In this study,we introduce a method for directly synthesizing various siloxanes from hydrosilanes and silanols under ambient conditions.This process relies on the use of Stryker’s reagent([(PPh_(3))CuH]_(6))as the fi...In this study,we introduce a method for directly synthesizing various siloxanes from hydrosilanes and silanols under ambient conditions.This process relies on the use of Stryker’s reagent([(PPh_(3))CuH]_(6))as the first copper catalyst,enabling this specific cross-dehydrogenative coupling.This method stands out for its exceptional chemoselectivity,making it a superb alternative to established catalytic systems.It operates under mild conditions yet maintains high process efficiency.Throughout the investigation,we demonstrated the potential for modifying the resulting hydrosiloxanes through alcoholysis to produce silyl ethers and via hydrosilylation to yield functionalized siloxanes.展开更多
When stereochemically-active-lone-pair(SCALP)cations are introduced into chalcogenide systems,it is beneficial to produce a remarkable second-harmonic generation(SHG)response(d_(eff)),but it also causes a narrow band ...When stereochemically-active-lone-pair(SCALP)cations are introduced into chalcogenide systems,it is beneficial to produce a remarkable second-harmonic generation(SHG)response(d_(eff)),but it also causes a narrow band gap(E_(g)),which ultimately results in negative two-photon and free-carrier absorption.Hence,how to obtain a wide E_(g)(>2.33 eV)while maintaining a strong d_(eff)remains a significant challenge in this domain.In this work,Rb is partially replaced by SCALP Pb in the known ternary centrosymmetric(CS)Rb3PS_(4)(space group:Pnma).This results in a quaternary non-centrosymmetric(NCS)RbPbPS_(4)(space group:P212121),which possesses distinct 2D[PbPS_(4)]−layers and Rb+occupies the interlayer spaces as the counter cations.Notably,RbPbPS_(4)exhibits a promising overall performance,including strong d_(eff)(2.5×AgGaS_(2)),wide IR transmittance cutoff edge(up to 18.1μm)along with the large E_(g)(2.75 eV),resulting in an improved laser-induced damage threshold(7.5×AgGaS_(2)).Theoretical calculations further indicated that the favorable balance between strong d_(eff)and large E_(g)in RbPbPS_(4)can be attributed to the synergies of the[PbS7]and[PS_(4)]nonlinear optical(NLO)-active units.This study not only presents a high-performance Pb-based IR-NLO candidate but also underscores the effectiveness of partial substitution of SCALP cations in inducing a CS-to-NCS structural transformation.展开更多
Physiological supporting systems,such as the vascular network and excretion system,are crucial for the effective functioning of organs.This study demonstrates that when a body-on-a-chip microdevice is coupled with min...Physiological supporting systems,such as the vascular network and excretion system,are crucial for the effective functioning of organs.This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support systems,it can create a multi-organ microphysiological system capable of more accurately mimicking the physiological complexity of a body,thereby offering potential for preclinical drug testing.To exemplify this concept,we have developed a model system comprising 18 types of microtissues interconnected by a vascular network that replicates the in vivo blood distribution among the organs.Furthermore,this system includes an excretory system with a micro-stirrer that ensures elimination efficiency akin to in vivo conditions.Our findings indicate that this system can:(1)survive and function for almost two months;(2)achieve two-compartment pharmacokinetics of a drug;(3)investigate the dynamic relationship between the tissue distribution and toxicity of a drug;(4)establish the multimorbidity model and evaluate the effectiveness of polypharmacy,challenging tasks with traditional animal models;(5)reduce animal usage in drug evaluations.Notably,features from points(2)to(4)are capabilities not achievable by other in vitro models.The strategy proposed in this study can also be applied to the development of multi-organ microphysiological systems that mimic the physiological complexity of human organs or the entire body.展开更多
基金supported by a National Science Centre Grant UMO-2021/43/D/ST4/00132.
文摘In this study,we introduce a method for directly synthesizing various siloxanes from hydrosilanes and silanols under ambient conditions.This process relies on the use of Stryker’s reagent([(PPh_(3))CuH]_(6))as the first copper catalyst,enabling this specific cross-dehydrogenative coupling.This method stands out for its exceptional chemoselectivity,making it a superb alternative to established catalytic systems.It operates under mild conditions yet maintains high process efficiency.Throughout the investigation,we demonstrated the potential for modifying the resulting hydrosiloxanes through alcoholysis to produce silyl ethers and via hydrosilylation to yield functionalized siloxanes.
基金supported by the National Natural Science Foundation of China(22175175)Natural Science Foundation of Fujian Province(2022L3092 and 2023H0041)+1 种基金Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(2021ZR118)the Youth Innovation Promotion Association CAS(2022303).
文摘When stereochemically-active-lone-pair(SCALP)cations are introduced into chalcogenide systems,it is beneficial to produce a remarkable second-harmonic generation(SHG)response(d_(eff)),but it also causes a narrow band gap(E_(g)),which ultimately results in negative two-photon and free-carrier absorption.Hence,how to obtain a wide E_(g)(>2.33 eV)while maintaining a strong d_(eff)remains a significant challenge in this domain.In this work,Rb is partially replaced by SCALP Pb in the known ternary centrosymmetric(CS)Rb3PS_(4)(space group:Pnma).This results in a quaternary non-centrosymmetric(NCS)RbPbPS_(4)(space group:P212121),which possesses distinct 2D[PbPS_(4)]−layers and Rb+occupies the interlayer spaces as the counter cations.Notably,RbPbPS_(4)exhibits a promising overall performance,including strong d_(eff)(2.5×AgGaS_(2)),wide IR transmittance cutoff edge(up to 18.1μm)along with the large E_(g)(2.75 eV),resulting in an improved laser-induced damage threshold(7.5×AgGaS_(2)).Theoretical calculations further indicated that the favorable balance between strong d_(eff)and large E_(g)in RbPbPS_(4)can be attributed to the synergies of the[PbS7]and[PS_(4)]nonlinear optical(NLO)-active units.This study not only presents a high-performance Pb-based IR-NLO candidate but also underscores the effectiveness of partial substitution of SCALP cations in inducing a CS-to-NCS structural transformation.
基金National Natural Science Foundation of China(Grant No.82373840)Jiangsu Key Laboratory of Neuropsychiatric Diseases(Grants BM2013003 and ZZ2009).
文摘Physiological supporting systems,such as the vascular network and excretion system,are crucial for the effective functioning of organs.This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support systems,it can create a multi-organ microphysiological system capable of more accurately mimicking the physiological complexity of a body,thereby offering potential for preclinical drug testing.To exemplify this concept,we have developed a model system comprising 18 types of microtissues interconnected by a vascular network that replicates the in vivo blood distribution among the organs.Furthermore,this system includes an excretory system with a micro-stirrer that ensures elimination efficiency akin to in vivo conditions.Our findings indicate that this system can:(1)survive and function for almost two months;(2)achieve two-compartment pharmacokinetics of a drug;(3)investigate the dynamic relationship between the tissue distribution and toxicity of a drug;(4)establish the multimorbidity model and evaluate the effectiveness of polypharmacy,challenging tasks with traditional animal models;(5)reduce animal usage in drug evaluations.Notably,features from points(2)to(4)are capabilities not achievable by other in vitro models.The strategy proposed in this study can also be applied to the development of multi-organ microphysiological systems that mimic the physiological complexity of human organs or the entire body.
