We propose a method to estimate the average fidelity using the unitary 2t-design of a twirled noisy channel, which is suitable for large-scale quantum circuits. Compared with the unitary 2-design in randomized benchma...We propose a method to estimate the average fidelity using the unitary 2t-design of a twirled noisy channel, which is suitable for large-scale quantum circuits. Compared with the unitary 2-design in randomized benchmarking, the unitary2t-design for the twirling of noisy channels is more flexible in construction and can provide more information. In addition,we prove that the proposed method provides an efficient and reliable estimation of the average fidelity in benchmarking multistage quantum gates and estimating the weakly gate-and time-dependent noise. For time-dependent noise, we provide a scheme of moment superoperator to analyze the noise in different experiments. In particular, we give a lower bound on the average fidelity of a channel with imperfect implementation of benchmarking and state preparation and measurement errors(SPAM).展开更多
A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ)...A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ) design for some v,k,γ.In this paper,we give a generalization of t-design called balanced n-ary t-design,and obtain some properties of the new combinatorial structure.展开更多
目的:筛选柯萨奇病毒B3(Coxsackievirus B3,CVB3)中可被细胞毒性T细胞(cytotoxic T lymphocytes,CTL)高效识别的抗原表位,为开发针对CVB3及其他肠道病毒的广谱疫苗提供理论依据。方法:基于免疫表位数据库(Immune Epitope Database,IEDB)...目的:筛选柯萨奇病毒B3(Coxsackievirus B3,CVB3)中可被细胞毒性T细胞(cytotoxic T lymphocytes,CTL)高效识别的抗原表位,为开发针对CVB3及其他肠道病毒的广谱疫苗提供理论依据。方法:基于免疫表位数据库(Immune Epitope Database,IEDB)及NetMHCpan EL 4.1算法预测CVB3的CTL候选表位;针对HLA-A*02:01限制性表位,通过AlphaFold 2.3.2模拟其与人类白细胞抗原的复合物结构,分析表位保守性及交叉免疫潜力;利用T2细胞结合实验验证候选表位与HLA-A*02:01的亲和力。结果:共鉴定71个潜在CTL表位,筛选出6个HLA-A*02:01高亲和力表位(评分>0.9)。体外实验证实其中5个表位(CTL1~5)可显著诱导HLA-A*02:01表达(P<0.05),而CTL6无结合活性。保守性分析显示,CTL1~6表位在柯萨奇病毒、埃可病毒及肠道病毒中高度保守,提示其交叉保护潜力。结论:鉴定了CVB3的HLA-A*02:01限制性CTL表位,为开发针对CVB3及其他肠道病毒的广谱疫苗提供了关键靶点。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61372076 and 61701375)the 111 Project,China(Grant No.B08038)+1 种基金the Key Research and Development Plan of Shannxi Province,China(Grant No.BBD24017290001)the Foundation of Science and Technology on Communication Networks Laboratory,China(Grant No.KX172600031)
文摘We propose a method to estimate the average fidelity using the unitary 2t-design of a twirled noisy channel, which is suitable for large-scale quantum circuits. Compared with the unitary 2-design in randomized benchmarking, the unitary2t-design for the twirling of noisy channels is more flexible in construction and can provide more information. In addition,we prove that the proposed method provides an efficient and reliable estimation of the average fidelity in benchmarking multistage quantum gates and estimating the weakly gate-and time-dependent noise. For time-dependent noise, we provide a scheme of moment superoperator to analyze the noise in different experiments. In particular, we give a lower bound on the average fidelity of a channel with imperfect implementation of benchmarking and state preparation and measurement errors(SPAM).
文摘A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ) design for some v,k,γ.In this paper,we give a generalization of t-design called balanced n-ary t-design,and obtain some properties of the new combinatorial structure.
文摘目的:筛选柯萨奇病毒B3(Coxsackievirus B3,CVB3)中可被细胞毒性T细胞(cytotoxic T lymphocytes,CTL)高效识别的抗原表位,为开发针对CVB3及其他肠道病毒的广谱疫苗提供理论依据。方法:基于免疫表位数据库(Immune Epitope Database,IEDB)及NetMHCpan EL 4.1算法预测CVB3的CTL候选表位;针对HLA-A*02:01限制性表位,通过AlphaFold 2.3.2模拟其与人类白细胞抗原的复合物结构,分析表位保守性及交叉免疫潜力;利用T2细胞结合实验验证候选表位与HLA-A*02:01的亲和力。结果:共鉴定71个潜在CTL表位,筛选出6个HLA-A*02:01高亲和力表位(评分>0.9)。体外实验证实其中5个表位(CTL1~5)可显著诱导HLA-A*02:01表达(P<0.05),而CTL6无结合活性。保守性分析显示,CTL1~6表位在柯萨奇病毒、埃可病毒及肠道病毒中高度保守,提示其交叉保护潜力。结论:鉴定了CVB3的HLA-A*02:01限制性CTL表位,为开发针对CVB3及其他肠道病毒的广谱疫苗提供了关键靶点。
