Objective and Impact Statement:A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking.Here,we report a novel multifunctional ablative gastrointestinal imaging capsul...Objective and Impact Statement:A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking.Here,we report a novel multifunctional ablative gastrointestinal imaging capsule(MAGIC)technology platform to address this clinical need.The MAGIC technology could also facilitate the clinical translation and adoption of the tethered capsule endomicroscopy(TCE)technology.Introduction:Recently developed optical coherence tomography(OCT)TCE technologies have shown a promising potential for surveillance of Barrett’s esophagus and esophageal cancer in awake patients without the need for sedation.However,it remains challenging with the current TCE technology for detecting early lesions and clinical adoption due to its suboptimal resolution,imaging contrast,and lack of visual guidance during imaging.Methods:Our technology reported here integrates dual-wavelength OCT imaging(operating at 800 and 1300 nm),an ultracompact endoscope camera,and an ablation laser,aiming to enable comprehensive surveillance,guidance,and potential ablative treatment of the esophagus.Results:The MAGIC has been successfully developed with its multimodality imaging and ablation capabilities demonstrated by imaging swine esophagus ex vivo and in vivo.The 800-nm OCT imaging offers exceptional resolution and contrast for the superficial layers,well suited for detecting subtle changes associated with early neoplasia.The 1300-nm OCT imaging provides deeper penetration,essential for assessing lesion invasion.The built-in miniature camera affords a conventional endoscopic view for assisting capsule deployment and laser ablation.Conclusion:By offering complementary and clinically viable functions in a single device,the reported technology represents an effective solution for endoscopic screening,diagnosis,and potential ablation treatment of the esophagus of a patient in an office setting.展开更多
In recent years, China's social and economic development has advanced by leaps and bounds, and water conservancy has also been greatly developed. Under the current situation, the scale of water conservancy and hyd...In recent years, China's social and economic development has advanced by leaps and bounds, and water conservancy has also been greatly developed. Under the current situation, the scale of water conservancy and hydropower projects in China is constantly expanding, and it is playing an increasingly important role in agriculture, shipping and hydropower generation. Slope construction is an important part of water conservancy and hydropower projects, and the quality of slope construction directly affects the overall construction level of water conservancy and hydropower projects. However, it is worth noting that there are still some shortcomings in the slope construction of water conservancy and hydropower projects in China at this stage. Some construction units have weak sense of responsibility, and pay low attention to the slope construction, so they cannot strengthen their management. In this case, the slope construction quality of water conservancy and hydropower projects is difficult to be guaranteed, which has a great impact on the subsequent use of water conservancy and hydropower projects, and poses a certain threat to the lives and property safety of people around the project. In this paper, the slope excavation technology and supporting technology in water conservancy and hydropower projects are studied in detail, and some suggestions are put forward, in order to help the construction unit to strengthen the control of the slope construction quality of water conservancy and hydropower projects and improve the slope construction level.展开更多
基金supported in part by the National Institutes of Health under grants R01 CA153023 and P41 EB032840.
文摘Objective and Impact Statement:A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking.Here,we report a novel multifunctional ablative gastrointestinal imaging capsule(MAGIC)technology platform to address this clinical need.The MAGIC technology could also facilitate the clinical translation and adoption of the tethered capsule endomicroscopy(TCE)technology.Introduction:Recently developed optical coherence tomography(OCT)TCE technologies have shown a promising potential for surveillance of Barrett’s esophagus and esophageal cancer in awake patients without the need for sedation.However,it remains challenging with the current TCE technology for detecting early lesions and clinical adoption due to its suboptimal resolution,imaging contrast,and lack of visual guidance during imaging.Methods:Our technology reported here integrates dual-wavelength OCT imaging(operating at 800 and 1300 nm),an ultracompact endoscope camera,and an ablation laser,aiming to enable comprehensive surveillance,guidance,and potential ablative treatment of the esophagus.Results:The MAGIC has been successfully developed with its multimodality imaging and ablation capabilities demonstrated by imaging swine esophagus ex vivo and in vivo.The 800-nm OCT imaging offers exceptional resolution and contrast for the superficial layers,well suited for detecting subtle changes associated with early neoplasia.The 1300-nm OCT imaging provides deeper penetration,essential for assessing lesion invasion.The built-in miniature camera affords a conventional endoscopic view for assisting capsule deployment and laser ablation.Conclusion:By offering complementary and clinically viable functions in a single device,the reported technology represents an effective solution for endoscopic screening,diagnosis,and potential ablation treatment of the esophagus of a patient in an office setting.
文摘In recent years, China's social and economic development has advanced by leaps and bounds, and water conservancy has also been greatly developed. Under the current situation, the scale of water conservancy and hydropower projects in China is constantly expanding, and it is playing an increasingly important role in agriculture, shipping and hydropower generation. Slope construction is an important part of water conservancy and hydropower projects, and the quality of slope construction directly affects the overall construction level of water conservancy and hydropower projects. However, it is worth noting that there are still some shortcomings in the slope construction of water conservancy and hydropower projects in China at this stage. Some construction units have weak sense of responsibility, and pay low attention to the slope construction, so they cannot strengthen their management. In this case, the slope construction quality of water conservancy and hydropower projects is difficult to be guaranteed, which has a great impact on the subsequent use of water conservancy and hydropower projects, and poses a certain threat to the lives and property safety of people around the project. In this paper, the slope excavation technology and supporting technology in water conservancy and hydropower projects are studied in detail, and some suggestions are put forward, in order to help the construction unit to strengthen the control of the slope construction quality of water conservancy and hydropower projects and improve the slope construction level.
