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Introduction to the Special Issue on Advanced Artificial Intelligence and Machine Learning Methods Applied to Energy Systems
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作者 Wei-Chiang Hong Yi Liang 《Computer Modeling in Engineering & Sciences》 2026年第3期29-33,共5页
Diverse energy and power systems have been playing a significantly critical role in the revolution of sustainable energy supply for the future,which have a great impact on energy resources and efficiencies.Due to the ... Diverse energy and power systems have been playing a significantly critical role in the revolution of sustainable energy supply for the future,which have a great impact on energy resources and efficiencies.Due to the emerging artificial intelligence and machine learning,traditional modeling techniques in these energy systems have met challenges in still leveraging physics model and first principle-based approaches.Moreover,with the rapid development of hardware and computing techniques,new modeling approaches for energy systems have become more and more important for system design,integration,analysis,control,and management. 展开更多
关键词 energy power systems modeling techniques physics model energy resources MACHINELEARNING machine learningtraditional energy systems ARTIFICIALINTELLIGENCE
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Blockchain-Enabled AI Recommendation Systems Using IoT-Asisted Trusted Networks
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作者 Mekhled Alharbi Khalid Haseeb Mamoona Humayun 《Computers, Materials & Continua》 2026年第5期527-539,共13页
The Internet of Things(IoT)and cloud computing have significantly contributed to the development of smart cities,enabling real-time monitoring,intelligent decision-making,and efficient resource management.These system... The Internet of Things(IoT)and cloud computing have significantly contributed to the development of smart cities,enabling real-time monitoring,intelligent decision-making,and efficient resource management.These systems,particularly in IoT networks,rely on numerous interconnected devices that handle time-sensitive data for critical applications.In related approaches,trusted communication and reliable device interaction have been overlooked,thereby lowering security when sharing sensitive IoT data.Moreover,it incurs additional energy consumption and overhead while addressing potential threats in the dynamic environment.In this research,an Artificial Intelligence(AI)recommended fault-tolerant framework is proposed that leverages blockchain technology,aiming to enhance device trustworthiness and ensure data privacy.In addition,the intelligence of the proposed framework enables more authentic and authorized device involvement in data routing,thereby enabling seamless transmission in smart cities integrated with lightweight computing.To evaluate dynamic network conditions,the proposed framework offers a timely decision-making system to ensure robust delivery of IoT-assisted services.Using simulations,the efficacy of the proposed framework is validated by comparing it with existing approaches across various network metrics,demonstrating remarkable performance while achieving energy efficiency and optimizing network resources. 展开更多
关键词 Artificial intelligence blockchain data security IOT recommendation systems
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An index for characterizing bioavailability and risk of metals in soil-vegetable systems
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作者 Lanqin YANG Yuechen YU +2 位作者 Yuanming WANG Biao HUANG Wenyou HU 《Pedosphere》 2026年第1期358-362,共5页
Dear Editor,With the growing food demands and the rapid development of intensive vegetable cultivation,the vegetable yield and planting area have increased to 230 million tons and 2.13 million hectares,respectively,in... Dear Editor,With the growing food demands and the rapid development of intensive vegetable cultivation,the vegetable yield and planting area have increased to 230 million tons and 2.13 million hectares,respectively,in China in 2021(MARAPRC,2023). 展开更多
关键词 METALS BIOAVAILABILITY RisK soil vegetable systems intensive vegetable cultivationthe
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Animal models of benign airway stenosis:Advances in construction techniques,evaluation systems,and perspectives
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作者 Wusheng Zhang Yilin Chen +4 位作者 Chengcheng Yang Yuchao Dong Haidong Huang Hui Shi Chong Bai 《Animal Models and Experimental Medicine》 2026年第2期280-297,共18页
The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention a... The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies. 展开更多
关键词 airway stenosis animal models benign airway stenosis evaluation systems
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Dual-Mode Data-Driven Iterative Learning Control:Applications in Precision Manufacturing and Intelligent Transportation Systems
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作者 Lei Wang Menghan Wei +3 位作者 Ziwei Huangfu Shunjie Zhu Xuejian Ge Zhengquan Li 《Computers, Materials & Continua》 2026年第2期153-184,共32页
Iterative Learning Control(ILC)provides an effective framework for optimizing repetitive tasks,making it particularly suitable for high-precision applications in both precision manufacturing and intelligent transporta... Iterative Learning Control(ILC)provides an effective framework for optimizing repetitive tasks,making it particularly suitable for high-precision applications in both precision manufacturing and intelligent transportation systems(ITS).This paper presents a systematic review of ILC's developmental progress,current methodologies,and practical implementations across these two critical domains.The review first analyzes the key technical challenges encountered when integrating ILC into precision manufacturing workflows.Through case studies,it evaluates demonstrated improvements in positioning accuracy,surface finish quality,and production throughput.Furthermore,the study examines ILC’s applications in ITS,with particular focus on vehicular motion control applications including autonomous vehicle trajectory tracking,platoon coordination,and traffic signal timing optimization,where its data-driven characteristics enhance adaptability to dynamic environments.Finally,the paper proposes targeted future research directions that are essential for fully realizing ILC’s potential in advancing these interconnected yet distinct fields. 展开更多
关键词 Iterative learning control systematic review precisionmanufacturing intelligent transportation systems
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Distributed unsupervised meta-learning algorithm over multi-agent systems
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作者 Zhenzhen Wang Bing He +3 位作者 Zixin Jiang Xianyang Zhang Haidi Dong Di Ye 《Digital Communications and Networks》 2026年第1期134-142,共9页
Multi-Agent Systems(MAS),which consist of multiple interacting agents,are crucial in Cyber-Physical Systems(CPS),because they improve system adaptability,efficiency,and robustness through parallel processing and colla... Multi-Agent Systems(MAS),which consist of multiple interacting agents,are crucial in Cyber-Physical Systems(CPS),because they improve system adaptability,efficiency,and robustness through parallel processing and collaboration.However,most existing unsupervised meta-learning methods are centralized and not suitable for multi-agent systems where data are distributed stored and inaccessible to all agents.Meta-GMVAE,based on Variational Autoencoder(VAE)and set-level variational inference,represents a sophisticated unsupervised meta-learning model that improves generative performance by efficiently learning data representations across various tasks,increasing adaptability and reducing sample requirements.Inspired by these advancements,we propose a novel Distributed Unsupervised Meta-Learning(DUML)framework based on Meta-GMVAE and a fusion strategy.Furthermore,we present a DUML algorithm based on Gaussian Mixture Model(DUMLGMM),where the parameters of the Gaussian-mixture are solved by an Expectation-Maximization algorithm.Simulations on Omniglot and Mini Image Net datasets show that DUMLGMM can achieve the performance of the corresponding centralized algorithm and outperform non-cooperative algorithm. 展开更多
关键词 Unsupervised meta-learning Multi-agent systems Variational autoencoder Gaussian mixture model
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Water quality and biofilm growth in drinking water distribution systems with the low-dose sodium hypochlorite disinfection after ultrafiltration pretreatment
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作者 Yu Zhou Kangbing Zou +4 位作者 Xiaokai Wang Zhihong Wang Wei Song Xing Du Dachao Lin 《Journal of Environmental Sciences》 2026年第2期647-655,共9页
In this study,the effects of low-dose sodium hypochlorite disinfection on water quality and biofilm growth in drinking water distribution systems(DWDS)after ultrafiltration pretreatment was investigated.The influence ... In this study,the effects of low-dose sodium hypochlorite disinfection on water quality and biofilm growth in drinking water distribution systems(DWDS)after ultrafiltration pretreatment was investigated.The influence of pipeline hydraulic residence time(HRT)on disinfection efficiency,by-product formation,microbial activity,and biofilm growth were considered.The results show that both microbial activities and metabolite secretion were stimulated by increasing HRT,aggravating the potential risk of microbial pollution in DWDS.The enhanced microbial metabolism could further weaken disinfection efficiency by consuming extra residual Chlorine,after which the formation of disinfection by-products was facilitated.Residual Chlorine was found negatively correlated with HRT.With prolonging HRT from 5 to 40 h,the concentration of disinfection by-products(Chlorate,Chlorite,and Trichloromethane)was on a continuously increasing trend by 37%,140%,and 75%,respectively.But the water kept in pipeline still reliably satisfied the Standards for drinking water quality in China(GB5749–2022).Besides,more biofilm with denser morphologies developed on rubber pipeline gaskets rather than the iron/plastic ones.Rubber material was inappropriate for DWDS due to its potential risk of secondary biological pollution.Prolonging HRT also enhanced the accumulation of dominant bacteria(e.g.Bradyrhizobium and Obscuribacter)and decreased microbial diversity. 展开更多
关键词 ULTRAFILTRATION Sodium hypochlorite DisINFECTION Water quality Drinking water distribution systems
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Spatio-Temporal Earthquake Analysis via Data Warehousing for Big Data-Driven Decision Systems
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作者 Georgia Garani George Pramantiotis Francisco Javier Moreno Arboleda 《Computers, Materials & Continua》 2026年第3期1963-1988,共26页
Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from sei... Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from seismic networks,satellite observations,and geospatial repositories,creating the need for scalable infrastructures capable of integrating and analyzing such data to support intelligent decision-making.Data warehousing technologies provide a robust foundation for this purpose;however,existing earthquake-oriented data warehouses remain limited,often relying on simplified schemas,domain-specific analytics,or cataloguing efforts.This paper presents the design and implementation of a spatio-temporal data warehouse for seismic activity.The framework integrates spatial and temporal dimensions in a unified schema and introduces a novel array-based approach for managing many-to-many relationships between facts and dimensions without intermediate bridge tables.A comparative evaluation against a conventional bridge-table schema demonstrates that the array-based design improves fact-centric query performance,while the bridge-table schema remains advantageous for dimension-centric queries.To reconcile these trade-offs,a hybrid schema is proposed that retains both representations,ensuring balanced efficiency across heterogeneous workloads.The proposed framework demonstrates how spatio-temporal data warehousing can address schema complexity,improve query performance,and support multidimensional visualization.In doing so,it provides a foundation for integrating seismic analysis into broader big data-driven intelligent decision systems for disaster resilience,risk mitigation,and emergency management. 展开更多
关键词 Data warehouse data analysis big data decision systems SEisMOLOGY data visualization
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Fault-Tolerant Control Achieving Prescribed Tracking Accuracy Within Given Time for Euler-Lagrange Systems Under Unknown Actuation Characteristics and Fading Powering Faults
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作者 Jie Su Yongduan Song 《IEEE/CAA Journal of Automatica Sinica》 2026年第1期72-82,共11页
This paper proposes a fault-tolerant control scheme for Euler-Lagrange systems that ensures the tracking error decays to a pre-specified accuracy level within a prescribed time period,despite unknown actuation charact... This paper proposes a fault-tolerant control scheme for Euler-Lagrange systems that ensures the tracking error decays to a pre-specified accuracy level within a prescribed time period,despite unknown actuation characteristics and potential fading powering faults.By performing deliberately designed coordinate transformations on the tracking error,the complex and demanding problem of“reaching specified precision within a given time”is transformed into a bounded control problem,facilitating the development of the control scheme.To enhance practicality,the design incorporates smooth function fitting and dynamic surface control techniques.Additionally,the proposed control algorithm is robust to faults,effectively handling a combination of fading powering faults and additive actuator faults without requiring additional human intervention.Numerical simulations on a two-link robotic manipulator verify the effectiveness of the proposed control algorithm. 展开更多
关键词 Actuation characteristics actuator faults EulerLagrange systems pre-specified accuracy level prescribed-time control
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Natural Frequency-Based Sensitivity Analysis of Pipe Systems with Uncertain Clamp Stiffness and Position Parameters
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作者 Yan Shi Xin Wang +3 位作者 Yi Wang Bingfeng Zhao Shang Ren Xufang Zhang 《Computer Modeling in Engineering & Sciences》 2026年第3期362-387,共26页
This paper introduces a computationally efficient global sensitivity analysis method for quantifying the influence of uncertain clamp support conditions on the natural frequencies of aero-engine pipe systems.The dynam... This paper introduces a computationally efficient global sensitivity analysis method for quantifying the influence of uncertain clamp support conditions on the natural frequencies of aero-engine pipe systems.The dynamic model is based on a three-dimensional Timoshenko beam finite element formulation,with clamps represented as distributed spring elements possessing anisotropic stiffness.To overcome the prohibitive cost of traditional Monte Carlo simulation,the multiplicative dimensional reduction method(M-DRM)is integrated with variance decomposition theory.This approach approximates the high-dimensional frequency response function as a product of univariate components,enabling rapid computation of Sobol’sensitivity indices with a computational cost reduced by three orders of magnitude.Numerical case studies on a planar Z-shaped pipe and a spatial series-parallel configuration reveal that clamp position parameters dominate the system’s natural frequency characteristics.For critical clamps,Sobol’indices exceed 0.8 across multiple vibration modes,whereas stiffness parameters exhibit negligible influence.The proposed methodology provides a rigorous and efficient tool for identifying dominant uncertainty sources,guiding tolerance allocation in manufacturing,and informing robust support design for vibration-sensitive piping systems. 展开更多
关键词 Natural frequencies multiplicative dimensionality reduction method sobol’index clamp-pipe systems
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A Robust Vision-Based Framework for Traffic Sign and Light Detection in Automated Driving Systems
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作者 Mohammed Al-Mahbashi Ali Ahmed +3 位作者 Abdolraheem Khader Shakeel Ahmad Mohamed A.Damos Ahmed Abdu 《Computer Modeling in Engineering & Sciences》 2026年第1期1207-1232,共26页
Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection mo... Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection models often exhibit significant performance degradation in real-world environments characterized by high dynamic range and complex lighting conditions.To overcome these limitations,this research presents FED-YOLOv10s,an improved and lightweight object detection framework based on You Only look Once v10(YOLOv10).The proposed model integrates a C2f-Faster block derived from FasterNet to reduce parameters and floating-point operations,an Efficient Multiscale Attention(EMA)mechanism to improve TSL-invariant feature extraction,and a deformable Convolution Networks v4(DCNv4)module to enhance multiscale spatial adaptability.Experimental findings demonstrate that the proposed architecture achieves an optimal balance between computational efficiency and detection accuracy,attaining an F1-score of 91.8%,and mAP@0.5 of 95.1%,while reducing parameters to 8.13 million.Comparative analyses across multiple traffic sign detection benchmarks demonstrate that FED-YOLOv10s outperforms state-of-the-art models in precision,recall,and mAP.These results highlight FED-YOLOv10s as a robust,efficient,and deployable solution for intelligent traffic perception in ADS. 展开更多
关键词 Automated driving systems traffic sign and light recognition YOLO EMA DCNv4
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Adaptability Analysis of Dual Clearing Systems in Spot Electricity Markets Based on Fuzzy Evaluation Metrics:An Inner Mongolia Case Study
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作者 Kai Xie Shaoqing Yuan +4 位作者 Dayun Zou Jinran Wang Genjun Chen Ciwei Gao Yinghao Cao 《Energy Engineering》 2026年第2期348-368,共21页
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ... The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty. 展开更多
关键词 Spot electricity markets dual clearing systems fuzzy comprehensive evaluation system adaptability primary-backup switching
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Neural Adaptive Sliding-Mode Control of Vehicular Cyber-Physical Systems With Uniformly Quantized Communication Data and Disturbances
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作者 Yuan Zhao Mengchao Li +3 位作者 Zhongchang Liu Lichuan Liu Shixi Wen Lei Ding 《IEEE/CAA Journal of Automatica Sinica》 2026年第1期149-160,共12页
This paper investigates the platoon control of heterogeneous vehicular cyber-physical systems(VCPSs) subject to external disturbances by using neural network and uniformly quantized communication data.To reduce the ad... This paper investigates the platoon control of heterogeneous vehicular cyber-physical systems(VCPSs) subject to external disturbances by using neural network and uniformly quantized communication data.To reduce the adverse effects of quantization errors on system performance,a coupling sliding mode surface is established for each following vehicle.The radial basis function(RBF) neural networks are employed to approximate the unknown external disturbances.Then,a novel platoon control law is proposed for cooperative tracking in which each following vehicle only uses the uniformly quantized data of the neighboring vehicles.And the designed controllers in this paper are fully distributed due to the fact that the selection of each vehicle's controller parameters is independent of the entire communication topology.The string stability of VCPSs in the entire control process is ensured rather than only ensuring the string stability after the sliding mode surface converges to zero.Compared with the existing controller design methods and quantization mechanisms,the neural adaptive sliding-mode platoon controller proposed in this paper is superior in performances including tracking errors,driving comfort and fuel economy.Numerical simulations illustrate the effectiveness and superiority of the designed control strategy. 展开更多
关键词 Neural adaptive sliding-mode control quantized communication string stability vehicular cyber-physical systems(VCPSs)
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Planning model for electro–hydrogen coupling systems for multistage emission reduction and carbon–green-certificate markets
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作者 Jingbo Zhao Zhengping Gao +3 位作者 Tianhui Zhao Cheng Huang Zhe Chen Dajiang Wang 《Global Energy Interconnection》 2026年第1期68-82,共15页
Hydrogen,as a zero-carbon secondary energy carrier,provides a unified pathway for low-carbon energy transformation.In electro–hydrogen coupling systems(EHCSs),surplus renewable power is stored via water electrolysis ... Hydrogen,as a zero-carbon secondary energy carrier,provides a unified pathway for low-carbon energy transformation.In electro–hydrogen coupling systems(EHCSs),surplus renewable power is stored via water electrolysis and later reconverted to electricity using fuel cells or gas turbines,enhancing the system’s flexibility and reliability in support of deep decarbonization.This study constructs an electricity–hydrogen energy-recycling model based on a coupling relationship considering the bidirectional conversion between electricity and hydrogen.A multistage carbon-emission-reduction indicator constraint is also established.Additionally,the green-certificate and carbon trading markets are introduced to optimize equipment investment and operation costs while achieving carbon-emission reduction.A case study reveals that the proposed EHCS planning model effectively allocates carbon emissions across different system stages,while mitigating economic repercussions,thus ensuring closer alignment with China’s emission-reduction policies.Incorporating diverse market mechanisms significantly enhances the system’s economy and decision-making flexibility,particularly in addressing future challenges in the energy market. 展开更多
关键词 Hydrogen energy Environmental impact Electro-hydrogen coupling systems Multimarket and multistage emission reduction Dual carbon goals
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Special Section on Perception,Control,and Decision-Making of Embodied Intelligent Systems
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《Journal of Systems Engineering and Electronics》 2026年第1期F0002-F0002,共1页
Embodied intelligent systems integrate perception,control,and decision-making within physical agents,and have become a cornerstone of modern aerospace,autonomous driving,and cooperative robotic applications.When opera... Embodied intelligent systems integrate perception,control,and decision-making within physical agents,and have become a cornerstone of modern aerospace,autonomous driving,and cooperative robotic applications.When operating in uncertain and dynamic environments,such systems must address challenges arising from incomplete sensing,unpredictable maneuvers,communication constraints,disturbances,and evolving network structures. 展开更多
关键词 incomplete sensingunpredictable decision making embodied intelligent systems aerospaceautonomous drivingand CONTROL cooperative robotic applicationswhen evolving network structures PERCEPTION
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Cybersecurity Opportunities and Risks of Artificial Intelligence in Industrial Control Systems:A Survey
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作者 Ka-Kyung Kim Joon-Seok Kim +1 位作者 Dong-Hyuk Shin Ieck-Chae Euom 《Computer Modeling in Engineering & Sciences》 2026年第2期186-233,共48页
As attack techniques evolve and data volumes increase,the integration of artificial intelligence-based security solutions into industrial control systems has become increasingly essential.Artificial intelligence holds... As attack techniques evolve and data volumes increase,the integration of artificial intelligence-based security solutions into industrial control systems has become increasingly essential.Artificial intelligence holds significant potential to improve the operational efficiency and cybersecurity of these systems.However,its dependence on cyber-based infrastructures expands the attack surface and introduces the risk that adversarial manipulations of artificial intelligence models may cause physical harm.To address these concerns,this study presents a comprehensive review of artificial intelligence-driven threat detection methods and adversarial attacks targeting artificial intelligence within industrial control environments,examining both their benefits and associated risks.A systematic literature review was conducted across major scientific databases,including IEEE,Elsevier,Springer Nature,ACM,MDPI,and Wiley,covering peer-reviewed journal and conference papers published between 2017 and 2026.Studies were selected based on predefined inclusion and exclusion criteria following a structured screening process.Based on an analysis of 101 selected studies,this survey categorizes artificial intelligence-based threat detection approaches across the physical,control,and application layers of industrial control systems and examines poisoning,evasion,and extraction attacks targeting industrial artificial intelligence.The findings identify key research trends,highlight unresolved security challenges,and discuss implications for the secure deployment of artificial intelligence-enabled cybersecurity solutions in industrial control systems. 展开更多
关键词 Industrial control system industrial Internet of Things cyber-physical systems artificial intelligence machine learning adversarial attacks CYBERSECURITY cyber threat SURVEY
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Innovative gene delivery systems for retinal disease therapy
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作者 Hongguang Wu Ling Dong +2 位作者 Shibo Jin Yongwang Zhao Lili Zhu 《Neural Regeneration Research》 2026年第2期542-552,共11页
The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can... The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions. 展开更多
关键词 adeno-associated viruses delivery systems gene delivery gene therapy LENTIVIRUS nanoparticle delivery non-viral delivery retinal disease RETINA small molecular delivery
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SmartAxis,a software for accurate and rapid zone axis alignment of nanocrystalline materials 被引量:1
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作者 Jinfei Zhou Yujiao Wang +7 位作者 Binbin Lu Jia Lyu Nini Wei Jianfeng Huang Lingmei Liu Xiao Li Xinghua Li Daliang Zhang 《Nano Materials Science》 2025年第2期297-303,共7页
Nanocrystals have emerged as cutting-edge functional materials benefiting from the increased surface and enhanced coupling of electronic states.High-resolution imaging in transmission electron microscope can provide i... Nanocrystals have emerged as cutting-edge functional materials benefiting from the increased surface and enhanced coupling of electronic states.High-resolution imaging in transmission electron microscope can provide invaluable structural information of crystalline materials,albeit it remains greatly challenging to nanocrystals due to the arduousness of accurate zone axis adjustment.Herein,a homemade software package,called SmartAxis,is developed for rapid yet accurate zone axis alignment of nanocrystals.Incident electron beam tilt is employed as an eccentric goniometer to measure the angular deviation of a crystal to a zone axis,and then serves as a linkage to calculate theαandβtilts of goniometer based on an accurate quantitative relationship.In this way,high-resolution imaging of one identical small Au nanocrystal,as well as electron beam-sensitive MIL-101 metal-organic framework crystals,along multiple zone axes,was performed successfully by using this accurate,time-and electron dose-saving zone axis alignment software package. 展开更多
关键词 Zone axis alignment NANOCRYSTALS Beam tilt Electron beam-sensitive materials
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Accumulative-Error-Based Event-Triggered Control for Discrete-Time Linear Systems:A Discrete-Time Looped Functional Method 被引量:2
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作者 Xian-Ming Zhang Qing-Long Han +1 位作者 Xiaohua Ge Bao-Lin Zhang 《IEEE/CAA Journal of Automatica Sinica》 2025年第4期683-693,共11页
This paper is concerned with event-triggered control of discrete-time systems with or without input saturation.First,an accumulative-error-based event-triggered scheme is devised for control updates.When the accumulat... This paper is concerned with event-triggered control of discrete-time systems with or without input saturation.First,an accumulative-error-based event-triggered scheme is devised for control updates.When the accumulated error between the current state and the latest control update exceeds a certain threshold,an event is triggered.Such a scheme can ensure the event-generator works at a relatively low rate rather than falls into hibernation especially after the system steps into its steady state.Second,the looped functional method for continuous-time systems is extended to discrete-time systems.By introducing an innovative looped functional that links the event-triggered scheme,some sufficient conditions for the co-design of control gain and event-triggered parameters are obtained in terms of linear matrix inequalities with a couple of tuning parameters.Then,the proposed method is applied to discrete-time systems with input saturation.As a result,both suitable control gains and event-triggered parameters are also co-designed to ensure the system trajectories converge to the region of attraction.Finally,an unstable reactor system and an inverted pendulum system are given to show the effectiveness of the proposed method. 展开更多
关键词 Discrete-time linear systems event-triggered control input saturation looped functional method
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Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction
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作者 Shi Li Didi Sun 《Computers, Materials & Continua》 SCIE EI 2025年第1期1069-1086,共18页
With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions... With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying reasons.This comprehension is crucial for making informed strategic decisions in various business and societal contexts.However,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause extraction.To address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment mechanisms.The model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause pairs.Second,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among tasks.The proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 score.Experimental results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its effectiveness.This research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-cause pair extraction.However,the study’s limitation lies in the data sources,potentially restricting the generalizability of the findings. 展开更多
关键词 Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms
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