Chimeric antigen receptor T(CAR-T)cell therapy involves genetically modifying T cells so that they can target and kill abnormal cells.It has achieved remarkable success in treating hematologic malignancies,marking a s...Chimeric antigen receptor T(CAR-T)cell therapy involves genetically modifying T cells so that they can target and kill abnormal cells.It has achieved remarkable success in treating hematologic malignancies,marking a significant milestone in the development of tumor immunotherapy.It is also emerging rapidly as a hotspot in the biopharmaceutical sector.A bibliometric analysis of scientific literature reveals that basic research on CAR-T therapy on a global scale remains highly active,with the United States and China leading the field.An analysis of knowledge mapping using VOSviewer shows that China has established close collaborative networks with the United States,Germany,and the United Kingdom,among other countries,in basic research on CAR-T therapy.Current research hotspots focus primarily on four key areas:core technologies and basic research,efficacy improvement,clinical applications in oncology,and emerging applications in non-oncological fields.Future research in this field will concentrate on technological innovation,personalized medicine,and international collaboration.展开更多
文摘Chimeric antigen receptor T(CAR-T)cell therapy involves genetically modifying T cells so that they can target and kill abnormal cells.It has achieved remarkable success in treating hematologic malignancies,marking a significant milestone in the development of tumor immunotherapy.It is also emerging rapidly as a hotspot in the biopharmaceutical sector.A bibliometric analysis of scientific literature reveals that basic research on CAR-T therapy on a global scale remains highly active,with the United States and China leading the field.An analysis of knowledge mapping using VOSviewer shows that China has established close collaborative networks with the United States,Germany,and the United Kingdom,among other countries,in basic research on CAR-T therapy.Current research hotspots focus primarily on four key areas:core technologies and basic research,efficacy improvement,clinical applications in oncology,and emerging applications in non-oncological fields.Future research in this field will concentrate on technological innovation,personalized medicine,and international collaboration.
