To the Editor:Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,[1]particularly among elderly individuals,bringing huge socio-medical burdens due to its link to ischemic stroke.[2]Although systemi...To the Editor:Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,[1]particularly among elderly individuals,bringing huge socio-medical burdens due to its link to ischemic stroke.[2]Although systemic oral anticoagulant(OAC)medication is highly efficacious,many patients struggle with adverse effects,issues with adherence,and concerns about quality of life.[3]Percutaneous left atrial appendage occlusion(LAAO)is an alternative to anticoagulation for patients with AF and contraindications for long-term anticoagulant treatment,which has been endorsed in guidelines from the American College of Cardiology(ACC)and the European Society of Cardiology(ESC).[2]Notably,the pivotal randomized controlled trials(RCTs)and registries that have investigated LAAO and provided the evidence base for these guidelines were predominantly carried out in the United States or Europe,with 92–94%of the participants being Caucasian while other ethnic groups significantly underrepresented.展开更多
文摘To the Editor:Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,[1]particularly among elderly individuals,bringing huge socio-medical burdens due to its link to ischemic stroke.[2]Although systemic oral anticoagulant(OAC)medication is highly efficacious,many patients struggle with adverse effects,issues with adherence,and concerns about quality of life.[3]Percutaneous left atrial appendage occlusion(LAAO)is an alternative to anticoagulation for patients with AF and contraindications for long-term anticoagulant treatment,which has been endorsed in guidelines from the American College of Cardiology(ACC)and the European Society of Cardiology(ESC).[2]Notably,the pivotal randomized controlled trials(RCTs)and registries that have investigated LAAO and provided the evidence base for these guidelines were predominantly carried out in the United States or Europe,with 92–94%of the participants being Caucasian while other ethnic groups significantly underrepresented.
