Bionic limbs require reliable,low-noise and high-comfort interfaces between electrodes and the prosthetic system.This work presents the first fully flexible,wearable myoelectric control system compatible with both dry...Bionic limbs require reliable,low-noise and high-comfort interfaces between electrodes and the prosthetic system.This work presents the first fully flexible,wearable myoelectric control system compatible with both dry and wet electrodes.It features a low-noise front-end circuit on foil using amorphous Indium-Gallium-Zinc-Oxide(a-IGZO)Thin-Film Transistors,optimized for multi-electrode sensing.The design includes an autozeroed pre-charging buffer to minimize offset and 1/f noise while maintaining high input impedance(841 MΩat 50 Hz).The front-end achieves 22µVrms input noise,<-90 dBc crosstalk,and a 4.6 mV input offset consuming 55.3µW per channel.EMG signals measured by this AFE were used to drive an elbow musculoskeletal model and predict the resulting human elbow flexion-extension moments,which in turn were used to realize a closed-loop real-time control in a simulated bionic elbow joint,using both dry and wet electrodes.Experiments done with a series of movements show a 20°rms error in angular control.展开更多
Recent researchhas shown that probiotics,particularly Lactobacillus sp.,have potential as modulators of the immune system.This review explores the immunotherapeutic potential of Lactobacillus species via adjuvant ther...Recent researchhas shown that probiotics,particularly Lactobacillus sp.,have potential as modulators of the immune system.This review explores the immunotherapeutic potential of Lactobacillus species via adjuvant therapy with immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1,programmed death ligand-1,and cytotoxic T-lymphocyte antigen-4 inhibitors,which have revolutionized cancer treatment by enhancing T-cell-mediated antitumor immunity.However,patient response remains questionable,prompting further study into the role of the gut microbiota in modulating these therapies.These probiotics influence immune responses through interactions with immune cells such as dendritic cells,macrophages,and T cells.These interactions promote cytokine production,enhance CD8+T-cell activity,and improve the gut barrier.Specific Lactobacillus strains can increase ICI efficacy through the production of proinflammatory cytokines and associated side effects.Optimizing Lactobacillus-based therapies and integrating them with existing cancer treatments may lead to improved patient outcomes.Although the formulation of probiotic species in advanced drug delivery systems,such as niosomes and liposomes,may prove to be successful,regulatory guidelines need to be followed to support their nontoxic effects in preclinical trials followed by clinical studies.Although the concomitant administration of probiotics with ICIs remains a promising strategy,the underlying mechanisms need to be explored to support their systemic nontoxic effects.展开更多
基金project Smart-Sense(with project number17608)which is(partly)financed by the Dutch Research Council(NWO)。
文摘Bionic limbs require reliable,low-noise and high-comfort interfaces between electrodes and the prosthetic system.This work presents the first fully flexible,wearable myoelectric control system compatible with both dry and wet electrodes.It features a low-noise front-end circuit on foil using amorphous Indium-Gallium-Zinc-Oxide(a-IGZO)Thin-Film Transistors,optimized for multi-electrode sensing.The design includes an autozeroed pre-charging buffer to minimize offset and 1/f noise while maintaining high input impedance(841 MΩat 50 Hz).The front-end achieves 22µVrms input noise,<-90 dBc crosstalk,and a 4.6 mV input offset consuming 55.3µW per channel.EMG signals measured by this AFE were used to drive an elbow musculoskeletal model and predict the resulting human elbow flexion-extension moments,which in turn were used to realize a closed-loop real-time control in a simulated bionic elbow joint,using both dry and wet electrodes.Experiments done with a series of movements show a 20°rms error in angular control.
文摘Recent researchhas shown that probiotics,particularly Lactobacillus sp.,have potential as modulators of the immune system.This review explores the immunotherapeutic potential of Lactobacillus species via adjuvant therapy with immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1,programmed death ligand-1,and cytotoxic T-lymphocyte antigen-4 inhibitors,which have revolutionized cancer treatment by enhancing T-cell-mediated antitumor immunity.However,patient response remains questionable,prompting further study into the role of the gut microbiota in modulating these therapies.These probiotics influence immune responses through interactions with immune cells such as dendritic cells,macrophages,and T cells.These interactions promote cytokine production,enhance CD8+T-cell activity,and improve the gut barrier.Specific Lactobacillus strains can increase ICI efficacy through the production of proinflammatory cytokines and associated side effects.Optimizing Lactobacillus-based therapies and integrating them with existing cancer treatments may lead to improved patient outcomes.Although the formulation of probiotic species in advanced drug delivery systems,such as niosomes and liposomes,may prove to be successful,regulatory guidelines need to be followed to support their nontoxic effects in preclinical trials followed by clinical studies.Although the concomitant administration of probiotics with ICIs remains a promising strategy,the underlying mechanisms need to be explored to support their systemic nontoxic effects.
