Differential inequalities generated in an extended Lyapunov framework are employed in the stability and instability analyses of a class of switched continuous-time second-and higher order linear systems with an arbitr...Differential inequalities generated in an extended Lyapunov framework are employed in the stability and instability analyses of a class of switched continuous-time second-and higher order linear systems with an arbitrary number of switching matrices.The exponential stability and instability(ESI)conditions so obtained involve the supremum and infimum of ratios of certain quadratic forms of the matrices,leading to global time-averages of their activity intervals.Further,motivated by linear switching system examples of(i)instability with stable matrices and(ii)stability with unstable matrices(found in the literature primarily for second-order systems),the proposed framework is generalized to establish ESI conditions that include both the activity intervals of the matrices and their switching rates,the latter being governed by a certain logarithmic measure of the normalized magnitudes of discontinuities caused by switching.In effect,(the new,globally averaged)dwell-time is flexibly traded,apparently for the first time,but under specific conditions(related,in part,to the eigenvalues of the matrices),for switching discontinuity-based conditions.Two further novel aspects of the proposed approach are:(i)For second-order matrices,switching lines in phase space can be chosen for periodic switching to stabilize or destabilize the system,and even generate oscillations,depending on the eigenvalues of the system matrices.But for third-(and higher)order matrices,such an analytically tractable(and controlled)periodical switching entails solution of an explicit non-convex multi-parameter optimization problem for which a stochastic optimization algorithm from the literature can be invoked.(ii)Lower and upper bounds on the solutions of the system equations can be quantified to reflect the stability/instability/oscillatory property of the system.Illustrative examples,which demonstrate the novelty of the derived stability and instability conditions,are presented in part 2 which is advisedly to be read along with this part 1 for a coherent merging of theory with practice.展开更多
In this second part of the paper,bearing the same title as above,but with the last hyphenated phrase replaced by part 1(Theory),the exponential stability and instability(ESI)Theorems 1–4 of part 1 are illustrated by ...In this second part of the paper,bearing the same title as above,but with the last hyphenated phrase replaced by part 1(Theory),the exponential stability and instability(ESI)Theorems 1–4 of part 1 are illustrated by applying them to second-andby,say,third-order linear switched systems with different eigenvalue structures to demonstrate the versatility,novelty and superiority(over many of the results found in the literature,especially for second-order switched lined systems)of the new theoretical results.The computational procedure that is employed with reference to the third-order systems is generic,in the sense that it is applicable to higher(i.e.,greater than third-)order linear switched systems.A pseudo-code for a computer implementation of the stability/instability conditions is also presented.With the principal aim of facilitating an independent reading of this part 2 of the paper,some crucial mathematical notations,definitions and results of part 1 have been repeated,thereby making the contents as self-contained as possible.展开更多
The problem of stabilizing a class of large-scale non-linear multiple delay systems is considered.The complicated system is decomposed into several subsystems; each function of them is expressed by a set of components...The problem of stabilizing a class of large-scale non-linear multiple delay systems is considered.The complicated system is decomposed into several subsystems; each function of them is expressed by a set of components of the overall state vector,with interconnections between them, and the subsystems are coupled by the delayed state. In this paper, a method is devised to be a suitable choice of state feedback controls of every subsystems, moreover, it is proved that the large-scale system is exponential stable.展开更多
In this paper,we study the uniqueness of positive solutions to the following semilinear equations{-Δu=λ|x|^(α)ue^(u^(2)),in B_(1),u=0,onδB_(1)ueu2;in B_(1);u=0;on@B_(1);whereλ>0,α>-2;B_(1)denotes the unit ...In this paper,we study the uniqueness of positive solutions to the following semilinear equations{-Δu=λ|x|^(α)ue^(u^(2)),in B_(1),u=0,onδB_(1)ueu2;in B_(1);u=0;on@B_(1);whereλ>0,α>-2;B_(1)denotes the unit disk in R^(2):By delicate and relatively complicated computation of radial solutions to the above equation and the asymptotic expansion of solutions near the boundary of B_(1),the uniqueness of positive solutions is obtained.The results of this paper extend the uniqueness result for the semilinear equation with critical exponential growth in CHEN et al.(2022)to the case that includes a Henon term.展开更多
This survey presents a comprehensive examination of sensor fusion research spanning four decades,tracing the methodological evolution,application domains,and alignment with classical hierarchical models.Building on th...This survey presents a comprehensive examination of sensor fusion research spanning four decades,tracing the methodological evolution,application domains,and alignment with classical hierarchical models.Building on this long-term trajectory,the foundational approaches such as probabilistic inference,early neural networks,rulebasedmethods,and feature-level fusion established the principles of uncertainty handling andmulti-sensor integration in the 1990s.The fusion methods of 2000s marked the consolidation of these ideas through advanced Kalman and particle filtering,Bayesian–Dempster–Shafer hybrids,distributed consensus algorithms,and machine learning ensembles for more robust and domain-specific implementations.From 2011 to 2020,the widespread adoption of deep learning transformed the field driving some major breakthroughs in the autonomous vehicles domain.A key contribution of this work is the assessment of contemporary methods against the JDL model,revealing gaps at higher levels-especially in situation and impact assessment.Contemporary methods offer only limited implementation of higher-level fusion.The survey also reviews the benchmark multi-sensor datasets,noting their role in advancing the field while identifying major shortcomings like the lack of domain diversity and hierarchical coverage.By synthesizing developments across decades and paradigms,this survey provides both a historical narrative and a forward-looking perspective.It highlights unresolved challenges in transparency,scalability,robustness,and trustworthiness,while identifying emerging paradigms such as neuromorphic fusion and explainable AI as promising directions.This paves the way forward for advancing sensor fusion towards transparent and adaptive next-generation autonomous systems.展开更多
Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention a...The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.展开更多
Malignant pleural effusion(MPE) is a serious disease caused by malignant tumors with high morbidity and mortality.Chemotherapy,immunotherapy,and antiangiogenic therapy are common treatments for MPE at present.However,...Malignant pleural effusion(MPE) is a serious disease caused by malignant tumors with high morbidity and mortality.Chemotherapy,immunotherapy,and antiangiogenic therapy are common treatments for MPE at present.However,traditional chemotherapeutic drugs have many side effects and can easily lead to drug resistance in patients.The complex tumor microenvironment(TME) of MPE directly reduces the antitumor efficacy of immunotherapy.Fortunately,drug delivery systems(DDSs) based on biomaterials have the ability to overcome some of the drawbacks of conventional treatments by improving drug stability,increasing the accuracy of tumor cell targeting,reducing toxic side effects,and remodeling TME,ultimately improving drug efficacy.Therefore,the purpose of this review is to provide an overview and discussion of the latest progress in biomaterial-based DDSs for the treatment of MPE.We discuss the application of biomaterials in the treatment of MPE from multiple perspectives,including chemotherapy,immunotherapy,combination therapy,and pleurodesis,where microspheres,cell membrane-derived microparticles(MPs),micelles,nanoparticles,and liposomes,are involved.The application of these biomaterials has been proven to have great potential in the treatment of MPE,providing a new idea for follow-up research.展开更多
Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from sei...Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from seismic networks,satellite observations,and geospatial repositories,creating the need for scalable infrastructures capable of integrating and analyzing such data to support intelligent decision-making.Data warehousing technologies provide a robust foundation for this purpose;however,existing earthquake-oriented data warehouses remain limited,often relying on simplified schemas,domain-specific analytics,or cataloguing efforts.This paper presents the design and implementation of a spatio-temporal data warehouse for seismic activity.The framework integrates spatial and temporal dimensions in a unified schema and introduces a novel array-based approach for managing many-to-many relationships between facts and dimensions without intermediate bridge tables.A comparative evaluation against a conventional bridge-table schema demonstrates that the array-based design improves fact-centric query performance,while the bridge-table schema remains advantageous for dimension-centric queries.To reconcile these trade-offs,a hybrid schema is proposed that retains both representations,ensuring balanced efficiency across heterogeneous workloads.The proposed framework demonstrates how spatio-temporal data warehousing can address schema complexity,improve query performance,and support multidimensional visualization.In doing so,it provides a foundation for integrating seismic analysis into broader big data-driven intelligent decision systems for disaster resilience,risk mitigation,and emergency management.展开更多
Energy storage-equipped photovoltaic(PV-storage)systems can meet frequency regulation requirements under various operating conditions,and their coordinated support for grid frequency has become a future trend.To addre...Energy storage-equipped photovoltaic(PV-storage)systems can meet frequency regulation requirements under various operating conditions,and their coordinated support for grid frequency has become a future trend.To address frequency stability issues caused by low inertia and weak damping,this paper proposes a multi-timescale frequency regulation coordinated control strategy for PV-storage integrated systems.First,a self-synchronizing control strategy for grid-connected inverters is designed based on DC voltage dynamics,enabling active inertia support while transmitting frequency variation information.Next,an energy storage inertia support control strategy is developed to enhance the frequency nadir,and an active frequency support control strategy for PV system considering a frequency regulation deadband is proposed,where the deadband value is determined based on the power regulation margin of synchronous generators,allowing the PV-storage system to adaptively switch between inertia support and primary frequency regulation under different disturbance conditions.This approach ensures system frequency stability while fully leveraging the regulation capabilities of heterogeneous resources.Finally,the real-time digital simulation results of the PV-storage integrated system demonstrate that,compared to existing control methods,the proposed strategy effectively reduces the rate of change of frequency and improves the frequency nadir under various disturbance scenarios,verifying its effectiveness.展开更多
Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection mo...Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection models often exhibit significant performance degradation in real-world environments characterized by high dynamic range and complex lighting conditions.To overcome these limitations,this research presents FED-YOLOv10s,an improved and lightweight object detection framework based on You Only look Once v10(YOLOv10).The proposed model integrates a C2f-Faster block derived from FasterNet to reduce parameters and floating-point operations,an Efficient Multiscale Attention(EMA)mechanism to improve TSL-invariant feature extraction,and a deformable Convolution Networks v4(DCNv4)module to enhance multiscale spatial adaptability.Experimental findings demonstrate that the proposed architecture achieves an optimal balance between computational efficiency and detection accuracy,attaining an F1-score of 91.8%,and mAP@0.5 of 95.1%,while reducing parameters to 8.13 million.Comparative analyses across multiple traffic sign detection benchmarks demonstrate that FED-YOLOv10s outperforms state-of-the-art models in precision,recall,and mAP.These results highlight FED-YOLOv10s as a robust,efficient,and deployable solution for intelligent traffic perception in ADS.展开更多
In this manuscript,we consider a non-autonomous dynamical system.Using the Carathéodory structure,we define a BS dimension on an arbitrary subset and obtain a Bowen’s equation that illustrates the relation of th...In this manuscript,we consider a non-autonomous dynamical system.Using the Carathéodory structure,we define a BS dimension on an arbitrary subset and obtain a Bowen’s equation that illustrates the relation of the BS dimension to the Pesin-Pitskel topological pressure given by Nazarian[24].Moreover,we establish a variational principle and an inverse variational principle for the BS dimension of non-autonomous dynamical systems.Finally,we also get an analogue of Billingsley’s theorem for the BS dimension of non-autonomous dynamical systems.展开更多
The increasing number of interconnected devices and the incorporation of smart technology into contemporary healthcare systems have significantly raised the attack surface of cyber threats.The early detection of threa...The increasing number of interconnected devices and the incorporation of smart technology into contemporary healthcare systems have significantly raised the attack surface of cyber threats.The early detection of threats is both necessary and complex,yet these interconnected healthcare settings generate enormous amounts of heterogeneous data.Traditional Intrusion Detection Systems(IDS),which are generally centralized and machine learning-based,often fail to address the rapidly changing nature of cyberattacks and are challenged by ethical concerns related to patient data privacy.Moreover,traditional AI-driven IDS usually face challenges in handling large-scale,heterogeneous healthcare data while ensuring data privacy and operational efficiency.To address these issues,emerging technologies such as Big Data Analytics(BDA)and Federated Learning(FL)provide a hybrid framework for scalable,adaptive intrusion detection in IoT-driven healthcare systems.Big data techniques enable processing large-scale,highdimensional healthcare data,and FL can be used to train a model in a decentralized manner without transferring raw data,thereby maintaining privacy between institutions.This research proposes a privacy-preserving Federated Learning–based model that efficiently detects cyber threats in connected healthcare systems while ensuring distributed big data processing,privacy,and compliance with ethical regulations.To strengthen the reliability of the reported findings,the resultswere validated using cross-dataset testing and 95%confidence intervals derived frombootstrap analysis,confirming consistent performance across heterogeneous healthcare data distributions.This solution takes a significant step toward securing next-generation healthcare infrastructure by combining scalability,privacy,adaptability,and earlydetection capabilities.The proposed global model achieves a test accuracy of 99.93%±0.03(95%CI)and amiss-rate of only 0.07%±0.02,representing state-of-the-art performance in privacy-preserving intrusion detection.The proposed FL-driven IDS framework offers an efficient,privacy-preserving,and scalable solution for securing next-generation healthcare infrastructures by combining adaptability,early detection,and ethical data management.展开更多
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ...The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.展开更多
Trajectory tracking for nonlinear robotic systems remains a fundamental yet challenging problem in control engineering,particularly when both precision and efficiency must be ensured.Conventional control methods are o...Trajectory tracking for nonlinear robotic systems remains a fundamental yet challenging problem in control engineering,particularly when both precision and efficiency must be ensured.Conventional control methods are often effective for stabilization but may not directly optimize long-term performance.To address this limitation,this study develops an integrated framework that combines optimal control principles with reinforcement learning for a single-link robotic manipulator.The proposed scheme adopts an actor–critic structure,where the critic network approximates the value function associated with the Hamilton–Jacobi–Bellman equation,and the actor network generates near-optimal control signals in real time.This dual adaptation enables the controller to refine its policy online without explicit system knowledge.Stability of the closed-loop system is analyzed through Lyapunov theory,ensuring boundedness of the tracking error.Numerical simulations on the single-link manipulator demonstrate that themethod achieves accurate trajectory followingwhile maintaining lowcontrol effort.The results further showthat the actor–critic learning mechanism accelerates convergence of the control policy compared with conventional optimization-based strategies.This work highlights the potential of reinforcement learning integrated with optimal control for robotic manipulators and provides a foundation for future extensions to more complex multi-degree-of-freedom systems.The proposed controller is further validated in a physics-based virtual Gazebo environment,demonstrating stable adaptation and real-time feasibility.展开更多
文摘Differential inequalities generated in an extended Lyapunov framework are employed in the stability and instability analyses of a class of switched continuous-time second-and higher order linear systems with an arbitrary number of switching matrices.The exponential stability and instability(ESI)conditions so obtained involve the supremum and infimum of ratios of certain quadratic forms of the matrices,leading to global time-averages of their activity intervals.Further,motivated by linear switching system examples of(i)instability with stable matrices and(ii)stability with unstable matrices(found in the literature primarily for second-order systems),the proposed framework is generalized to establish ESI conditions that include both the activity intervals of the matrices and their switching rates,the latter being governed by a certain logarithmic measure of the normalized magnitudes of discontinuities caused by switching.In effect,(the new,globally averaged)dwell-time is flexibly traded,apparently for the first time,but under specific conditions(related,in part,to the eigenvalues of the matrices),for switching discontinuity-based conditions.Two further novel aspects of the proposed approach are:(i)For second-order matrices,switching lines in phase space can be chosen for periodic switching to stabilize or destabilize the system,and even generate oscillations,depending on the eigenvalues of the system matrices.But for third-(and higher)order matrices,such an analytically tractable(and controlled)periodical switching entails solution of an explicit non-convex multi-parameter optimization problem for which a stochastic optimization algorithm from the literature can be invoked.(ii)Lower and upper bounds on the solutions of the system equations can be quantified to reflect the stability/instability/oscillatory property of the system.Illustrative examples,which demonstrate the novelty of the derived stability and instability conditions,are presented in part 2 which is advisedly to be read along with this part 1 for a coherent merging of theory with practice.
文摘In this second part of the paper,bearing the same title as above,but with the last hyphenated phrase replaced by part 1(Theory),the exponential stability and instability(ESI)Theorems 1–4 of part 1 are illustrated by applying them to second-andby,say,third-order linear switched systems with different eigenvalue structures to demonstrate the versatility,novelty and superiority(over many of the results found in the literature,especially for second-order switched lined systems)of the new theoretical results.The computational procedure that is employed with reference to the third-order systems is generic,in the sense that it is applicable to higher(i.e.,greater than third-)order linear switched systems.A pseudo-code for a computer implementation of the stability/instability conditions is also presented.With the principal aim of facilitating an independent reading of this part 2 of the paper,some crucial mathematical notations,definitions and results of part 1 have been repeated,thereby making the contents as self-contained as possible.
文摘The problem of stabilizing a class of large-scale non-linear multiple delay systems is considered.The complicated system is decomposed into several subsystems; each function of them is expressed by a set of components of the overall state vector,with interconnections between them, and the subsystems are coupled by the delayed state. In this paper, a method is devised to be a suitable choice of state feedback controls of every subsystems, moreover, it is proved that the large-scale system is exponential stable.
基金Supported by the Natural Science Foundation of China(12571122,12061010)。
文摘In this paper,we study the uniqueness of positive solutions to the following semilinear equations{-Δu=λ|x|^(α)ue^(u^(2)),in B_(1),u=0,onδB_(1)ueu2;in B_(1);u=0;on@B_(1);whereλ>0,α>-2;B_(1)denotes the unit disk in R^(2):By delicate and relatively complicated computation of radial solutions to the above equation and the asymptotic expansion of solutions near the boundary of B_(1),the uniqueness of positive solutions is obtained.The results of this paper extend the uniqueness result for the semilinear equation with critical exponential growth in CHEN et al.(2022)to the case that includes a Henon term.
文摘This survey presents a comprehensive examination of sensor fusion research spanning four decades,tracing the methodological evolution,application domains,and alignment with classical hierarchical models.Building on this long-term trajectory,the foundational approaches such as probabilistic inference,early neural networks,rulebasedmethods,and feature-level fusion established the principles of uncertainty handling andmulti-sensor integration in the 1990s.The fusion methods of 2000s marked the consolidation of these ideas through advanced Kalman and particle filtering,Bayesian–Dempster–Shafer hybrids,distributed consensus algorithms,and machine learning ensembles for more robust and domain-specific implementations.From 2011 to 2020,the widespread adoption of deep learning transformed the field driving some major breakthroughs in the autonomous vehicles domain.A key contribution of this work is the assessment of contemporary methods against the JDL model,revealing gaps at higher levels-especially in situation and impact assessment.Contemporary methods offer only limited implementation of higher-level fusion.The survey also reviews the benchmark multi-sensor datasets,noting their role in advancing the field while identifying major shortcomings like the lack of domain diversity and hierarchical coverage.By synthesizing developments across decades and paradigms,this survey provides both a historical narrative and a forward-looking perspective.It highlights unresolved challenges in transparency,scalability,robustness,and trustworthiness,while identifying emerging paradigms such as neuromorphic fusion and explainable AI as promising directions.This paves the way forward for advancing sensor fusion towards transparent and adaptive next-generation autonomous systems.
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金National Natural Science Foundation of China,Grant/Award Number:82000102 and 82270112。
文摘The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.
基金financial support from the Noncommunicable Chronic Diseases-National Science and Technology Major Project (Nos.2024ZD0522800,2024ZD0522803)the National Natural Science Foundation of China (Nos.U21A20417,31930067,31800797)+2 种基金the Natural Science Foundation of Sichuan Province (No.2024NSFSC0046)the Sichuan Science and Technology Program (No.2022YFS0333)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University (No.ZYGD24003)。
文摘Malignant pleural effusion(MPE) is a serious disease caused by malignant tumors with high morbidity and mortality.Chemotherapy,immunotherapy,and antiangiogenic therapy are common treatments for MPE at present.However,traditional chemotherapeutic drugs have many side effects and can easily lead to drug resistance in patients.The complex tumor microenvironment(TME) of MPE directly reduces the antitumor efficacy of immunotherapy.Fortunately,drug delivery systems(DDSs) based on biomaterials have the ability to overcome some of the drawbacks of conventional treatments by improving drug stability,increasing the accuracy of tumor cell targeting,reducing toxic side effects,and remodeling TME,ultimately improving drug efficacy.Therefore,the purpose of this review is to provide an overview and discussion of the latest progress in biomaterial-based DDSs for the treatment of MPE.We discuss the application of biomaterials in the treatment of MPE from multiple perspectives,including chemotherapy,immunotherapy,combination therapy,and pleurodesis,where microspheres,cell membrane-derived microparticles(MPs),micelles,nanoparticles,and liposomes,are involved.The application of these biomaterials has been proven to have great potential in the treatment of MPE,providing a new idea for follow-up research.
文摘Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from seismic networks,satellite observations,and geospatial repositories,creating the need for scalable infrastructures capable of integrating and analyzing such data to support intelligent decision-making.Data warehousing technologies provide a robust foundation for this purpose;however,existing earthquake-oriented data warehouses remain limited,often relying on simplified schemas,domain-specific analytics,or cataloguing efforts.This paper presents the design and implementation of a spatio-temporal data warehouse for seismic activity.The framework integrates spatial and temporal dimensions in a unified schema and introduces a novel array-based approach for managing many-to-many relationships between facts and dimensions without intermediate bridge tables.A comparative evaluation against a conventional bridge-table schema demonstrates that the array-based design improves fact-centric query performance,while the bridge-table schema remains advantageous for dimension-centric queries.To reconcile these trade-offs,a hybrid schema is proposed that retains both representations,ensuring balanced efficiency across heterogeneous workloads.The proposed framework demonstrates how spatio-temporal data warehousing can address schema complexity,improve query performance,and support multidimensional visualization.In doing so,it provides a foundation for integrating seismic analysis into broader big data-driven intelligent decision systems for disaster resilience,risk mitigation,and emergency management.
基金supported by the State Grid Corporation of China under Grant for Science and Technology Projects(No.SGNXJYOOZWJS2500029).
文摘Energy storage-equipped photovoltaic(PV-storage)systems can meet frequency regulation requirements under various operating conditions,and their coordinated support for grid frequency has become a future trend.To address frequency stability issues caused by low inertia and weak damping,this paper proposes a multi-timescale frequency regulation coordinated control strategy for PV-storage integrated systems.First,a self-synchronizing control strategy for grid-connected inverters is designed based on DC voltage dynamics,enabling active inertia support while transmitting frequency variation information.Next,an energy storage inertia support control strategy is developed to enhance the frequency nadir,and an active frequency support control strategy for PV system considering a frequency regulation deadband is proposed,where the deadband value is determined based on the power regulation margin of synchronous generators,allowing the PV-storage system to adaptively switch between inertia support and primary frequency regulation under different disturbance conditions.This approach ensures system frequency stability while fully leveraging the regulation capabilities of heterogeneous resources.Finally,the real-time digital simulation results of the PV-storage integrated system demonstrate that,compared to existing control methods,the proposed strategy effectively reduces the rate of change of frequency and improves the frequency nadir under various disturbance scenarios,verifying its effectiveness.
基金funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,Saudi Arabia under Grant No.IPP:172-830-2025.
文摘Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection models often exhibit significant performance degradation in real-world environments characterized by high dynamic range and complex lighting conditions.To overcome these limitations,this research presents FED-YOLOv10s,an improved and lightweight object detection framework based on You Only look Once v10(YOLOv10).The proposed model integrates a C2f-Faster block derived from FasterNet to reduce parameters and floating-point operations,an Efficient Multiscale Attention(EMA)mechanism to improve TSL-invariant feature extraction,and a deformable Convolution Networks v4(DCNv4)module to enhance multiscale spatial adaptability.Experimental findings demonstrate that the proposed architecture achieves an optimal balance between computational efficiency and detection accuracy,attaining an F1-score of 91.8%,and mAP@0.5 of 95.1%,while reducing parameters to 8.13 million.Comparative analyses across multiple traffic sign detection benchmarks demonstrate that FED-YOLOv10s outperforms state-of-the-art models in precision,recall,and mAP.These results highlight FED-YOLOv10s as a robust,efficient,and deployable solution for intelligent traffic perception in ADS.
基金supported by the NSFC(12461012)and the NSF of Chongqing(CSTB2024NSCQ-MSX1246).
文摘In this manuscript,we consider a non-autonomous dynamical system.Using the Carathéodory structure,we define a BS dimension on an arbitrary subset and obtain a Bowen’s equation that illustrates the relation of the BS dimension to the Pesin-Pitskel topological pressure given by Nazarian[24].Moreover,we establish a variational principle and an inverse variational principle for the BS dimension of non-autonomous dynamical systems.Finally,we also get an analogue of Billingsley’s theorem for the BS dimension of non-autonomous dynamical systems.
文摘The increasing number of interconnected devices and the incorporation of smart technology into contemporary healthcare systems have significantly raised the attack surface of cyber threats.The early detection of threats is both necessary and complex,yet these interconnected healthcare settings generate enormous amounts of heterogeneous data.Traditional Intrusion Detection Systems(IDS),which are generally centralized and machine learning-based,often fail to address the rapidly changing nature of cyberattacks and are challenged by ethical concerns related to patient data privacy.Moreover,traditional AI-driven IDS usually face challenges in handling large-scale,heterogeneous healthcare data while ensuring data privacy and operational efficiency.To address these issues,emerging technologies such as Big Data Analytics(BDA)and Federated Learning(FL)provide a hybrid framework for scalable,adaptive intrusion detection in IoT-driven healthcare systems.Big data techniques enable processing large-scale,highdimensional healthcare data,and FL can be used to train a model in a decentralized manner without transferring raw data,thereby maintaining privacy between institutions.This research proposes a privacy-preserving Federated Learning–based model that efficiently detects cyber threats in connected healthcare systems while ensuring distributed big data processing,privacy,and compliance with ethical regulations.To strengthen the reliability of the reported findings,the resultswere validated using cross-dataset testing and 95%confidence intervals derived frombootstrap analysis,confirming consistent performance across heterogeneous healthcare data distributions.This solution takes a significant step toward securing next-generation healthcare infrastructure by combining scalability,privacy,adaptability,and earlydetection capabilities.The proposed global model achieves a test accuracy of 99.93%±0.03(95%CI)and amiss-rate of only 0.07%±0.02,representing state-of-the-art performance in privacy-preserving intrusion detection.The proposed FL-driven IDS framework offers an efficient,privacy-preserving,and scalable solution for securing next-generation healthcare infrastructures by combining adaptability,early detection,and ethical data management.
基金supported by NARI Relays Electric Co.,Ltd.under the Project“Research on Evaluation of Clearing Results and Switching Criteria for Primary-Backup Systems in Electricity SpotMarkets”(Project No.CGSQ240800443).
文摘The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.
基金supported in part by the National Science and Technology Council under Grant NSTC 114-2221-E-027-104.
文摘Trajectory tracking for nonlinear robotic systems remains a fundamental yet challenging problem in control engineering,particularly when both precision and efficiency must be ensured.Conventional control methods are often effective for stabilization but may not directly optimize long-term performance.To address this limitation,this study develops an integrated framework that combines optimal control principles with reinforcement learning for a single-link robotic manipulator.The proposed scheme adopts an actor–critic structure,where the critic network approximates the value function associated with the Hamilton–Jacobi–Bellman equation,and the actor network generates near-optimal control signals in real time.This dual adaptation enables the controller to refine its policy online without explicit system knowledge.Stability of the closed-loop system is analyzed through Lyapunov theory,ensuring boundedness of the tracking error.Numerical simulations on the single-link manipulator demonstrate that themethod achieves accurate trajectory followingwhile maintaining lowcontrol effort.The results further showthat the actor–critic learning mechanism accelerates convergence of the control policy compared with conventional optimization-based strategies.This work highlights the potential of reinforcement learning integrated with optimal control for robotic manipulators and provides a foundation for future extensions to more complex multi-degree-of-freedom systems.The proposed controller is further validated in a physics-based virtual Gazebo environment,demonstrating stable adaptation and real-time feasibility.
