It is necessary to develop a new strategy for treatment of lung cancer since it is the main cause of cancer death.Tanshinone IIA(Tan IIA),an active ingredient of a commonly used traditional Chinese herb Salvia miltior...It is necessary to develop a new strategy for treatment of lung cancer since it is the main cause of cancer death.Tanshinone IIA(Tan IIA),an active ingredient of a commonly used traditional Chinese herb Salvia miltiorrhiza,provides a new direction to develop a new strategy for the treatment.It has been found that Tan IIA could inhibit lung cancer in vitro and in vivo by inducing autophagic apoptosis.Tan IIA increased apoptotic cells and the expression of cleaved caspase 3 and cleaved caspase 9,decreased B-cell lymphoma-2(Bcl-2)/Bcl-2 associated X protein(Bax)ratio in human non-small cell lung cancer(NSCLC)cell lines,which was promoted by an autophagy activator Rapamycin,and weaken by autophagy inhibitor 3-methyladenine(3-MA).In addition,Tan IIA induced more autophagosomes,up-regulated light chain 3b(LC-3B)I and LC-3B II conversion and less sequestosome 1(SQSTM1/p62)expression,which cannot be weakened by the caspase 3 antagonist.Moreover,overexpression of LC-3B gene(LC3B)and downregulation of autophagic gene 5(ATG5)further confirmed that Tan IIA induced autophagic apoptosis in NSCLC cell lines.Beclin-1 gene(BECN1)overexpression and silence attenuated the effects of Tan IIA,suggesting autophagic apoptosis that Tan IIA induced was dependent on Beclin-1.Overall,our study demonstrated a new treatment mechanism of Tan IIA and suggested that Tan IIA is a potential new anti-cancer therapeutic option.展开更多
TaN coatings were deposited on Ti bipolar plates by magnetron sputtering to improve corrosion resistance and service life.The influence of N_(2) flow rate on the surface morphology,hydrophobicity,crystallinity,corrosi...TaN coatings were deposited on Ti bipolar plates by magnetron sputtering to improve corrosion resistance and service life.The influence of N_(2) flow rate on the surface morphology,hydrophobicity,crystallinity,corrosion resistance,and interfacial contact resistance of TaN coatings was studied.Results show that as the N_(2) flow rate increases,the roughness of TaN coatings decreases firstly and then increases,and the hydrophobicity increases firstly and then decreases.At the N_(2) flow rate of 3 mL/min,TaN coating with larger grain size presents lower roughness and high hydrophobicity.The coating possesses the lowest corrosion current density of 2.82µA·cm^(−2) and the highest corrosion potential of−0.184 V vs.SCE in the simulated proton exchange membrane water electrolyser environment.After a potentiostatic polarization test for 10 h,a few corrosion pits are observed on the TaN coatings deposited at an N_(2) flow rate of 3 mL/min.After 75 h of electrolytic water performance testing,the TaN coating on bipolar plate improves the corrosion resistance and thus enhances the electrolysis efficiency(68.87%),greatly reducing the cost of bipolar plates.展开更多
While walking in Xiamen University,you can enjoy the gentle ocean breezes,the blue sky and the exquisite Tan Kah-Kee-style architecture.It has architectural styles from both the East and the West.To have a deeper unde...While walking in Xiamen University,you can enjoy the gentle ocean breezes,the blue sky and the exquisite Tan Kah-Kee-style architecture.It has architectural styles from both the East and the West.To have a deeper understanding of the design,I’ll introduce a prominent community leader and philanthropist(慈善家),Tan Kah Kee(or Chen Jiageng)who was also a founder of Xiamen University and Jimei University to you.展开更多
Promoting positive urban–rural interactions is a key strategy for addressing rural decline and advancing regional sustainable development.This study examines the impacts of urban–rural interactions on rural developm...Promoting positive urban–rural interactions is a key strategy for addressing rural decline and advancing regional sustainable development.This study examines the impacts of urban–rural interactions on rural development and explores their mechanisms for advancing sustainability within urban agglomeration areas.Using the Chang–Zhu–Tan(CZT)urban agglomeration as a case study,with an indicator system to measure urban–rural interactions and rural sustainable development,we analyze the mediating effects of resource flows in the process of urban–rural interactions driving rural sustainability through a mediation model.The results show that spatial connectivity,industrial convergence,and social integration between urban and rural areas positively contribute to the economic and social sustainability of rural areas.However,urban–rural spatial connectivity and social integration may negatively impact on rural environment.In this process,capital,technology,and labor play significant mediating roles,whereas the influence of land is less pronounced.Based on these findings,we propose several recommendations for strategically leveraging the benefits of urban–rural interactions across various social-ecological contexts while mitigating their drawbacks.展开更多
基金The study was supported by grants from the National Natural Science Foundation of China(81903943 and 82074219)the Natural Science Foundation of Guangdong Province(2017A030310502)+1 种基金The study was also supported by the Key Projects of Educational Commission of Guangdong Province(2018KZDXM020)the Science and Technology Planning Project of Guangzhou(202002030009).
文摘It is necessary to develop a new strategy for treatment of lung cancer since it is the main cause of cancer death.Tanshinone IIA(Tan IIA),an active ingredient of a commonly used traditional Chinese herb Salvia miltiorrhiza,provides a new direction to develop a new strategy for the treatment.It has been found that Tan IIA could inhibit lung cancer in vitro and in vivo by inducing autophagic apoptosis.Tan IIA increased apoptotic cells and the expression of cleaved caspase 3 and cleaved caspase 9,decreased B-cell lymphoma-2(Bcl-2)/Bcl-2 associated X protein(Bax)ratio in human non-small cell lung cancer(NSCLC)cell lines,which was promoted by an autophagy activator Rapamycin,and weaken by autophagy inhibitor 3-methyladenine(3-MA).In addition,Tan IIA induced more autophagosomes,up-regulated light chain 3b(LC-3B)I and LC-3B II conversion and less sequestosome 1(SQSTM1/p62)expression,which cannot be weakened by the caspase 3 antagonist.Moreover,overexpression of LC-3B gene(LC3B)and downregulation of autophagic gene 5(ATG5)further confirmed that Tan IIA induced autophagic apoptosis in NSCLC cell lines.Beclin-1 gene(BECN1)overexpression and silence attenuated the effects of Tan IIA,suggesting autophagic apoptosis that Tan IIA induced was dependent on Beclin-1.Overall,our study demonstrated a new treatment mechanism of Tan IIA and suggested that Tan IIA is a potential new anti-cancer therapeutic option.
基金National Key Research and Development Program of China(2022YFB4002100)National Natural Science Foundation of China(52271136)Natural Science Foundation of Shaanxi Province(2021JC-06)。
文摘TaN coatings were deposited on Ti bipolar plates by magnetron sputtering to improve corrosion resistance and service life.The influence of N_(2) flow rate on the surface morphology,hydrophobicity,crystallinity,corrosion resistance,and interfacial contact resistance of TaN coatings was studied.Results show that as the N_(2) flow rate increases,the roughness of TaN coatings decreases firstly and then increases,and the hydrophobicity increases firstly and then decreases.At the N_(2) flow rate of 3 mL/min,TaN coating with larger grain size presents lower roughness and high hydrophobicity.The coating possesses the lowest corrosion current density of 2.82µA·cm^(−2) and the highest corrosion potential of−0.184 V vs.SCE in the simulated proton exchange membrane water electrolyser environment.After a potentiostatic polarization test for 10 h,a few corrosion pits are observed on the TaN coatings deposited at an N_(2) flow rate of 3 mL/min.After 75 h of electrolytic water performance testing,the TaN coating on bipolar plate improves the corrosion resistance and thus enhances the electrolysis efficiency(68.87%),greatly reducing the cost of bipolar plates.
文摘While walking in Xiamen University,you can enjoy the gentle ocean breezes,the blue sky and the exquisite Tan Kah-Kee-style architecture.It has architectural styles from both the East and the West.To have a deeper understanding of the design,I’ll introduce a prominent community leader and philanthropist(慈善家),Tan Kah Kee(or Chen Jiageng)who was also a founder of Xiamen University and Jimei University to you.
基金funded by the National Natural Science Foundation of China(Grants No.42071225 and 42471243)the Natural Science Foundation of Hunan Province(Grant No.2020JJ4056)the Postgraduate Scientific Research Innovation Project of Hunan Province(Grant No.QL20230126).
文摘Promoting positive urban–rural interactions is a key strategy for addressing rural decline and advancing regional sustainable development.This study examines the impacts of urban–rural interactions on rural development and explores their mechanisms for advancing sustainability within urban agglomeration areas.Using the Chang–Zhu–Tan(CZT)urban agglomeration as a case study,with an indicator system to measure urban–rural interactions and rural sustainable development,we analyze the mediating effects of resource flows in the process of urban–rural interactions driving rural sustainability through a mediation model.The results show that spatial connectivity,industrial convergence,and social integration between urban and rural areas positively contribute to the economic and social sustainability of rural areas.However,urban–rural spatial connectivity and social integration may negatively impact on rural environment.In this process,capital,technology,and labor play significant mediating roles,whereas the influence of land is less pronounced.Based on these findings,we propose several recommendations for strategically leveraging the benefits of urban–rural interactions across various social-ecological contexts while mitigating their drawbacks.
