The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo tech.There are so many uncertainties because it is conditioned by a lot of factors,we can not make a rati...The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo tech.There are so many uncertainties because it is conditioned by a lot of factors,we can not make a rational forecasting by traditional assessment method.So this paper gives a comprehensive consideration to the factors that influence production and makes some modification to production function, and establishes the life cycle of technology assessmet model by the method of fuzzy mathematics. So it quantifies the risk of investment.We can take it as one foundational index for the decision making of the investment.展开更多
Background:Minor glomerular abnormalities(MGAs)are histopathologically heterogeneous renal lesions with subtle struc-tural changes and latent clinical manifestations,yet their molecular mechanisms remain poorly charac...Background:Minor glomerular abnormalities(MGAs)are histopathologically heterogeneous renal lesions with subtle struc-tural changes and latent clinical manifestations,yet their molecular mechanisms remain poorly characterized and underex-plored.Methods:In this study,we employed pressure cycling technology-assisted sample preparation combined with data-independent acquisition mass spectrometry to systematically compare the proteomic profiles of distant non-neoplastic tis-sues(n=24)and MGA tissues(n=27).Results:A total of 9529 protein groups were quantified with a false discovery rate<1%,and 1338 differentially expressed pro-tein groups were identified(fold-change>2 or<0.5,P<0.05),including 190 downregulated and 1148 upregulated protein groups in MGA tissues.Gene ontology analysis revealed that the downregulated proteins were enriched in cell adhesion,ion binding,and molecular transport,whereas the upregulated proteins were enriched in transcriptional regulation,DNA repli-cation/repair,and nucleic acid binding.Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated inhibition of metabolic pathways and the peroxisome proliferator-activated receptor signaling pathway,as well as the activation of basal transcription factors and nucleotide excision repair in MGAs.Further screening revealed 13 core upregulated nuclear proteins(e.g.YY1,TAF9,RFC1,and POLR1D)with a>90%detection rate in MGA tissues;these proteins are functionally associated with renal inflammation,cell proliferation,and the DNA damage response.Conclusion:Our study establishes a high-resolution proteomic landscape of MGAs,provides novel insights into their molecular pathogenesis,and identifies potential tissue biomarkers and therapeutic targets.The pressure cycling technology-assisted data-independent acquisition workflow also offers a robust technical framework for proteomic analysis of microscale renal biopsy samples.展开更多
Purpose:Following the typical features of the grey-rhino event as predictability and profound influence,we attempt to find a special pattern called the grey-rhino in eminent technologies via patent analysis.Design/met...Purpose:Following the typical features of the grey-rhino event as predictability and profound influence,we attempt to find a special pattern called the grey-rhino in eminent technologies via patent analysis.Design/methodology/approach:We propose to combine triadic patent families and technology life cycle to define the grey-rhino model.Firstly,we design the indicator rhino-index Rh=ST/SP and descriptor sequence{Rh},where ST and SP are the accumulative number of triadic patent families and all patent families respectively for a specific technology.Secondly,according to the two typical features of the grey-rhino event,a grey-rhino is defined as a technology that meets both qualitative and quantitative conditions.Qualitatively,this technology has a profound influence.Quantitatively,in the emerging stage,Rh≥Rae,where Rae is the average level of the proportion of triadic patent families.Finally,this model is verified in three datasets,namely Encyclopedia Britannica’s list for the greatest inventions(EB technologies for short),MIT breakthrough technologies(MIT technologies)and Derwent Manual Code technologies(MAN technologies).Findings:The result shows that there are 64.71%EB technologies and 50.00%MIT technologies meeting the quantitative standard of the grey-rhino model,but only 14.71%MAN technologies fit the quantitative standard.This falling trend indicates the quantitative standard of the grey-rhino model is reasonable.EB technologies and MIT technologies have profound influence on society,which means they satisfy the qualitative standard of the grey-rhino model.Hence,64.71%EB technologies and 50.00%MIT technologies are grey-rhinos.In 14.71%MAN technologies meeting the quantitative standard,we make some qualitative judgments and deem U11-A01A,U12-A01A1A,and W01-A01A as grey-rhino technologies.In addition,grey-rhinos and non-grey-rhinos have some differences.Rh values of grey-rhinos have a downward trend,while Rh values of non-grey-rhinos have a contrary trend.Rh values of grey-rhinos are scattered relatively in the early stage and centralize gradually,but non-grey-rhinos do not have this feature.Research limitations:There are four main limitations.First,if a technology satisfies the quantitative standard of the model,it is likely to be a grey-rhino but expert judgments are necessary.Second,we don’t know why it will be eminent,which involves technical contents.Thirdly,we did not consider the China National Intellectual Property Administration(CNIPA)and the German Patent and Trademark Office(DPMA)which also play important roles in worldwide patents,so we hope to expand our study to the CNIPA and the DPMA.Furthermore,we did not compare the rhino-index with other patent indicators.Practical implications:If a technology meets the quantitative standard,this can be seen as early warning signals and the technology may become a grey-rhino in the future,which can catch people’s attention in the emerging stage and make people seize the technical opportunity early.Originality/value:We define and verify a new pattern called the grey-rhino model in eminent technologies.展开更多
Information technologies(ITs)have been playing an important role in improving our society,and the fast evolution of ITs creates a competitive environment not only for companies but also for regions.Hence,recognizing t...Information technologies(ITs)have been playing an important role in improving our society,and the fast evolution of ITs creates a competitive environment not only for companies but also for regions.Hence,recognizing the future trend of technologies can be effective in decision-making with regard to technology selection and investment.Blockchain technology with its vast and impressive applications has received considerable attention from researchers,investors,and public agencies.The purpose of this research is to investigate blockchain technology to explore its trends according to their classification by use of the World Intellectual Property Organization(WIPO)database.Furthermore,we particularly evaluate the registered patents in the world's most well-known patent databases such as the USA patent database.We drew the current technology trends in blockchain patents by applying the text mining and clustering approach.The results represent that the registered patents in the USA patent database have been achieved in the growth phase.That means,attention to the blockchain is rising nowadays and most patents focused the cryptocurrencies and their applications in finance.However,blockchain technology is in the emergence phase and is evolving by researchers and inventors.展开更多
Driven by the goal of global carbon neutrality,electrocatalytic carbon dioxide reduction reaction(eCO_(2)RR)technology has become a research hotspot due to its potential to efficiently convert CO_(2)into high value-ad...Driven by the goal of global carbon neutrality,electrocatalytic carbon dioxide reduction reaction(eCO_(2)RR)technology has become a research hotspot due to its potential to efficiently convert CO_(2)into high value-added products,such as ethylene and ethanol.Cu-based catalysts become the core material under their unique electronic structure and C–C coupling ability.It is precisely designed by single atomic sites(SACs)and diatomic site catalysts(DASCs).Combined with the stabilizing effect of composite carriers(such as metal–organic framework(MOF)materials)on the Cu active site,the product selectivity and reaction kinetics were significantly improved.In situ characterization and computational simulation revealed the dynamic reconfiguration of Cu sites and the adsorption mechanism of*CO intermediates.This result confirms that low-coordination Cu sites promote C–C coupling through the Eley–Rideal(ER)pathway,and high-pressure/high-temperature conditions can regulate the reaction path.Despite outstanding laboratory performance,industrial applications still face low stability at high current densities,high-scale preparation costs,and system integration challenges.In the future,it is necessary to focus on the analysis of atomic-level reaction mechanisms,the development of intelligent response materials,and the coupling technology of photoelectric and electrocatalysis,combined with green power matching and carbon tax policy coordination,to promote the leapfrog development of copper-based catalysts from basic research to industrial carbon cycle technology.展开更多
Advancing portable electronics and electric vehicles is heavily dependent on the cutting-edge lithium-ion (Li-ion) battery technology, which is closely linked to the properties of cathode materials. Identifying trends...Advancing portable electronics and electric vehicles is heavily dependent on the cutting-edge lithium-ion (Li-ion) battery technology, which is closely linked to the properties of cathode materials. Identifying trends and prospects of cathode materials based on patent analysis is considered a kernel to optimize and refine battery related markets. In this paper, a patent analysis is performed on 6 popular cathode materials by comprehensively considering performance comparison, development trend, annual installed capacity, technology life cycle, and distribution among regions and patent assignees. In the technology life cycle, the cathode materials majorly used in electric vehicle have entered maturity stage, while the lithium cobalt oxide (LCO) cathode that is widely used in portable electronics is still in the growth stage. In global patent distributions, China holds more than 50% of total patents. In the top 10 patent assignees of 6 cathode materials, 2 institutes are from China with the rest being Japan (6) and Republic of Korea (2), indicating that the technology of cathode materials in China is relatively scattered while cathode research is highly concentrated in Japan and Republic of Korea. Moreover, the patent distribution has to consider practical issues as well as the impacts of core patents. For example, the high cost discourages the intention of applying international patents. This paper is expected to stimulate battery research, understand technical layout of various countries, and probably forecast innovative technology breakthroughs.展开更多
文摘The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo tech.There are so many uncertainties because it is conditioned by a lot of factors,we can not make a rational forecasting by traditional assessment method.So this paper gives a comprehensive consideration to the factors that influence production and makes some modification to production function, and establishes the life cycle of technology assessmet model by the method of fuzzy mathematics. So it quantifies the risk of investment.We can take it as one foundational index for the decision making of the investment.
基金support from the National Nat-ural Science Foundation of China(grant No.92478101)National Key R&D Program of China(grant No.2022YFF0608401)+1 种基金Natu-ral Science Foundation of Sichuan Province(grant No.2024NS-FSC0587)Sichuan Science and Technology Program(grant No.2025YFHZ0213).
文摘Background:Minor glomerular abnormalities(MGAs)are histopathologically heterogeneous renal lesions with subtle struc-tural changes and latent clinical manifestations,yet their molecular mechanisms remain poorly characterized and underex-plored.Methods:In this study,we employed pressure cycling technology-assisted sample preparation combined with data-independent acquisition mass spectrometry to systematically compare the proteomic profiles of distant non-neoplastic tis-sues(n=24)and MGA tissues(n=27).Results:A total of 9529 protein groups were quantified with a false discovery rate<1%,and 1338 differentially expressed pro-tein groups were identified(fold-change>2 or<0.5,P<0.05),including 190 downregulated and 1148 upregulated protein groups in MGA tissues.Gene ontology analysis revealed that the downregulated proteins were enriched in cell adhesion,ion binding,and molecular transport,whereas the upregulated proteins were enriched in transcriptional regulation,DNA repli-cation/repair,and nucleic acid binding.Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated inhibition of metabolic pathways and the peroxisome proliferator-activated receptor signaling pathway,as well as the activation of basal transcription factors and nucleotide excision repair in MGAs.Further screening revealed 13 core upregulated nuclear proteins(e.g.YY1,TAF9,RFC1,and POLR1D)with a>90%detection rate in MGA tissues;these proteins are functionally associated with renal inflammation,cell proliferation,and the DNA damage response.Conclusion:Our study establishes a high-resolution proteomic landscape of MGAs,provides novel insights into their molecular pathogenesis,and identifies potential tissue biomarkers and therapeutic targets.The pressure cycling technology-assisted data-independent acquisition workflow also offers a robust technical framework for proteomic analysis of microscale renal biopsy samples.
基金This work is supported by the National Natural Science Foundation of China(Grant No.71673131).
文摘Purpose:Following the typical features of the grey-rhino event as predictability and profound influence,we attempt to find a special pattern called the grey-rhino in eminent technologies via patent analysis.Design/methodology/approach:We propose to combine triadic patent families and technology life cycle to define the grey-rhino model.Firstly,we design the indicator rhino-index Rh=ST/SP and descriptor sequence{Rh},where ST and SP are the accumulative number of triadic patent families and all patent families respectively for a specific technology.Secondly,according to the two typical features of the grey-rhino event,a grey-rhino is defined as a technology that meets both qualitative and quantitative conditions.Qualitatively,this technology has a profound influence.Quantitatively,in the emerging stage,Rh≥Rae,where Rae is the average level of the proportion of triadic patent families.Finally,this model is verified in three datasets,namely Encyclopedia Britannica’s list for the greatest inventions(EB technologies for short),MIT breakthrough technologies(MIT technologies)and Derwent Manual Code technologies(MAN technologies).Findings:The result shows that there are 64.71%EB technologies and 50.00%MIT technologies meeting the quantitative standard of the grey-rhino model,but only 14.71%MAN technologies fit the quantitative standard.This falling trend indicates the quantitative standard of the grey-rhino model is reasonable.EB technologies and MIT technologies have profound influence on society,which means they satisfy the qualitative standard of the grey-rhino model.Hence,64.71%EB technologies and 50.00%MIT technologies are grey-rhinos.In 14.71%MAN technologies meeting the quantitative standard,we make some qualitative judgments and deem U11-A01A,U12-A01A1A,and W01-A01A as grey-rhino technologies.In addition,grey-rhinos and non-grey-rhinos have some differences.Rh values of grey-rhinos have a downward trend,while Rh values of non-grey-rhinos have a contrary trend.Rh values of grey-rhinos are scattered relatively in the early stage and centralize gradually,but non-grey-rhinos do not have this feature.Research limitations:There are four main limitations.First,if a technology satisfies the quantitative standard of the model,it is likely to be a grey-rhino but expert judgments are necessary.Second,we don’t know why it will be eminent,which involves technical contents.Thirdly,we did not consider the China National Intellectual Property Administration(CNIPA)and the German Patent and Trademark Office(DPMA)which also play important roles in worldwide patents,so we hope to expand our study to the CNIPA and the DPMA.Furthermore,we did not compare the rhino-index with other patent indicators.Practical implications:If a technology meets the quantitative standard,this can be seen as early warning signals and the technology may become a grey-rhino in the future,which can catch people’s attention in the emerging stage and make people seize the technical opportunity early.Originality/value:We define and verify a new pattern called the grey-rhino model in eminent technologies.
基金partially supported by CAS President's International Fellowship Initiative,China(grant number 2021VTB0002,2021).
文摘Information technologies(ITs)have been playing an important role in improving our society,and the fast evolution of ITs creates a competitive environment not only for companies but also for regions.Hence,recognizing the future trend of technologies can be effective in decision-making with regard to technology selection and investment.Blockchain technology with its vast and impressive applications has received considerable attention from researchers,investors,and public agencies.The purpose of this research is to investigate blockchain technology to explore its trends according to their classification by use of the World Intellectual Property Organization(WIPO)database.Furthermore,we particularly evaluate the registered patents in the world's most well-known patent databases such as the USA patent database.We drew the current technology trends in blockchain patents by applying the text mining and clustering approach.The results represent that the registered patents in the USA patent database have been achieved in the growth phase.That means,attention to the blockchain is rising nowadays and most patents focused the cryptocurrencies and their applications in finance.However,blockchain technology is in the emergence phase and is evolving by researchers and inventors.
基金supported by the Science and Technology Major Project of Henan Province,Henan,China(No.CX0001F01800).
文摘Driven by the goal of global carbon neutrality,electrocatalytic carbon dioxide reduction reaction(eCO_(2)RR)technology has become a research hotspot due to its potential to efficiently convert CO_(2)into high value-added products,such as ethylene and ethanol.Cu-based catalysts become the core material under their unique electronic structure and C–C coupling ability.It is precisely designed by single atomic sites(SACs)and diatomic site catalysts(DASCs).Combined with the stabilizing effect of composite carriers(such as metal–organic framework(MOF)materials)on the Cu active site,the product selectivity and reaction kinetics were significantly improved.In situ characterization and computational simulation revealed the dynamic reconfiguration of Cu sites and the adsorption mechanism of*CO intermediates.This result confirms that low-coordination Cu sites promote C–C coupling through the Eley–Rideal(ER)pathway,and high-pressure/high-temperature conditions can regulate the reaction path.Despite outstanding laboratory performance,industrial applications still face low stability at high current densities,high-scale preparation costs,and system integration challenges.In the future,it is necessary to focus on the analysis of atomic-level reaction mechanisms,the development of intelligent response materials,and the coupling technology of photoelectric and electrocatalysis,combined with green power matching and carbon tax policy coordination,to promote the leapfrog development of copper-based catalysts from basic research to industrial carbon cycle technology.
基金the Shaanxi Provincial Philosophy and Social Science Research Project(Grant No.2023QN0169)the National and Regional Research projects of the Ministry of Education,China(Grant No.2021-G37)the 2023 Xi’an International Studies University Graduate Research Project.
文摘Advancing portable electronics and electric vehicles is heavily dependent on the cutting-edge lithium-ion (Li-ion) battery technology, which is closely linked to the properties of cathode materials. Identifying trends and prospects of cathode materials based on patent analysis is considered a kernel to optimize and refine battery related markets. In this paper, a patent analysis is performed on 6 popular cathode materials by comprehensively considering performance comparison, development trend, annual installed capacity, technology life cycle, and distribution among regions and patent assignees. In the technology life cycle, the cathode materials majorly used in electric vehicle have entered maturity stage, while the lithium cobalt oxide (LCO) cathode that is widely used in portable electronics is still in the growth stage. In global patent distributions, China holds more than 50% of total patents. In the top 10 patent assignees of 6 cathode materials, 2 institutes are from China with the rest being Japan (6) and Republic of Korea (2), indicating that the technology of cathode materials in China is relatively scattered while cathode research is highly concentrated in Japan and Republic of Korea. Moreover, the patent distribution has to consider practical issues as well as the impacts of core patents. For example, the high cost discourages the intention of applying international patents. This paper is expected to stimulate battery research, understand technical layout of various countries, and probably forecast innovative technology breakthroughs.
