The integration of multiple electrophysiological biomarkers is crucial for monitoring neonatal seizure dynamics.The present study aimed to characterize the temporal dynamics of neonatal seizures by analyzing intrinsic...The integration of multiple electrophysiological biomarkers is crucial for monitoring neonatal seizure dynamics.The present study aimed to characterize the temporal dynamics of neonatal seizures by analyzing intrinsic waveforms of epileptic electroencephalogram(EEG)signals.We proposed a complementary set of methods considering envelope power,focal sharpness changes,and nonlinear patterns of EEG signals of 79 neonates with seizures.Features derived from EEG signals were used as input to the machine learning classifier.All three characteristics were significantly elevated during seizure events,as agreed upon by all viewers(P<0.0001).Envelope power was elevated in the entire seizure period,and the degree of nonlinearity rose at the termination of a seizure event.Epileptic sharpness effectively characterizes an entire seizure event,complementing the role of envelope power in identifying its onset.However,the degree of nonlinearity showed superior discriminability for the termination of a seizure event.The proposed computational methods for intrinsic sharp or nonlinear EEG patterns evolving during neonatal seizure could share some features with envelope power.Current findings may be helpful in developing strategies to improve neonatal seizure monitoring.展开更多
基金partially supported by the National Natural Science Foundation of China(Nos.62171028 and 62001026)the Beijing Natural Science Foundation(No.L232139)+2 种基金the Open Project of Key Laboratory of Medical Electronics and Digital Health of Zhejiang Province(Nos.MEDH202204 and MEDC202303)the High-Level Fellow Research Fund Program(No.3050012222022)the BIT Research and Innovation Promoting Project(No.2023YCXZ009).
文摘The integration of multiple electrophysiological biomarkers is crucial for monitoring neonatal seizure dynamics.The present study aimed to characterize the temporal dynamics of neonatal seizures by analyzing intrinsic waveforms of epileptic electroencephalogram(EEG)signals.We proposed a complementary set of methods considering envelope power,focal sharpness changes,and nonlinear patterns of EEG signals of 79 neonates with seizures.Features derived from EEG signals were used as input to the machine learning classifier.All three characteristics were significantly elevated during seizure events,as agreed upon by all viewers(P<0.0001).Envelope power was elevated in the entire seizure period,and the degree of nonlinearity rose at the termination of a seizure event.Epileptic sharpness effectively characterizes an entire seizure event,complementing the role of envelope power in identifying its onset.However,the degree of nonlinearity showed superior discriminability for the termination of a seizure event.The proposed computational methods for intrinsic sharp or nonlinear EEG patterns evolving during neonatal seizure could share some features with envelope power.Current findings may be helpful in developing strategies to improve neonatal seizure monitoring.
