The temperature-Altitude Test System(TATS)supplies various testing environments.The traditional PID method controls the temperature in TATS Temperature-Pressure Cabin(TPC)over a long adjusting time and with a large ov...The temperature-Altitude Test System(TATS)supplies various testing environments.The traditional PID method controls the temperature in TATS Temperature-Pressure Cabin(TPC)over a long adjusting time and with a large overshoot.In order to solve this problem simply,a temperature control strategy with temperature difference corresponding factors is presented through a dynamic analysis and modeling of TPC temperature change.The TPC temperature descending process is simulated,and the results show that this control strategy can allot the proportion of PID heating controller and PID cooling controller in the whole control process and TPC temperature can be controlled at a set point quickly and effectively.展开更多
Members of the British Textile Machinery Association(BTMA)can look back on 2025 as a year marked by notable technological advances and continued progress in global trade,despite an uncertain and volatile market.“Our ...Members of the British Textile Machinery Association(BTMA)can look back on 2025 as a year marked by notable technological advances and continued progress in global trade,despite an uncertain and volatile market.“Our members have been very active over the past 12 months and this has resulted in new technologies for the production of technical fibres and fabrics,the introduction of AI and machine learning into process control systems and significant advances in materials testing,”says BTMA CEO Jason Kent.“There’s real excitement about what can be achieved in 2026 as we look ahead to upcoming exhibitions such as JEC Composites in Paris in March and Techtextil in Frankfurt in April.”展开更多
The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we condu...The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we conducted a series of triaxial tests on calcareous sand with varying Dri and stress paths,examining particle breakage and critical state behavior.Key findingsinclude:(1)At a constant stress ratio(η),B follows a hyperbolic relationship with mean effective stress(p'),and for a given p',B increases proportionally withη;(2)The critical state line(CSL)moves downward with increasing Dri,whereas the critical state friction angle(φcs)decreases with increasing B.Based on these findings,we propose a unifiedbreakage evolution model to quantify particle breakage in calcareous sand under various loading conditions.Integrating this model with the Normal Consolidation Line(NCL)and CSL equations,we successfully simulate the steepening of NCL and CSL slopes as B increases with the onset of particle breakage.Furthermore,we quantitatively evaluate the effect of B onφcs.Finally,within the framework of Critical State Soil Mechanics and Hypoplasticity theory,we develop a hypoplastic model incorporating B and Dri.The model is validated through strong agreement with experimental results across various initial relative densities,stress paths and drainage conditions.展开更多
High geo-stress and high temperature in deep rock engineering increase the possibility of engineering and geological disasters in discontinuous rocks.However,the influence of thermomechanical coupling on the shear beh...High geo-stress and high temperature in deep rock engineering increase the possibility of engineering and geological disasters in discontinuous rocks.However,the influence of thermomechanical coupling on the shear behavior and damage evolution of prefractured granite remains immature.In this context,true triaxial laboratory tests and discrete element method simulations under different confining pressures(σ3=3 MPa,σ2=4 MPa,andσ3=80 MPa,σ2=100 MPa)and temperatures(25℃-500℃)were carried out on rough granite fractures with two different orientations.Results indicate that high temperature and high confining pressure increase the peak strength of the prefractured specimen,leading to more microcracks in the host rock and more gouges between the surfaces.Thermal strengthening at low temperatures(<300℃)and residual stick-slip only occur under a greater confining pressure for prefractured specimens.High confining pressure suppresses generation of the thermal microcracks in the heating stage.Cracks first initiate in the asperities on the fracture surfaces,and then propagate into the rock matrix during the mechanical loading stage.In addition,prefractured granite with a larger fracture angle is characterized by smaller peak and residual strength,faster residual slip,fewer new cracks on the specimen surface,and a more pronounced thermal strengthening effect on peak strength.The slip tendency analysis indicates that a higher maximum principal stress(s1)and a large fracture angle(45°-75°)generally result in a higher potential for fracture slip or activation.This study will contribute to a better understanding of the fracture shear mechanism under true triaxial thermomechanical coupling conditions and provides new insights into the stability evaluation of deep dynamic geological hazards.展开更多
Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining...Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining technique that overcomes these issues by using impact to create strong bonds without melting the substrate materials.This study investigates the weldability of aluminum alloy Al-5754 with Al-7075 and MARS 380 steel,used in armouring solutions of defense systems,by the use of MPW.In this work,weldability windows are investigated by varying standoff distances between the coating material and its substrate(0.25-4.5 mm)and discharge energies(5-13 kJ)with both O-shape and U-shape inductors.Mechanical strength of the welded joints were assessed through single lap shear tests,identifying optimal welding parameters.Then,the velocity profiles of the flyer plates were measured using heterodyne velocimetry to understand the dynamics of the impact.Then,substructures assembled with the optimal welding conditions were subjected to ballistic testing using 7.62 mm×51 mm NATO and 9 mm×19 mm Parabellum munitions to evaluate the resilience of the welds under ballistic impact.The outcomes demonstrate that MPW effectively joins Al-5754 with both Al-7075 and MARS 380,producing robust welds capable of withstanding ballistic impacts under certain conditions.This research advances the application of MPW in lightweight ballistic protection of defense systems,contributing to the development of more resilient and lighter protective structures.展开更多
It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and er...It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.展开更多
Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detecti...Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 10^(1.7)TCID_(50)/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015).展开更多
Hydraulic stimulation technology is widely employed to enhance the permeability of geothermal reservoirs.Nevertheless,accurately predicting hydraulic fracture propagation in complex geological conditions remains chall...Hydraulic stimulation technology is widely employed to enhance the permeability of geothermal reservoirs.Nevertheless,accurately predicting hydraulic fracture propagation in complex geological conditions remains challenging,thereby hindering the effective utilization of existing natural fractures.In this study,a phase field model was developed utilizing the finite element method to examine the influence of fluid presence,stress conditions,and natural fractures on the initiation and propagation of hydraulic fractures.The model employs Biot's poroelasticity theory to establish the coupling between the displacement field and the fluid field,while the phase field theory is applied to simulate fracture behavior.The results show that whenσ_(x0)/σ_(y0)<3 or qf<20 kg/(m^(3)·s),the presence of natural fractures can alter the original propagation direction of hydraulic fractures.Conversely,in the absence of these conditions,the propagation path of natural fractures is predominantly influenced by the initial stress field.Furthermore,based on the analysis of breakdown pressure and damage area,the optimal intersection angle between natural fractures and hydraulic fractures is determined to range from 45°to 60°.Finally,once a dominant channel forms,initiating and propagating hydraulic fractures in other directions becomes increasingly difficult,even in highly fractured areas.This method tackles the challenges of initiating and propagating hydraulic fractures in complex geological conditions,providing a theoretical basis for optimizing Enhanced Geothermal System(EGS)projects.展开更多
NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a nec...NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a necessary option for the detection of existing exhaust emission standards. At present, there is limited and scattered information on knowledge and test methods of NOx sensors, the research of NOx sensors has become a challenging research topic at home and abroad. Based on these requirements, the article systematically integrates the knowledge of principle and testing methods. First of all, through introducing functional description of NOx sensors and the basic principle of NOx sensors, the relevant scholars can have an overall understanding of the product and master the operation mode of products. Secondly, the current status of performance test bench and methods of NOx sensors were described, which can contribute to having a clear understanding of the development process. After that, a new structure of NOx sensors test bench was purposed, which contains six major units including standard gas source, gas mixing unit, analyzer measurement unit, sensor measurement unit, data processing and display unit, exhaust gas treatment unit. And the test bench was validated. The experimental results show that the test bench has the advantages of high-repeatability, high reliability and low cost. And it can realize automatic detection of multiple target values, which is worthy further promotion. Thereby, the article can contribute to the development of its technology indirectly.展开更多
Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely int...Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely integrated into routine clinical diagnostics of gastric cancer to guide personalized treatment.Human epidermal growth factor receptor 2(HER2)was the first molecular biomarker to be used in gastric cancer with trastuzumab being the first approved targeted therapy for HER2-positive gastric cancer.Programmed death-ligand 1 positivity and microsatellite instability can guide the use of immunotherapies,such as pembrolizumab and nivolumab.More recently,zolbetuximab has been approved for patients with claudin 18.2-positive diseases in some countries.More targeted therapies,including savolitinib for MET-positive patients,are currently under clinical investigation.However,the clinical application of these diagnostic approaches could be hampered by many existing challenges,including invasive and costly sampling methods,variability in immunohistochemistry interpretation,high costs and long turnaround times for next-generation sequencing,the absence of standardized and clinically validated diagnostic cut-off values for some biomarkers,and tumor heterogeneity.Novel testing and analysis techniques,such as artificial intelligence-assisted image analysis and multiplex immunohistochemistry,and emerging therapeutic strategies,including combination therapies that integrate immune checkpoint inhibitors with targeted therapies,offer potential solutions to some of these challenges.This article reviews recent progress in gastric cancer testing,outlines current challenges,and explores future directions for biomarker testing and targeted therapy for gastric cancer.展开更多
The rapid progress in the construction of heavy-haul and high-speed railways has led to a surge in rail defects and unforeseen failures.Addressing this issue necessitates the implementation of more sophisticated rail ...The rapid progress in the construction of heavy-haul and high-speed railways has led to a surge in rail defects and unforeseen failures.Addressing this issue necessitates the implementation of more sophisticated rail inspection methods,specifically involving real-time,precise detection,and assessment of rail defects.Current applications fail to address the evolving requirements,prompting the need for advancements.This paper provides a summary of various types of rail defects and outlines both traditional and innovative non-destructive inspection techniques,examining their fundamental features,benefits,drawbacks,and practical suitability for railway track inspection.It also explores potential enhancements to equipment and software.The comprehensive review draws upon pertinent international research and review papers.Furthermore,the paper introduces a fusion of inspection methods aimed at enhancing the overall reliability of defect detection.展开更多
Accurate macaque paternity identification is of great significance in various fields,yet relevant research remains scarce.Our study aimed to screen effective microsatellite markers for macaque paternity testing.Initia...Accurate macaque paternity identification is of great significance in various fields,yet relevant research remains scarce.Our study aimed to screen effective microsatellite markers for macaque paternity testing.Initially,300 microsatellite markers were randomly selected from the genome of the crab-eating macaque(Macaca fascicularis),and 12 highly polymorphic tetra-nucleotide repeat markers were identified.These markers'genetic parameters and exclusion probabilities in both crab-eating and rhesus macaque(Macaca mulatta)populations were calculated,meeting the paternity testing requirements for both species.To validate the markers,16 crab-eating macaque and 10 rhesus macaque families with known pedigrees were randomly chosen for testing.The genotypes of the 12 markers in the macaques'offspring could be traced back to their parents,confirming the accuracy and applicability of the marker combination for paternity identification in both macaque species.展开更多
The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analys...The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.展开更多
Radio frequency(RF)cavities for advanced storage rings,also known as diffraction-limited storage rings,are under development.To this end,a competitive and promising approach involves normal-conducting continuous wave ...Radio frequency(RF)cavities for advanced storage rings,also known as diffraction-limited storage rings,are under development.To this end,a competitive and promising approach involves normal-conducting continuous wave technology.The design and preliminary test of a 499.654 MHz RF cavity for the Wuhan Advanced Light Source(WALS)based on specific beam parameters were conducted at the SSRF.Multi-objective evolutionary algorithms have been utilized to optimize RF properties,such as the power loss and power density,resulting in better performance in the continuous wave mode.Further improvements were made to suppress multipacting effects in the working area.To operate stably with the beam,higher-order mode dampers were applied to better address the coupling bunch instability than in previous designs,along with thermal analysis to achieve the desired RF performance.Comprehensive simulation studies demonstrated the stable operation of the RF cavity at the defined beam parameters in the WALS design.A prototype RF cavity was then developed,and the RF performance results in a low-power test showed good agreement with the design and simulation,exhibiting readiness for high-power experiments and operation.展开更多
The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements.However,the hydromechanical coupling effect has not been considered in current constitutive models.A macro-micro analy...The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements.However,the hydromechanical coupling effect has not been considered in current constitutive models.A macro-micro analysis scheme is proposed in this paper to investigate the soil deformation behavior under the coupling of stress and drying-wetting cycles.A new device is developed based on CT(computerized tomography)workstation to apply certain normal and shear stresses on a soil specimen during drying-wetting cycles.A series of tests are conducted on a type of loess with various coupling of stress paths and drying-wetting cycles.At macroscopic level,stress sensor and laser sensor are used to acquire stress and strain,respectively.The shear and volumetric strain increase during the first few drying-wetting cycles and then become stable.The increase of the shear stress level or confining pressure would cause higher increase rate and the value of shear strain in the process of drying-wetting cycles.At microscopic level,the grayscale value(GSV)of CT scanning image is characterized as the proportion of soil particles to voids.A fabric state parameter is proposed to characterize soil microstructures under the influence of stress and drying-wetting cycle.Test results indicate that the macroand micro-responses show high consistence and relevance.The stress and drying-wetting cycles would both induce collapse of the soil microstructure,which dominants degradation of the soil mechanical properties.The evolution of the macro-mechanical property of soil exhibits a positive linear relationship with the micro-evolution of the fabric state parameter.展开更多
With the depletion of fossil fuels and increasing environmental concerns,the development of renewable energy,such as wave energy,has become a critical component of global energy strategies.However,challenges persist i...With the depletion of fossil fuels and increasing environmental concerns,the development of renewable energy,such as wave energy,has become a critical component of global energy strategies.However,challenges persist in the field testing methodologies for wave energy converters(WECs).In this paper,a numerical wave field of the Dawanshan Island Sea Area in Zhuhai City is constructed based on the MIKE21 SW wave model and by using an NCEP wind field driving model.In conjunction with the IEC-62600-100 standard,by taking site testing of the“Wanshan”wave energy converter on which a sea trial has been conducted in Dawanshan Island of Zhuhai city as an example,research on-site testing method for a wave energy converter has been carried out.The wave measurement position for the“Wanshan”converter was determined by combining statistically analyzed field data with a validated numerical wave model.By comparing a valid wave height at the position where a wave rider is located with a valid wave height at the position where the“Wanshan”wave energy converter is situated,the correlation coefficient between simulation and observed data reached 0.90,with a root-mean-square error of 0.19.The representativeness of wave measurement data during site testing is verified and can be used as a basis for calculating the input energy of the“Wanshan”wave energy converter.展开更多
文摘The temperature-Altitude Test System(TATS)supplies various testing environments.The traditional PID method controls the temperature in TATS Temperature-Pressure Cabin(TPC)over a long adjusting time and with a large overshoot.In order to solve this problem simply,a temperature control strategy with temperature difference corresponding factors is presented through a dynamic analysis and modeling of TPC temperature change.The TPC temperature descending process is simulated,and the results show that this control strategy can allot the proportion of PID heating controller and PID cooling controller in the whole control process and TPC temperature can be controlled at a set point quickly and effectively.
文摘Members of the British Textile Machinery Association(BTMA)can look back on 2025 as a year marked by notable technological advances and continued progress in global trade,despite an uncertain and volatile market.“Our members have been very active over the past 12 months and this has resulted in new technologies for the production of technical fibres and fabrics,the introduction of AI and machine learning into process control systems and significant advances in materials testing,”says BTMA CEO Jason Kent.“There’s real excitement about what can be achieved in 2026 as we look ahead to upcoming exhibitions such as JEC Composites in Paris in March and Techtextil in Frankfurt in April.”
基金support to this study from the National Natural Science Foundation of China,NSFC(Grant No.52278367)The Belt and Road Special Foundation of the National Key Laboratory ofWater Disaster Prevention(Grant No.2024nkms08).
文摘The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we conducted a series of triaxial tests on calcareous sand with varying Dri and stress paths,examining particle breakage and critical state behavior.Key findingsinclude:(1)At a constant stress ratio(η),B follows a hyperbolic relationship with mean effective stress(p'),and for a given p',B increases proportionally withη;(2)The critical state line(CSL)moves downward with increasing Dri,whereas the critical state friction angle(φcs)decreases with increasing B.Based on these findings,we propose a unifiedbreakage evolution model to quantify particle breakage in calcareous sand under various loading conditions.Integrating this model with the Normal Consolidation Line(NCL)and CSL equations,we successfully simulate the steepening of NCL and CSL slopes as B increases with the onset of particle breakage.Furthermore,we quantitatively evaluate the effect of B onφcs.Finally,within the framework of Critical State Soil Mechanics and Hypoplasticity theory,we develop a hypoplastic model incorporating B and Dri.The model is validated through strong agreement with experimental results across various initial relative densities,stress paths and drainage conditions.
基金support from the National Key Research and Development Program of China(Grant No.2022YFE0137200)supported by the Taishan Scholars Program and Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering Safety(Grant No.SKLGME023003).
文摘High geo-stress and high temperature in deep rock engineering increase the possibility of engineering and geological disasters in discontinuous rocks.However,the influence of thermomechanical coupling on the shear behavior and damage evolution of prefractured granite remains immature.In this context,true triaxial laboratory tests and discrete element method simulations under different confining pressures(σ3=3 MPa,σ2=4 MPa,andσ3=80 MPa,σ2=100 MPa)and temperatures(25℃-500℃)were carried out on rough granite fractures with two different orientations.Results indicate that high temperature and high confining pressure increase the peak strength of the prefractured specimen,leading to more microcracks in the host rock and more gouges between the surfaces.Thermal strengthening at low temperatures(<300℃)and residual stick-slip only occur under a greater confining pressure for prefractured specimens.High confining pressure suppresses generation of the thermal microcracks in the heating stage.Cracks first initiate in the asperities on the fracture surfaces,and then propagate into the rock matrix during the mechanical loading stage.In addition,prefractured granite with a larger fracture angle is characterized by smaller peak and residual strength,faster residual slip,fewer new cracks on the specimen surface,and a more pronounced thermal strengthening effect on peak strength.The slip tendency analysis indicates that a higher maximum principal stress(s1)and a large fracture angle(45°-75°)generally result in a higher potential for fracture slip or activation.This study will contribute to a better understanding of the fracture shear mechanism under true triaxial thermomechanical coupling conditions and provides new insights into the stability evaluation of deep dynamic geological hazards.
基金funded on the one hand by Agence de l'Innovation de Défense(AID)grant reference number 2021650044on the other hand by Ecole Centrale de Nantes。
文摘Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining technique that overcomes these issues by using impact to create strong bonds without melting the substrate materials.This study investigates the weldability of aluminum alloy Al-5754 with Al-7075 and MARS 380 steel,used in armouring solutions of defense systems,by the use of MPW.In this work,weldability windows are investigated by varying standoff distances between the coating material and its substrate(0.25-4.5 mm)and discharge energies(5-13 kJ)with both O-shape and U-shape inductors.Mechanical strength of the welded joints were assessed through single lap shear tests,identifying optimal welding parameters.Then,the velocity profiles of the flyer plates were measured using heterodyne velocimetry to understand the dynamics of the impact.Then,substructures assembled with the optimal welding conditions were subjected to ballistic testing using 7.62 mm×51 mm NATO and 9 mm×19 mm Parabellum munitions to evaluate the resilience of the welds under ballistic impact.The outcomes demonstrate that MPW effectively joins Al-5754 with both Al-7075 and MARS 380,producing robust welds capable of withstanding ballistic impacts under certain conditions.This research advances the application of MPW in lightweight ballistic protection of defense systems,contributing to the development of more resilient and lighter protective structures.
文摘It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.
基金financially supported by the National Key Research and Development Program of China(2021YFF0703600)。
文摘Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 10^(1.7)TCID_(50)/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015).
基金supported by the National Key Research and Development Program(2021YFB150740401)National Natural Science Foundation of China(42202336)the CAS Pioneer Hundred Talents Program in China(Y826031C01)。
文摘Hydraulic stimulation technology is widely employed to enhance the permeability of geothermal reservoirs.Nevertheless,accurately predicting hydraulic fracture propagation in complex geological conditions remains challenging,thereby hindering the effective utilization of existing natural fractures.In this study,a phase field model was developed utilizing the finite element method to examine the influence of fluid presence,stress conditions,and natural fractures on the initiation and propagation of hydraulic fractures.The model employs Biot's poroelasticity theory to establish the coupling between the displacement field and the fluid field,while the phase field theory is applied to simulate fracture behavior.The results show that whenσ_(x0)/σ_(y0)<3 or qf<20 kg/(m^(3)·s),the presence of natural fractures can alter the original propagation direction of hydraulic fractures.Conversely,in the absence of these conditions,the propagation path of natural fractures is predominantly influenced by the initial stress field.Furthermore,based on the analysis of breakdown pressure and damage area,the optimal intersection angle between natural fractures and hydraulic fractures is determined to range from 45°to 60°.Finally,once a dominant channel forms,initiating and propagating hydraulic fractures in other directions becomes increasingly difficult,even in highly fractured areas.This method tackles the challenges of initiating and propagating hydraulic fractures in complex geological conditions,providing a theoretical basis for optimizing Enhanced Geothermal System(EGS)projects.
文摘NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a necessary option for the detection of existing exhaust emission standards. At present, there is limited and scattered information on knowledge and test methods of NOx sensors, the research of NOx sensors has become a challenging research topic at home and abroad. Based on these requirements, the article systematically integrates the knowledge of principle and testing methods. First of all, through introducing functional description of NOx sensors and the basic principle of NOx sensors, the relevant scholars can have an overall understanding of the product and master the operation mode of products. Secondly, the current status of performance test bench and methods of NOx sensors were described, which can contribute to having a clear understanding of the development process. After that, a new structure of NOx sensors test bench was purposed, which contains six major units including standard gas source, gas mixing unit, analyzer measurement unit, sensor measurement unit, data processing and display unit, exhaust gas treatment unit. And the test bench was validated. The experimental results show that the test bench has the advantages of high-repeatability, high reliability and low cost. And it can realize automatic detection of multiple target values, which is worthy further promotion. Thereby, the article can contribute to the development of its technology indirectly.
基金support by grants from Capital’s Funds for Health Improvement and Research(Grant No.2024-2-1024)Beijing Natural Science Foundation(Grant No.7232018).
文摘Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely integrated into routine clinical diagnostics of gastric cancer to guide personalized treatment.Human epidermal growth factor receptor 2(HER2)was the first molecular biomarker to be used in gastric cancer with trastuzumab being the first approved targeted therapy for HER2-positive gastric cancer.Programmed death-ligand 1 positivity and microsatellite instability can guide the use of immunotherapies,such as pembrolizumab and nivolumab.More recently,zolbetuximab has been approved for patients with claudin 18.2-positive diseases in some countries.More targeted therapies,including savolitinib for MET-positive patients,are currently under clinical investigation.However,the clinical application of these diagnostic approaches could be hampered by many existing challenges,including invasive and costly sampling methods,variability in immunohistochemistry interpretation,high costs and long turnaround times for next-generation sequencing,the absence of standardized and clinically validated diagnostic cut-off values for some biomarkers,and tumor heterogeneity.Novel testing and analysis techniques,such as artificial intelligence-assisted image analysis and multiplex immunohistochemistry,and emerging therapeutic strategies,including combination therapies that integrate immune checkpoint inhibitors with targeted therapies,offer potential solutions to some of these challenges.This article reviews recent progress in gastric cancer testing,outlines current challenges,and explores future directions for biomarker testing and targeted therapy for gastric cancer.
文摘The rapid progress in the construction of heavy-haul and high-speed railways has led to a surge in rail defects and unforeseen failures.Addressing this issue necessitates the implementation of more sophisticated rail inspection methods,specifically involving real-time,precise detection,and assessment of rail defects.Current applications fail to address the evolving requirements,prompting the need for advancements.This paper provides a summary of various types of rail defects and outlines both traditional and innovative non-destructive inspection techniques,examining their fundamental features,benefits,drawbacks,and practical suitability for railway track inspection.It also explores potential enhancements to equipment and software.The comprehensive review draws upon pertinent international research and review papers.Furthermore,the paper introduces a fusion of inspection methods aimed at enhancing the overall reliability of defect detection.
基金Nanhu Laboratory Self-Initiated Research Project,Grant/Award Number:NSS2023A00001-2。
文摘Accurate macaque paternity identification is of great significance in various fields,yet relevant research remains scarce.Our study aimed to screen effective microsatellite markers for macaque paternity testing.Initially,300 microsatellite markers were randomly selected from the genome of the crab-eating macaque(Macaca fascicularis),and 12 highly polymorphic tetra-nucleotide repeat markers were identified.These markers'genetic parameters and exclusion probabilities in both crab-eating and rhesus macaque(Macaca mulatta)populations were calculated,meeting the paternity testing requirements for both species.To validate the markers,16 crab-eating macaque and 10 rhesus macaque families with known pedigrees were randomly chosen for testing.The genotypes of the 12 markers in the macaques'offspring could be traced back to their parents,confirming the accuracy and applicability of the marker combination for paternity identification in both macaque species.
文摘The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.
基金supported by National Natural Science Foundation of China(Nos.12222513,12105345,12175292,and No.12405178)。
文摘Radio frequency(RF)cavities for advanced storage rings,also known as diffraction-limited storage rings,are under development.To this end,a competitive and promising approach involves normal-conducting continuous wave technology.The design and preliminary test of a 499.654 MHz RF cavity for the Wuhan Advanced Light Source(WALS)based on specific beam parameters were conducted at the SSRF.Multi-objective evolutionary algorithms have been utilized to optimize RF properties,such as the power loss and power density,resulting in better performance in the continuous wave mode.Further improvements were made to suppress multipacting effects in the working area.To operate stably with the beam,higher-order mode dampers were applied to better address the coupling bunch instability than in previous designs,along with thermal analysis to achieve the desired RF performance.Comprehensive simulation studies demonstrated the stable operation of the RF cavity at the defined beam parameters in the WALS design.A prototype RF cavity was then developed,and the RF performance results in a low-power test showed good agreement with the design and simulation,exhibiting readiness for high-power experiments and operation.
基金funded by National Key R&D Program of China(Grant No.2023YFC3007001)Beijing Natural Science Foundation(Grant No.8244053)China Postdoctoral Science Foundation(Grant No.2024M754065).
文摘The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements.However,the hydromechanical coupling effect has not been considered in current constitutive models.A macro-micro analysis scheme is proposed in this paper to investigate the soil deformation behavior under the coupling of stress and drying-wetting cycles.A new device is developed based on CT(computerized tomography)workstation to apply certain normal and shear stresses on a soil specimen during drying-wetting cycles.A series of tests are conducted on a type of loess with various coupling of stress paths and drying-wetting cycles.At macroscopic level,stress sensor and laser sensor are used to acquire stress and strain,respectively.The shear and volumetric strain increase during the first few drying-wetting cycles and then become stable.The increase of the shear stress level or confining pressure would cause higher increase rate and the value of shear strain in the process of drying-wetting cycles.At microscopic level,the grayscale value(GSV)of CT scanning image is characterized as the proportion of soil particles to voids.A fabric state parameter is proposed to characterize soil microstructures under the influence of stress and drying-wetting cycle.Test results indicate that the macroand micro-responses show high consistence and relevance.The stress and drying-wetting cycles would both induce collapse of the soil microstructure,which dominants degradation of the soil mechanical properties.The evolution of the macro-mechanical property of soil exhibits a positive linear relationship with the micro-evolution of the fabric state parameter.
基金supported by the“National Ocean Technology Center Innovation Fund”under Project No.N3220Z002,led by Ning Jia.The official website of the National Ocean Technology Center is accessible at:http://www.notcsoa.org.cn/.
文摘With the depletion of fossil fuels and increasing environmental concerns,the development of renewable energy,such as wave energy,has become a critical component of global energy strategies.However,challenges persist in the field testing methodologies for wave energy converters(WECs).In this paper,a numerical wave field of the Dawanshan Island Sea Area in Zhuhai City is constructed based on the MIKE21 SW wave model and by using an NCEP wind field driving model.In conjunction with the IEC-62600-100 standard,by taking site testing of the“Wanshan”wave energy converter on which a sea trial has been conducted in Dawanshan Island of Zhuhai city as an example,research on-site testing method for a wave energy converter has been carried out.The wave measurement position for the“Wanshan”converter was determined by combining statistically analyzed field data with a validated numerical wave model.By comparing a valid wave height at the position where a wave rider is located with a valid wave height at the position where the“Wanshan”wave energy converter is situated,the correlation coefficient between simulation and observed data reached 0.90,with a root-mean-square error of 0.19.The representativeness of wave measurement data during site testing is verified and can be used as a basis for calculating the input energy of the“Wanshan”wave energy converter.
