rheological testing,and infrared spectroscopy on multiple scales.The results show that the best preparation process for TB-modified asphalt is stirring at 260℃ for 4 h at 400 rpm,which significantly reduces the modification time of the asphalt.From a physical property viewpoint,the TB composite-modified asphalt sample with 5% styrene-butadiene-styrene(SBS)+1% aromatics+0.1% sulfur exhibits high-comprehensive,high-and low-temperature properties.More-over,its crosslinked mesh structure comprises black rubber particles uniformly interwoven in the middle,which further enhances the performance of the asphalt and results in an excellent performance formulation.In addition,the sample with 5%SBS content has a higher G*value and smaller δ value than that with 3%SBS content,indicating that its high-temperature resistance is improved.The effect of adding 3%SBS content on the viscoelastic ratio is,to some extent,less than that caused by 20% rubber powder.展开更多
The vertical GaN-on-GaN Schottky barrier diode with boron-implanted termination was fabricated and characterized.Compared with the Schottky barrier diode(SBD)without boron-implanted termination,this SBD effectively im...The vertical GaN-on-GaN Schottky barrier diode with boron-implanted termination was fabricated and characterized.Compared with the Schottky barrier diode(SBD)without boron-implanted termination,this SBD effectively improved the breakdown voltage from 189 V to 585 V and significantly reduced the reverse leakage current by 10^5 times.In addition,a high Ion/Ioff ratio of ~10^8 was achieved by the boron-implanted technology.We used Technology Computer Aided Design(TCAD)to analyze reasons for the improved performance of the SBD with boron-implanted termination.The improved performance of diodes may be attributed to that B+could confine free carriers to suppress electron field crowding at the edge of the diode,which could improve the breakdown voltage and suppress the reverse leakage current.展开更多
基金supported by the IITP(Institute for Information&Communications Technology Planning&Evaluation)under the ITRC(Information Technology Research Center)support program(IITP-2025-RS-2024-00438288)grant funded by the Korea government(MSIT)+1 种基金National Research Council of Science&Technology(NST)grant by the MSIT(Aerospace Semiconductor Strategy Research Project No.GTL25051-000)supported by the IC Design Education Center(IDEC),Korea。
文摘This work presents a systematic analysis of proton-induced total ionizing dose(TID)effects in 1.2 k V silicon carbide(SiC)power devices with various edge termination structures.Three edge terminations including ring-assisted junction termination extension(RA-JTE),multiple floating zone JTE(MFZ-JTE),and field limiting rings(FLR)were fabricated and irradiated with45 Me V protons at fluences ranging from 1×10^(12) to 1×10^(14) cm^(-2).Experimental results,supported by TCAD simulations,show that the RA-JTE structure maintained stable breakdown performance with less than 1%variation due to its effective electric field redistribution by multiple P+rings.In contrast,MFZ-JTE and FLR exhibit breakdown voltage shifts of 6.1%and 15.2%,respectively,under the highest fluence.These results demonstrate the superior radiation tolerance of the RA-JTE structure under TID conditions and provide practical design guidance for radiation-hardened Si C power devices in space and other highradiation environments.
基金supported by the National Natural Science Foundation of China (No.62275193)。
文摘In this paper,an improved error-rate sliding window decoder is proposed for spatially coupled low-density parity-check(SC-LDPC)codes.For the conventional sliding window decoder,the message retention mechanism causes unreliable messages along the edges of belief propagation(BP)decoding in the current window to be kept for subsequent window decoding.To improve the reliability of the retained messages during the window transition,a reliable termination method is embedded,where the retained messages undergo more reliable parity checks.Additionally,decoding failure is unavoidable and even causes error propagation when the number of errors exceeds the error-correcting capability of the window.To mitigate this problem,a channel value reuse mechanism is designed,where the received channel values are utilized to reinitialize the window.Furthermore,considering the complexity and performance of decoding,a feasible sliding optimized window decoding(SOWD)scheme is introduced.Finally,simulation results confirm the superior performance of the proposed SOWD scheme in both the waterfall and error floor regions.This work has great potential in the applications of wireless optical communication and fiber optic communication.
基金supported by the National Key Research and Development Program of China(2021YFF1000304)the National Natural Science Foundation of China(32222060)Anhui Agricultural University(RC422404)to J.Y.
文摘Mitochondria are semi-autonomous organelles present in eukaryotic cells,containing their own genome and transcriptional machinery.However,their functions are intricately linked to proteins encoded by the nuclear genome.Mitochondrial transcription termination factors(mTERFs)are nucleic acid-binding proteins involved in RNA splicing and transcription termination within plant mitochondria and chloroplasts.Despite their recognized importance,the specific roles of mTERF proteins in maize remain largely unexplored.Here,we clone and functionally characterize the maize mTERF18 gene.Our findings reveal that mTERF18 mutations lead to severely undifferentiated embryos,resulting in abortive phenotypes.Early kernel exhibits abnormal basal endosperm transfer layer and a significant reduction in both starch and protein accumulation in mterf18.We identify the mTERF18 gene through mapping-based cloning and validate this gene through allelic tests.mTERF18 is widely expressed across various maize tissues and encodes a highly conserved mitochondrial protein.Transcriptome data reveal that mTERF18 mutations disrupt transcriptional termination of the nad6 gene,leading to undetectable levels of Nad6 protein and reduced complex I assembly and activity.Furthermore,transmission electron microscopy observation of mterf18 endosperm uncover severe mitochondrial defects.Collectively,these findings highlight the critical role of mTERF18 in mitochondrial gene transcription termination and its pivotal impact on maize kernel development.
文摘目的探讨血清前Ⅲ型胶原氨基端肽(typeⅢprocollagen,PRO-C3)与高尔基体蛋白73(golgi protein 73,GP73)动态变化对人工肝治疗乙型肝炎慢加急性肝衰竭(hepatitis B virus-related acute-on-chronic liver failure,HBV-ACLF)患者短期预后的评估价值。方法回顾性分析138例接受≥3次人工肝治疗的HBV-ACLF患者(生存组85例,死亡组53例)。检测基线及治疗2周后血清PRO-C3、GP73水平及常规肝肾功能指标,分析其与临床预后的相关性。血清PRO-C3采用罗氏cobas®分析仪(ECLIA法)检测;血清GP73采用ELISA法(北京热景生物试剂盒)检测。通过多因素Cox回归构建联合预测模型,并采用ROC曲线评估预测效能。结果对两组基线情况进行对比分析,结果显示,死亡组的总胆红素、肌酐、MELD水平均显著高于生存组(总胆红素535.5±118.7 vs 380.9±108.0μmol/L、肌酐96.6±29.6 vs 66.9±28.6μmol/L、MELD评分33.5±5.5 vs 20.7±4.3,均P<0.001);生存组PRO-C3与GP73降幅显著大于死亡组(P<0.001);多因素Cox回归显示,MELD评分为独立危险因素,PRO-C3降幅和GP73降幅为保护因素;联合动态指标(ΔPRO-C3%+ΔGP73%+MELD)的AUC达0.993,阴性预测值89.8%;按标志物降幅分组(良好/部分/无应答),3个月生存率分别为95.2%、65.5%、11.4%(P<0.001)。结论PRO-C3联合GP73的动态监测可精准评估人工肝治疗应答,其构建的预测模型对HBV-ACLF患者3个月预后具有显著的判别价值,尤其阴性预测效能突出。
基金Funded by the National Natural Science Foundation of China(No.52278446)。
文摘To explore the best preparation process for terminal blend(TB)composite-modified asphalt and to filter its formulation with excellent performance,this study evaluates the performance of TB composite modified asphalt by physical property index,microscopic morphology,rheological testing,and infrared spectroscopy on multiple scales.The results show that the best preparation process for TB-modified asphalt is stirring at 260℃ for 4 h at 400 rpm,which significantly reduces the modification time of the asphalt.From a physical property viewpoint,the TB composite-modified asphalt sample with 5% styrene-butadiene-styrene(SBS)+1% aromatics+0.1% sulfur exhibits high-comprehensive,high-and low-temperature properties.More-over,its crosslinked mesh structure comprises black rubber particles uniformly interwoven in the middle,which further enhances the performance of the asphalt and results in an excellent performance formulation.In addition,the sample with 5%SBS content has a higher G*value and smaller δ value than that with 3%SBS content,indicating that its high-temperature resistance is improved.The effect of adding 3%SBS content on the viscoelastic ratio is,to some extent,less than that caused by 20% rubber powder.
基金Project supported by the National Key R&D Program of China(Grant No.2017YFB0404100)Science and Technology Planning Project of Guangdong Province,China(Grant No.2017B010112001)。
文摘The vertical GaN-on-GaN Schottky barrier diode with boron-implanted termination was fabricated and characterized.Compared with the Schottky barrier diode(SBD)without boron-implanted termination,this SBD effectively improved the breakdown voltage from 189 V to 585 V and significantly reduced the reverse leakage current by 10^5 times.In addition,a high Ion/Ioff ratio of ~10^8 was achieved by the boron-implanted technology.We used Technology Computer Aided Design(TCAD)to analyze reasons for the improved performance of the SBD with boron-implanted termination.The improved performance of diodes may be attributed to that B+could confine free carriers to suppress electron field crowding at the edge of the diode,which could improve the breakdown voltage and suppress the reverse leakage current.
