Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol(1) and 22α-hydroxy-20-taraxasten-30β, 30-triol(2), have been obtai...Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol(1) and 22α-hydroxy-20-taraxasten-30β, 30-triol(2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer(A2780) and colon cancer(HCT-8) cell lines.展开更多
A new taraxastane-20β, 28β-epoxy-28-hydroxy-3β, 11 α-diol- 11-p-hydroxylbenzoate was isolated from the roots of Potentilla multicaulis. Its structure was elucidated by spectroscopic methods, especially 2D NMR tech...A new taraxastane-20β, 28β-epoxy-28-hydroxy-3β, 11 α-diol- 11-p-hydroxylbenzoate was isolated from the roots of Potentilla multicaulis. Its structure was elucidated by spectroscopic methods, especially 2D NMR techniques.展开更多
Two new taraxastane-type triterpenes. 3 beta. 21 beta -dihydroxyl-20(30)-en-taraxastane 1 and 3 beta. 30-dihydroxy-20(21)-en-taraxastane 2. were isolated from Saussurea petrovii. Their structures were elucidated by sp...Two new taraxastane-type triterpenes. 3 beta. 21 beta -dihydroxyl-20(30)-en-taraxastane 1 and 3 beta. 30-dihydroxy-20(21)-en-taraxastane 2. were isolated from Saussurea petrovii. Their structures were elucidated by spectral methods (EIMS. IR. 1D and 2DNMR).展开更多
基金supported by the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee(No.KZ201811417049)the National Natural Science Foundation of China(Nos.81522050,81773589 and 81760783)+1 种基金the Science and Technology program of Qinghai(No.2018-ZJ-739)the Scientific Research Common Program of Beijing Municipal Commission of Education(No.KM201811417008)
文摘Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol(1) and 22α-hydroxy-20-taraxasten-30β, 30-triol(2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer(A2780) and colon cancer(HCT-8) cell lines.
文摘A new taraxastane-20β, 28β-epoxy-28-hydroxy-3β, 11 α-diol- 11-p-hydroxylbenzoate was isolated from the roots of Potentilla multicaulis. Its structure was elucidated by spectroscopic methods, especially 2D NMR techniques.
基金the Department of Science and Technology of China for financial support (Grant No. G1998051113).
文摘Two new taraxastane-type triterpenes. 3 beta. 21 beta -dihydroxyl-20(30)-en-taraxastane 1 and 3 beta. 30-dihydroxy-20(21)-en-taraxastane 2. were isolated from Saussurea petrovii. Their structures were elucidated by spectral methods (EIMS. IR. 1D and 2DNMR).
