To the Editor:Surgery-induced tissue damage leads to the release of damage-associated molecular patterns(DAMPs),triggering the inflammatory response.Similarly,perioperative trauma and stress can disrupt the neuroendoc...To the Editor:Surgery-induced tissue damage leads to the release of damage-associated molecular patterns(DAMPs),triggering the inflammatory response.Similarly,perioperative trauma and stress can disrupt the neuroendocrine and immune systems,activate the hypothalamic-pituitary-adrenal(HPA)axis and sympathetic nervous system,and promote the release of catecholamines and changes in cytokines.The principal functions of the inflammatory biomarkers are detailed in Supplementary Table 1,http://links.lww.com/CM9/C539.The initial pro-inflammatory cytokine storm is followed by a proportional compensatory anti-inflammatory response,with a reduction in apoptotic T cells and a shift toward the immunosuppressive T helper 2(Th2)phenotype after surgery.展开更多
基金The study was supported by a grant the Zhongda Hospital Affiliated to Southeast University,Jiangsu Province High-Level Hospital Construction Fund(No.2024GSPKY21).
文摘To the Editor:Surgery-induced tissue damage leads to the release of damage-associated molecular patterns(DAMPs),triggering the inflammatory response.Similarly,perioperative trauma and stress can disrupt the neuroendocrine and immune systems,activate the hypothalamic-pituitary-adrenal(HPA)axis and sympathetic nervous system,and promote the release of catecholamines and changes in cytokines.The principal functions of the inflammatory biomarkers are detailed in Supplementary Table 1,http://links.lww.com/CM9/C539.The initial pro-inflammatory cytokine storm is followed by a proportional compensatory anti-inflammatory response,with a reduction in apoptotic T cells and a shift toward the immunosuppressive T helper 2(Th2)phenotype after surgery.
