Transcranial direct current stimulation （tDCS）, an emerging technique for non-invasive brain stimulation, is increasingly used to induce changes in cortical excitability and modulate motor behavior, especially for u...Transcranial direct current stimulation （tDCS）, an emerging technique for non-invasive brain stimulation, is increasingly used to induce changes in cortical excitability and modulate motor behavior, especially for upper limbs. The purpose of this study was to investigate the effects of tDCS of the primary motor cortex on visuomotor coordination based on three levels of task difficulty in healthy subjects. Thirty-eight healthy participants underwent real tDCS or sham tDCS. Using a single-blind, sham-controlled crossover design, tDCS was applied to the primary motor cortex. For real tDCS conditions, tDCS intensity was 1 mA while stimulation was applied for 15 minutes. For the sham tDCS, electrodes were placed in the same position, but the stimu- lator was turned off after 5 seconds. Visuomotor tracking task, consisting of three levels （levels 1, 2, 3） of difficulty with higher level indicating greater difficulty, was performed before and after tDCS application. At level 2, real tDCS of the primary motor cortex improved the accurate index compared to the sham tDCS. However, at levels 1 and 3, the accurate index was not significantly increased after real tDCS compared to the sham tDCS. These findings suggest that tasks of mod- erate difficulty may improve visuomotor coordination in healthy subjects when tDCS is applied compared with easier or more difficult tasks.展开更多
目的筛选能够在功能性核磁共振造影(functional magnetic resonance imaging,fMRI)上稳定激活Wernicke区的汉语听觉任务刺激模式。方法选用正常右利手中国汉族人10例,采用组块设计,应用西门子SONATA1.5TMRI分别进行不同的汉语语言听觉...目的筛选能够在功能性核磁共振造影(functional magnetic resonance imaging,fMRI)上稳定激活Wernicke区的汉语听觉任务刺激模式。方法选用正常右利手中国汉族人10例,采用组块设计,应用西门子SONATA1.5TMRI分别进行不同的汉语语言听觉刺激任务下的脑功能成像,汉语语言听觉刺激任务分2组:词汇理解组、段落理解组。同时以音乐组作为单纯听觉刺激对照。图像资料经处理后获得脑区激活图。结果音乐组可见双侧颞横回激活,激活以右侧颞叶为主;词汇理解组与段落理解组10例均可见以左颞叶为主的激活(Wernicke区),其中段落理解组激活信号更加强烈,时间-信号强度动态曲线稳定。结论汉语的段落理解任务可以作为临床观察fMRI中激活Wernicke区的听觉语言任务刺激模式。展开更多
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT&Future Planning,No.2012R1A1B4003477
文摘Transcranial direct current stimulation （tDCS）, an emerging technique for non-invasive brain stimulation, is increasingly used to induce changes in cortical excitability and modulate motor behavior, especially for upper limbs. The purpose of this study was to investigate the effects of tDCS of the primary motor cortex on visuomotor coordination based on three levels of task difficulty in healthy subjects. Thirty-eight healthy participants underwent real tDCS or sham tDCS. Using a single-blind, sham-controlled crossover design, tDCS was applied to the primary motor cortex. For real tDCS conditions, tDCS intensity was 1 mA while stimulation was applied for 15 minutes. For the sham tDCS, electrodes were placed in the same position, but the stimu- lator was turned off after 5 seconds. Visuomotor tracking task, consisting of three levels （levels 1, 2, 3） of difficulty with higher level indicating greater difficulty, was performed before and after tDCS application. At level 2, real tDCS of the primary motor cortex improved the accurate index compared to the sham tDCS. However, at levels 1 and 3, the accurate index was not significantly increased after real tDCS compared to the sham tDCS. These findings suggest that tasks of mod- erate difficulty may improve visuomotor coordination in healthy subjects when tDCS is applied compared with easier or more difficult tasks.
文摘目的筛选能够在功能性核磁共振造影(functional magnetic resonance imaging,fMRI)上稳定激活Wernicke区的汉语听觉任务刺激模式。方法选用正常右利手中国汉族人10例,采用组块设计,应用西门子SONATA1.5TMRI分别进行不同的汉语语言听觉刺激任务下的脑功能成像,汉语语言听觉刺激任务分2组:词汇理解组、段落理解组。同时以音乐组作为单纯听觉刺激对照。图像资料经处理后获得脑区激活图。结果音乐组可见双侧颞横回激活,激活以右侧颞叶为主;词汇理解组与段落理解组10例均可见以左颞叶为主的激活(Wernicke区),其中段落理解组激活信号更加强烈,时间-信号强度动态曲线稳定。结论汉语的段落理解任务可以作为临床观察fMRI中激活Wernicke区的听觉语言任务刺激模式。
