In this paper, the drawbacks of conventional target fluctuation models used in radar target modeling are set out. It is usually difficult to statistically model a real target because there are very few parameters whic...In this paper, the drawbacks of conventional target fluctuation models used in radar target modeling are set out. It is usually difficult to statistically model a real target because there are very few parameters which can be used to approximate the probability density function (PDF) of a real target's radar cross section (RCS) in conventional target models. A new method of statistical modeling is suggested, according to which the first nth central moment of real target's RCS, combined with the Legendre orthogonal polynomials, is used to reconstruct the PDF of the target's RCS. The relationship between the coefficients of the Legendre polynomials and the central moments of RCS are deduced mathematically. Through a practical computing example, the error-of-fit is shown as a function of the orders of Legendre coefficients. By comparing the errors-of-fit caused by both the new model and the conventional models, it is concluded that the new nonparametric method for statistical modeling of radar targets is superior.展开更多
By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentratio...By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.展开更多
A theoretical study is presented herein on the pen- etration of a semi-infinite target by a spherical-headed long rod for Yp 〉 S, where Yp is the penetrator strength and S is the static target resistance. For Yp 〉 S...A theoretical study is presented herein on the pen- etration of a semi-infinite target by a spherical-headed long rod for Yp 〉 S, where Yp is the penetrator strength and S is the static target resistance. For Yp 〉 S, depending upon initial impact velocity, there exist three types of penetration, namely, penetration by a rigid long rod, penetration by a deforming non-erosive long rod and penetration by an erosive long rod. If the impact velocity of the penetrator is higher than the hydrodynamic velocity （VH）, it will penetrate the target in an erosive mode; if the impact velocity lies between the hydrodynamic velocity （VH） and the rigid body velocity （VR）, it will penetrate the target in a deformable mode; if the impact velocity is less than the rigid body velocity （VR）, it will penetrate the target in a rigid mode. The critical conditions for the transition among these three penetration modes are proposed. It is demonstrated that the present model predictions correlate well with the experimental observations in terms of depth of penetration （DOP） and the critical transition conditions.展开更多
Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxi...Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxic instrument under intraperitoneal anesthesia. Based on the rat brain stereotaxic map, a 1-mm hole was made 10 mm posterior to bregma and 0.8 mm left of sagittal suture. A microsyringe was inserted perpendicularly to the surface of the brain to a depth of 9.7 mm, and 15 wL of ethanol was slowly injected to establish a rat model of spastic cerebral palsy. After modeling, the rats appeared to have necrotic voids in the pyramidal tract and exhibited typical signs and symptoms of flexion spasms that lasted for a long period of time. These findings indicate that this is an effective and easy method of establishing a rat model of spastic cerebral palsy with good reproducibility. Ethanol as a chemical ablation agent specifically and thoroughly damages the py- ramidal tract, and therefore, the animals display flexion spasms, which are a typical symptom of the disease.展开更多
The Dashuigou tellurium(Te) deposit in Shimian city, Sichuan Province is the only known independent Te ore deposit in China. Samples were collected by1/50,000 stream sediment survey and analyzed by inductively coupled...The Dashuigou tellurium(Te) deposit in Shimian city, Sichuan Province is the only known independent Te ore deposit in China. Samples were collected by1/50,000 stream sediment survey and analyzed by inductively coupled plasma–mass spectrometry, X-ray fluorescence spectrometry, emission spectrometry, and atomic absorption spectroscopy. An ore prospecting model for the Dashuigou Te deposit was then established. In the Dashuigou area, bismuth(Bi), Te, and gold(Au) concentrations in stream sediment samples displayed weak-positive anomalies, while silver(Ag) displayed a weaknegative anomaly. Bi, Te, Ag, and Au anomalies are regarded as indicators of Te deposits; the greater the ratio of Te+Bi/Au+Ag, the larger the possibility of an independent tellurobismuthite deposit. The ratio calculated from our samples is 7.288. Five locations were identified for prospecting for Te minerals by this model, including the northern part of the Dashuigou Te deposit, Majiagou,Tizigou, southeastern Miaoping, and northern Baishuihe.These five regions are within the Dashuigou dome anticline, the exposed strata of which are controlled by tracing the tensile shear fracture; the metallogenic geological conditions and geochemical characteristics are the same as those of the known Dashuigou Te deposit. Already, Te–Bi veins have been found in some of these areas.展开更多
In this paper, an improved implementation of multiple model Gaussian mixture probability hypothesis density （MM-GM-PHD） filter is proposed. For maneuvering target tracking, based on joint distribution, the existing ...In this paper, an improved implementation of multiple model Gaussian mixture probability hypothesis density （MM-GM-PHD） filter is proposed. For maneuvering target tracking, based on joint distribution, the existing MM-GM-PHD filter is relatively complex. To simplify the filter, model conditioned distribution and model probability are used in the improved MM-GM-PHD filter. In the algorithm, every Gaussian components describing existing, birth and spawned targets are estimated by multiple model method. The final results of the Gaussian components are the fusion of multiple model estimations. The algorithm does not need to compute the joint PHD distribution and has a simpler computation procedure. Compared with single model GM-PHD, the algorithm gives more accurate estimation on the number and state of the targets. Compared with the existing MM-GM-PHD algorithm, it saves computation time by more than 30%. Moreover, it also outperforms the interacting multiple model joint probabilistic data association （IMMJPDA） filter in a relatively dense clutter environment.展开更多
Model-set is utilized in state estimation for maneuver- ing target tracking. Two minimal symmetric model-subsets are designed and investigated by moment matching method, which include hypersphere-symmetric model-subse...Model-set is utilized in state estimation for maneuver- ing target tracking. Two minimal symmetric model-subsets are designed and investigated by moment matching method, which include hypersphere-symmetric model-subset and axis-symmetric model-subset, if system mode is a random variable and obeys certain probability distribution. They can be used as the fun- damental model-subset for multiple models estimation with fixed structure, variable structure and moving bank. The model-groups constructed by above designed subsets are given, which give the practical guidance for use of model-set in multiple models ap- proach with a variable structure. Simulation results show that the performances of two minimal model-set significantly outperform the corresponding model-sets with fixed spacing.展开更多
To mitigate the deleterious effects of clutter and jammer, modern radars have adopted adaptive processing techniques such as constant false alarm rate(CFAR) detectors which are widely used to prevent clutter and noise...To mitigate the deleterious effects of clutter and jammer, modern radars have adopted adaptive processing techniques such as constant false alarm rate(CFAR) detectors which are widely used to prevent clutter and noise interference from saturating the radar’s display and preventing targets from being obscured.This paper concerns with the detection analysis of the novel version of CFAR schemes(cell-averaging generalized trimmed-mean,CATM) in the presence of additional outlying targets other than the target under research. The spurious targets as well as the tested one are assumed to be fluctuating in accordance with the χ~2-model with two-degrees of freedom. In this situation, the processor performance is enclosed by the swerling models(SWI and SWII). Between these bounds, there is an important class of target fluctuation which is known as moderately fluctuating targets. The detection of this class has many practical applications. Structure of the CATM detector is described briefly. Detection performances for optimal, CAM, CA, trimmed-mean(TM) and ordered-statistic(OS) CFAR strategies have been analyzed and compared for desired probability of false alarm and determined size of the reference window. False alarm rate performance of these processors has been evaluated for different strengths of interfering signal and the effect of correlation among the target returns on the detection and false alarm performances has also been studied. Our numerical results show that, with a proper choice of trimming parameters,the novel model CAM presents an ideal detection performance outweighing that of the Neyman-Pearson detector on condition that the tested target obeys the SWII model in its fluctuation. Although the new models CAS and CAM can be treated as special cases of the CATM algorithm, their multi-target performance is modest even it has an enhancement relative to that of the classical CAcheme. Additionally, they fail to maintain the false alarm rate constant when the operating environment is of type target multiplicity. Moreover, the non-coherent integration of M pulses ameliorates the processor performance either it operates in homogeneous or multi-target environment.展开更多
This study aimed to establish a new propofol target-controlled infusion（TCI） model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and ...This study aimed to establish a new propofol target-controlled infusion（TCI） model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and propofol（10 mg/kg） was administrated intravenously. Artery blood samples were collected at various time points after injection, and plasma concentrations of propofol were measured. Pharmacokinetic modeling was performed using Win Nonlin software. Propofol TCI within the acquired parameters integrated was conducted to achieve different anesthetic depths in rabbits, monitored by narcotrend. The pharmacodynamics was analyzed using a sigmoidal inhibitory maximal effect model for narcotrend index（NI） versus effect-site concentration. The results showed the pharmacokinetics of propofol in Japanese white rabbits was best described by a two-compartment model. The target plasma concentrations of propofol required at light anesthetic depth was 9.77±0.23 μg/m L, while 12.52±0.69 μg/m L at deep anesthetic depth. NI was 76.17±4.25 at light anesthetic depth, while 27.41±5.77 at deep anesthetic depth. The effect-site elimination rate constant（ke0） was 0.263/min, and the propofol dose required to achieve a 50% decrease in the NI value from baseline was 11.19 μg/m L（95% CI, 10.25–13.67）. Our results established a new propofol TCI animal model and proved the model controlled the anesthetic depth accurately and stably in rabbits. The study provides a powerful method for exploring general anesthetic mechanisms at different anesthetic depths in vivo.展开更多
The basic"current"statistical model and adaptive Kalman filter algorithm can not track a weakly maneuvering target precisely,though it has good estimate accuracy for strongly maneuvering target.In order to s...The basic"current"statistical model and adaptive Kalman filter algorithm can not track a weakly maneuvering target precisely,though it has good estimate accuracy for strongly maneuvering target.In order to solve this problem,a novel nonlinear fuzzy membership function was presented to adjust the upper and lower limit of target acceleration adaptively,and then the validity of the new algorithm for feeblish maneuvering target was proved in theory.At last,the computer simulation experiments indicated that the new algorithm has a great advantage over the basic"current"statistical model and adaptive algorithm.展开更多
For target detection algorithm under global motion scene, this paper suggests a target detection algorithm based on motion attention fusion model. Firstly, the motion vector field is pre-processed by accumulation and ...For target detection algorithm under global motion scene, this paper suggests a target detection algorithm based on motion attention fusion model. Firstly, the motion vector field is pre-processed by accumulation and median filter;Then, according to the temporal and spatial character of motion vector, the attention fusion model is defined, which is used to detect moving target;Lastly, the edge of video moving target is made exactly by morphologic operation and edge tracking algorithm. The experimental results of different global motion video sequences show the proposed algorithm has a better veracity and speedup than other algorithm.展开更多
Public benchmark datasets have been widely used to evaluate multi-target tracking algorithms. Ideally, the benchmark datasets should include the video scenes of all scenarios that need to be tested. However, a limited...Public benchmark datasets have been widely used to evaluate multi-target tracking algorithms. Ideally, the benchmark datasets should include the video scenes of all scenarios that need to be tested. However, a limited amount of the currently available benchmark datasets does not comprehensively cover all necessary test scenarios. This limits the evaluation of multitarget tracking algorithms with various test scenarios. This paper introduced a computer simulation model that generates benchmark datasets for evaluating multi-target tracking algorithms with the complexity of multitarget tracking scenarios directly controlled by simulation inputs such as target birth and death rates, target movement, the rates of target merges and splits, target appearances, and image noise types and levels. The simulation model generated a simulated video and also provides the ground-truth target tracking for the simulated video, so the evaluation of multitarget tracking algorithms can be easily performed without any manual video annotation process. We demonstrated the use of the proposed simulation model for evaluating tracking-by-detection algorithms and filtering-based tracking algorithms.展开更多
In order to improve the accuracy and efficiency of early warning system, the incident chain model and the targeted dissemination technology are proposed in this paper. Firstly, the occurrence probability, affected are...In order to improve the accuracy and efficiency of early warning system, the incident chain model and the targeted dissemination technology are proposed in this paper. Firstly, the occurrence probability, affected area and duration of disaster are predicted with the incident chain model and GIS. According to prediction results, the early warning system can accurately deliver early warning information specifically to the affected areas through targeted dissemination. Moreover, dissemination performance can also be evaluated in real time after early warning information dissemination, so that everyone in the affected area can receive early warning information successfully. The incident chain model and the targeted dissemination technology presented in this study are of great significance for improving the information dissemination ability of early warning system.展开更多
Fusarium head blight (FHB) is a destructive disease of wheat and other cereals. FHB occurs in Europe, North America and around the world causing significant losses in production and endangers human and animal health. ...Fusarium head blight (FHB) is a destructive disease of wheat and other cereals. FHB occurs in Europe, North America and around the world causing significant losses in production and endangers human and animal health. In this article, we provide the strategic steps for the specific target selection for the phytopathogen system wheat-Fusarium graminearum. The economic impact of FHB leads to the need for innovation. Currently used fungicides have been shown to be effective over the years, but recently cereal infecting Fusaria have developed resistance. Our work presents a new perspective on target selection to allow the development of new fungicides. We developed an innovative approach combining both genomic analysis and molecular modeling to increase the discovery for new chemical compounds with both safety and low environmental impact. Our protein targets selection revealed 13 candidates with high specificity, essentiality and potentially assayable with a favorable accessibility to drug activity. Among them, three proteins: trichodiene synthase, endoglucanase-5 and ERG6 were selected for deeper structural analyses to identify new putative fungicides. Overall, the bioinformatics filtering for novel protein targets applied for agricultural purposes is a response to the demand for chemical crop protection. The availability of the genome, secretome and PHI-base allowed the enrichment of the search that combined experimental data in planta. The homology modeling and molecular dynamics simulations allowed the acquisition of three robust and stable conformers. From this step, approximately ten thousand compounds have been virtually screened against three candidates. Forty-five top-ranked compounds were selected from docking results as presenting better interactions and energy at the binding pockets and no toxicity. These compounds may act as inhibitors and lead to the development of new fungicides.展开更多
A new modeling and filtering approach for tracking maneuvering targets is presented in thispaper.The approach,which makes optimal estimate for the model With the random variable possible,depends on random step modelin...A new modeling and filtering approach for tracking maneuvering targets is presented in thispaper.The approach,which makes optimal estimate for the model With the random variable possible,depends on random step modeling of target maneuvers.In the new model,the unknown targetacceleration is treated as a random variable and then estimated directly.A detector is designed tofind out the target maneuvers and the estimation algorithm will be restarted when the maneuvers oc-cur.Combination of three-dimention Kalman filter with a detector forms a tracker for maneuveringtargets.The new tracking scheme is easy to implement and its capability is illustrated in two trackingexamples in which the new approach is compared with Mooses’on the performance.展开更多
Target detection is always an important application in hyperspectral image processing field. In this paper, a spectral-spatial target detection algorithm for hyperspectral data is proposed.The spatial feature and spec...Target detection is always an important application in hyperspectral image processing field. In this paper, a spectral-spatial target detection algorithm for hyperspectral data is proposed.The spatial feature and spectral feature were unified based on the data filed theory and extracted by weighted manifold embedding. The novelties of the proposed method lie in two aspects. One is the way in which the spatial features and spectral features were fused as a new feature based on the data field theory, and the other is that local information was introduced to describe the decision boundary and explore the discriminative features for target detection. The extracted features based on data field modeling and manifold embedding techniques were considered for a target detection task.Three standard hyperspectral datasets were considered in the analysis. The effectiveness of the proposed target detection algorithm based on data field theory was proved by the higher detection rates with lower False Alarm Rates（FARs） with respect to those achieved by conventional hyperspectral target detectors.展开更多
An algorithm of highly maneuvering target tracking is proposed to solve the problem of large tracking error caused by strong maneuver. In this algorithm, a new estimator, named as multi-parameter fusion Singer (MF-Sin...An algorithm of highly maneuvering target tracking is proposed to solve the problem of large tracking error caused by strong maneuver. In this algorithm, a new estimator, named as multi-parameter fusion Singer (MF-Singer) model is derived based on the Singer model and the fuzzy reasoning method by using radial acceleration and velocity of the target, and applied to the problem of maneuvering target tracking in strong maneuvering environment and operating environment. The tracking performance of the MF-Singer model is evaluated and compared with other manuevering tracking models. It is shown that the MF-Singer model outperforms these algorithms in several examples.展开更多
In the technique of video multi-target tracking,the common particle filter can not deal well with uncertain relations among multiple targets.To solve this problem,many researchers use data association method to reduce...In the technique of video multi-target tracking,the common particle filter can not deal well with uncertain relations among multiple targets.To solve this problem,many researchers use data association method to reduce the multi-target uncertainty.However,the traditional data association method is difficult to track accurately when the target is occluded.To remove the occlusion in the video,combined with the theory of data association,this paper adopts the probabilistic graphical model for multi-target modeling and analysis of the targets relationship in the particle filter framework.Ex-perimental results show that the proposed algorithm can solve the occlusion problem better compared with the traditional algorithm.展开更多
It is urgent to find a technology accurately to better diagnose and treat to brain tumor.Eu-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chl...It is urgent to find a technology accurately to better diagnose and treat to brain tumor.Eu-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chlorotoxin(CTX)via PEGylation,hydrazone bond and sulfur bond(named as CTXNRs-Dox),and these NRs could release more Dox in lower pH environment.The results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells,as well as good fluorescence imaging behavior.The orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells(U87 MG).The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation,leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors.A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was proposed.Our research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma.展开更多
Among the proposed techniques for delivering drugs to specific locations within human body, magnetic drug targeting prevails due to its non-invasive character and its high targeting efficiency. Magnetic targeting drug...Among the proposed techniques for delivering drugs to specific locations within human body, magnetic drug targeting prevails due to its non-invasive character and its high targeting efficiency. Magnetic targeting drug delivery is a method of carrying drug-loaded magnetic nanoparticles to a target tissue target under the applied magnetic field. This method increases the drug concentration in the target while reducing the adverse side-effects. Although there have been some theoretical analyses for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel. A mathematical model is presented to describe the hydrodynamics of ferrofiuids as drug carriers flowing in a blood vessel under the applied magnetic field. In this model, magnetic force and asymmetrical force are added, and an angular momentum equation of magnetic nanoparticles in the applied magnetic field is modeled. Engineering approximations are achieved by retaining the physically most significant items in the model due to the mathematical complexity of the motion equations. Numerical simulations are performed to obtain better insight into the theoretical model with computational fluid dynamics. Simulation results demonstrate the important parameters leading to adequate drug delivery to the target site depending on the magnetic field intensity, which coincident with those of animal experiments. Results of the analysis provide important information and suggest strategies for improving delivery in clinical application.展开更多
文摘In this paper, the drawbacks of conventional target fluctuation models used in radar target modeling are set out. It is usually difficult to statistically model a real target because there are very few parameters which can be used to approximate the probability density function (PDF) of a real target's radar cross section (RCS) in conventional target models. A new method of statistical modeling is suggested, according to which the first nth central moment of real target's RCS, combined with the Legendre orthogonal polynomials, is used to reconstruct the PDF of the target's RCS. The relationship between the coefficients of the Legendre polynomials and the central moments of RCS are deduced mathematically. Through a practical computing example, the error-of-fit is shown as a function of the orders of Legendre coefficients. By comparing the errors-of-fit caused by both the new model and the conventional models, it is concluded that the new nonparametric method for statistical modeling of radar targets is superior.
文摘By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.
基金supported by the National Natural Science Foundation of China (10872195)
文摘A theoretical study is presented herein on the pen- etration of a semi-infinite target by a spherical-headed long rod for Yp 〉 S, where Yp is the penetrator strength and S is the static target resistance. For Yp 〉 S, depending upon initial impact velocity, there exist three types of penetration, namely, penetration by a rigid long rod, penetration by a deforming non-erosive long rod and penetration by an erosive long rod. If the impact velocity of the penetrator is higher than the hydrodynamic velocity （VH）, it will penetrate the target in an erosive mode; if the impact velocity lies between the hydrodynamic velocity （VH） and the rigid body velocity （VR）, it will penetrate the target in a deformable mode; if the impact velocity is less than the rigid body velocity （VR）, it will penetrate the target in a rigid mode. The critical conditions for the transition among these three penetration modes are proposed. It is demonstrated that the present model predictions correlate well with the experimental observations in terms of depth of penetration （DOP） and the critical transition conditions.
文摘Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxic instrument under intraperitoneal anesthesia. Based on the rat brain stereotaxic map, a 1-mm hole was made 10 mm posterior to bregma and 0.8 mm left of sagittal suture. A microsyringe was inserted perpendicularly to the surface of the brain to a depth of 9.7 mm, and 15 wL of ethanol was slowly injected to establish a rat model of spastic cerebral palsy. After modeling, the rats appeared to have necrotic voids in the pyramidal tract and exhibited typical signs and symptoms of flexion spasms that lasted for a long period of time. These findings indicate that this is an effective and easy method of establishing a rat model of spastic cerebral palsy with good reproducibility. Ethanol as a chemical ablation agent specifically and thoroughly damages the py- ramidal tract, and therefore, the animals display flexion spasms, which are a typical symptom of the disease.
基金supported by the Institute of Geochemistry, Chinese Academy of Sciences (03JY029-027-1)Sichuan Geological Survey (12120113051400)the State Key Laboratory of Ore Deposit Geochemistry, Chinese Academy of Sciences for its open program funding
文摘The Dashuigou tellurium(Te) deposit in Shimian city, Sichuan Province is the only known independent Te ore deposit in China. Samples were collected by1/50,000 stream sediment survey and analyzed by inductively coupled plasma–mass spectrometry, X-ray fluorescence spectrometry, emission spectrometry, and atomic absorption spectroscopy. An ore prospecting model for the Dashuigou Te deposit was then established. In the Dashuigou area, bismuth(Bi), Te, and gold(Au) concentrations in stream sediment samples displayed weak-positive anomalies, while silver(Ag) displayed a weaknegative anomaly. Bi, Te, Ag, and Au anomalies are regarded as indicators of Te deposits; the greater the ratio of Te+Bi/Au+Ag, the larger the possibility of an independent tellurobismuthite deposit. The ratio calculated from our samples is 7.288. Five locations were identified for prospecting for Te minerals by this model, including the northern part of the Dashuigou Te deposit, Majiagou,Tizigou, southeastern Miaoping, and northern Baishuihe.These five regions are within the Dashuigou dome anticline, the exposed strata of which are controlled by tracing the tensile shear fracture; the metallogenic geological conditions and geochemical characteristics are the same as those of the known Dashuigou Te deposit. Already, Te–Bi veins have been found in some of these areas.
文摘In this paper, an improved implementation of multiple model Gaussian mixture probability hypothesis density （MM-GM-PHD） filter is proposed. For maneuvering target tracking, based on joint distribution, the existing MM-GM-PHD filter is relatively complex. To simplify the filter, model conditioned distribution and model probability are used in the improved MM-GM-PHD filter. In the algorithm, every Gaussian components describing existing, birth and spawned targets are estimated by multiple model method. The final results of the Gaussian components are the fusion of multiple model estimations. The algorithm does not need to compute the joint PHD distribution and has a simpler computation procedure. Compared with single model GM-PHD, the algorithm gives more accurate estimation on the number and state of the targets. Compared with the existing MM-GM-PHD algorithm, it saves computation time by more than 30%. Moreover, it also outperforms the interacting multiple model joint probabilistic data association （IMMJPDA） filter in a relatively dense clutter environment.
基金supported by Liaoning Province Innovative Team of Higher Education(2008T090)
文摘Model-set is utilized in state estimation for maneuver- ing target tracking. Two minimal symmetric model-subsets are designed and investigated by moment matching method, which include hypersphere-symmetric model-subset and axis-symmetric model-subset, if system mode is a random variable and obeys certain probability distribution. They can be used as the fun- damental model-subset for multiple models estimation with fixed structure, variable structure and moving bank. The model-groups constructed by above designed subsets are given, which give the practical guidance for use of model-set in multiple models ap- proach with a variable structure. Simulation results show that the performances of two minimal model-set significantly outperform the corresponding model-sets with fixed spacing.
文摘To mitigate the deleterious effects of clutter and jammer, modern radars have adopted adaptive processing techniques such as constant false alarm rate(CFAR) detectors which are widely used to prevent clutter and noise interference from saturating the radar’s display and preventing targets from being obscured.This paper concerns with the detection analysis of the novel version of CFAR schemes(cell-averaging generalized trimmed-mean,CATM) in the presence of additional outlying targets other than the target under research. The spurious targets as well as the tested one are assumed to be fluctuating in accordance with the χ~2-model with two-degrees of freedom. In this situation, the processor performance is enclosed by the swerling models(SWI and SWII). Between these bounds, there is an important class of target fluctuation which is known as moderately fluctuating targets. The detection of this class has many practical applications. Structure of the CATM detector is described briefly. Detection performances for optimal, CAM, CA, trimmed-mean(TM) and ordered-statistic(OS) CFAR strategies have been analyzed and compared for desired probability of false alarm and determined size of the reference window. False alarm rate performance of these processors has been evaluated for different strengths of interfering signal and the effect of correlation among the target returns on the detection and false alarm performances has also been studied. Our numerical results show that, with a proper choice of trimming parameters,the novel model CAM presents an ideal detection performance outweighing that of the Neyman-Pearson detector on condition that the tested target obeys the SWII model in its fluctuation. Although the new models CAS and CAM can be treated as special cases of the CATM algorithm, their multi-target performance is modest even it has an enhancement relative to that of the classical CAcheme. Additionally, they fail to maintain the false alarm rate constant when the operating environment is of type target multiplicity. Moreover, the non-coherent integration of M pulses ameliorates the processor performance either it operates in homogeneous or multi-target environment.
基金supported by a grant from Shenzhen Baoan Hospital Affiliated to Southern Medical University
文摘This study aimed to establish a new propofol target-controlled infusion（TCI） model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and propofol（10 mg/kg） was administrated intravenously. Artery blood samples were collected at various time points after injection, and plasma concentrations of propofol were measured. Pharmacokinetic modeling was performed using Win Nonlin software. Propofol TCI within the acquired parameters integrated was conducted to achieve different anesthetic depths in rabbits, monitored by narcotrend. The pharmacodynamics was analyzed using a sigmoidal inhibitory maximal effect model for narcotrend index（NI） versus effect-site concentration. The results showed the pharmacokinetics of propofol in Japanese white rabbits was best described by a two-compartment model. The target plasma concentrations of propofol required at light anesthetic depth was 9.77±0.23 μg/m L, while 12.52±0.69 μg/m L at deep anesthetic depth. NI was 76.17±4.25 at light anesthetic depth, while 27.41±5.77 at deep anesthetic depth. The effect-site elimination rate constant（ke0） was 0.263/min, and the propofol dose required to achieve a 50% decrease in the NI value from baseline was 11.19 μg/m L（95% CI, 10.25–13.67）. Our results established a new propofol TCI animal model and proved the model controlled the anesthetic depth accurately and stably in rabbits. The study provides a powerful method for exploring general anesthetic mechanisms at different anesthetic depths in vivo.
文摘The basic"current"statistical model and adaptive Kalman filter algorithm can not track a weakly maneuvering target precisely,though it has good estimate accuracy for strongly maneuvering target.In order to solve this problem,a novel nonlinear fuzzy membership function was presented to adjust the upper and lower limit of target acceleration adaptively,and then the validity of the new algorithm for feeblish maneuvering target was proved in theory.At last,the computer simulation experiments indicated that the new algorithm has a great advantage over the basic"current"statistical model and adaptive algorithm.
文摘For target detection algorithm under global motion scene, this paper suggests a target detection algorithm based on motion attention fusion model. Firstly, the motion vector field is pre-processed by accumulation and median filter;Then, according to the temporal and spatial character of motion vector, the attention fusion model is defined, which is used to detect moving target;Lastly, the edge of video moving target is made exactly by morphologic operation and edge tracking algorithm. The experimental results of different global motion video sequences show the proposed algorithm has a better veracity and speedup than other algorithm.
文摘Public benchmark datasets have been widely used to evaluate multi-target tracking algorithms. Ideally, the benchmark datasets should include the video scenes of all scenarios that need to be tested. However, a limited amount of the currently available benchmark datasets does not comprehensively cover all necessary test scenarios. This limits the evaluation of multitarget tracking algorithms with various test scenarios. This paper introduced a computer simulation model that generates benchmark datasets for evaluating multi-target tracking algorithms with the complexity of multitarget tracking scenarios directly controlled by simulation inputs such as target birth and death rates, target movement, the rates of target merges and splits, target appearances, and image noise types and levels. The simulation model generated a simulated video and also provides the ground-truth target tracking for the simulated video, so the evaluation of multitarget tracking algorithms can be easily performed without any manual video annotation process. We demonstrated the use of the proposed simulation model for evaluating tracking-by-detection algorithms and filtering-based tracking algorithms.
文摘In order to improve the accuracy and efficiency of early warning system, the incident chain model and the targeted dissemination technology are proposed in this paper. Firstly, the occurrence probability, affected area and duration of disaster are predicted with the incident chain model and GIS. According to prediction results, the early warning system can accurately deliver early warning information specifically to the affected areas through targeted dissemination. Moreover, dissemination performance can also be evaluated in real time after early warning information dissemination, so that everyone in the affected area can receive early warning information successfully. The incident chain model and the targeted dissemination technology presented in this study are of great significance for improving the information dissemination ability of early warning system.
文摘Fusarium head blight (FHB) is a destructive disease of wheat and other cereals. FHB occurs in Europe, North America and around the world causing significant losses in production and endangers human and animal health. In this article, we provide the strategic steps for the specific target selection for the phytopathogen system wheat-Fusarium graminearum. The economic impact of FHB leads to the need for innovation. Currently used fungicides have been shown to be effective over the years, but recently cereal infecting Fusaria have developed resistance. Our work presents a new perspective on target selection to allow the development of new fungicides. We developed an innovative approach combining both genomic analysis and molecular modeling to increase the discovery for new chemical compounds with both safety and low environmental impact. Our protein targets selection revealed 13 candidates with high specificity, essentiality and potentially assayable with a favorable accessibility to drug activity. Among them, three proteins: trichodiene synthase, endoglucanase-5 and ERG6 were selected for deeper structural analyses to identify new putative fungicides. Overall, the bioinformatics filtering for novel protein targets applied for agricultural purposes is a response to the demand for chemical crop protection. The availability of the genome, secretome and PHI-base allowed the enrichment of the search that combined experimental data in planta. The homology modeling and molecular dynamics simulations allowed the acquisition of three robust and stable conformers. From this step, approximately ten thousand compounds have been virtually screened against three candidates. Forty-five top-ranked compounds were selected from docking results as presenting better interactions and energy at the binding pockets and no toxicity. These compounds may act as inhibitors and lead to the development of new fungicides.
文摘A new modeling and filtering approach for tracking maneuvering targets is presented in thispaper.The approach,which makes optimal estimate for the model With the random variable possible,depends on random step modeling of target maneuvers.In the new model,the unknown targetacceleration is treated as a random variable and then estimated directly.A detector is designed tofind out the target maneuvers and the estimation algorithm will be restarted when the maneuvers oc-cur.Combination of three-dimention Kalman filter with a detector forms a tracker for maneuveringtargets.The new tracking scheme is easy to implement and its capability is illustrated in two trackingexamples in which the new approach is compared with Mooses’on the performance.
文摘Target detection is always an important application in hyperspectral image processing field. In this paper, a spectral-spatial target detection algorithm for hyperspectral data is proposed.The spatial feature and spectral feature were unified based on the data filed theory and extracted by weighted manifold embedding. The novelties of the proposed method lie in two aspects. One is the way in which the spatial features and spectral features were fused as a new feature based on the data field theory, and the other is that local information was introduced to describe the decision boundary and explore the discriminative features for target detection. The extracted features based on data field modeling and manifold embedding techniques were considered for a target detection task.Three standard hyperspectral datasets were considered in the analysis. The effectiveness of the proposed target detection algorithm based on data field theory was proved by the higher detection rates with lower False Alarm Rates（FARs） with respect to those achieved by conventional hyperspectral target detectors.
基金supported by the National Natural Science Foundation of China(6153102061471383)
文摘An algorithm of highly maneuvering target tracking is proposed to solve the problem of large tracking error caused by strong maneuver. In this algorithm, a new estimator, named as multi-parameter fusion Singer (MF-Singer) model is derived based on the Singer model and the fuzzy reasoning method by using radial acceleration and velocity of the target, and applied to the problem of maneuvering target tracking in strong maneuvering environment and operating environment. The tracking performance of the MF-Singer model is evaluated and compared with other manuevering tracking models. It is shown that the MF-Singer model outperforms these algorithms in several examples.
基金Supported by the National High Technology Research and Development Program of China (No. 2007AA11Z227)the Natural Science Foundation of Jiangsu Province of China(No. BK2009352)the Fundamental Research Funds for the Central Universities of China (No. 2010B16414)
文摘In the technique of video multi-target tracking,the common particle filter can not deal well with uncertain relations among multiple targets.To solve this problem,many researchers use data association method to reduce the multi-target uncertainty.However,the traditional data association method is difficult to track accurately when the target is occluded.To remove the occlusion in the video,combined with the theory of data association,this paper adopts the probabilistic graphical model for multi-target modeling and analysis of the targets relationship in the particle filter framework.Ex-perimental results show that the proposed algorithm can solve the occlusion problem better compared with the traditional algorithm.
基金supported by the National Natural Science Foundation of China (Nos.51273122,51872190)Sichuan Science and Technology Project (No.2018JY0535)supported by the Fundamental of Research Funds for the Central University (Nos.SCU2017A001,2018SCUH0024)
文摘It is urgent to find a technology accurately to better diagnose and treat to brain tumor.Eu-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chlorotoxin(CTX)via PEGylation,hydrazone bond and sulfur bond(named as CTXNRs-Dox),and these NRs could release more Dox in lower pH environment.The results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells,as well as good fluorescence imaging behavior.The orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells(U87 MG).The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation,leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors.A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was proposed.Our research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma.
基金the National Basic Research Program of China(973 Program)(No.2007CB936004)the National Natural Science Foundation of China(No.50875169)
文摘Among the proposed techniques for delivering drugs to specific locations within human body, magnetic drug targeting prevails due to its non-invasive character and its high targeting efficiency. Magnetic targeting drug delivery is a method of carrying drug-loaded magnetic nanoparticles to a target tissue target under the applied magnetic field. This method increases the drug concentration in the target while reducing the adverse side-effects. Although there have been some theoretical analyses for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel. A mathematical model is presented to describe the hydrodynamics of ferrofiuids as drug carriers flowing in a blood vessel under the applied magnetic field. In this model, magnetic force and asymmetrical force are added, and an angular momentum equation of magnetic nanoparticles in the applied magnetic field is modeled. Engineering approximations are achieved by retaining the physically most significant items in the model due to the mathematical complexity of the motion equations. Numerical simulations are performed to obtain better insight into the theoretical model with computational fluid dynamics. Simulation results demonstrate the important parameters leading to adequate drug delivery to the target site depending on the magnetic field intensity, which coincident with those of animal experiments. Results of the analysis provide important information and suggest strategies for improving delivery in clinical application.
