Cisplatin is widely used to treat osteosarcoma,but recurrent cases often develop resistance,allowing the disease to progress and complicating clinical management.This study aimed to elucidate the immune microenvironme...Cisplatin is widely used to treat osteosarcoma,but recurrent cases often develop resistance,allowing the disease to progress and complicating clinical management.This study aimed to elucidate the immune microenvironment of osteosarcoma,providing insights into the mechanisms of recurrence and identifying potential therapeutic strategies.By analyzing multiple single-cell and bulk RNA-sequencing datasets,we discovered that the SUMOylation-related gene ZNF451 promotes osteosarcoma recurrence and alters its immune microenvironment.ZNF451 was found to importantly enhance the growth,migration,and invasion of resistant cells while also reducing their sensitivity to cisplatin and lowering their apoptosis rate.Moreover,our data indicated that ZNF451 plays a crucial role in bone resorption and epithelial–mesenchymal transition.ZNF451 also regulates CD8^(+)T cell function,leading to their exhaustion and transition to the CD8T.EXH state.Additionally,β-cryptoxanthin has been identified as a potential therapeutic agent that inhibits osteosarcoma progression by targeting ZNF451.In summary,these findings highlight the critical role of ZNF451 in promoting osteosarcoma progression and underscore its potential as a therapeutic target and biomarker for osteosarcoma.展开更多
The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provinci...The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provincial level is still incomplete. This paper firstly uses Stochastic Impacts by Regression on Population, Affluence and Technology model(STIRPAT) model to analyze the time series evolution of China’s aviation carbon emissions from 2000 to 2019. Secondly, it uses the Logarithmic Mean Divisia Index(LDMI) model to analyze the influencing characteristics and degree of four factors on China’s aviation carbon emissions, which are air transportation revenue, aviation route structure, air transportation intensity and aviation energy intensity. Thirdly, it determines the various factors’ influencing direction and evolution trend of 31 provinces’ aviation carbon emissions in China(not including Hong Kong, Macao, Taiwan of China due to incomplete data). Finally, it derives the decoupling effort model and analyzes the decoupling relationship and decoupling effort degree between air carbon emissions and air transportation revenue in different provinces. The study found that from 2000 to2019, China’s total aviation carbon emissions continued to grow, while the growth rate of aviation carbon emissions showed a fluctuating downward trend. Air transportation revenue and aviation route structure promote the growth of total aviation carbon emissions, and air transportation intensity and aviation energy intensity have a restraining effect on the growth of total aviation carbon emissions. The scope of negative driving effect of air transportation revenue and air transportation intensity on total aviation carbon emissions in various provinces has increased. While the scope of positive driving influence of aviation route structure on total aviation carbon emissions of various provinces has increased, aviation energy intensity mainly has negative driving influence on total aviation carbon emissions of each province. Overall, the emission reduction trend in the areas to the west and north of the Qinling-Huaihe River Line is obvious. The decoupling mode between air carbon emissions and air transportation revenue in 31 provinces is mainly expansion negative decoupling.The air transportation intensity effect shows strong decoupling efforts in most provinces, the decoupling effort of aviation route structure effect and aviation energy intensity effect is not prominent.展开更多
Rapidly monitoring regional water quality and the changing trend is of great practical and scientific significance,especially for the Beijing-Tianjin-Hebei(BTH)region of China where water resources are relatively scar...Rapidly monitoring regional water quality and the changing trend is of great practical and scientific significance,especially for the Beijing-Tianjin-Hebei(BTH)region of China where water resources are relatively scarce and inland water bodies are generally small.The remote sensing data of the GF 1 satellite launched in 2013 have characteristics of high spatial and temporal resolution,which can be used for the dynamic monitoring of the water environment in small lakes and reservoirs.However,the water quality remote sensing monitoring model based on the GF 1 satellite data for lakes and reservoirs in BTH is still lacking because of the considerable differences in the optical characteristics of the lakes and reservoirs.In this paper,the typical reservoirs in BTH-Guanting Reservoir,Yuqiao Reservoir,Panjiakou Reservoir,and Daheiting Reservoir are taken as the study areas.In the atmospheric correction of GF 1-WFV,the relative radiation normalized atmospheric correction was adopted after comparing it with other methods,such as 6 S and FLAASH.In the water clarity retrieval,a water color hue angle based model was proposed and outperformed other available published models,with the R 2 of 0.74 and MRE of 31.7%.The clarity products of the four typical reservoirs in the BTH region in 2013-2019 were produced using the GF 1-WFV data.Based on the products,temporal and spatial changes in clarity were analyzed,and the main influencing factors for each water body were discussed.It was found that the clarity of Guanting,Daheiting,and Panjiakou reservoirs showed an upward trend during this period,while that of Yuqiao Reservoir showed a downward trend.In the influencing factors,the water level of the water bodies can be an important factor related to the water clarity changes in this region.展开更多
The penetration and use of social media services differs from city to city.This paper is aimed to provide a comparison of the use of Twitter between different cities of the world.We present a temporal analysis of acti...The penetration and use of social media services differs from city to city.This paper is aimed to provide a comparison of the use of Twitter between different cities of the world.We present a temporal analysis of activity on Twitter in 15 cities.Our study consists of two parts:First,we created temporal graphs of the activity in the 15 cities,through which hours of high and low activity could be identified.Second,we created heat map visualizations of the Twitter activities during the period of 19 September 2012–25 September 2013.The heat map visualizations make the periods of intense and sparse activity apparent and provide a snapshot of the activity during the whole year.展开更多
This study aims to analyze temporal changes in land use and land cover change (LUCC) as well as identify areas for natural regeneration and potential areas for forest restoration in the Huasteca region for the period ...This study aims to analyze temporal changes in land use and land cover change (LUCC) as well as identify areas for natural regeneration and potential areas for forest restoration in the Huasteca region for the period from 1976 to 2007. Changes were quantified in numbers and, additionally, cartography was used to identify and map the main affected areas. Different models based on Geographic Information Systems (GIS) demonstrated that LUCC have occurred on an area of 11718.82 km2, representing 17.84% of the region’s surface. Agriculture and the growth of pasture could be identified as the main human-induced activities that have led to landscape modification. In addition, forest cover is affected by a deforestation rate which is higher than the national average. Further important changes include a change from natural land cover to non-original land cover, affecting an area of 4911.88 km2 in the period from 1976-1993, and an area of 1892.5 km2 in the period from 1993-2002. Smaller changes could be observed for the period from 1993-2002 with an affected area of 1029.78 km2. At the same time, a natural regeneration from nonoriginal to original land cover took place from 1976-1993 on an area of 1318.68 km2, and also on an area of 974.18 km2 between 1993 an 2002. The surface that underwent a natural regeneration of forest cover made up 1932.07 km2. At the same time, an area of 5739.29 km2 for potential forest restoration was identified. Drawing on GIS methods and techniques, the development of thematic maps for land use, land use and land cover changes for the years of analysis (1976-1993-2002-2007) proved to be very adequate for the evaluation and analysis of the land cover and land use change, in particular with regard to the decrease of natural vegetation cover.展开更多
In this study, we use the Bohai Sea area as an example to investigate the characteristics of secondary microseisms and their impact on seismic noise based on the temporal frequency spectral analysis of observation dat...In this study, we use the Bohai Sea area as an example to investigate the characteristics of secondary microseisms and their impact on seismic noise based on the temporal frequency spectral analysis of observation data from 33 broadband seismic stations during strong gust periods, and new perspectives are proposed on the generation mechanisms of secondary microseisms. The results show that short-period double- frequency (SPDF) and long-period double-frequency (LPDF) microseisms exhibit significant alternating trends of strengthening and weakening in the northwest area of the Bohai Sea. SPDF microseisms are generated by irregular wind waves during strong off shore wind periods, with a broad frequency band distributed in the range of 0.2-1 Hz;LPDF microseisms are generated by regular swells during periods of sea wind weakening, with a narrow frequency band concentrated between 0.15 and 0.3 Hz. In terms of temporal dimensions, as the sea wind weakens, the energy of SPDF microseisms weakens, and the dominant frequencies increase, whereas the energy of LPDF microseisms strengthens and the dominant frequencies decrease, which is consistent with the process of the decay of wind waves and the growth of swells. In terms of spatial dimensions, as the microseisms propagate inland areas, the advantageous frequency band and energy of SPDF microseisms are reduced and significantly attenuated, respectively, whereas LPDF microseisms show no significant changes. And during the propagation process in high-elevation areas, LPDF microseisms exhibit a certain site amplifi cation eff ect when the energy is strong. The results provide important supplements to the basic theory of secondary microseisms, preliminarily reveal the relationship between the atmosphere, ocean, and seismic noise, and provide important theoretical references for conducting geological and oceanographic research based on the characteristics of secondary microseisms.展开更多
The original temporal clustering analysis (OTCA) is an effective technique for obtaining brain activation maps when the timing and location of the activation are completely unknown, but its deficiency of sensitivity i...The original temporal clustering analysis (OTCA) is an effective technique for obtaining brain activation maps when the timing and location of the activation are completely unknown, but its deficiency of sensitivity is exposed in processing brain activation signal which is relatively weak. The time slice analysis method based on OTCA is proposed considering the weakness of the functional magnetic resonance imaging (fMRI) signal of the rat model. By dividing the stimulation period into several time slices and analyzing each slice to detect the activated pixels respectively after the background removal, the sensitivity is significantly improved. The inhibitory response in the hypothalamus after glucose loading is detected successfully with this method in the experiment on rat. Combined with the OTCA method, the time slice analysis method based on OTCA is effective on detecting when, where and which type of response will happen after stimulation, even if the fMRI signal is weak.展开更多
With China entering the stage of high-quality development,the issue of carbon emission has become a hot research topic.This paper analyzes the different temporal and spatial effects of per capita income on household i...With China entering the stage of high-quality development,the issue of carbon emission has become a hot research topic.This paper analyzes the different temporal and spatial effects of per capita income on household indirect carbon emissions in western China.Based on the data of Chinese Family Panel Studies(CFPS)in 2016 and 2018 in the western China,this paper uses Regression analysis and Bayesian correlation analysis to study the relationship between per capita income and household indirect carbon emissions.The results showed that the indirect carbon emissions generated by the expenditure on food,housing and household equipment in the household consumption structure in the western China were relatively high.In 2016-2018,the per capita income and per capita household consumption indirect carbon emissions in the western China showed an increasing trend.There was a positive correlation between per capita income and indirect carbon emissions of per capita household consumption,and its correlation was gradually enhanced in time dimension.In the spatial dimension,the household indirect carbon emissions in Yunnan,Qinghai,Guangxi Zhuang and Ningxia in the western China were greatly affected by per capita income,while the household indirect carbon emissions in Guizhou was least affected by per capita income.Finally,the paper puts forward some problems that we should consider in the process of facing the per capita income growth and climate change:the collection of carbon tax,the optimization of household consumption structure,the research and development of low-carbon products,and the differentiated carbon reduction.展开更多
Intelligent spatial-temporal data analysis,leveraging data such as multivariate time series and geographic information,provides researchers with powerful tools to uncover multiscale patterns and enhance decision-makin...Intelligent spatial-temporal data analysis,leveraging data such as multivariate time series and geographic information,provides researchers with powerful tools to uncover multiscale patterns and enhance decision-making processes.As artificial intelligence advances,intelligent spatial-temporal algorithms have found extensive applications across various disciplines,such as geosciences,biology,and public health.1 Compared to traditional methods,these algorithms are data driven,making them well suited for addressing the complexities of modeling real-world systems.However,their reliance on substantial domain-specific expertise limits their broader applicability.Recently,significant advancements have been made in spatial-temporal large models.Trained on large-scale data,these models exhibit a vast parameter scale,superior generalization capabilities,and multitasking advantages over previous methods.Their high versatility and scalability position them as promising super hubs for multidisciplinary research,integrating knowledge,intelligent algorithms,and research communities from different fields.Nevertheless,achieving this vision will require overcoming numerous critical challenges,offering an expansive and profound space for future exploration.展开更多
In the past decade, numerical modelling has been increasingly used for simulating the mechanical behaviour of naturally fractured rock masses. In this paper, we introduce new algorithms for spatial and temporal analys...In the past decade, numerical modelling has been increasingly used for simulating the mechanical behaviour of naturally fractured rock masses. In this paper, we introduce new algorithms for spatial and temporal analyses of newly generated fractures and blocks using an integrated discrete fracture network (DFN)-finite-discrete element method (FDEM) (DFN-FDEM) modelling approach. A fracture line calculator and analysis technique (i.e. discrete element method (DEM) fracture analysis, DEMFA) calculates the geometrical aspects of induced fractures using a dilation criterion. The resultant two-dimensional (2D) blocks are then identified and characterised using a graph structure. Block tracking trees allow track of newly generated blocks across timesteps and to analyse progressive breakage of these blocks into smaller blocks. Fracture statistics (number and total length of initial and induced fractures) are then related to the block forming processes to investigate damage evolution. The combination of various proposed methodologies together across various stages of modelling processes provides new insights to investigate the dependency of structure's resistance on the initial fracture configuration.展开更多
Numerous scientific challenges arise when designing a soil monitoring network (SMN), especially when assessing large areas and several properties that are driven by numerous controlling factors of various origins and ...Numerous scientific challenges arise when designing a soil monitoring network (SMN), especially when assessing large areas and several properties that are driven by numerous controlling factors of various origins and scales. Different broad approaches to the establishment of SMNs are distinguished. It is essential to establish an adequate sampling protocol that can be applied rigorously at each sampling location and time. We make recommendations regarding the within-site sampling of soil. Different statistical methods should be associated with the different types of sampling design. We review new statistical methods that account for different sources of uncertainty. Except for those parameters for which a consensus exists, the question of testing method harmonisation remains a very difficult issue. The establishment of benchmark sites devoted to harmonisation and inter-calibration is advocated as a technical solution. However, to our present knowledge, no study has addressed crucial scientific issues such as how many calibration sites are necessary and how to locate them.展开更多
Applying quantitative temporal analysis of products reactor measurements, we studied the reactive removal of active oxygen present on Au/TiO2 catalysts after calcination at elevated temperatures （400 ＆#176;C） by CO...Applying quantitative temporal analysis of products reactor measurements, we studied the reactive removal of active oxygen present on Au/TiO2 catalysts after calcination at elevated temperatures （400 ＆#176;C） by CO pulses and its replenishment by O2 pulses at 80 ＆#176;C, focusing on the nature of the active oxygen species. In contrast to previous studies, which mainly focused on and clarified the nature of the active oxygen species for the catalytic CO oxidation, which is reversibly formed and replenished under typical reaction conditions, this study demonstrates that directly after calcina‐tion an additional oxygen species is present. This species is also active for the CO oxidation, but it is not or only very little formed under typical reaction conditions. Implications of these results on the mechanistic understanding of the CO oxidation on Au/TiO2, in particular on the role of different active oxygen species, will be discussed.展开更多
Urban evolution becomes a space-transforming agent capable of changing Normalised Difference Vegetation Index(NDVI)and Land Surface Temperature(LST)emissivity reflectance on the land surface.Therefore,this study ident...Urban evolution becomes a space-transforming agent capable of changing Normalised Difference Vegetation Index(NDVI)and Land Surface Temperature(LST)emissivity reflectance on the land surface.Therefore,this study identifies NDVI and LST variations locally,but it can also be applied in other cities on a global scale.In general,it aims to analyse NDVI and LST on surface areas of avenues and urban streets of Sector 1,located in downtown Passo Fundo,in the southern region of Brazil,from 2013 to 2020.Methodologically,treated Landsat 8 satellite images were used to obtain NDVI and LST variations in this study.Subsequently,data of 80 points in the avenues and streets of Sector 1 were collected over a distance of 100 meters spaced from each point.These data were statistically analysed concerning the dispersion of NDVI and LST from 2013 to 2020.The results revealed a strong interaction between NDVI and LST,demonstrating the need to conserve urban vegetation to improve temperature,which positively favours urban ambience indexes.展开更多
Current methods of evaluating long term Sustainable Development seldom take into account the time period over which an evaluation is made except through simplistic economic models which heavily discount the future. If...Current methods of evaluating long term Sustainable Development seldom take into account the time period over which an evaluation is made except through simplistic economic models which heavily discount the future. If sustainable development is to be a serious issue then the impact on the future of decisions made today must be properly assessed and evaluated. This requires a new understanding of time as a key feature of the Sustainability debate and new models of how this new understanding can be brought into the evaluation process. This was at the heart of the Torino declaration signed by the University organisations of the G8, G20 and developing nations in April 2009. Time is a critical part of the sustainability debate and is seldom addressed directly. This paper will provide a possible solution based on a strong theoretical and philosophical framework of how this difficult subject can be approached and applied to sustainable urban planning. The work presented is based on a philosophical model of the cosmos which has both internal and external credibility. It forms the basis ofa PhD study and has been applied to small case studies in Italy and elsewhere. These will be presented to encourage further study into this important area within the evaluation and assessment of sustainable development.展开更多
Pakistan is potentially a good tourist destination for cultural and heritage overs because the Indus and Gandhara Civilizations, and a great Mughals heritage also exists in Pakistan particularly in Lahore city. Touris...Pakistan is potentially a good tourist destination for cultural and heritage overs because the Indus and Gandhara Civilizations, and a great Mughals heritage also exists in Pakistan particularly in Lahore city. Tourism is the fastest growing industry in modern world. This study is based on the number of foreign tourist who visited the heritage sites of Lahore. The purpose of the study is to examine the number of foreign tourist who visited the heritage sites of the Lahore at Shalimar Gardens, Lahore Fort and Lahore Museum and to find the tourism trend in Lahore whether it is declining or growing high. The secondary source of data was used and data was collected from archeology department, Lahore Museum and Pakistan Year Book of Statics 2014. Tools used for research purpose were Microsoft excel, Microsoft word and ARC GIS. The number of foreign tourists that visited Lahore fort were highest in 2006 i.e. 21,178 this is the highest number of tourists who visited Lahore Fort in 15 years and 2906 lowest number of foreign tourist who visited Lahore fort, at Shalimar Gardens highest number of foreign tourists was 8558 in 2000 and the lowest number was 309 in 2013 and at Lahore Museum in 7242 tourists is the highest number of Foreign tourist who visited museum in 2000 and the lowest number of foreign tourists that visited Lahore Museum was 1825 in 2010. The trend of foreign tourism in Lahore is declining after the incident of nine eleven due to terrorism. But now with the efforts of government and work of Walled city authority foreign tourism industry is growing in Lahore as it is the Queen of cities having major and attractive heritage places for tourist.展开更多
This paper focuses on prediction of change in agricultural lands by using ART2 algorithm. The existing method used ENVI and ARCGIS software to predict the changes in land, which showed less accuracy due to human error...This paper focuses on prediction of change in agricultural lands by using ART2 algorithm. The existing method used ENVI and ARCGIS software to predict the changes in land, which showed less accuracy due to human errors. To overcome this user friendly GUI based ART2 algorithm has been developed in java to obtain more accuracy in prediction of changes in land. The input is satellite temporal images of the years 1990 and 2014. By using the ART2 algorithm, the input images of the years 1990 and 2014 are classified, where the features are identified to form cluster. The clustered image is given as input and pixel to pixel comparison method in ART2 is implemented in java, for detecting the changes in agricultural lands. The comparison results of ENVI and ARCGIS and GUI based ART2 with in situ data show that the prediction of changes in agricultural land is more accurate in the case of GUI based ART2 implementation.展开更多
Based on the observation by a Regional Air Quality Monitoring Network including 16 monitoring stations, temporal and spatial variations of ozone （O3）, NO2 and total oxidant （Ox） were analyzed by both linear regres...Based on the observation by a Regional Air Quality Monitoring Network including 16 monitoring stations, temporal and spatial variations of ozone （O3）, NO2 and total oxidant （Ox） were analyzed by both linear regression and cluster analysis. A fast increase of regional O3 concentrations of 0.86 ppbWyr was found for the annual averaged values from 2006 to 2011 in Guangdong, China. Such fast O3 increase is accompanied by a correspondingly fast NOx reduction as indicated by a fast NO2 reduction rate of 0,61 ppbV/yr. Based on a cluster analysis, the monitoring stations were classified into two major categories - rural stations （non-urban） and suburban/urban stations. The 03 concentrations at rural stations were relatively conserved while those at suburban/urban stations showed a fast increase rate of 2.0 ppbV/yr accompanied by a NO2 reduction rate of 1.2 ppbV/yr. Moreover, a rapid increase of the averaged O3 concentrations in springtime （13%/yr referred to 2006 level） was observed, which may result from the increase of solar duration, reduction of precipitation in Guangdong and transport from Eastern Central China. Application of smog production algorithm showed that the photochemical O3 production is mainly volatile organic compounds （VOC）-controlled. However, the photochemical O3 production is sensitive to both NOx and VOC for O3 pollution episode. Accordingly, it is expected that a combined NOx and VOC reduction will be helpful for the reduction of the O3 pollution episodes in Pearl River Delta while stringent VOC emission control is in general required for the regional O3 pollution control.展开更多
A novel data processing procedure for fMRI was suggested in this paper, by which spatial and temporal characteristics of stimuli-induced signal dynamic responses can be investigated simultaneously. First the multitape...A novel data processing procedure for fMRI was suggested in this paper, by which spatial and temporal characteristics of stimuli-induced signal dynamic responses can be investigated simultaneously. First the multitaper spectral estimation was utilized to estimate the spectrum of each voxel; the significance of the line frequency components at the interested frequency was tested to detect the task-related cortex areas; the temporal independent component analysis (tICA) was then applied to the activated voxels to obtain stimuli-induced signal dynamic responses. The advantages of this procedure are: few assumptions are needed for the cerebral hemodynamics and spatial distribution of task-related areas, problems which often appear in tICA analysis of fMRI data, such as the lack of stability, reliability and robustness, are overcome by the suggested method.展开更多
Radar high-resolution range profiles(HRRPs)are typical high-dimensional and interdimension dependently distributed data,the statistical modeling of which is a challenging task for HRRP-based target recognition.Supposi...Radar high-resolution range profiles(HRRPs)are typical high-dimensional and interdimension dependently distributed data,the statistical modeling of which is a challenging task for HRRP-based target recognition.Supposing that HRRP samples are independent and jointly Gaussian distributed,a recent work[Du L,Liu H W,Bao Z.IEEE Transactions on Signal Processing,2008,56(5):1931–1944]applied factor analysis(FA)to model HRRP data with a two-phase approach for model selection,which achieved satisfactory recognition performance.The theoretical analysis and experimental results reveal that there exists high temporal correlation among adjacent HRRPs.This paper is thus motivated to model the spatial and temporal structure of HRRP data simultaneously by employing temporal factor analysis(TFA)model.For a limited size of high-dimensional HRRP data,the two-phase approach for parameter learning and model selection suffers from intensive computation burden and deteriorated evaluation.To tackle these problems,this work adopts the Bayesian Ying-Yang(BYY)harmony learning that has automatic model selection ability during parameter learning.Experimental results show stepwise improved recognition and rejection performances from the twophase learning based FA,to the two-phase learning based TFA and to the BYY harmony learning based TFA with automatic model selection.In addition,adding many extra free parameters to the classic FA model and thus becoming even worse in identifiability,the model of a general linear dynamical system is even inferior to the classic FA model.展开更多
Compound action potentials of the auditory nerve in response to amplitude modulating tones were recorded in guinea pigs with electrode implanted to the exit of the internal auditory meatus and temporal sequential corr...Compound action potentials of the auditory nerve in response to amplitude modulating tones were recorded in guinea pigs with electrode implanted to the exit of the internal auditory meatus and temporal sequential correlation between the responses and the modulators was studied in a paradigm of systematically changing acoustic parameters. Three kinds of modulators were used. continuous or burst sinusoids of fixed frequency (in the range of 40 Hz-5 kHz), short bursts of sinusoids with changing frequency and short segments of speech signal. Ranges of parametric variation were 500 Hz-20 kHz for carrier frequency, 5%-95% for modulation depth and 20 dB-90 dB SPL for intensity. For continuous or burst sinusoidal modulators of fixed frequencies, the correlation coefficient (r) remained quite high in most parametric conditions, ranging from 0.80 to 0.95. It became smaller mainly in instances of decreased response amplitude on account of unfavourable parameters. For burst modulators of changing frequency, r varied around 0.66-0.86. When segments of speech signal served as the modulators, significant correlation (r around 0.50 ) also existed, indicating the validity of the timing mode of information encoding for speech sound at the cochlear nerve level. Some theoretical and technical points in studying the timing mechanism of audition is discussed.展开更多
基金supported by the National Natural Science Foundation of China(nos.82260365 and 82372315)supported by grants from the Project of Kunlun Elite,High-End Innovation and Entrepreneurship Talents of Qinghai Province(2021 No.13)+3 种基金Basic Research Program of Qinghai Province—Applied Basic Research Program(2023-ZJ-716)Postgraduate Scientific Research Innovation Project of Hunan Province(CX20230296)Liuzhou Science and Technology Program(2021YB0104B060)Liuzhou City Science and Technology Program Project(2024YB0103A012).
文摘Cisplatin is widely used to treat osteosarcoma,but recurrent cases often develop resistance,allowing the disease to progress and complicating clinical management.This study aimed to elucidate the immune microenvironment of osteosarcoma,providing insights into the mechanisms of recurrence and identifying potential therapeutic strategies.By analyzing multiple single-cell and bulk RNA-sequencing datasets,we discovered that the SUMOylation-related gene ZNF451 promotes osteosarcoma recurrence and alters its immune microenvironment.ZNF451 was found to importantly enhance the growth,migration,and invasion of resistant cells while also reducing their sensitivity to cisplatin and lowering their apoptosis rate.Moreover,our data indicated that ZNF451 plays a crucial role in bone resorption and epithelial–mesenchymal transition.ZNF451 also regulates CD8^(+)T cell function,leading to their exhaustion and transition to the CD8T.EXH state.Additionally,β-cryptoxanthin has been identified as a potential therapeutic agent that inhibits osteosarcoma progression by targeting ZNF451.In summary,these findings highlight the critical role of ZNF451 in promoting osteosarcoma progression and underscore its potential as a therapeutic target and biomarker for osteosarcoma.
基金Under the auspices of the National Natural Science Foundation of China(No.42071266)the Third Batch of Hebei Youth Top Talent ProjectNatural Science Foundation of Hebei Province(No.D2021205003)。
文摘The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provincial level is still incomplete. This paper firstly uses Stochastic Impacts by Regression on Population, Affluence and Technology model(STIRPAT) model to analyze the time series evolution of China’s aviation carbon emissions from 2000 to 2019. Secondly, it uses the Logarithmic Mean Divisia Index(LDMI) model to analyze the influencing characteristics and degree of four factors on China’s aviation carbon emissions, which are air transportation revenue, aviation route structure, air transportation intensity and aviation energy intensity. Thirdly, it determines the various factors’ influencing direction and evolution trend of 31 provinces’ aviation carbon emissions in China(not including Hong Kong, Macao, Taiwan of China due to incomplete data). Finally, it derives the decoupling effort model and analyzes the decoupling relationship and decoupling effort degree between air carbon emissions and air transportation revenue in different provinces. The study found that from 2000 to2019, China’s total aviation carbon emissions continued to grow, while the growth rate of aviation carbon emissions showed a fluctuating downward trend. Air transportation revenue and aviation route structure promote the growth of total aviation carbon emissions, and air transportation intensity and aviation energy intensity have a restraining effect on the growth of total aviation carbon emissions. The scope of negative driving effect of air transportation revenue and air transportation intensity on total aviation carbon emissions in various provinces has increased. While the scope of positive driving influence of aviation route structure on total aviation carbon emissions of various provinces has increased, aviation energy intensity mainly has negative driving influence on total aviation carbon emissions of each province. Overall, the emission reduction trend in the areas to the west and north of the Qinling-Huaihe River Line is obvious. The decoupling mode between air carbon emissions and air transportation revenue in 31 provinces is mainly expansion negative decoupling.The air transportation intensity effect shows strong decoupling efforts in most provinces, the decoupling effort of aviation route structure effect and aviation energy intensity effect is not prominent.
基金Supported by the International Partnership Program of Chinese Academy of Sciences(No.313GJHZ2022085 FN)the Dragon 5 Cooperation(No.59193)。
文摘Rapidly monitoring regional water quality and the changing trend is of great practical and scientific significance,especially for the Beijing-Tianjin-Hebei(BTH)region of China where water resources are relatively scarce and inland water bodies are generally small.The remote sensing data of the GF 1 satellite launched in 2013 have characteristics of high spatial and temporal resolution,which can be used for the dynamic monitoring of the water environment in small lakes and reservoirs.However,the water quality remote sensing monitoring model based on the GF 1 satellite data for lakes and reservoirs in BTH is still lacking because of the considerable differences in the optical characteristics of the lakes and reservoirs.In this paper,the typical reservoirs in BTH-Guanting Reservoir,Yuqiao Reservoir,Panjiakou Reservoir,and Daheiting Reservoir are taken as the study areas.In the atmospheric correction of GF 1-WFV,the relative radiation normalized atmospheric correction was adopted after comparing it with other methods,such as 6 S and FLAASH.In the water clarity retrieval,a water color hue angle based model was proposed and outperformed other available published models,with the R 2 of 0.74 and MRE of 31.7%.The clarity products of the four typical reservoirs in the BTH region in 2013-2019 were produced using the GF 1-WFV data.Based on the products,temporal and spatial changes in clarity were analyzed,and the main influencing factors for each water body were discussed.It was found that the clarity of Guanting,Daheiting,and Panjiakou reservoirs showed an upward trend during this period,while that of Yuqiao Reservoir showed a downward trend.In the influencing factors,the water level of the water bodies can be an important factor related to the water clarity changes in this region.
基金This work was completed as part of the EPSRC research Grant“The Uncertainty of Identity:Linking Spatiotemporal Information in the Real and Virtual Worlds”(EP/J005266/1).
文摘The penetration and use of social media services differs from city to city.This paper is aimed to provide a comparison of the use of Twitter between different cities of the world.We present a temporal analysis of activity on Twitter in 15 cities.Our study consists of two parts:First,we created temporal graphs of the activity in the 15 cities,through which hours of high and low activity could be identified.Second,we created heat map visualizations of the Twitter activities during the period of 19 September 2012–25 September 2013.The heat map visualizations make the periods of intense and sparse activity apparent and provide a snapshot of the activity during the whole year.
文摘This study aims to analyze temporal changes in land use and land cover change (LUCC) as well as identify areas for natural regeneration and potential areas for forest restoration in the Huasteca region for the period from 1976 to 2007. Changes were quantified in numbers and, additionally, cartography was used to identify and map the main affected areas. Different models based on Geographic Information Systems (GIS) demonstrated that LUCC have occurred on an area of 11718.82 km2, representing 17.84% of the region’s surface. Agriculture and the growth of pasture could be identified as the main human-induced activities that have led to landscape modification. In addition, forest cover is affected by a deforestation rate which is higher than the national average. Further important changes include a change from natural land cover to non-original land cover, affecting an area of 4911.88 km2 in the period from 1976-1993, and an area of 1892.5 km2 in the period from 1993-2002. Smaller changes could be observed for the period from 1993-2002 with an affected area of 1029.78 km2. At the same time, a natural regeneration from nonoriginal to original land cover took place from 1976-1993 on an area of 1318.68 km2, and also on an area of 974.18 km2 between 1993 an 2002. The surface that underwent a natural regeneration of forest cover made up 1932.07 km2. At the same time, an area of 5739.29 km2 for potential forest restoration was identified. Drawing on GIS methods and techniques, the development of thematic maps for land use, land use and land cover changes for the years of analysis (1976-1993-2002-2007) proved to be very adequate for the evaluation and analysis of the land cover and land use change, in particular with regard to the decrease of natural vegetation cover.
基金supported by Earthquake Science and Technology Spark Program of China Earthquake Administration (No. XH20006Y)Local Standards Formulation and Revision Program of Hebei Province (No. FW202154)+1 种基金Earthquake Science and Technology Spark Program of Hebei Earthquake Agency (No. DZ2024112100002)2023 Seismological Data Sharing Project of China Earthquake Networks Center (Dataset Project)。
文摘In this study, we use the Bohai Sea area as an example to investigate the characteristics of secondary microseisms and their impact on seismic noise based on the temporal frequency spectral analysis of observation data from 33 broadband seismic stations during strong gust periods, and new perspectives are proposed on the generation mechanisms of secondary microseisms. The results show that short-period double- frequency (SPDF) and long-period double-frequency (LPDF) microseisms exhibit significant alternating trends of strengthening and weakening in the northwest area of the Bohai Sea. SPDF microseisms are generated by irregular wind waves during strong off shore wind periods, with a broad frequency band distributed in the range of 0.2-1 Hz;LPDF microseisms are generated by regular swells during periods of sea wind weakening, with a narrow frequency band concentrated between 0.15 and 0.3 Hz. In terms of temporal dimensions, as the sea wind weakens, the energy of SPDF microseisms weakens, and the dominant frequencies increase, whereas the energy of LPDF microseisms strengthens and the dominant frequencies decrease, which is consistent with the process of the decay of wind waves and the growth of swells. In terms of spatial dimensions, as the microseisms propagate inland areas, the advantageous frequency band and energy of SPDF microseisms are reduced and significantly attenuated, respectively, whereas LPDF microseisms show no significant changes. And during the propagation process in high-elevation areas, LPDF microseisms exhibit a certain site amplifi cation eff ect when the energy is strong. The results provide important supplements to the basic theory of secondary microseisms, preliminarily reveal the relationship between the atmosphere, ocean, and seismic noise, and provide important theoretical references for conducting geological and oceanographic research based on the characteristics of secondary microseisms.
基金the National Natural Science Foundation of China (30370432)
文摘The original temporal clustering analysis (OTCA) is an effective technique for obtaining brain activation maps when the timing and location of the activation are completely unknown, but its deficiency of sensitivity is exposed in processing brain activation signal which is relatively weak. The time slice analysis method based on OTCA is proposed considering the weakness of the functional magnetic resonance imaging (fMRI) signal of the rat model. By dividing the stimulation period into several time slices and analyzing each slice to detect the activated pixels respectively after the background removal, the sensitivity is significantly improved. The inhibitory response in the hypothalamus after glucose loading is detected successfully with this method in the experiment on rat. Combined with the OTCA method, the time slice analysis method based on OTCA is effective on detecting when, where and which type of response will happen after stimulation, even if the fMRI signal is weak.
基金supported by the National Natural Science Foundation of China(Grant No.72264035)。
文摘With China entering the stage of high-quality development,the issue of carbon emission has become a hot research topic.This paper analyzes the different temporal and spatial effects of per capita income on household indirect carbon emissions in western China.Based on the data of Chinese Family Panel Studies(CFPS)in 2016 and 2018 in the western China,this paper uses Regression analysis and Bayesian correlation analysis to study the relationship between per capita income and household indirect carbon emissions.The results showed that the indirect carbon emissions generated by the expenditure on food,housing and household equipment in the household consumption structure in the western China were relatively high.In 2016-2018,the per capita income and per capita household consumption indirect carbon emissions in the western China showed an increasing trend.There was a positive correlation between per capita income and indirect carbon emissions of per capita household consumption,and its correlation was gradually enhanced in time dimension.In the spatial dimension,the household indirect carbon emissions in Yunnan,Qinghai,Guangxi Zhuang and Ningxia in the western China were greatly affected by per capita income,while the household indirect carbon emissions in Guizhou was least affected by per capita income.Finally,the paper puts forward some problems that we should consider in the process of facing the per capita income growth and climate change:the collection of carbon tax,the optimization of household consumption structure,the research and development of low-carbon products,and the differentiated carbon reduction.
基金supported by NSFC No.62372430the Youth Innovation Promotion As-sociation CAS No.2023112.
文摘Intelligent spatial-temporal data analysis,leveraging data such as multivariate time series and geographic information,provides researchers with powerful tools to uncover multiscale patterns and enhance decision-making processes.As artificial intelligence advances,intelligent spatial-temporal algorithms have found extensive applications across various disciplines,such as geosciences,biology,and public health.1 Compared to traditional methods,these algorithms are data driven,making them well suited for addressing the complexities of modeling real-world systems.However,their reliance on substantial domain-specific expertise limits their broader applicability.Recently,significant advancements have been made in spatial-temporal large models.Trained on large-scale data,these models exhibit a vast parameter scale,superior generalization capabilities,and multitasking advantages over previous methods.Their high versatility and scalability position them as promising super hubs for multidisciplinary research,integrating knowledge,intelligent algorithms,and research communities from different fields.Nevertheless,achieving this vision will require overcoming numerous critical challenges,offering an expansive and profound space for future exploration.
文摘In the past decade, numerical modelling has been increasingly used for simulating the mechanical behaviour of naturally fractured rock masses. In this paper, we introduce new algorithms for spatial and temporal analyses of newly generated fractures and blocks using an integrated discrete fracture network (DFN)-finite-discrete element method (FDEM) (DFN-FDEM) modelling approach. A fracture line calculator and analysis technique (i.e. discrete element method (DEM) fracture analysis, DEMFA) calculates the geometrical aspects of induced fractures using a dilation criterion. The resultant two-dimensional (2D) blocks are then identified and characterised using a graph structure. Block tracking trees allow track of newly generated blocks across timesteps and to analyse progressive breakage of these blocks into smaller blocks. Fracture statistics (number and total length of initial and induced fractures) are then related to the block forming processes to investigate damage evolution. The combination of various proposed methodologies together across various stages of modelling processes provides new insights to investigate the dependency of structure's resistance on the initial fracture configuration.
文摘Numerous scientific challenges arise when designing a soil monitoring network (SMN), especially when assessing large areas and several properties that are driven by numerous controlling factors of various origins and scales. Different broad approaches to the establishment of SMNs are distinguished. It is essential to establish an adequate sampling protocol that can be applied rigorously at each sampling location and time. We make recommendations regarding the within-site sampling of soil. Different statistical methods should be associated with the different types of sampling design. We review new statistical methods that account for different sources of uncertainty. Except for those parameters for which a consensus exists, the question of testing method harmonisation remains a very difficult issue. The establishment of benchmark sites devoted to harmonisation and inter-calibration is advocated as a technical solution. However, to our present knowledge, no study has addressed crucial scientific issues such as how many calibration sites are necessary and how to locate them.
文摘Applying quantitative temporal analysis of products reactor measurements, we studied the reactive removal of active oxygen present on Au/TiO2 catalysts after calcination at elevated temperatures （400 ＆#176;C） by CO pulses and its replenishment by O2 pulses at 80 ＆#176;C, focusing on the nature of the active oxygen species. In contrast to previous studies, which mainly focused on and clarified the nature of the active oxygen species for the catalytic CO oxidation, which is reversibly formed and replenished under typical reaction conditions, this study demonstrates that directly after calcina‐tion an additional oxygen species is present. This species is also active for the CO oxidation, but it is not or only very little formed under typical reaction conditions. Implications of these results on the mechanistic understanding of the CO oxidation on Au/TiO2, in particular on the role of different active oxygen species, will be discussed.
文摘Urban evolution becomes a space-transforming agent capable of changing Normalised Difference Vegetation Index(NDVI)and Land Surface Temperature(LST)emissivity reflectance on the land surface.Therefore,this study identifies NDVI and LST variations locally,but it can also be applied in other cities on a global scale.In general,it aims to analyse NDVI and LST on surface areas of avenues and urban streets of Sector 1,located in downtown Passo Fundo,in the southern region of Brazil,from 2013 to 2020.Methodologically,treated Landsat 8 satellite images were used to obtain NDVI and LST variations in this study.Subsequently,data of 80 points in the avenues and streets of Sector 1 were collected over a distance of 100 meters spaced from each point.These data were statistically analysed concerning the dispersion of NDVI and LST from 2013 to 2020.The results revealed a strong interaction between NDVI and LST,demonstrating the need to conserve urban vegetation to improve temperature,which positively favours urban ambience indexes.
文摘Current methods of evaluating long term Sustainable Development seldom take into account the time period over which an evaluation is made except through simplistic economic models which heavily discount the future. If sustainable development is to be a serious issue then the impact on the future of decisions made today must be properly assessed and evaluated. This requires a new understanding of time as a key feature of the Sustainability debate and new models of how this new understanding can be brought into the evaluation process. This was at the heart of the Torino declaration signed by the University organisations of the G8, G20 and developing nations in April 2009. Time is a critical part of the sustainability debate and is seldom addressed directly. This paper will provide a possible solution based on a strong theoretical and philosophical framework of how this difficult subject can be approached and applied to sustainable urban planning. The work presented is based on a philosophical model of the cosmos which has both internal and external credibility. It forms the basis ofa PhD study and has been applied to small case studies in Italy and elsewhere. These will be presented to encourage further study into this important area within the evaluation and assessment of sustainable development.
文摘Pakistan is potentially a good tourist destination for cultural and heritage overs because the Indus and Gandhara Civilizations, and a great Mughals heritage also exists in Pakistan particularly in Lahore city. Tourism is the fastest growing industry in modern world. This study is based on the number of foreign tourist who visited the heritage sites of Lahore. The purpose of the study is to examine the number of foreign tourist who visited the heritage sites of the Lahore at Shalimar Gardens, Lahore Fort and Lahore Museum and to find the tourism trend in Lahore whether it is declining or growing high. The secondary source of data was used and data was collected from archeology department, Lahore Museum and Pakistan Year Book of Statics 2014. Tools used for research purpose were Microsoft excel, Microsoft word and ARC GIS. The number of foreign tourists that visited Lahore fort were highest in 2006 i.e. 21,178 this is the highest number of tourists who visited Lahore Fort in 15 years and 2906 lowest number of foreign tourist who visited Lahore fort, at Shalimar Gardens highest number of foreign tourists was 8558 in 2000 and the lowest number was 309 in 2013 and at Lahore Museum in 7242 tourists is the highest number of Foreign tourist who visited museum in 2000 and the lowest number of foreign tourists that visited Lahore Museum was 1825 in 2010. The trend of foreign tourism in Lahore is declining after the incident of nine eleven due to terrorism. But now with the efforts of government and work of Walled city authority foreign tourism industry is growing in Lahore as it is the Queen of cities having major and attractive heritage places for tourist.
文摘This paper focuses on prediction of change in agricultural lands by using ART2 algorithm. The existing method used ENVI and ARCGIS software to predict the changes in land, which showed less accuracy due to human errors. To overcome this user friendly GUI based ART2 algorithm has been developed in java to obtain more accuracy in prediction of changes in land. The input is satellite temporal images of the years 1990 and 2014. By using the ART2 algorithm, the input images of the years 1990 and 2014 are classified, where the features are identified to form cluster. The clustered image is given as input and pixel to pixel comparison method in ART2 is implemented in java, for detecting the changes in agricultural lands. The comparison results of ENVI and ARCGIS and GUI based ART2 with in situ data show that the prediction of changes in agricultural land is more accurate in the case of GUI based ART2 implementation.
基金supported by the National Natural Science Foundation of China(No.21190052,41121004)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB05010500)+1 种基金the National Public Benefit Special Fund for Environmental Protection Research(No.201009001-4)the Special Fund of State Key Joint Laboratory of Environment Simulation and Pollution Control(No.13Z02ESPCP)
文摘Based on the observation by a Regional Air Quality Monitoring Network including 16 monitoring stations, temporal and spatial variations of ozone （O3）, NO2 and total oxidant （Ox） were analyzed by both linear regression and cluster analysis. A fast increase of regional O3 concentrations of 0.86 ppbWyr was found for the annual averaged values from 2006 to 2011 in Guangdong, China. Such fast O3 increase is accompanied by a correspondingly fast NOx reduction as indicated by a fast NO2 reduction rate of 0,61 ppbV/yr. Based on a cluster analysis, the monitoring stations were classified into two major categories - rural stations （non-urban） and suburban/urban stations. The 03 concentrations at rural stations were relatively conserved while those at suburban/urban stations showed a fast increase rate of 2.0 ppbV/yr accompanied by a NO2 reduction rate of 1.2 ppbV/yr. Moreover, a rapid increase of the averaged O3 concentrations in springtime （13%/yr referred to 2006 level） was observed, which may result from the increase of solar duration, reduction of precipitation in Guangdong and transport from Eastern Central China. Application of smog production algorithm showed that the photochemical O3 production is mainly volatile organic compounds （VOC）-controlled. However, the photochemical O3 production is sensitive to both NOx and VOC for O3 pollution episode. Accordingly, it is expected that a combined NOx and VOC reduction will be helpful for the reduction of the O3 pollution episodes in Pearl River Delta while stringent VOC emission control is in general required for the regional O3 pollution control.
基金This work was supported by the National Science Fund for Distinguished Young Scholars(Grant No.60225015)the National Natural Science Foundation of China(Grant Nos.30370416.30100054)+1 种基金the Ministry of Science and Technology of China(Grant No.2001CCA04 100)the Ministry of Education of China(TRAPOYT).
文摘A novel data processing procedure for fMRI was suggested in this paper, by which spatial and temporal characteristics of stimuli-induced signal dynamic responses can be investigated simultaneously. First the multitaper spectral estimation was utilized to estimate the spectrum of each voxel; the significance of the line frequency components at the interested frequency was tested to detect the task-related cortex areas; the temporal independent component analysis (tICA) was then applied to the activated voxels to obtain stimuli-induced signal dynamic responses. The advantages of this procedure are: few assumptions are needed for the cerebral hemodynamics and spatial distribution of task-related areas, problems which often appear in tICA analysis of fMRI data, such as the lack of stability, reliability and robustness, are overcome by the suggested method.
基金The work described in this paper was supported by a grant of the General Research Fund(GRF)from the Research Grant Council of the Hong Kong SAR(No.CUHK4180/10E)the National Natural Science Foundation of China(Grant Nos.60901067 and 61001212)+1 种基金Program for New Century Excellent Talents in University(No.NCET-09-0630)Program for Changjiang Scholars and Innovative Research Team in University(No.IRT0954),and the Fundamental Research Funds for the Central Universities.
文摘Radar high-resolution range profiles(HRRPs)are typical high-dimensional and interdimension dependently distributed data,the statistical modeling of which is a challenging task for HRRP-based target recognition.Supposing that HRRP samples are independent and jointly Gaussian distributed,a recent work[Du L,Liu H W,Bao Z.IEEE Transactions on Signal Processing,2008,56(5):1931–1944]applied factor analysis(FA)to model HRRP data with a two-phase approach for model selection,which achieved satisfactory recognition performance.The theoretical analysis and experimental results reveal that there exists high temporal correlation among adjacent HRRPs.This paper is thus motivated to model the spatial and temporal structure of HRRP data simultaneously by employing temporal factor analysis(TFA)model.For a limited size of high-dimensional HRRP data,the two-phase approach for parameter learning and model selection suffers from intensive computation burden and deteriorated evaluation.To tackle these problems,this work adopts the Bayesian Ying-Yang(BYY)harmony learning that has automatic model selection ability during parameter learning.Experimental results show stepwise improved recognition and rejection performances from the twophase learning based FA,to the two-phase learning based TFA and to the BYY harmony learning based TFA with automatic model selection.In addition,adding many extra free parameters to the classic FA model and thus becoming even worse in identifiability,the model of a general linear dynamical system is even inferior to the classic FA model.
文摘Compound action potentials of the auditory nerve in response to amplitude modulating tones were recorded in guinea pigs with electrode implanted to the exit of the internal auditory meatus and temporal sequential correlation between the responses and the modulators was studied in a paradigm of systematically changing acoustic parameters. Three kinds of modulators were used. continuous or burst sinusoids of fixed frequency (in the range of 40 Hz-5 kHz), short bursts of sinusoids with changing frequency and short segments of speech signal. Ranges of parametric variation were 500 Hz-20 kHz for carrier frequency, 5%-95% for modulation depth and 20 dB-90 dB SPL for intensity. For continuous or burst sinusoidal modulators of fixed frequencies, the correlation coefficient (r) remained quite high in most parametric conditions, ranging from 0.80 to 0.95. It became smaller mainly in instances of decreased response amplitude on account of unfavourable parameters. For burst modulators of changing frequency, r varied around 0.66-0.86. When segments of speech signal served as the modulators, significant correlation (r around 0.50 ) also existed, indicating the validity of the timing mode of information encoding for speech sound at the cochlear nerve level. Some theoretical and technical points in studying the timing mechanism of audition is discussed.
