Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminar...Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminary progress has been made in enhancing their stability,loading efficiency,and targeted delivery effi-ciency.These advancements have led to their wide use in disease prevention,nutritional intervention,and improvement of functional foods.This review provides a comprehensive overview of the recent development of EXOs in functional foods and precision nutrition,with a specific focus on their encapsulation,protection,and delivery performance for various bioactive phenolic compounds.Additionally,the advanced surface function-alization strategies using polysaccharides and small bioactive molecules,aiming at improving the targeted ability of EXOs,are discussed.It has been shown that EXOs possess a unique constellation of advantages,including biocompatibility and safety,inherent stability with a robust lipid bilayer that protects cargo from enzymatic degradation and harsh pH conditions,and innate bio-interactivity allowing them to be recognized and inter-nalized by human cells.However,the research on EXOs is still in its infancy due to the difficulty in scalability and clinical translation,and little information on the in vivo biodistribution,metabolic destiny,and long-term safety profiles of EXOs.展开更多
基金supported by the National Key Research and Develop-ment Program of China(2022YFF1100205)National Science Foundation of China for Young Scholars(32101879).
文摘Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminary progress has been made in enhancing their stability,loading efficiency,and targeted delivery effi-ciency.These advancements have led to their wide use in disease prevention,nutritional intervention,and improvement of functional foods.This review provides a comprehensive overview of the recent development of EXOs in functional foods and precision nutrition,with a specific focus on their encapsulation,protection,and delivery performance for various bioactive phenolic compounds.Additionally,the advanced surface function-alization strategies using polysaccharides and small bioactive molecules,aiming at improving the targeted ability of EXOs,are discussed.It has been shown that EXOs possess a unique constellation of advantages,including biocompatibility and safety,inherent stability with a robust lipid bilayer that protects cargo from enzymatic degradation and harsh pH conditions,and innate bio-interactivity allowing them to be recognized and inter-nalized by human cells.However,the research on EXOs is still in its infancy due to the difficulty in scalability and clinical translation,and little information on the in vivo biodistribution,metabolic destiny,and long-term safety profiles of EXOs.
