Non-aqueous emulsions have a wide range of applications in cosmetics,drug-controlled release,and the preparation of functional nanoparticles.However,due to the weaker polarity of non-aqueous solvents,these emulsions o...Non-aqueous emulsions have a wide range of applications in cosmetics,drug-controlled release,and the preparation of functional nanoparticles.However,due to the weaker polarity of non-aqueous solvents,these emulsions often exhibit inferior stability compared to their aqueous counterparts.In this experiment,the properties of quaternary ammonium surfactants in glycerol were investigated through surface tension measurements,to further enhance the stability of n-decane/glycerol emulsions,hydrophilic nanoparticles SiO_(2) were modified in situ using double tailed quaternary ammonium surfactants Di-C_(12)DAB and Di-C_(16)DAB.Stable n-decane/glycerol Pickering emulsions were successfully prepared.These emulsions were stable at 45℃for over six months,and no significant changes in droplet size occurred.The minimum droplet size of the emulsion was only 2-3μm.Contact angle measurements showed that the wettability of the silica surface was tremendously affected by the concentration and the alkyl chain length of the double-tailed surfactants.In the presence of Di-C_(12)DAB,the contact angle of glycerol on the silica surface increased monotonically with the surfactant concentration.This explains the phenomenon that the Pickering emulsions containing Di-C_(12)DAB and silica particles were stable within the contact angle range of 80°-120°.Comparatively,the contact angle of the glycerol on the silica surface in the presence of Di-C_(16)DAB first increased with surfactant concentrations and then decreased,reaching a maximum at 0.6 mmol/L.It can be concluded that Di-C_(12)DAB formed monolayers at the surface of silica particles within all investigated concentrations.On the contrary,Di-C_(16)DAB formed monolayers at concentrations below 0.6 mmol/L and formed double layers at concentrations above 0.6 mmol/L,leading to a non-monotonic change in the contact angle with respect to concentration.Using these stable non-aqueous Pickering emulsions as templates,polymer microspheres with a particle size of 2-3μm were successfully prepared with high yield.This work is helpful to expand the potential applications of non-aqueous emulsions in the encapsulation of drug,controlled release,material preparation,and cosmetic formulations.展开更多
High-dimensional heterogeneous data have acquired increasing attention and discussion in the past decade.In the context of heterogeneity,semiparametric regression emerges as a popular method to model this type of data...High-dimensional heterogeneous data have acquired increasing attention and discussion in the past decade.In the context of heterogeneity,semiparametric regression emerges as a popular method to model this type of data in statistics.In this paper,we leverage the benefits of expectile regression for computational efficiency and analytical robustness in heterogeneity,and propose a regularized partially linear additive expectile regression model with a nonconvex penalty,such as SCAD or MCP,for high-dimensional heterogeneous data.We focus on a more realistic scenario where the regression error exhibits a heavy-tailed distribution with only finite moments.This scenario challenges the classical sub-gaussian distribution assumption and is more prevalent in practical applications.Under certain regular conditions,we demonstrate that with probability tending to one,the oracle estimator is one of the local minima of the induced optimization problem.Our theoretical analysis suggests that the dimensionality of linear covariates that our estimation procedure can handle is fundamentally limited by the moment condition of the regression error.Computationally,given the nonconvex and nonsmooth nature of the induced optimization problem,we have developed a two-step algorithm.Finally,our method’s effectiveness is demonstrated through its high estimation accuracy and effective model selection,as evidenced by Monte Carlo simulation studies and a real-data application.Furthermore,by taking various expectile weights,our method effectively detects heterogeneity and explores the complete conditional distribution of the response variable,underscoring its utility in analyzing high-dimensional heterogeneous data.展开更多
In an effort to simplify the procedure and to reduce the cost of fluorescence SSR analysis, the conditions of the multiplex PCR and the multiplex gel electrophoresis were optimized in the genetic analysis of sunflower...In an effort to simplify the procedure and to reduce the cost of fluorescence SSR analysis, the conditions of the multiplex PCR and the multiplex gel electrophoresis were optimized in the genetic analysis of sunflower (Helianthus annuus L.) inbred lines. Results indicated that factors for a successful multiplex PCR assay were related to the cycling touchdown annealing temperature, the balance of primer concentration at the various loci, the concentration of PCR buffer and the Taq DNA polymerase. Based on the optimization, a tailed primer strategy was outlined, and the effective ways were proposed to overcome the troubleshootings commonly encountered in the multiplex PCR and the multiplex gel electrophoresis.展开更多
Abstract A hybrid sheath model, including a fluid model and a Monte Carlo （MC） method, is proposed to study ion energy distributions （IEDs） driven by a radiofrequency （RF） with a tailed pulse-bias on an insulati...Abstract A hybrid sheath model, including a fluid model and a Monte Carlo （MC） method, is proposed to study ion energy distributions （IEDs） driven by a radiofrequency （RF） with a tailed pulse-bias on an insulating substrate, where a charging effect is obviously caused by the ions accumulated. This surface charging effect will significantly affect the IEDs on the insulating substrate. In this paper, a voltage compensation method is employed to eliminate the charging effect by making the pulse-bias waveform have a certain gradient. Furthermore, we investigate the IEDs under the condition of different pulse-bias duty ratios, waveforms, amplitudes, and cycle proportions. It is found that the parameters of the pulsed source can effectively modulate the IEDs on the insulating substrate and the charging effect, and more desired IEDs are obtained by using the voltage compensation method with modulations of pulse parameters.展开更多
Three new 'tailed' porphyrins and their corresponding Mn(Ⅲ) metalloporphyrins were synthesized and characterized. The potentiometric response characteristics of the PVC membrane electrode based on the Mn(Ⅲ...Three new 'tailed' porphyrins and their corresponding Mn(Ⅲ) metalloporphyrins were synthesized and characterized. The potentiometric response characteristics of the PVC membrane electrode based on the Mn(Ⅲ) complexes of the three new 'tailed' porphyrins toward SCN- have been studied.展开更多
This paper considers a Manpower system where “exits” of employed personnel produce some wastage or loss. This system monitors these wastages over the sequence of exit epochs {t0 = 0 and tk;k = 1, 2,…} that form a r...This paper considers a Manpower system where “exits” of employed personnel produce some wastage or loss. This system monitors these wastages over the sequence of exit epochs {t0 = 0 and tk;k = 1, 2,…} that form a recurrent process and admit recruitment when the cumulative loss of man hours crosses a threshold level Y, which is also called the breakdown level. It is assumed that the inter-exit times Tk = tk-1 - tk, k = 1, 2,… are independent and identically distributed random variables with a common cumulative distribution function (CDF) B(t) = P(Tk t) which has a tail 1 – B(t) behaving like t-v with 1 v as t → ∞. The amounts {Xk} of wastages incurred during these inter-exit times {Tk} are independent and identically distributed random variables with CDF P(Xk X) = G(x) and Y is distributed, independently of {Xk} and {tk}, as an exponentiated exponential law with CDF H(y) = P(Y y) = (1 - e-λy)n. The mean waiting time to break down of the system has been obtained assuming B(t) to be heavy tailed and as well as light tailed. For the exponential case of G(x), a comparative study has also been made between heavy tailed mean waiting time to break down and light tailed mean waiting time to break down values. The recruitment policy operating under the heavy tailed case is shown to be more economical in all types of manpower systems.展开更多
In this article, the dependent steps of a negative drift random walk are modelled as a two-sided linear process. Xn=-u＋∑j=-∞^∞ φn-jεj, where { ε, εn; -∞〈n〈＋∞} is a sequence of independent, identically di...In this article, the dependent steps of a negative drift random walk are modelled as a two-sided linear process. Xn=-u＋∑j=-∞^∞ φn-jεj, where { ε, εn; -∞〈n〈＋∞} is a sequence of independent, identically distributed random variables with zero mean, u 〉 0 is a constant and the coefficients {φi; -∞〈i〈∞} satisfy 0〈 ∑j=-∞^∞ ｜jφj｜〈 ∞ . Under the conditions that the distribution function of ｜ε｜ has dominated variation and ε satisfies certain tail balance conditions, the asymptotic behavior of P{sup n≥0 （-qu＋∑j=-∞^∞ εj βnj）〉x} is discussed. Then the result is applied to ultimate ruin probability.展开更多
In this paper, we study the precise large deviations for the prospectiveloss process with consistently varying tails. The obtained results improve some related known ones.
One hundred and eleven users of IUD were recruited and classified into two groups. 40 cases were in the tailed group, and 71 cases in the tailless group. The samples ol each case were obtained from vaginal vault, the ...One hundred and eleven users of IUD were recruited and classified into two groups. 40 cases were in the tailed group, and 71 cases in the tailless group. The samples ol each case were obtained from vaginal vault, the internal os of the cervix and uterine cavity. The cultures for detection of aerobic and anaerobic micro-morganisms were indentified.The results indicated that 11 cases were of positive test in the internal os samples. Among them 8 cases were in the tailed group and 3 cases in the tailless group. There was a very signilicant difference (P<0.01). 7 cases were found to be positive cultivation in the uterine cavity group among which 5 were in the tailed group and 2 in the tailless group. There was a signilicant difference (P<0.05).It is noteworthy that the increased incidence of bacteria ascending from the internal os to the uterine cavity was lound in the tailed group than that in the tailless group. However, severe pelvic inflammatory diseases in general have not been observed.展开更多
Sudden and uncertain events often cause cross-contagion of risk among various sectors of the macroeconomy.This paper introduces the stochastic volatility shock that follows a thick-tailed Student’s t-distribution int...Sudden and uncertain events often cause cross-contagion of risk among various sectors of the macroeconomy.This paper introduces the stochastic volatility shock that follows a thick-tailed Student’s t-distribution into a high-order approximate dynamic stochastic general equilibrium(DSGE)model with Epstein–Zin preference to better analyze the dynamic effect of uncertainty risk on macroeconomics.Then,the high-dimensional DSGE model(DSGE-SV-t)is developed to examine the impact of uncertainty risk on the transmission mechanism among macroeconomic sectors.The empirical research found that uncertainty risk generates heterogeneous impacts on macroeconomic dynamics under different inflation levels and economic states.Among them,a technological shock has the strongest impact on employment and consumption channels.The crowding-out effect of a fiscal policy stimulus on consumption and private investments is relatively weakened when considering uncertainty risk but is more pronounced during periods of high inflation.Uncertainty risk can partly explain the decline in investments and the increase in interest rates and employment rates,given the impact of an agent’s risk preferences.Compared with external economic conditions,the inflation factor has a stronger impact on the macro transmission mechanism caused by uncertainty risk.展开更多
Abstract Let X1, X2,... be a sequence of dependent and heavy-tailed random variables with distributions F1, F2,.. on （-∞,∞）, and let T be a nonnegative integer-valued random variable independent of the sequence {X...Abstract Let X1, X2,... be a sequence of dependent and heavy-tailed random variables with distributions F1, F2,.. on （-∞,∞）, and let T be a nonnegative integer-valued random variable independent of the sequence {Xk, k 〉 1}. In this framework, the asymptotic behavior of the tail probabilities of the quantities Sn = fi Xk and S（n） =∑ k=1 n 〉 1, and their randomized versions ST and S（τ） are studied. Some risk theory are presented. max Sk for 1〈k〈n applications to the展开更多
We study the tail probability of the stationary distribution of nonparametric nonlinear autoregressive functional conditional heteroscedastic (NARFCH) model with heavytailed innovations. Our result shows that the tail...We study the tail probability of the stationary distribution of nonparametric nonlinear autoregressive functional conditional heteroscedastic (NARFCH) model with heavytailed innovations. Our result shows that the tail of the stationary marginal distribution of an NARFCH series is heavily dependent on its conditional variance. When the innovations are heavy-tailed, the tail of the stationary marginal distribution of the series will become heavier or thinner than that of its innovations. We give some specific formulas to show how the increment or decrement of tail heaviness depends on the assumption on the conditional variance function. Some examples are given.展开更多
Rapid industrialization in China has caused significant environmental challenges,particularly heavy metal pollution from mine tailings.Toxic heavy metals such as lead(Pb),cadmium(Cd),and mercury(Hg)are released during...Rapid industrialization in China has caused significant environmental challenges,particularly heavy metal pollution from mine tailings.Toxic heavy metals such as lead(Pb),cadmium(Cd),and mercury(Hg)are released during the processing of mining wastewater and leaching of mine tailings.Owing to their excellent physicochemical properties,cementitious materials are widely used for the solidification/stabilization of heavy metals,immobilizing heavy metals via two distinct mechanisms.Physically,their favorable characteristics,including high mechanical strength,low porosity,and durable matrix,create effective barriers.Chemically,the alkaline environment facilitates the precipitation of metal hydroxides/carbonates.Conversely,hydration products(calcium silicate hydrate gels and ettringite)contribute to immobilization through adsorption and physical encapsulation.This study systematically investigated the migration mechanisms of heavy metal contaminants in mine tailings;further,it elucidated the multifaceted immobilization pathways of cementitious materials,which involve synergistic adsorption,precipitation,and encapsulation by hydration products combined with homocrystalline substitution.A comprehensive analysis indicated that cementitious materials significantly reduced the mobility and bioavailability of heavy metals.Nonetheless,their long-term stability and potential environmental impact require further investigation.This study aims to provide theoretical support for environmental management and sustainable resource utilization,and to explore the broader application potential of cementitious technology for heavy metal stabilization,thereby establishing a theoretical foundation for future research on heavy metals in low-cement solidified/stabilized tailings.展开更多
Recently the“control through detailed planning”has become a popular research subject allover China.This article discusses about its origin,nature,content,depth and its aesthetic princi-ples as well,aiming at enhanci...Recently the“control through detailed planning”has become a popular research subject allover China.This article discusses about its origin,nature,content,depth and its aesthetic princi-ples as well,aiming at enhancing the research on this subject.展开更多
As underground mining advances to greater depths,cemented paste backfill(CPB)is increasingly subjected to complex thermo-mechanical loading conditions,including multiaxial stress states and elevated temperatures.This ...As underground mining advances to greater depths,cemented paste backfill(CPB)is increasingly subjected to complex thermo-mechanical loading conditions,including multiaxial stress states and elevated temperatures.This study investigates the coupled effects of field-representative vertical self-weight and horizontal rockwall closure stresses,along with in-situ temperatures,on the mechanical behavior and pore water pressure(PWP)evolution of CPB.Experiments were conducted using a novel apparatus capable of controlling multiaxial stress and temperature during curing,replicating in-situ stress paths and thermal profiles typical of deep mine environments.Results show that multiaxial stress enhances CPB strength and stiffness by promoting denser particle packing,reducing porosity,and increasing frictional resistance.Elevated temperatures independently accelerate early-age cement hydration,further improving bond strength and stiffness.When combined,multiaxial stress and elevated temperature produce a synergistic enhancement in unconfined compressive strength(UCS)and elastic modulus,as confirmed by two-way ANOVA and synergy index analysis.PWP responses were also highly sensitive to thermo-mechanical conditions.The evolution of positive and negative PWP was governed by the interplay of thermal expansion,hydration-induced desaturation,and mechanical compaction.Multiaxial stress amplified early positive PWP and delayed its dissipation,whereas elevated temperature accelerated hydration and reduced pore pressure,leading to enhanced suction at later ages.A transient“stress-induced resaturation”effect was observed under late-stage excessive horizontal stress but was mitigated by elevated temperatures.These findings provide critical insights into the coupled mechanical and hydraulic behavior of CPB under realistic field conditions and offer guidance for optimizing backfill design,binder content,and barricade stability in deep mining applications.展开更多
Polypropylene fibers(PPFs) have been widely used in composite materials due to their sound crack resistance and toughness. In cement-based composites, the incorporation of PPFs can significantly improve their dynamic ...Polypropylene fibers(PPFs) have been widely used in composite materials due to their sound crack resistance and toughness. In cement-based composites, the incorporation of PPFs can significantly improve their dynamic mechanical properties. However, cement-iron ore tailings foam composite(CIFC), a sustainable material utilizing iron ore tailings to partially replace cement, has not been investigated under dynamic loading. This study investigates the dynamic compressive behavior of CIFC with 1%–2.5% PPF content and 3–12 mm PPF lengths under various strain rates. The microstructural characteristics were analyzed prior to dynamic testing. X-ray diffraction(XRD) identified crystalline phases including CaCO_(3)Fe_(2)O_(3), SiO, C-S-H gel, and ettringite. Scanning electron microscopy(SEM) observations demonstrated that appropriate PPF_(2) parameters(e.g., C2L9, a CIFC specimen containing 2% PPF with 9 mm length) enhance fiber-matrix bonding and minimize interconnected pores and microcracks, revealing pronounced fiber bridging effects. Split Hopkinson pressure bar(SHPB) tests were then conducted at strain rates of 120–250 s^(-1), showing that the dynamic properties of CIFC were highly dependent on both strain rates and PPF parameters. Compared to other specimens, C2L9 exhibited a more intact failure pattern with superior compressive strength and energy dissipation capacity, despite showing reduced dynamic increase factor(DIF) and normalized energy dissipation(NED) values. These findings provide practical guidance for applying CIFC with varying PPF parameters in impact-resistant structural designs.展开更多
Background:Minimally invasive distal pancreatectomy(MIDP)is increasingly being used,although its oncologic safety for pancreatic ductal adenocarcinoma(PDAC)remains controversial.In Japan,MIDP for PDAC has limited endo...Background:Minimally invasive distal pancreatectomy(MIDP)is increasingly being used,although its oncologic safety for pancreatic ductal adenocarcinoma(PDAC)remains controversial.In Japan,MIDP for PDAC has limited endorsement due to insufficient data.This study aimed to compare the perioperative and long-term outcomes of open distal pancreatectomy(ODP)and MIDP for PDAC.Methods:We retrospectively analyzed patients with resectable pancreatic body and tail cancer treated with ODP or MIDP(laparoscopic or robotic)between January 2007 and July 2022.The surgical procedures(ODP and MIDP)were compared and the patient characteristics,perioperative outcomes,and long-term outcomes were analyzed.We also compared the outcomes of patients with neoadjuvant chemotherapy(NAC)and without NAC.Results:A total of 72 distal pancreatectomies were performed(37 ODPs and 35 MIDPs).In the upfront group,MIDP resulted in significantly less blood loss than ODP(P<0.01),despite similar operative time.There was no statistically significant difference in the 2-year recurrence-free survival(RFS)rates between ODP and MIDP(39.7%vs.57.8%,P=0.60)or in the overall survival(OS)rates(66.7%vs.74.1%,P=0.43).Similarly,in the NAC group,MIDP resulted in significantly less blood loss than ODP(P=0.01);ODP and MIDP had similar 2-year RFS rates(41.7%and 60.0%,P=0.75)and OS rates(50.0%and 70.0%,P=0.36).The interval from surgery to adjuvant chemotherapy initiation did not significantly differ between the ODP and MIDP subgroups in both the upfront group(P=0.13)and the NAC group(P=0.14).The incidence of recurrence was 64.8%for ODP and 42.8%for MIDP(P=0.06).Both procedures showed similar distributions of local and distant recurrence.Conclusions:MIDP caused less blood loss and had similar oncologic safety compared with ODP.MIDP could become a feasible,minimally invasive option with sufficient oncologic safety for pancreatic body and tail cancers.展开更多
The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the...The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the stability of underground mining engineering,this paper simulates the generation of different degrees of initial defects inside the CTB by adding different contents of air-entraining agent(AEA),investigates the acoustic emission RA/AF eigenvalues of CTB with different contents of AEA under uniaxial compression,and adopts various denoising algorithms(e.g.,moving average smoothing,median filtering,and outlier detection)to improve the accuracy of the data.The variance and autocorrelation coefficients of RA/AF parameters were analyzed in conjunction with the critical slowing down(CSD)theory.The results show that the acoustic emission RA/AF values can be used to characterize the progressive damage evolution of CTB.The denoising algorithm processed the AE signals to reduce the effects of extraneous noise and anomalous spikes.Changes in the variance curves provide clear precursor information,while abrupt changes in the autocorrelation coefficient can be used as an auxiliary localization warning signal.The phenomenon of dramatic increase in the variance and autocorrelation coefficient curves during the compression-tightening stage,which is influenced by the initial defects,can lead to false warnings.As the initial defects of the CTB increase,its instability precursor time and instability time are prolonged,the peak stress decreases,and the time difference between the CTB and the instability damage is smaller.The results provide a new method for real-time monitoring and early warning of CTB instability damage.展开更多
In 2007,Chen and Ng investigated infinite-time ruin probability with constant interest forceand negatively quadrant dependent and extended regularly varying-tailed claims.Following this work,the authors obtain a weakl...In 2007,Chen and Ng investigated infinite-time ruin probability with constant interest forceand negatively quadrant dependent and extended regularly varying-tailed claims.Following this work,the authors obtain a weakly asymptotic equivalent formula for the finite-time and infinite-time ruinprobability with constant interest force,negatively quadrant dependent,and dominated varying-tailedclaims and negatively lower orthant dependent inter-arrival times.In particular,when the claims areconsistently varying-tailed,an asymptotic equivalent formula is presented.展开更多
文摘Non-aqueous emulsions have a wide range of applications in cosmetics,drug-controlled release,and the preparation of functional nanoparticles.However,due to the weaker polarity of non-aqueous solvents,these emulsions often exhibit inferior stability compared to their aqueous counterparts.In this experiment,the properties of quaternary ammonium surfactants in glycerol were investigated through surface tension measurements,to further enhance the stability of n-decane/glycerol emulsions,hydrophilic nanoparticles SiO_(2) were modified in situ using double tailed quaternary ammonium surfactants Di-C_(12)DAB and Di-C_(16)DAB.Stable n-decane/glycerol Pickering emulsions were successfully prepared.These emulsions were stable at 45℃for over six months,and no significant changes in droplet size occurred.The minimum droplet size of the emulsion was only 2-3μm.Contact angle measurements showed that the wettability of the silica surface was tremendously affected by the concentration and the alkyl chain length of the double-tailed surfactants.In the presence of Di-C_(12)DAB,the contact angle of glycerol on the silica surface increased monotonically with the surfactant concentration.This explains the phenomenon that the Pickering emulsions containing Di-C_(12)DAB and silica particles were stable within the contact angle range of 80°-120°.Comparatively,the contact angle of the glycerol on the silica surface in the presence of Di-C_(16)DAB first increased with surfactant concentrations and then decreased,reaching a maximum at 0.6 mmol/L.It can be concluded that Di-C_(12)DAB formed monolayers at the surface of silica particles within all investigated concentrations.On the contrary,Di-C_(16)DAB formed monolayers at concentrations below 0.6 mmol/L and formed double layers at concentrations above 0.6 mmol/L,leading to a non-monotonic change in the contact angle with respect to concentration.Using these stable non-aqueous Pickering emulsions as templates,polymer microspheres with a particle size of 2-3μm were successfully prepared with high yield.This work is helpful to expand the potential applications of non-aqueous emulsions in the encapsulation of drug,controlled release,material preparation,and cosmetic formulations.
基金Supported by the Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of Chi-na(LHZY24A010002)the MOE Project of Humanities and Social Sciences(21YJCZH235).
文摘High-dimensional heterogeneous data have acquired increasing attention and discussion in the past decade.In the context of heterogeneity,semiparametric regression emerges as a popular method to model this type of data in statistics.In this paper,we leverage the benefits of expectile regression for computational efficiency and analytical robustness in heterogeneity,and propose a regularized partially linear additive expectile regression model with a nonconvex penalty,such as SCAD or MCP,for high-dimensional heterogeneous data.We focus on a more realistic scenario where the regression error exhibits a heavy-tailed distribution with only finite moments.This scenario challenges the classical sub-gaussian distribution assumption and is more prevalent in practical applications.Under certain regular conditions,we demonstrate that with probability tending to one,the oracle estimator is one of the local minima of the induced optimization problem.Our theoretical analysis suggests that the dimensionality of linear covariates that our estimation procedure can handle is fundamentally limited by the moment condition of the regression error.Computationally,given the nonconvex and nonsmooth nature of the induced optimization problem,we have developed a two-step algorithm.Finally,our method’s effectiveness is demonstrated through its high estimation accuracy and effective model selection,as evidenced by Monte Carlo simulation studies and a real-data application.Furthermore,by taking various expectile weights,our method effectively detects heterogeneity and explores the complete conditional distribution of the response variable,underscoring its utility in analyzing high-dimensional heterogeneous data.
文摘In an effort to simplify the procedure and to reduce the cost of fluorescence SSR analysis, the conditions of the multiplex PCR and the multiplex gel electrophoresis were optimized in the genetic analysis of sunflower (Helianthus annuus L.) inbred lines. Results indicated that factors for a successful multiplex PCR assay were related to the cycling touchdown annealing temperature, the balance of primer concentration at the various loci, the concentration of PCR buffer and the Taq DNA polymerase. Based on the optimization, a tailed primer strategy was outlined, and the effective ways were proposed to overcome the troubleshootings commonly encountered in the multiplex PCR and the multiplex gel electrophoresis.
基金supported by National Natural Science Foundation of China(No.11375040)the Important National Science&Technology Specific Project of China(No.2011ZX02403-001)
文摘Abstract A hybrid sheath model, including a fluid model and a Monte Carlo （MC） method, is proposed to study ion energy distributions （IEDs） driven by a radiofrequency （RF） with a tailed pulse-bias on an insulating substrate, where a charging effect is obviously caused by the ions accumulated. This surface charging effect will significantly affect the IEDs on the insulating substrate. In this paper, a voltage compensation method is employed to eliminate the charging effect by making the pulse-bias waveform have a certain gradient. Furthermore, we investigate the IEDs under the condition of different pulse-bias duty ratios, waveforms, amplitudes, and cycle proportions. It is found that the parameters of the pulsed source can effectively modulate the IEDs on the insulating substrate and the charging effect, and more desired IEDs are obtained by using the voltage compensation method with modulations of pulse parameters.
文摘Three new 'tailed' porphyrins and their corresponding Mn(Ⅲ) metalloporphyrins were synthesized and characterized. The potentiometric response characteristics of the PVC membrane electrode based on the Mn(Ⅲ) complexes of the three new 'tailed' porphyrins toward SCN- have been studied.
文摘This paper considers a Manpower system where “exits” of employed personnel produce some wastage or loss. This system monitors these wastages over the sequence of exit epochs {t0 = 0 and tk;k = 1, 2,…} that form a recurrent process and admit recruitment when the cumulative loss of man hours crosses a threshold level Y, which is also called the breakdown level. It is assumed that the inter-exit times Tk = tk-1 - tk, k = 1, 2,… are independent and identically distributed random variables with a common cumulative distribution function (CDF) B(t) = P(Tk t) which has a tail 1 – B(t) behaving like t-v with 1 v as t → ∞. The amounts {Xk} of wastages incurred during these inter-exit times {Tk} are independent and identically distributed random variables with CDF P(Xk X) = G(x) and Y is distributed, independently of {Xk} and {tk}, as an exponentiated exponential law with CDF H(y) = P(Y y) = (1 - e-λy)n. The mean waiting time to break down of the system has been obtained assuming B(t) to be heavy tailed and as well as light tailed. For the exponential case of G(x), a comparative study has also been made between heavy tailed mean waiting time to break down and light tailed mean waiting time to break down values. The recruitment policy operating under the heavy tailed case is shown to be more economical in all types of manpower systems.
基金Research supported by National Science Foundation of China (70671018 and 10371117)
文摘In this article, the dependent steps of a negative drift random walk are modelled as a two-sided linear process. Xn=-u＋∑j=-∞^∞ φn-jεj, where { ε, εn; -∞〈n〈＋∞} is a sequence of independent, identically distributed random variables with zero mean, u 〉 0 is a constant and the coefficients {φi; -∞〈i〈∞} satisfy 0〈 ∑j=-∞^∞ ｜jφj｜〈 ∞ . Under the conditions that the distribution function of ｜ε｜ has dominated variation and ε satisfies certain tail balance conditions, the asymptotic behavior of P{sup n≥0 （-qu＋∑j=-∞^∞ εj βnj）〉x} is discussed. Then the result is applied to ultimate ruin probability.
文摘In this paper, we study the precise large deviations for the prospectiveloss process with consistently varying tails. The obtained results improve some related known ones.
文摘One hundred and eleven users of IUD were recruited and classified into two groups. 40 cases were in the tailed group, and 71 cases in the tailless group. The samples ol each case were obtained from vaginal vault, the internal os of the cervix and uterine cavity. The cultures for detection of aerobic and anaerobic micro-morganisms were indentified.The results indicated that 11 cases were of positive test in the internal os samples. Among them 8 cases were in the tailed group and 3 cases in the tailless group. There was a very signilicant difference (P<0.01). 7 cases were found to be positive cultivation in the uterine cavity group among which 5 were in the tailed group and 2 in the tailless group. There was a signilicant difference (P<0.05).It is noteworthy that the increased incidence of bacteria ascending from the internal os to the uterine cavity was lound in the tailed group than that in the tailless group. However, severe pelvic inflammatory diseases in general have not been observed.
基金supported by the National Natural Science Foundation of China(Nos.72141304,71790594,71901130)。
文摘Sudden and uncertain events often cause cross-contagion of risk among various sectors of the macroeconomy.This paper introduces the stochastic volatility shock that follows a thick-tailed Student’s t-distribution into a high-order approximate dynamic stochastic general equilibrium(DSGE)model with Epstein–Zin preference to better analyze the dynamic effect of uncertainty risk on macroeconomics.Then,the high-dimensional DSGE model(DSGE-SV-t)is developed to examine the impact of uncertainty risk on the transmission mechanism among macroeconomic sectors.The empirical research found that uncertainty risk generates heterogeneous impacts on macroeconomic dynamics under different inflation levels and economic states.Among them,a technological shock has the strongest impact on employment and consumption channels.The crowding-out effect of a fiscal policy stimulus on consumption and private investments is relatively weakened when considering uncertainty risk but is more pronounced during periods of high inflation.Uncertainty risk can partly explain the decline in investments and the increase in interest rates and employment rates,given the impact of an agent’s risk preferences.Compared with external economic conditions,the inflation factor has a stronger impact on the macro transmission mechanism caused by uncertainty risk.
基金supported by the National Natural Science Foundation of China (No. 11171179)the Research Fund for the Doctoral Program of Higher Education of China (No. 20093705110002)
文摘Abstract Let X1, X2,... be a sequence of dependent and heavy-tailed random variables with distributions F1, F2,.. on （-∞,∞）, and let T be a nonnegative integer-valued random variable independent of the sequence {Xk, k 〉 1}. In this framework, the asymptotic behavior of the tail probabilities of the quantities Sn = fi Xk and S（n） =∑ k=1 n 〉 1, and their randomized versions ST and S（τ） are studied. Some risk theory are presented. max Sk for 1〈k〈n applications to the
基金supported by the National Natural Science Foundation of China(Grant No.10471005).
文摘We study the tail probability of the stationary distribution of nonparametric nonlinear autoregressive functional conditional heteroscedastic (NARFCH) model with heavytailed innovations. Our result shows that the tail of the stationary marginal distribution of an NARFCH series is heavily dependent on its conditional variance. When the innovations are heavy-tailed, the tail of the stationary marginal distribution of the series will become heavier or thinner than that of its innovations. We give some specific formulas to show how the increment or decrement of tail heaviness depends on the assumption on the conditional variance function. Some examples are given.
基金supported by the National Natural Science Foundation of China(No.52374121)the Henan Province Science and Technology Research and Development Joint Fund,China(No.235200810016)the National Key Research and Development Program,China(No.2023YFC2907203).
文摘Rapid industrialization in China has caused significant environmental challenges,particularly heavy metal pollution from mine tailings.Toxic heavy metals such as lead(Pb),cadmium(Cd),and mercury(Hg)are released during the processing of mining wastewater and leaching of mine tailings.Owing to their excellent physicochemical properties,cementitious materials are widely used for the solidification/stabilization of heavy metals,immobilizing heavy metals via two distinct mechanisms.Physically,their favorable characteristics,including high mechanical strength,low porosity,and durable matrix,create effective barriers.Chemically,the alkaline environment facilitates the precipitation of metal hydroxides/carbonates.Conversely,hydration products(calcium silicate hydrate gels and ettringite)contribute to immobilization through adsorption and physical encapsulation.This study systematically investigated the migration mechanisms of heavy metal contaminants in mine tailings;further,it elucidated the multifaceted immobilization pathways of cementitious materials,which involve synergistic adsorption,precipitation,and encapsulation by hydration products combined with homocrystalline substitution.A comprehensive analysis indicated that cementitious materials significantly reduced the mobility and bioavailability of heavy metals.Nonetheless,their long-term stability and potential environmental impact require further investigation.This study aims to provide theoretical support for environmental management and sustainable resource utilization,and to explore the broader application potential of cementitious technology for heavy metal stabilization,thereby establishing a theoretical foundation for future research on heavy metals in low-cement solidified/stabilized tailings.
文摘Recently the“control through detailed planning”has become a popular research subject allover China.This article discusses about its origin,nature,content,depth and its aesthetic princi-ples as well,aiming at enhancing the research on this subject.
基金the University of Ottawa, the China Scholarship Council and the Natural Sciences and Engineering Research Council of Canada (NSERC) for their financial support.
文摘As underground mining advances to greater depths,cemented paste backfill(CPB)is increasingly subjected to complex thermo-mechanical loading conditions,including multiaxial stress states and elevated temperatures.This study investigates the coupled effects of field-representative vertical self-weight and horizontal rockwall closure stresses,along with in-situ temperatures,on the mechanical behavior and pore water pressure(PWP)evolution of CPB.Experiments were conducted using a novel apparatus capable of controlling multiaxial stress and temperature during curing,replicating in-situ stress paths and thermal profiles typical of deep mine environments.Results show that multiaxial stress enhances CPB strength and stiffness by promoting denser particle packing,reducing porosity,and increasing frictional resistance.Elevated temperatures independently accelerate early-age cement hydration,further improving bond strength and stiffness.When combined,multiaxial stress and elevated temperature produce a synergistic enhancement in unconfined compressive strength(UCS)and elastic modulus,as confirmed by two-way ANOVA and synergy index analysis.PWP responses were also highly sensitive to thermo-mechanical conditions.The evolution of positive and negative PWP was governed by the interplay of thermal expansion,hydration-induced desaturation,and mechanical compaction.Multiaxial stress amplified early positive PWP and delayed its dissipation,whereas elevated temperature accelerated hydration and reduced pore pressure,leading to enhanced suction at later ages.A transient“stress-induced resaturation”effect was observed under late-stage excessive horizontal stress but was mitigated by elevated temperatures.These findings provide critical insights into the coupled mechanical and hydraulic behavior of CPB under realistic field conditions and offer guidance for optimizing backfill design,binder content,and barricade stability in deep mining applications.
基金supported by the National Science Foundation for Excellent Young Scholars of China (Grant No.52422809)the National Natural Science Foundation of China (Grant No.52208491)。
文摘Polypropylene fibers(PPFs) have been widely used in composite materials due to their sound crack resistance and toughness. In cement-based composites, the incorporation of PPFs can significantly improve their dynamic mechanical properties. However, cement-iron ore tailings foam composite(CIFC), a sustainable material utilizing iron ore tailings to partially replace cement, has not been investigated under dynamic loading. This study investigates the dynamic compressive behavior of CIFC with 1%–2.5% PPF content and 3–12 mm PPF lengths under various strain rates. The microstructural characteristics were analyzed prior to dynamic testing. X-ray diffraction(XRD) identified crystalline phases including CaCO_(3)Fe_(2)O_(3), SiO, C-S-H gel, and ettringite. Scanning electron microscopy(SEM) observations demonstrated that appropriate PPF_(2) parameters(e.g., C2L9, a CIFC specimen containing 2% PPF with 9 mm length) enhance fiber-matrix bonding and minimize interconnected pores and microcracks, revealing pronounced fiber bridging effects. Split Hopkinson pressure bar(SHPB) tests were then conducted at strain rates of 120–250 s^(-1), showing that the dynamic properties of CIFC were highly dependent on both strain rates and PPF parameters. Compared to other specimens, C2L9 exhibited a more intact failure pattern with superior compressive strength and energy dissipation capacity, despite showing reduced dynamic increase factor(DIF) and normalized energy dissipation(NED) values. These findings provide practical guidance for applying CIFC with varying PPF parameters in impact-resistant structural designs.
文摘Background:Minimally invasive distal pancreatectomy(MIDP)is increasingly being used,although its oncologic safety for pancreatic ductal adenocarcinoma(PDAC)remains controversial.In Japan,MIDP for PDAC has limited endorsement due to insufficient data.This study aimed to compare the perioperative and long-term outcomes of open distal pancreatectomy(ODP)and MIDP for PDAC.Methods:We retrospectively analyzed patients with resectable pancreatic body and tail cancer treated with ODP or MIDP(laparoscopic or robotic)between January 2007 and July 2022.The surgical procedures(ODP and MIDP)were compared and the patient characteristics,perioperative outcomes,and long-term outcomes were analyzed.We also compared the outcomes of patients with neoadjuvant chemotherapy(NAC)and without NAC.Results:A total of 72 distal pancreatectomies were performed(37 ODPs and 35 MIDPs).In the upfront group,MIDP resulted in significantly less blood loss than ODP(P<0.01),despite similar operative time.There was no statistically significant difference in the 2-year recurrence-free survival(RFS)rates between ODP and MIDP(39.7%vs.57.8%,P=0.60)or in the overall survival(OS)rates(66.7%vs.74.1%,P=0.43).Similarly,in the NAC group,MIDP resulted in significantly less blood loss than ODP(P=0.01);ODP and MIDP had similar 2-year RFS rates(41.7%and 60.0%,P=0.75)and OS rates(50.0%and 70.0%,P=0.36).The interval from surgery to adjuvant chemotherapy initiation did not significantly differ between the ODP and MIDP subgroups in both the upfront group(P=0.13)and the NAC group(P=0.14).The incidence of recurrence was 64.8%for ODP and 42.8%for MIDP(P=0.06).Both procedures showed similar distributions of local and distant recurrence.Conclusions:MIDP caused less blood loss and had similar oncologic safety compared with ODP.MIDP could become a feasible,minimally invasive option with sufficient oncologic safety for pancreatic body and tail cancers.
基金Projects(52374138,51764013)supported by the National Natural Science Foundation of ChinaProject(20204BCJ22005)supported by the Training Plan for Academic and Technical Leaders of Major Disciplines of Jiangxi Province,China+1 种基金Project(2019M652277)supported by the China Postdoctoral Science FoundationProject(20192ACBL21014)supported by the Natural Science Youth Foundation Key Projects of Jiangxi Province,China。
文摘The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the stability of underground mining engineering,this paper simulates the generation of different degrees of initial defects inside the CTB by adding different contents of air-entraining agent(AEA),investigates the acoustic emission RA/AF eigenvalues of CTB with different contents of AEA under uniaxial compression,and adopts various denoising algorithms(e.g.,moving average smoothing,median filtering,and outlier detection)to improve the accuracy of the data.The variance and autocorrelation coefficients of RA/AF parameters were analyzed in conjunction with the critical slowing down(CSD)theory.The results show that the acoustic emission RA/AF values can be used to characterize the progressive damage evolution of CTB.The denoising algorithm processed the AE signals to reduce the effects of extraneous noise and anomalous spikes.Changes in the variance curves provide clear precursor information,while abrupt changes in the autocorrelation coefficient can be used as an auxiliary localization warning signal.The phenomenon of dramatic increase in the variance and autocorrelation coefficient curves during the compression-tightening stage,which is influenced by the initial defects,can lead to false warnings.As the initial defects of the CTB increase,its instability precursor time and instability time are prolonged,the peak stress decreases,and the time difference between the CTB and the instability damage is smaller.The results provide a new method for real-time monitoring and early warning of CTB instability damage.
基金supported by the National Science Foundation of China under Grant No. 10671139.
文摘In 2007,Chen and Ng investigated infinite-time ruin probability with constant interest forceand negatively quadrant dependent and extended regularly varying-tailed claims.Following this work,the authors obtain a weakly asymptotic equivalent formula for the finite-time and infinite-time ruinprobability with constant interest force,negatively quadrant dependent,and dominated varying-tailedclaims and negatively lower orthant dependent inter-arrival times.In particular,when the claims areconsistently varying-tailed,an asymptotic equivalent formula is presented.
