Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grad...Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grade and discriminating San-Huang Tablets (SHT) of different commercial brands. The systematic quantified fingerprint method (SQFM) was applied to evaluate, qualitatively and quantitatively, the quality consistency of the herbal preparation. It was possible to deduce that the quantitative similarity analysis by SQFM was enabled to make a good discrimination of the tested samples. It was a particularly useful method for the overall quality evaluation of herbal medicine and their preparations.展开更多
The present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets(SHT), a widely used and commercially available herbal preparation, where high performance liquid ...The present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets(SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography(HPLC) with a diode array detector(DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method(SLQFM)coupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively. Additionally, the component–activity relationship between chromatographic fingerprints and total radical-scavenging capacity in vitro(as assessed using the 1, 1-diphenyl-2-picrylhydrazyl(DPPH) assay) was investigated by partial least squares regression(PLSR) analysis to predict the antioxidant capacity of new samples from the chromatographic fingerprints and identify the main active constituents that can be used as the target markers for the quality control of SHT. In conclusion, the strategy developed in the present study was effective and reliable, which can be employed for holistic evaluation and accurate discrimination for the quality consistency of SHT preparations and other traditional Chinese medicine(TCM) and herbal preparations as well.展开更多
In this paper we aimed to determine the surface tension of traditional Chinese medicine (TCM) tablet and tried to provide a key reference parameter to control tablet film coating quality. Using contact angle tester, t...In this paper we aimed to determine the surface tension of traditional Chinese medicine (TCM) tablet and tried to provide a key reference parameter to control tablet film coating quality. Using contact angle tester, the Chinese medicine tablet, a famous Fufang Danshen tablet CP as a model example, was determined by Zisman critical surface tension method. Our study showed that the critical surface tension of Fufang Danshen tablet CP was determined to be 18.00 dyne/cm. The Zisman method, hence, can determine successfully the critical surface tension of Chinese medicine tablet and will become an effective manner to control tablet film coating quality.展开更多
文摘Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grade and discriminating San-Huang Tablets (SHT) of different commercial brands. The systematic quantified fingerprint method (SQFM) was applied to evaluate, qualitatively and quantitatively, the quality consistency of the herbal preparation. It was possible to deduce that the quantitative similarity analysis by SQFM was enabled to make a good discrimination of the tested samples. It was a particularly useful method for the overall quality evaluation of herbal medicine and their preparations.
基金financially supported by the National Natural Science Foundation of China(No.81560695)the Doctoral Research Fund of Dali University(No.KYBS201512)
文摘The present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets(SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography(HPLC) with a diode array detector(DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method(SLQFM)coupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively. Additionally, the component–activity relationship between chromatographic fingerprints and total radical-scavenging capacity in vitro(as assessed using the 1, 1-diphenyl-2-picrylhydrazyl(DPPH) assay) was investigated by partial least squares regression(PLSR) analysis to predict the antioxidant capacity of new samples from the chromatographic fingerprints and identify the main active constituents that can be used as the target markers for the quality control of SHT. In conclusion, the strategy developed in the present study was effective and reliable, which can be employed for holistic evaluation and accurate discrimination for the quality consistency of SHT preparations and other traditional Chinese medicine(TCM) and herbal preparations as well.
文摘In this paper we aimed to determine the surface tension of traditional Chinese medicine (TCM) tablet and tried to provide a key reference parameter to control tablet film coating quality. Using contact angle tester, the Chinese medicine tablet, a famous Fufang Danshen tablet CP as a model example, was determined by Zisman critical surface tension method. Our study showed that the critical surface tension of Fufang Danshen tablet CP was determined to be 18.00 dyne/cm. The Zisman method, hence, can determine successfully the critical surface tension of Chinese medicine tablet and will become an effective manner to control tablet film coating quality.
