Famatinite(Cu_(3)SbS_(4),p-type)and chalcopyrite(CuFeS_(2),n-type)are well-recognized sustainable minerals with good intermediate-temperature thermoelectric performance.In this article,we utilize the inherent thermoel...Famatinite(Cu_(3)SbS_(4),p-type)and chalcopyrite(CuFeS_(2),n-type)are well-recognized sustainable minerals with good intermediate-temperature thermoelectric performance.In this article,we utilize the inherent thermoelectric properties of these compounds to demonstrate real-time operational performance as a coupled thermoelectric generator(TEG)for waste heat recovery applications.First,we synthesized the polycrystalline and nano-grained famatinite and chalcopyrite materials with high purity through a sustainable synthesis process of mechanical alloying followed by hot pressing.A maximum output power of~5 mW by the developed TEG was demonstrated while harvesting from a waste heat source of 723 K.Furthermore,the TEG performance via computational simulations for varied thermal gradients was validated.Our results highlight the sustainable development of thermoelectric power generator from earth-abundant minerals having strong stability and capacity to convert waste heat to electricity,which opens a new direction for fabricating a low-cost TEG for intermediate-temperature applications.展开更多
Background:Thromboelastography(TEG)is a widely utilized clinical testing method for real-time monitoring of platelet function and the thrombosis process.Lipid metab-olism disorders are crucial risk factors for thrombo...Background:Thromboelastography(TEG)is a widely utilized clinical testing method for real-time monitoring of platelet function and the thrombosis process.Lipid metab-olism disorders are crucial risk factors for thrombosis.The lipid metabolism charac-teristics of hamsters resemble those of humans more closely than mice and rats,and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to plasma lipid mechanisms.Whole blood samples from golden Syrian hamsters and healthy humans were obtained following standard clinical pro-cedures.TEG was employed to evaluate coagulation factor function,fibrinogen(Fib)function,platelet function,and the fibrinolytic system.Methods:The whole blood from hamster or healthy human was isolated following the clinical procedure,and TEG was employed to evaluate the coagulation factor func-tion,Fib function,platelet function,and fibrinolytic system.Coagulation analysis used ACLTOP750 automatic coagulation analysis pipeline.Blood routine testing used XN-2000 automatic blood analyzer.Results:TEG parameters revealed that hamsters exhibited stronger coagulation fac-tor function than humans(reaction time[R],p=0.0117),with stronger Fib function(alpha angle,p<0.0001;K-time[K],p<0.0001).Platelet function did not differ signifi-cantly(maximum amplitude[MA],p=0.077).Hamsters displayed higher coagulation status than humans(coagulation index[CI],p=0.0023),and the rate of blood clot dissolution in hamsters differed from that in humans(percentage lysis 30 min after MA,p=0.02).Coagulation analysis parameters indicated that prothrombin time(PT)and activated partial thromboplastin time(APTT)were faster in hamsters than in hu-mans(PT,p=0.0014;APTT,p=0.03),whereas the Fib content was significantly lower in hamsters than in humans(p<0.0001).No significant difference was observed in thrombin time(p=0.1949).Conclusions:In summary,TEG could be used to evaluate thrombosis and bleeding parameters in whole blood samples from hamsters.The platelet function of hamsters closely resembled that of humans,whereas their coagulation function was signifi-cantly stronger.展开更多
基金supported by the Research Grants Council of Hong Kong Special Administrative Region under the Faculty Development Scheme Project no:UGC/FDS16/E01/23.
文摘Famatinite(Cu_(3)SbS_(4),p-type)and chalcopyrite(CuFeS_(2),n-type)are well-recognized sustainable minerals with good intermediate-temperature thermoelectric performance.In this article,we utilize the inherent thermoelectric properties of these compounds to demonstrate real-time operational performance as a coupled thermoelectric generator(TEG)for waste heat recovery applications.First,we synthesized the polycrystalline and nano-grained famatinite and chalcopyrite materials with high purity through a sustainable synthesis process of mechanical alloying followed by hot pressing.A maximum output power of~5 mW by the developed TEG was demonstrated while harvesting from a waste heat source of 723 K.Furthermore,the TEG performance via computational simulations for varied thermal gradients was validated.Our results highlight the sustainable development of thermoelectric power generator from earth-abundant minerals having strong stability and capacity to convert waste heat to electricity,which opens a new direction for fabricating a low-cost TEG for intermediate-temperature applications.
基金Student Research Training Program,Grant/Award Number:2022104391282Shandong Natural Science Foundation,Grant/Award Number:ZR2019MH021National Natural Science Foundation of China,Grant/Award Number:81970385。
文摘Background:Thromboelastography(TEG)is a widely utilized clinical testing method for real-time monitoring of platelet function and the thrombosis process.Lipid metab-olism disorders are crucial risk factors for thrombosis.The lipid metabolism charac-teristics of hamsters resemble those of humans more closely than mice and rats,and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to plasma lipid mechanisms.Whole blood samples from golden Syrian hamsters and healthy humans were obtained following standard clinical pro-cedures.TEG was employed to evaluate coagulation factor function,fibrinogen(Fib)function,platelet function,and the fibrinolytic system.Methods:The whole blood from hamster or healthy human was isolated following the clinical procedure,and TEG was employed to evaluate the coagulation factor func-tion,Fib function,platelet function,and fibrinolytic system.Coagulation analysis used ACLTOP750 automatic coagulation analysis pipeline.Blood routine testing used XN-2000 automatic blood analyzer.Results:TEG parameters revealed that hamsters exhibited stronger coagulation fac-tor function than humans(reaction time[R],p=0.0117),with stronger Fib function(alpha angle,p<0.0001;K-time[K],p<0.0001).Platelet function did not differ signifi-cantly(maximum amplitude[MA],p=0.077).Hamsters displayed higher coagulation status than humans(coagulation index[CI],p=0.0023),and the rate of blood clot dissolution in hamsters differed from that in humans(percentage lysis 30 min after MA,p=0.02).Coagulation analysis parameters indicated that prothrombin time(PT)and activated partial thromboplastin time(APTT)were faster in hamsters than in hu-mans(PT,p=0.0014;APTT,p=0.03),whereas the Fib content was significantly lower in hamsters than in humans(p<0.0001).No significant difference was observed in thrombin time(p=0.1949).Conclusions:In summary,TEG could be used to evaluate thrombosis and bleeding parameters in whole blood samples from hamsters.The platelet function of hamsters closely resembled that of humans,whereas their coagulation function was signifi-cantly stronger.
