Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder and the leading cause of dementia worldwide.It is characterized by the accumulation of extracellular amyloid-beta(Aβ)plaques and intracellul...Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder and the leading cause of dementia worldwide.It is characterized by the accumulation of extracellular amyloid-beta(Aβ)plaques and intracellular tau neurofibrillary tangles,leading to synaptic dysfunction,neuronal loss,and cognitive decline.These pathological changes can begin decades before clinical symptoms emerge,highlighting the critical need for early,accessible,and accurate diagnostic tools.展开更多
Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta(Aβ)plaques and neurofibrillary tangles(NFTs)composed of hyperphosphorylated Tau protein tau tangle...Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta(Aβ)plaques and neurofibrillary tangles(NFTs)composed of hyperphosphorylated Tau protein tau tangles,leading to cognitive decline and neuronal loss(Frisoni et al.2022;Self and Holtzman 2023).展开更多
文摘Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder and the leading cause of dementia worldwide.It is characterized by the accumulation of extracellular amyloid-beta(Aβ)plaques and intracellular tau neurofibrillary tangles,leading to synaptic dysfunction,neuronal loss,and cognitive decline.These pathological changes can begin decades before clinical symptoms emerge,highlighting the critical need for early,accessible,and accurate diagnostic tools.
基金supported by the National Natural Science Foundation of China(82471445 and 32170988 to R.L.)the Talent Scientific Fund of Lanzhou University(561120215 to R.L.).
文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta(Aβ)plaques and neurofibrillary tangles(NFTs)composed of hyperphosphorylated Tau protein tau tangles,leading to cognitive decline and neuronal loss(Frisoni et al.2022;Self and Holtzman 2023).
