Founded in 1929 by a group of pioneering Teochew immigrants,Teochew Poit Ip Huay Kuan is now the largest Teochew clan association in Singapore,representing more than 6,000 members.What began as a traditional clan orga...Founded in 1929 by a group of pioneering Teochew immigrants,Teochew Poit Ip Huay Kuan is now the largest Teochew clan association in Singapore,representing more than 6,000 members.What began as a traditional clan organization has transformed into a dynamic international platform that promotes cultural preservation,strengthens business networks,and supports people-to-people diplomacy between Singapore and China.With seven dedicated divisions including cultural education,youth engagement,international affairs,commerce,and public welfare,the association’s mission is to unite Teochew people worldwide,safeguard their heritage,and foster cooperation between Singapore and China.It played a founding role in several major federations including the Malaysian Federation of Teochew Poit It Huay Kuan and the Singapore Federation of Chinese Clan Associations.展开更多
BACKGROUND Coronary heart disease(CHD)is a prominent cause of mortality and disability worldwide.Like most complex diseases,the risk of CHD in individuals is regulated by the interaction between genetic factors and li...BACKGROUND Coronary heart disease(CHD)is a prominent cause of mortality and disability worldwide.Like most complex diseases,the risk of CHD in individuals is regulated by the interaction between genetic factors and lifestyle.APOE and SLCO1B1 genetic polymorphisms and LPA KIV-2 copy number variation may influence the development and progression of CHD.Clarifying gene polymor-phisms can guide clinical precision and prevention,thereby improving treatment outcomes.AIM To investigate the influence of APOE and SLCO1B1 gene polymorphisms,as well as LPA KIV-2 copy number variation on CHD in the Teochew population.METHODS A total of 324 patients with CHD and 143 control participants were involved in this study.Single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene,and rs2306283 and rs4149056 in the SLCO1B1 gene were analyzed via high-resolution melting curve analysis.Additionally,PCR was performed to detect KIV-2 copy number variations.Clinical risk factors and potential effects on CHD patients were subsequently assessed.RESULTS In the CHD group,the frequencies of APOE alleleε2,ε3,ε4 were 8.02%,82.97%,and 9.10%,respectively.Compared to the control groups(13.29%,79.37%,and 7.34%,respectively),theε2 allele frequency showed a significant difference(8.02%vs 13.29%,P=0.012).SLCO1B1 allele frequencies in the CHD group were not significantly different from those in the control group(*1a:26.69%vs 25.52%,*1b:61.17%vs 65.38%,*5:0.15%vs 0.35%,*15:11.83%vs 8.74%).The number of copies of the KIV-2 gene was significantly lower in the CHD group when compared to controls(23.35±8.78 vs 27.21±9.48;P<0.01).Logistic regression analysis revealed that sex,age,hypertension,diabetes,smoking,theε2 allele and KIV-2 copy number were factors influencing the presence of CHD.CONCLUSION In the Teochew population,the APOEε2 allele and a higher KIV-2 copy number were associated with a reduced risk of CHD.In contrast,the APOEε4 allele and SLCO1B1 gene were not associated with CHD.展开更多
This study explores the reform and innovation of experimental and practical teaching for the Teochew Gongfu Tea course within the framework of intangible cultural heritage(ICH)education.Through the construction of a&q...This study explores the reform and innovation of experimental and practical teaching for the Teochew Gongfu Tea course within the framework of intangible cultural heritage(ICH)education.Through the construction of a"Three-Dimensional Synergy,Four-Competency Progression,and Five-Integration"model,the research aims to establish a comprehensive and sustainable system that integrates ICH inheritance,technical training,and innovation education.Drawing on Outcome-Based Education(OBE)and constructivism learning theory,the reform introduces multi-source collaboration,hybrid learning,and competence-oriented assessment mechanisms.Through case-based teaching and iterative feedback,the model effectively enhances students cultural cognition,technical proficiency,creative thinking,and professional development.The findings demonstrate that this model not only improves students practical performance and engagement but also deepens their understanding and appreciation of traditional culture,offering a replicable model for other ICH-related programs in higher education.展开更多
文摘Founded in 1929 by a group of pioneering Teochew immigrants,Teochew Poit Ip Huay Kuan is now the largest Teochew clan association in Singapore,representing more than 6,000 members.What began as a traditional clan organization has transformed into a dynamic international platform that promotes cultural preservation,strengthens business networks,and supports people-to-people diplomacy between Singapore and China.With seven dedicated divisions including cultural education,youth engagement,international affairs,commerce,and public welfare,the association’s mission is to unite Teochew people worldwide,safeguard their heritage,and foster cooperation between Singapore and China.It played a founding role in several major federations including the Malaysian Federation of Teochew Poit It Huay Kuan and the Singapore Federation of Chinese Clan Associations.
基金Supported by Special Research Plan 2023 of Chaozhou,No.202303GY05。
文摘BACKGROUND Coronary heart disease(CHD)is a prominent cause of mortality and disability worldwide.Like most complex diseases,the risk of CHD in individuals is regulated by the interaction between genetic factors and lifestyle.APOE and SLCO1B1 genetic polymorphisms and LPA KIV-2 copy number variation may influence the development and progression of CHD.Clarifying gene polymor-phisms can guide clinical precision and prevention,thereby improving treatment outcomes.AIM To investigate the influence of APOE and SLCO1B1 gene polymorphisms,as well as LPA KIV-2 copy number variation on CHD in the Teochew population.METHODS A total of 324 patients with CHD and 143 control participants were involved in this study.Single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene,and rs2306283 and rs4149056 in the SLCO1B1 gene were analyzed via high-resolution melting curve analysis.Additionally,PCR was performed to detect KIV-2 copy number variations.Clinical risk factors and potential effects on CHD patients were subsequently assessed.RESULTS In the CHD group,the frequencies of APOE alleleε2,ε3,ε4 were 8.02%,82.97%,and 9.10%,respectively.Compared to the control groups(13.29%,79.37%,and 7.34%,respectively),theε2 allele frequency showed a significant difference(8.02%vs 13.29%,P=0.012).SLCO1B1 allele frequencies in the CHD group were not significantly different from those in the control group(*1a:26.69%vs 25.52%,*1b:61.17%vs 65.38%,*5:0.15%vs 0.35%,*15:11.83%vs 8.74%).The number of copies of the KIV-2 gene was significantly lower in the CHD group when compared to controls(23.35±8.78 vs 27.21±9.48;P<0.01).Logistic regression analysis revealed that sex,age,hypertension,diabetes,smoking,theε2 allele and KIV-2 copy number were factors influencing the presence of CHD.CONCLUSION In the Teochew population,the APOEε2 allele and a higher KIV-2 copy number were associated with a reduced risk of CHD.In contrast,the APOEε4 allele and SLCO1B1 gene were not associated with CHD.
文摘This study explores the reform and innovation of experimental and practical teaching for the Teochew Gongfu Tea course within the framework of intangible cultural heritage(ICH)education.Through the construction of a"Three-Dimensional Synergy,Four-Competency Progression,and Five-Integration"model,the research aims to establish a comprehensive and sustainable system that integrates ICH inheritance,technical training,and innovation education.Drawing on Outcome-Based Education(OBE)and constructivism learning theory,the reform introduces multi-source collaboration,hybrid learning,and competence-oriented assessment mechanisms.Through case-based teaching and iterative feedback,the model effectively enhances students cultural cognition,technical proficiency,creative thinking,and professional development.The findings demonstrate that this model not only improves students practical performance and engagement but also deepens their understanding and appreciation of traditional culture,offering a replicable model for other ICH-related programs in higher education.
