Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience...Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.展开更多
Magnesium gluconate is a classical organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ion. The present research described the in-depth study on soli...Magnesium gluconate is a classical organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ion. The present research described the in-depth study on solid state properties viz. physicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like Powder X-ray diffraction(PXRD), particle size analysis(PSA),Fourier transform infrared(FT-IR) spectrometry, ultraviolet–visible(UV–Vis) spectroscopy, thermogravimetric analysis(TGA)/differential thermogravimetric analysis(DTG), and differential scanning calorimetry(DSC).Magnesium gluconate was found to be crystalline in nature along with the crystallite size ranging from 14.10 to47.35 nm. The particle size distribution was at d(0.1)=6.552 μm, d(0.5)=38.299 μm, d(0.9)=173.712 μm and D(4,3)=67.122 μm along with the specific surface area of 0.372 m^2/g. The wavelength for the maximum absorbance was at 198.0 nm. Magnesium gluconate exhibited 88.51% weight loss with three stages of thermal degradation process up to 895.18 °C from room temperature. The TGA/DTG thermograms of the analyte indicated that magnesium gluconate was thermally stable up to around 165 °C. Consequently, the melting temperature of magnesium gluconate was found to be 169.90 °C along with the enthalpy of fusion of 308.7 J/g.Thus, the authors conclude that the achieved results from this study are very useful in pharmaceutical and nutraceutical industries for the identification, characterization and qualitative analysis of magnesium gluconate for preformulation studies and also for developing magnesium gluconate based novel formulation.展开更多
Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.T...Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.To contribute to a better understanding of the state of the art of smart techniques for engineering projects,this paper provides a comprehensive review of multi-criteria decision-making(MCDM)techniques,intelligent techniques,and their applications in CEM.First,a comprehensive framework detailing smart technologies for construction projects is developed.Next,the characteristics of CEM are summarized.A bibliometric review is then conducted to investigate the keywords,journals,and clusters related to the application of smart techniques in CEM during 2000-2022.Recent advancements in intelligent techniques are also discussed under the following six topics:①big data technology;②computer vision;③speech recognition;④natural language processing;⑤machine learning;and⑥knowledge representation,understanding,and reasoning.The applications of smart techniques are then illustrated via underground space exploitation.Finally,future research directions for the sustainable development of smart construction are highlighted.展开更多
As part of the LAMOST medium-resolution spectroscopic survey,the LAMOST-MRS-O is a non-time domain survey that aims to perform medium-resolution spectral observations for member stars in the open cluster areas.This su...As part of the LAMOST medium-resolution spectroscopic survey,the LAMOST-MRS-O is a non-time domain survey that aims to perform medium-resolution spectral observations for member stars in the open cluster areas.This survey plans to obtain the spectroscopic parameters such as radial velocity and metal abundances of member stars and provide data support for further study on the chemical and dynamical characteristics and evolution of open clusters in combination with Gaia data.We have completed the observations on ten open cluster fields and obtained 235184 medium-resolution spectra of 133792 stars.Based on the data analyzed of LAMOST DR11v1.1,for some clusters of particular concern,it is found that the sampling ratio of members stars with Gmag<15 mag can reach 70%,which indicates that the LAMOST-MRS-O has reached our initial design goal.展开更多
Precise transverse emittance assessment in electron beams is crucial for advancing high-brightness beam injectors.As opposed to intricate methodologies that use specialized devices,quadrupole focusing strength scannin...Precise transverse emittance assessment in electron beams is crucial for advancing high-brightness beam injectors.As opposed to intricate methodologies that use specialized devices,quadrupole focusing strength scanning(Q-scanning)techniques offer notable advantages for various injectors owing to their inherent convenience and cost-effectiveness.However,their stringent approximation conditions lead to inevitable errors in practical operation,thereby limiting their widespread application.This study addressed these challenges by revisiting the analytical derivation procedure and investigating the effects of the underlying approximation conditions.Preliminary corrections were explored through a combination of data processing analysis and numerical simulations.Furthermore,based on theoretical derivations,virtual measurements using beam dynamics calculations were employed to evaluate the correction reliability.Subsequent experimental validations were performed at the Huazhong University of Science and Technology injector to verify the effectiveness of the proposed compensation method.Both the virtual and experimental results confirm the feasibility and reliability of the enhanced Q-scanning-based diagnosis for transverse emittance in typical beam injectors operating under common conditions.Through the integration of these corrections and compensations,enhanced Q-scanning-based techniques emerge as promising alternatives to traditional emittance diagnosis methods.展开更多
This paper presents a high-fidelity lumpedparameter(LP)thermal model(HF-LPTM)for permanent magnet synchronous machines(PMSMs)in electric vehicle(EV)applications,where various cooling techniques are considered,includin...This paper presents a high-fidelity lumpedparameter(LP)thermal model(HF-LPTM)for permanent magnet synchronous machines(PMSMs)in electric vehicle(EV)applications,where various cooling techniques are considered,including frame forced air/liquid cooling,oil jet cooling for endwinding,and rotor shaft cooling.To address the temperature misestimation in the LP thermal modelling due to assumptions of concentrated loss input and uniform heat flows,the developed HF-LPTM introduces two compensation thermal resistances for the winding and PM components,which are analytically derived from the multi-dimensional heat transfer equations and are robust against different load/thermal conditions.As validated by the finite element analysis method and experiments,the conventional LPTMs exhibit significant winding temperature deviations,while the proposed HF-LPTM can accurately predict both the midpoint and average temperatures.The developed HFLPTM is further used to assess the effectiveness of various cooling techniques under different scenarios,i.e.,steady-state thermal states under the rated load condition,and transient temperature profiles under city,freeway,and hybrid(city+freeway)driving cycles.Results indicate that no single cooling technique can maintain both winding and PM temperatures within safety limits.The combination of frame liquid cooling and oil jet cooling for end winding can sufficiently mitigate PMSM thermal stress in EV applications.展开更多
With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly progressed...With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly progressed.This paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking techniques.Passive detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic tactics.In contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake content.We offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal evidence.Additionally,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking strategies.By systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.展开更多
Conductor materials with good mechanical performance as well as high electrical and thermal conductivities are particularly important to break through the current bottle-neck limit(~ 100 T) of pulsed magnets. Here, we...Conductor materials with good mechanical performance as well as high electrical and thermal conductivities are particularly important to break through the current bottle-neck limit(~ 100 T) of pulsed magnets. Here, we perform systematic studies on the elastic properties of the Cu–6wt% Ag alloy wire, which is a promising candidate material for the new-generation pulsed magnets, by employing two independent ultrasonic techniques, i.e., resonant ultrasound spectroscopy(RUS) and ultrasound pulse-echo experiments. Our RUS measurements manifest that the elastic properties of the Cu–6wt% Ag alloy wires can be improved by an electroplastic drawing procedure as compared with the conventional cold drawing. We also take this opportunity to test the availability of our newly-built ultrasound pulse-echo facility at the Wuhan National High Magnetic Field Center(WHMFC, China), and the results suggest that the elastic performance of the electroplastically-drawn Cu–6wt% Ag alloy wire remains excellent without anomalous softening under extreme conditions,e.g., in ultra-high magnetic field up to 50 T and nitrogen or helium cryogenic liquids.展开更多
One of the detection objectives of the Chinese Asteroid Exploration mission is to investigate the space environment near the Main-belt Comet(MBC,Active Asteroid)311P/PANSTARRS.This paper outlines the scientific object...One of the detection objectives of the Chinese Asteroid Exploration mission is to investigate the space environment near the Main-belt Comet(MBC,Active Asteroid)311P/PANSTARRS.This paper outlines the scientific objectives,measurement targets,and measurement requirements for the proposed Gas and Ion Analyzer(GIA).The GIA is designed for in-situ mass spectrometry of neutral gases and low-energy ions,such as hydrogen,carbon,and oxygen,in the vicinity of 311P.Ion sampling techniques are essential for the GIA's Time-of-Flight(TOF)mass analysis capabilities.In this paper,we present an enhanced ion sampling technique through the development of an ion attraction model and an ion source model.The ion attraction model demonstrates that adjusting attraction grid voltage can enhance the detection efficiency of low-energy ions and mitigate the repulsive force of ions during sampling,which is influenced by the satellite's surface positive charging.The ion source model simulates the processes of gas ionization and ion multiplication.Simulation results indicate that the GIA can achieve a lower pressure limit below 10-13Pa and possess a dynamic range exceeding 10~9.These performances ensure the generation of ions with stable and consistent current,which is crucial for high-resolution and broad dynamic range mass spectrometer analysis.Preliminary testing experiments have verified GIA's capability to detect gas compositions such as H2O and N2.In-situ measurements near 311P using GIA are expected to significantly contribute to our understanding of asteroid activity mechanisms,the evolution of the atmospheric and ionized environments of main-belt comets,the interactions with solar wind,and the origin of Earth's water.展开更多
Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We dis...Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior circulation.The article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and limitations.We emphasize the im-portance of accurate differentiation to avoid unnecessary surgical interventions.The potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic accuracy.This manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.展开更多
Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This r...Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This review mainly summarized the research reports on short process forming techniques for brazing and soldering materials.Firstly,the traditional process and its shortcomings were presented.Secondly,the latest research of short process forming technologies,such as continuous casting technique,atomization powder technique,solder ball forming technique,and rapid solidification technique,was summarized,and the traditional forming performance of several brazing and soldering materials was introduced.Finally,the current restrictions and research trends of short process forming technique for brazing and solder materials were put forward,providing theoretical guidance and reference for related research and technique development in brazing and soldering field.展开更多
Low-voltage direct current(DC)microgrids have recently emerged as a promising and viable alternative to traditional alternating cur-rent(AC)microgrids,offering numerous advantages.Consequently,researchers are explorin...Low-voltage direct current(DC)microgrids have recently emerged as a promising and viable alternative to traditional alternating cur-rent(AC)microgrids,offering numerous advantages.Consequently,researchers are exploring the potential of DC microgrids across var-ious configurations.However,despite the sustainability and accuracy offered by DC microgrids,they pose various challenges when integrated into modern power distribution systems.Among these challenges,fault diagnosis holds significant importance.Rapid fault detection in DC microgrids is essential to maintain stability and ensure an uninterrupted power supply to critical loads.A primary chal-lenge is the lack of standards and guidelines for the protection and safety of DC microgrids,including fault detection,location,and clear-ing procedures for both grid-connected and islanded modes.In response,this study presents a brief overview of various approaches for protecting DC microgrids.展开更多
BACKGROUND Uniportal full-endoscopy(UFE)technique has been continuously developed and applied for treating lumbar spinal stenosis.However,achieving effective decompression outcome of using the UFE technique remains te...BACKGROUND Uniportal full-endoscopy(UFE)technique has been continuously developed and applied for treating lumbar spinal stenosis.However,achieving effective decompression outcome of using the UFE technique remains technically demanding and uncertain.Previously,we have proposed the biportal full-endoscopy(BFE)technique to integrate the respective advantages of both UFE and unilateral biportal endoscopy technique.There is limited published data on the comparison of clinical outcomes between biportal and UFE techniques in lumbar spinal stenosis with bilateral symptoms.AIM To contrast the clinical outcomes between biportal and UFE techniques for treating lumbar spinal stenosis with bilateral symptoms.METHODS This study retrospectively examined 100 patients diagnosed with lumbar spinal stenosis and bilateral symptoms.Among them,52 cases were part of group A(BFE technique group),and 48 cases belonged to group B(UFE technique group).The visual analogue scale(VAS),Oswestry Disability Index(ODI),and modified Macnab criteria were used to evaluate the clinical outcomes.RESULTS Group A had significantly shorter operation time than group B.Both groups experienced substantial relief in lower back and lower extremity pain on the severe side at postoperative 3 days,3 months,and 12 months.Group A had notably lower VAS scores for mild side lower extremity pain at postoperative 3 months and 12 months compared to group B.Group A's ODI scores were significantly lower at postoperative 3 months and 12 months,whereas group B's scores did not significantly differ from preoperative values.Group A's ODI scores were significantly lower than group B's at postoperative 3 months and 12 months.Group A had a significantly higher excellent and good response rate(94.23%)compared to group B(81.25%)at postoperative 12 months based on the modified Macnab scale outcomes.CONCLUSION The BFE technique offers multiple benefits,including reduced trauma and quicker recovery as a minimally invasive surgery,and enhanced decompression efficiency over the UFE technique when treating lumbar spinal stenosis with bilateral symptoms.展开更多
The interstellar medium molecule thiocarbonyl thioketen,H_(2)CCS,has several stable isomers and has received considerable attention of as-tronomical observation in recent years.The positions of H,C,and S atoms of thre...The interstellar medium molecule thiocarbonyl thioketen,H_(2)CCS,has several stable isomers and has received considerable attention of as-tronomical observation in recent years.The positions of H,C,and S atoms of three isomers lead to di-verse dipole moments and spectro-scopic constants.The anharmonic force field and spectroscopic con-stants of thiocarbonyl thioketen and its isomers are calculated using MP2,B3LYP,and CCSD(T)methods employing correlation consistent basis sets.Molecule structures,rotational spectroscopic constants,and fundamental frequencies are compared with the available experimental data for thiocarbonyl thioketen.Ro-vibrational interaction constants,anharmonic constants,cubic and quartic force constants are predicted for thiocarbonyl thioketen.In addition,some rotational and vibrational spectroscopic parameters are predict-ed with the same level of theory for thioacetylene,HCCSH,and thiirene,(CH)_(2)S.The predic-tions of these spectroscopic constants are expected to guide the future astronomical observa-tion and high resolution experimental work for C_(2)H_(2)S isomers.展开更多
Semiconductor colloidal quantum wells(CQWs)with atomic-precision layer thickness are rapidly gaining attention for next-generation optoelectronic applications due to their tunable optical and electronic properties.In ...Semiconductor colloidal quantum wells(CQWs)with atomic-precision layer thickness are rapidly gaining attention for next-generation optoelectronic applications due to their tunable optical and electronic properties.In this study,we investigate the dielectric and optical characteristics of CdSe CQWs with monolayer numbers ranging from 2 to 7,synthesized via thermal injection and atomic layer(c-ALD)deposition techniques.Through a combination of spectroscopic ellipsometry(SE)and first-principles calculations,we demonstrate the significant tunability of the bandgap,refractive index,and extinction coefficient,driven by quantum confinement effects.Our results show a decrease in bandgap from 3.1 to 2.0 eV as the layer thickness increases.Furthermore,by employing a detailed analysis of the absorption spectra,accounting for exciton localization and asymmetric broadening,we precisely capture the relationship between monolayer number and exciton binding energy.These findings offer crucial insights for optimizing CdSe CQWs in optoelectronic device design by leveraging their layer-dependent properties.展开更多
Every second, a large volume of useful data is created in social media about the various kind of online purchases and in another forms of reviews. Particularly, purchased products review data is enormously growing in ...Every second, a large volume of useful data is created in social media about the various kind of online purchases and in another forms of reviews. Particularly, purchased products review data is enormously growing in different database repositories every day. Most of the review data are useful to new customers for theier further purchases as well as existing companies to view customers feedback about various products. Data Mining and Machine Leaning techniques are familiar to analyse such kind of data to visualise and know the potential use of the purchased items through online. The customers are making quality of products through their sentiments about the purchased items from different online companies. In this research work, it is analysed sentiments of Headphone review data, which is collected from online repositories. For the analysis of Headphone review data, some of the Machine Learning techniques like Support Vector Machines, Naive Bayes, Decision Trees and Random Forest Algorithms and a Hybrid method are applied to find the quality via the customers’ sentiments. The accuracy and performance of the taken algorithms are also analysed based on the three types of sentiments such as positive, negative and neutral.展开更多
The spectroscopic and transition properties of strontium chloride(SrCl)are investigated based on the theoretical approach of ab initio quantum chemistry.The calculation accuracy is improved by introducing Davidson cor...The spectroscopic and transition properties of strontium chloride(SrCl)are investigated based on the theoretical approach of ab initio quantum chemistry.The calculation accuracy is improved by introducing Davidson correction,core-valence correlation(CV),the scalar relativistic and spin–orbit coupling(SOC)effects.The results show that the spectroscopic constants of X^(2)S^(+)and A^(2)∏states are consistent with the experimental results.The spectroscopic and molecular constants of most highly excited electronic states are reported for the first time.The permanent dipole moment(PDMs)and the spin–orbit(SO)matrix element have a sudden change for the avoidance of crossing.The potential energy curves(PECs)of the 14 L–S states split into 30Ωstates.The splitting energy of A^(2)∏is 290.76 cm^(-1),which has a little difference from the experimental value 295.597 cm^(-1).Finally,the transition properties are given,including transition dipole moment(TDMs),Franck–Canton factor(FCFs)and radiation lifetime.It is found that the calculated radiation lifetime is in the order of 10 ns.The research will provide a theoretical reference for the feasibility of laser cooling of SrCl molecule.The dataset that supported the findings of this study is available in Science Data Bank,with the link https://www.doi.org/10.57760/sciencedb.j00113.00218.展开更多
To ensure the safety and efficacy of Chinese herbs,it is of great significance to conduct rapid quality detection of Chinese herbs at every link of their supply chain.Spectroscopic technology can reflect the overall c...To ensure the safety and efficacy of Chinese herbs,it is of great significance to conduct rapid quality detection of Chinese herbs at every link of their supply chain.Spectroscopic technology can reflect the overall chemical composition and structural characteristics of Chinese herbs,with the multi-component and multitarget characteristics of Chinese herbs.This review took the genus Paris as an example,and applications of spectroscopic technology with machine learning(ML)in supply chain of the genus Paris from seeds to medicinal materials were introduced.The specific contents included the confirmation of germplasm resources,identification of growth years,cultivar,geographical origin,and original processing and processing methods.The potential application of spectroscopic technology in genus Paris was pointed out,and the prospects of combining spectroscopic technology with blockchain were proposed.The summary and prospects presented in this paper will be beneficial to the quality control of the genus Paris in all links of its supply chain,so as to rationally use the genus Paris resources and ensure the safety and efficacy of medication.展开更多
Objectives:The objective of this study was to assess the impact of two relaxation techniques,the Jacobson’s progressive muscle relaxation technique(JPMR),and the Benson’s relaxation technique(BRT),on the levels of s...Objectives:The objective of this study was to assess the impact of two relaxation techniques,the Jacobson’s progressive muscle relaxation technique(JPMR),and the Benson’s relaxation technique(BRT),on the levels of stress and anxiety experienced by patients undergoing coronary angioplasty.Materials and Methods:Quantitative research approach with quasi-experimental pre-test and posttest control group design was conducted with seventy coronary angioplasty patients from the Institute of Medical Science,and SUM Hospital,Bhubaneswar,Odisha.The participants were purposively selected and divided into Experimental Group 1(n=35)and Experimental Group 2(n=35).Each group received either BRT or JPMR for three consecutive days.Pretest and posttest data were collected using a structured demographic questionnaire and the modified depression anxiety stress scale-21.Results:Both BRT and JPMR significantly decreased the levels of stress and anxiety among patients undergoing angioplasty compared to baseline(P<0.05).However,there was no significant difference between the two techniques based on Fisher’s exact P value.This suggests that both interventions are effective in reducing stress and anxiety among angioplasty patients.Conclusion:BRT or JPMR are noninvasive,nonpharmacological interventions that effectively reduce stress and anxiety in patients undergoing angioplasty.These findings underscore the importance of incorporating relaxation techniques into nursing practice and hospital programs to enhance patient care and promote holistic well-being post-angioplasty.展开更多
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金supported by the National Natural Science Foundation of China,No.31760290,82160688the Key Development Areas Project of Ganzhou Science and Technology,No.2022B-SF9554(all to XL)。
文摘Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.
基金GVK Biosciences Pvt. Ltd., Hyderabad, India, for their assistance and support during this work
文摘Magnesium gluconate is a classical organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia as a source of magnesium ion. The present research described the in-depth study on solid state properties viz. physicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like Powder X-ray diffraction(PXRD), particle size analysis(PSA),Fourier transform infrared(FT-IR) spectrometry, ultraviolet–visible(UV–Vis) spectroscopy, thermogravimetric analysis(TGA)/differential thermogravimetric analysis(DTG), and differential scanning calorimetry(DSC).Magnesium gluconate was found to be crystalline in nature along with the crystallite size ranging from 14.10 to47.35 nm. The particle size distribution was at d(0.1)=6.552 μm, d(0.5)=38.299 μm, d(0.9)=173.712 μm and D(4,3)=67.122 μm along with the specific surface area of 0.372 m^2/g. The wavelength for the maximum absorbance was at 198.0 nm. Magnesium gluconate exhibited 88.51% weight loss with three stages of thermal degradation process up to 895.18 °C from room temperature. The TGA/DTG thermograms of the analyte indicated that magnesium gluconate was thermally stable up to around 165 °C. Consequently, the melting temperature of magnesium gluconate was found to be 169.90 °C along with the enthalpy of fusion of 308.7 J/g.Thus, the authors conclude that the achieved results from this study are very useful in pharmaceutical and nutraceutical industries for the identification, characterization and qualitative analysis of magnesium gluconate for preformulation studies and also for developing magnesium gluconate based novel formulation.
基金funded by the project of Guangdong Provincial Basic and Applied Basic Research Fund Committee(2022A1515240073)the Pearl River Talent Recruitment Program(2019CX01G338),Guangdong Province.
文摘Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.To contribute to a better understanding of the state of the art of smart techniques for engineering projects,this paper provides a comprehensive review of multi-criteria decision-making(MCDM)techniques,intelligent techniques,and their applications in CEM.First,a comprehensive framework detailing smart technologies for construction projects is developed.Next,the characteristics of CEM are summarized.A bibliometric review is then conducted to investigate the keywords,journals,and clusters related to the application of smart techniques in CEM during 2000-2022.Recent advancements in intelligent techniques are also discussed under the following six topics:①big data technology;②computer vision;③speech recognition;④natural language processing;⑤machine learning;and⑥knowledge representation,understanding,and reasoning.The applications of smart techniques are then illustrated via underground space exploitation.Finally,future research directions for the sustainable development of smart construction are highlighted.
基金supported by the National Natural Science Foundation of China(NSFC)through grants 12090040,12090042,and 12073060the National Key R&D Program of China No.2019YFA0405501+2 种基金J.Z.acknowledges the Youth Innovation Promotion Association CASthe Science and Technology Commission of Shanghai Municipality(grant No.22dz1202400)the Program of Shanghai Academic/Technology Research Leader。
文摘As part of the LAMOST medium-resolution spectroscopic survey,the LAMOST-MRS-O is a non-time domain survey that aims to perform medium-resolution spectral observations for member stars in the open cluster areas.This survey plans to obtain the spectroscopic parameters such as radial velocity and metal abundances of member stars and provide data support for further study on the chemical and dynamical characteristics and evolution of open clusters in combination with Gaia data.We have completed the observations on ten open cluster fields and obtained 235184 medium-resolution spectra of 133792 stars.Based on the data analyzed of LAMOST DR11v1.1,for some clusters of particular concern,it is found that the sampling ratio of members stars with Gmag<15 mag can reach 70%,which indicates that the LAMOST-MRS-O has reached our initial design goal.
基金supported by the National Natural Science Foundation of China(Nos.12341501 and 11905074)。
文摘Precise transverse emittance assessment in electron beams is crucial for advancing high-brightness beam injectors.As opposed to intricate methodologies that use specialized devices,quadrupole focusing strength scanning(Q-scanning)techniques offer notable advantages for various injectors owing to their inherent convenience and cost-effectiveness.However,their stringent approximation conditions lead to inevitable errors in practical operation,thereby limiting their widespread application.This study addressed these challenges by revisiting the analytical derivation procedure and investigating the effects of the underlying approximation conditions.Preliminary corrections were explored through a combination of data processing analysis and numerical simulations.Furthermore,based on theoretical derivations,virtual measurements using beam dynamics calculations were employed to evaluate the correction reliability.Subsequent experimental validations were performed at the Huazhong University of Science and Technology injector to verify the effectiveness of the proposed compensation method.Both the virtual and experimental results confirm the feasibility and reliability of the enhanced Q-scanning-based diagnosis for transverse emittance in typical beam injectors operating under common conditions.Through the integration of these corrections and compensations,enhanced Q-scanning-based techniques emerge as promising alternatives to traditional emittance diagnosis methods.
文摘This paper presents a high-fidelity lumpedparameter(LP)thermal model(HF-LPTM)for permanent magnet synchronous machines(PMSMs)in electric vehicle(EV)applications,where various cooling techniques are considered,including frame forced air/liquid cooling,oil jet cooling for endwinding,and rotor shaft cooling.To address the temperature misestimation in the LP thermal modelling due to assumptions of concentrated loss input and uniform heat flows,the developed HF-LPTM introduces two compensation thermal resistances for the winding and PM components,which are analytically derived from the multi-dimensional heat transfer equations and are robust against different load/thermal conditions.As validated by the finite element analysis method and experiments,the conventional LPTMs exhibit significant winding temperature deviations,while the proposed HF-LPTM can accurately predict both the midpoint and average temperatures.The developed HFLPTM is further used to assess the effectiveness of various cooling techniques under different scenarios,i.e.,steady-state thermal states under the rated load condition,and transient temperature profiles under city,freeway,and hybrid(city+freeway)driving cycles.Results indicate that no single cooling technique can maintain both winding and PM temperatures within safety limits.The combination of frame liquid cooling and oil jet cooling for end winding can sufficiently mitigate PMSM thermal stress in EV applications.
基金supported by the National Fund Cultivation Project from China People’s Police University(Grant Number:JJPY202402)National Natural Science Foundation of China(Grant Number:62172165).
文摘With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly progressed.This paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking techniques.Passive detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic tactics.In contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake content.We offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal evidence.Additionally,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking strategies.By systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.
基金Project supported by the National Key R&D Program of China (Grant Nos. 2022YFA1602602 and 2023YFA1609600)the National Natural Science Foundation of China (Grant No. U23A20580)+3 种基金the open research fund of Songshan Lake Materials Laboratory (Grant No. 2022SLABFN27)Beijing National Laboratory for Condensed Matter Physics (Grant No. 2024BNLCMPKF004)Guangdong Basic and Applied Basic Research Foundation (Grant No. 2022B1515120020)the interdisciplinary program of Wuhan National High Magnetic Field Center at Huazhong University of Science and Technology (Grant No. WHMFC202132)。
文摘Conductor materials with good mechanical performance as well as high electrical and thermal conductivities are particularly important to break through the current bottle-neck limit(~ 100 T) of pulsed magnets. Here, we perform systematic studies on the elastic properties of the Cu–6wt% Ag alloy wire, which is a promising candidate material for the new-generation pulsed magnets, by employing two independent ultrasonic techniques, i.e., resonant ultrasound spectroscopy(RUS) and ultrasound pulse-echo experiments. Our RUS measurements manifest that the elastic properties of the Cu–6wt% Ag alloy wires can be improved by an electroplastic drawing procedure as compared with the conventional cold drawing. We also take this opportunity to test the availability of our newly-built ultrasound pulse-echo facility at the Wuhan National High Magnetic Field Center(WHMFC, China), and the results suggest that the elastic performance of the electroplastically-drawn Cu–6wt% Ag alloy wire remains excellent without anomalous softening under extreme conditions,e.g., in ultra-high magnetic field up to 50 T and nitrogen or helium cryogenic liquids.
基金Supported by the National Natural Science Foundation of China(42474239,41204128)China National Space Administration(Pre-research project on Civil Aerospace Technologies No.D010301)Strategic Priority Research Program of the Chinese Academy of Sciences(XDA17010303)。
文摘One of the detection objectives of the Chinese Asteroid Exploration mission is to investigate the space environment near the Main-belt Comet(MBC,Active Asteroid)311P/PANSTARRS.This paper outlines the scientific objectives,measurement targets,and measurement requirements for the proposed Gas and Ion Analyzer(GIA).The GIA is designed for in-situ mass spectrometry of neutral gases and low-energy ions,such as hydrogen,carbon,and oxygen,in the vicinity of 311P.Ion sampling techniques are essential for the GIA's Time-of-Flight(TOF)mass analysis capabilities.In this paper,we present an enhanced ion sampling technique through the development of an ion attraction model and an ion source model.The ion attraction model demonstrates that adjusting attraction grid voltage can enhance the detection efficiency of low-energy ions and mitigate the repulsive force of ions during sampling,which is influenced by the satellite's surface positive charging.The ion source model simulates the processes of gas ionization and ion multiplication.Simulation results indicate that the GIA can achieve a lower pressure limit below 10-13Pa and possess a dynamic range exceeding 10~9.These performances ensure the generation of ions with stable and consistent current,which is crucial for high-resolution and broad dynamic range mass spectrometer analysis.Preliminary testing experiments have verified GIA's capability to detect gas compositions such as H2O and N2.In-situ measurements near 311P using GIA are expected to significantly contribute to our understanding of asteroid activity mechanisms,the evolution of the atmospheric and ionized environments of main-belt comets,the interactions with solar wind,and the origin of Earth's water.
文摘Despite advancements in neuroimaging,false positive diagnoses of intracranial aneurysms remain a significant concern.This article examines the causes,prevalence,and implications of such false-positive diagnoses.We discuss how conditions like arterial occlusion with vascular stump formation and infundibular widening can mimic aneurysms,particularly in the anterior circulation.The article compares various imaging modalities,including computer tomography angiogram,magnetic resonance imaging/angiography,and digital subtraction angiogram,highlighting their strengths and limitations.We emphasize the im-portance of accurate differentiation to avoid unnecessary surgical interventions.The potential of emerging technologies,such as high-resolution vessel wall ima-ging and deep neural networks for automated detection,is explored as promising avenues for improving diagnostic accuracy.This manuscript underscores the need for continued research and clinical vigilance in the diagnosis of intracranial aneurysms.
基金National Key Research and Development Program(2021YFB3401101)。
文摘Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This review mainly summarized the research reports on short process forming techniques for brazing and soldering materials.Firstly,the traditional process and its shortcomings were presented.Secondly,the latest research of short process forming technologies,such as continuous casting technique,atomization powder technique,solder ball forming technique,and rapid solidification technique,was summarized,and the traditional forming performance of several brazing and soldering materials was introduced.Finally,the current restrictions and research trends of short process forming technique for brazing and solder materials were put forward,providing theoretical guidance and reference for related research and technique development in brazing and soldering field.
文摘Low-voltage direct current(DC)microgrids have recently emerged as a promising and viable alternative to traditional alternating cur-rent(AC)microgrids,offering numerous advantages.Consequently,researchers are exploring the potential of DC microgrids across var-ious configurations.However,despite the sustainability and accuracy offered by DC microgrids,they pose various challenges when integrated into modern power distribution systems.Among these challenges,fault diagnosis holds significant importance.Rapid fault detection in DC microgrids is essential to maintain stability and ensure an uninterrupted power supply to critical loads.A primary chal-lenge is the lack of standards and guidelines for the protection and safety of DC microgrids,including fault detection,location,and clear-ing procedures for both grid-connected and islanded modes.In response,this study presents a brief overview of various approaches for protecting DC microgrids.
基金Supported by National Natural Science Foundation of China,No.82202694Clinical Research Innovation Plan of Shanghai General Hospital,No.CTCCR-2021C10.
文摘BACKGROUND Uniportal full-endoscopy(UFE)technique has been continuously developed and applied for treating lumbar spinal stenosis.However,achieving effective decompression outcome of using the UFE technique remains technically demanding and uncertain.Previously,we have proposed the biportal full-endoscopy(BFE)technique to integrate the respective advantages of both UFE and unilateral biportal endoscopy technique.There is limited published data on the comparison of clinical outcomes between biportal and UFE techniques in lumbar spinal stenosis with bilateral symptoms.AIM To contrast the clinical outcomes between biportal and UFE techniques for treating lumbar spinal stenosis with bilateral symptoms.METHODS This study retrospectively examined 100 patients diagnosed with lumbar spinal stenosis and bilateral symptoms.Among them,52 cases were part of group A(BFE technique group),and 48 cases belonged to group B(UFE technique group).The visual analogue scale(VAS),Oswestry Disability Index(ODI),and modified Macnab criteria were used to evaluate the clinical outcomes.RESULTS Group A had significantly shorter operation time than group B.Both groups experienced substantial relief in lower back and lower extremity pain on the severe side at postoperative 3 days,3 months,and 12 months.Group A had notably lower VAS scores for mild side lower extremity pain at postoperative 3 months and 12 months compared to group B.Group A's ODI scores were significantly lower at postoperative 3 months and 12 months,whereas group B's scores did not significantly differ from preoperative values.Group A's ODI scores were significantly lower than group B's at postoperative 3 months and 12 months.Group A had a significantly higher excellent and good response rate(94.23%)compared to group B(81.25%)at postoperative 12 months based on the modified Macnab scale outcomes.CONCLUSION The BFE technique offers multiple benefits,including reduced trauma and quicker recovery as a minimally invasive surgery,and enhanced decompression efficiency over the UFE technique when treating lumbar spinal stenosis with bilateral symptoms.
基金supported by the Natural Science Foundation of Inner Mongolia(No.2020MS01023).
文摘The interstellar medium molecule thiocarbonyl thioketen,H_(2)CCS,has several stable isomers and has received considerable attention of as-tronomical observation in recent years.The positions of H,C,and S atoms of three isomers lead to di-verse dipole moments and spectro-scopic constants.The anharmonic force field and spectroscopic con-stants of thiocarbonyl thioketen and its isomers are calculated using MP2,B3LYP,and CCSD(T)methods employing correlation consistent basis sets.Molecule structures,rotational spectroscopic constants,and fundamental frequencies are compared with the available experimental data for thiocarbonyl thioketen.Ro-vibrational interaction constants,anharmonic constants,cubic and quartic force constants are predicted for thiocarbonyl thioketen.In addition,some rotational and vibrational spectroscopic parameters are predict-ed with the same level of theory for thioacetylene,HCCSH,and thiirene,(CH)_(2)S.The predic-tions of these spectroscopic constants are expected to guide the future astronomical observa-tion and high resolution experimental work for C_(2)H_(2)S isomers.
基金supported by the National Natural Science Foundation of China(62205180)the Natural Science Foundation of Shandong Province(ZR2022QF029)the Taishan Scholar Program of Shandong Province(Young Scientist).
文摘Semiconductor colloidal quantum wells(CQWs)with atomic-precision layer thickness are rapidly gaining attention for next-generation optoelectronic applications due to their tunable optical and electronic properties.In this study,we investigate the dielectric and optical characteristics of CdSe CQWs with monolayer numbers ranging from 2 to 7,synthesized via thermal injection and atomic layer(c-ALD)deposition techniques.Through a combination of spectroscopic ellipsometry(SE)and first-principles calculations,we demonstrate the significant tunability of the bandgap,refractive index,and extinction coefficient,driven by quantum confinement effects.Our results show a decrease in bandgap from 3.1 to 2.0 eV as the layer thickness increases.Furthermore,by employing a detailed analysis of the absorption spectra,accounting for exciton localization and asymmetric broadening,we precisely capture the relationship between monolayer number and exciton binding energy.These findings offer crucial insights for optimizing CdSe CQWs in optoelectronic device design by leveraging their layer-dependent properties.
文摘Every second, a large volume of useful data is created in social media about the various kind of online purchases and in another forms of reviews. Particularly, purchased products review data is enormously growing in different database repositories every day. Most of the review data are useful to new customers for theier further purchases as well as existing companies to view customers feedback about various products. Data Mining and Machine Leaning techniques are familiar to analyse such kind of data to visualise and know the potential use of the purchased items through online. The customers are making quality of products through their sentiments about the purchased items from different online companies. In this research work, it is analysed sentiments of Headphone review data, which is collected from online repositories. For the analysis of Headphone review data, some of the Machine Learning techniques like Support Vector Machines, Naive Bayes, Decision Trees and Random Forest Algorithms and a Hybrid method are applied to find the quality via the customers’ sentiments. The accuracy and performance of the taken algorithms are also analysed based on the three types of sentiments such as positive, negative and neutral.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11564019,11147158,and 12464032)the Department of Education Foundation of Jiangxi Province of China(Grant No.GJJ2401520).
文摘The spectroscopic and transition properties of strontium chloride(SrCl)are investigated based on the theoretical approach of ab initio quantum chemistry.The calculation accuracy is improved by introducing Davidson correction,core-valence correlation(CV),the scalar relativistic and spin–orbit coupling(SOC)effects.The results show that the spectroscopic constants of X^(2)S^(+)and A^(2)∏states are consistent with the experimental results.The spectroscopic and molecular constants of most highly excited electronic states are reported for the first time.The permanent dipole moment(PDMs)and the spin–orbit(SO)matrix element have a sudden change for the avoidance of crossing.The potential energy curves(PECs)of the 14 L–S states split into 30Ωstates.The splitting energy of A^(2)∏is 290.76 cm^(-1),which has a little difference from the experimental value 295.597 cm^(-1).Finally,the transition properties are given,including transition dipole moment(TDMs),Franck–Canton factor(FCFs)and radiation lifetime.It is found that the calculated radiation lifetime is in the order of 10 ns.The research will provide a theoretical reference for the feasibility of laser cooling of SrCl molecule.The dataset that supported the findings of this study is available in Science Data Bank,with the link https://www.doi.org/10.57760/sciencedb.j00113.00218.
基金funded by the Special Program for the Major Science and Technology Projects of Yunnan Province,China(Grant No.:202202AE090001).
文摘To ensure the safety and efficacy of Chinese herbs,it is of great significance to conduct rapid quality detection of Chinese herbs at every link of their supply chain.Spectroscopic technology can reflect the overall chemical composition and structural characteristics of Chinese herbs,with the multi-component and multitarget characteristics of Chinese herbs.This review took the genus Paris as an example,and applications of spectroscopic technology with machine learning(ML)in supply chain of the genus Paris from seeds to medicinal materials were introduced.The specific contents included the confirmation of germplasm resources,identification of growth years,cultivar,geographical origin,and original processing and processing methods.The potential application of spectroscopic technology in genus Paris was pointed out,and the prospects of combining spectroscopic technology with blockchain were proposed.The summary and prospects presented in this paper will be beneficial to the quality control of the genus Paris in all links of its supply chain,so as to rationally use the genus Paris resources and ensure the safety and efficacy of medication.
文摘Objectives:The objective of this study was to assess the impact of two relaxation techniques,the Jacobson’s progressive muscle relaxation technique(JPMR),and the Benson’s relaxation technique(BRT),on the levels of stress and anxiety experienced by patients undergoing coronary angioplasty.Materials and Methods:Quantitative research approach with quasi-experimental pre-test and posttest control group design was conducted with seventy coronary angioplasty patients from the Institute of Medical Science,and SUM Hospital,Bhubaneswar,Odisha.The participants were purposively selected and divided into Experimental Group 1(n=35)and Experimental Group 2(n=35).Each group received either BRT or JPMR for three consecutive days.Pretest and posttest data were collected using a structured demographic questionnaire and the modified depression anxiety stress scale-21.Results:Both BRT and JPMR significantly decreased the levels of stress and anxiety among patients undergoing angioplasty compared to baseline(P<0.05).However,there was no significant difference between the two techniques based on Fisher’s exact P value.This suggests that both interventions are effective in reducing stress and anxiety among angioplasty patients.Conclusion:BRT or JPMR are noninvasive,nonpharmacological interventions that effectively reduce stress and anxiety in patients undergoing angioplasty.These findings underscore the importance of incorporating relaxation techniques into nursing practice and hospital programs to enhance patient care and promote holistic well-being post-angioplasty.
