The effects of pH and water hardness on the foaming properties of sodium methyl cocoyl taurate and its performance in combination with zwitterionic surfactants were investigated.The irritation of sodium methyl cocoyl ...The effects of pH and water hardness on the foaming properties of sodium methyl cocoyl taurate and its performance in combination with zwitterionic surfactants were investigated.The irritation of sodium methyl cocoyl taurate and its application in a shampoo formula were also studied.According to the result of experiment,sodium methyl cocoyl taurate had a wide pH stability range and good resistance to hard water,and it showed good synergistic thickening effect with betaine surfactants,especially when mixed with acyl hydroxysulfo betaine;The skin cholesterol dissolution test and red blood cell hemolysis test showed that its irritation was very low.Sodium methyl cocoyl taurate was applied to the transparent shampoo formula,and the sulfate-free transparent shampoo thus prepared had good stability and low eye irritation.It was both mild and non-irritating to skin.展开更多
文摘The effects of pH and water hardness on the foaming properties of sodium methyl cocoyl taurate and its performance in combination with zwitterionic surfactants were investigated.The irritation of sodium methyl cocoyl taurate and its application in a shampoo formula were also studied.According to the result of experiment,sodium methyl cocoyl taurate had a wide pH stability range and good resistance to hard water,and it showed good synergistic thickening effect with betaine surfactants,especially when mixed with acyl hydroxysulfo betaine;The skin cholesterol dissolution test and red blood cell hemolysis test showed that its irritation was very low.Sodium methyl cocoyl taurate was applied to the transparent shampoo formula,and the sulfate-free transparent shampoo thus prepared had good stability and low eye irritation.It was both mild and non-irritating to skin.
基金Major State Basic Research Development Program of China(2023YFB3810000)National Natural Science Foundation of China(NSFC,Nos.32271447,32401176)+4 种基金the Natural Science Foundation of Fujian Province(Nos.2022J01021,2024J08337,2024J09005)Natural Science Foundation of Xiamen(No.3502Z202371026)the Xiamen Medical College Research Fund(No.K2023-17)Educational Research Project for Middle-aged and Young Teachers in Fujian Province(No.JAT231135)Fujian Province Joint Funding Project for Scientific and Technological Innovation(2024Y9727).
文摘Retinal neovascularization(RNV)drives dual pathological cascades:structural destruction characterized by intraretinal/vitreous hemorrhages and tractional retinal detachment,alongside functional decline marked by progressive neurodegeneration and irreversible vision loss.Current clinical interventions for RNV face critical limitations in targeting specificity and therapeutic durability.To address this,we engineer magnesium acetyl taurate/thalidomide co-assembled nanoparticles(MT NPs)via Super-stable Pure Nanomedicine Formulation Technology(SPFT),constructing solvent-free,coordination-driven nanostructures with dual-drug loading.The MT NPs are further coated with transferrin-modified cell membrane vesicles(Tfm)to form targeted nanocomposites(Tfm@MT NPs).In oxygen-induced retinopathy(OIR)mouse models,Tfm@MT NPs demonstrated:(1)specific targeting to pathological vascular endothelia and retinal ganglion cells(RGCs)via transferrin receptor-mediated uptake,(2)sustained drug release exceeding 10 days,and(3)potent therapeutic effects in restoring visual functions.This study establishes a safe and effective targeted nanotherapeutic strategy for RNV,with significant translational potential for retinopathy treatment.
