1 Results Several methods have been elaborated in this laboratory allowing preparation of macromolecules with phosphodiester bonds,and having sequence of atoms similar as in the chains of biomacromolecules - nucleic o...1 Results Several methods have been elaborated in this laboratory allowing preparation of macromolecules with phosphodiester bonds,and having sequence of atoms similar as in the chains of biomacromolecules - nucleic or teichoic acids (TA),namely:-(C)n-O-PO-,where n=2 (for teichoic acids) or 3.These methods,to be discussed in the lecture,are based on the ring-opening polymerization,transesterification,and recently elaborated direct addition of phosphoric acid to diepoxides.For the first time an attempt h...展开更多
Staphylococcus aureus is a major public health threat,largely due to its remarkable capacity to develop antimicro-bial resistance.Zhang et al.recently demonstrated a highly innovative approach to eradicate chronic met...Staphylococcus aureus is a major public health threat,largely due to its remarkable capacity to develop antimicro-bial resistance.Zhang et al.recently demonstrated a highly innovative approach to eradicate chronic methicillin-resistant S.aureus infections by inducing bacterial calcification with antibody-polysialic acid conjugates targeting wall teichoic acids,while simultaneously modulating host immune responses via enhanced calprotectin expres-sion and macrophage activation.Despite limitations,this strategy represents a promising and unconventional therapy to combat resistant S.aureus infections.展开更多
文摘1 Results Several methods have been elaborated in this laboratory allowing preparation of macromolecules with phosphodiester bonds,and having sequence of atoms similar as in the chains of biomacromolecules - nucleic or teichoic acids (TA),namely:-(C)n-O-PO-,where n=2 (for teichoic acids) or 3.These methods,to be discussed in the lecture,are based on the ring-opening polymerization,transesterification,and recently elaborated direct addition of phosphoric acid to diepoxides.For the first time an attempt h...
基金financially supported by Independent Research Fund,Denmark(2035-00110B)the Novo Nordisk Foundation,Denmark(NNF22OC0077593)awarded to Hanne Ingmer.
文摘Staphylococcus aureus is a major public health threat,largely due to its remarkable capacity to develop antimicro-bial resistance.Zhang et al.recently demonstrated a highly innovative approach to eradicate chronic methicillin-resistant S.aureus infections by inducing bacterial calcification with antibody-polysialic acid conjugates targeting wall teichoic acids,while simultaneously modulating host immune responses via enhanced calprotectin expres-sion and macrophage activation.Despite limitations,this strategy represents a promising and unconventional therapy to combat resistant S.aureus infections.
