Rational regulation of reactive oxygen species(ROS)plays a vital importance in maintaining homeostasis of living biological systems.For ROS-related pathologies,chemotherapy technology derived from metal nanomaterials ...Rational regulation of reactive oxygen species(ROS)plays a vital importance in maintaining homeostasis of living biological systems.For ROS-related pathologies,chemotherapy technology derived from metal nanomaterials currently occupies a pivotal position.However,they suffer from inherent issues such as complicated synthesis,batch-to-batch variability,high cost,and potential biological toxicity caused by metal elements.Here,we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalenestructured small-molecule enzyme imitator(DHKNase)exhibited 2-edged ROS regulation,catering to the execution of physiology-beneficial ROS destiny among diverse pathologies in living systems.Based on this,DHKNase is validated to enable remarkable therapeutic effects in 2 classic disease models,including the pathogen-infected wound-healing model and the dextran sulfate sodium(DSS)-caused inflammatory bowel disease(IBD).This work provides a guiding landmark for developing novel natural small-molecule enzyme imitator and significantly expands their application potential in the biomedical field.展开更多
基金supported by the Science and Technology Innovation Program of Hunan Province(2023RC3148)the Scientific Research Foundation of Hunan Provincial Education Department(22B0221)+3 种基金the Opening Foundation of the State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University(20230754)the National Natural Science Foundation of China(22004035 and 31672457)the Double first-class construction project of Hunan Agricultural University(CX20190497)the National Key Research and Development Program(2021YFD1300205-2)。
文摘Rational regulation of reactive oxygen species(ROS)plays a vital importance in maintaining homeostasis of living biological systems.For ROS-related pathologies,chemotherapy technology derived from metal nanomaterials currently occupies a pivotal position.However,they suffer from inherent issues such as complicated synthesis,batch-to-batch variability,high cost,and potential biological toxicity caused by metal elements.Here,we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalenestructured small-molecule enzyme imitator(DHKNase)exhibited 2-edged ROS regulation,catering to the execution of physiology-beneficial ROS destiny among diverse pathologies in living systems.Based on this,DHKNase is validated to enable remarkable therapeutic effects in 2 classic disease models,including the pathogen-infected wound-healing model and the dextran sulfate sodium(DSS)-caused inflammatory bowel disease(IBD).This work provides a guiding landmark for developing novel natural small-molecule enzyme imitator and significantly expands their application potential in the biomedical field.
