Integrated 2-dimensional(2D)photonic devices such as monolayer waveguide has generated exceptional interest because of their ultimate thinness.In particular,they potentially permit stereo photonic architecture through...Integrated 2-dimensional(2D)photonic devices such as monolayer waveguide has generated exceptional interest because of their ultimate thinness.In particular,they potentially permit stereo photonic architecture through bond-free van der Waals integration.However,little is known about the coupling and controlling of the single-atom guided wave to its photonic environment,which governs the design and application of integrated system.Here,we report the optical coupling of atomically guided waves to other photonic modes.We directly probe the mode beating between evanescent waves in a monolayer 2D waveguide and a silicon photonic waveguide,which constitutes a vertically integrated interferometer.The mode-coupling measures the dispersion relation of the guided wave inside the atomic waveguide and unveils it strongly modifies matter's electronic states,manifesting by the formation of a propagating polariton.We also demonstrated light modulating and spectral detecting in this compact nonplanar interferometer.These findings provide a generalizable and versatile platform toward monolithic 3-dimensional integrated photonics.展开更多
Tree shrews(TSs)possess a highly developed visual system.Here,we establish an age-related single-cell RNA sequencing atlas of retina cells from 15 TSs,covering 6 major retina cell classes and 3 glial cell types.An age...Tree shrews(TSs)possess a highly developed visual system.Here,we establish an age-related single-cell RNA sequencing atlas of retina cells from 15 TSs,covering 6 major retina cell classes and 3 glial cell types.An age effect is observed on the cell subset composition and gene expression pattern.We then verify the cell subtypes and identify specific markers in the TS retina including CA10 for bipolar cells,MEGF11 for H1 horizontal cells,and SLIT2,RUNX1,FOXP2,and SPP1 for retinal ganglion cell subpopulations.The cross-species analysis elucidates the cell type-specific transcriptional programs,different cell compositions,and cell communications.The comparisons also reveal that TS cones and subclasses of bipolar and amacrine cells exhibit the closest relationship with humans and macaques.Our results suggests that TS could be used as a better disease model to understand age-dependent cellular and genetic mechanisms of the retina,particularly for the retinal diseases associated with cones.展开更多
基金supported by the National Natural Science Foundation of China(62325404,61934004,and 91950119)the Fundamental Research Funds for the Central Universities(021014380174)+1 种基金L.S.acknowledges the support from the Pearl River Talent Recruitment Program(2019QN01C216)Shenzhen Science and Technology Program(JCYJ20210324140805014)。
文摘Integrated 2-dimensional(2D)photonic devices such as monolayer waveguide has generated exceptional interest because of their ultimate thinness.In particular,they potentially permit stereo photonic architecture through bond-free van der Waals integration.However,little is known about the coupling and controlling of the single-atom guided wave to its photonic environment,which governs the design and application of integrated system.Here,we report the optical coupling of atomically guided waves to other photonic modes.We directly probe the mode beating between evanescent waves in a monolayer 2D waveguide and a silicon photonic waveguide,which constitutes a vertically integrated interferometer.The mode-coupling measures the dispersion relation of the guided wave inside the atomic waveguide and unveils it strongly modifies matter's electronic states,manifesting by the formation of a propagating polariton.We also demonstrated light modulating and spectral detecting in this compact nonplanar interferometer.These findings provide a generalizable and versatile platform toward monolithic 3-dimensional integrated photonics.
基金supported by Guizhou Provincial Higher Education Science and Technological Innovation Team(grant number[2023]072)Guizhou Province Distinguished Young Scientific and Technological Talent Program(grant number YQK[2023]040)+3 种基金Zunyi Medical University 12345 Future Talent Training Program-Technology Elite(grant number ZYSE-2021-03)Zunyi City Innovative Talent Team Training Plan(grant number[2022]-2)National Natural Science Foundation of China(grant number 82001604)Jinzhou Medical University Talent Grant(2023-001).
文摘Tree shrews(TSs)possess a highly developed visual system.Here,we establish an age-related single-cell RNA sequencing atlas of retina cells from 15 TSs,covering 6 major retina cell classes and 3 glial cell types.An age effect is observed on the cell subset composition and gene expression pattern.We then verify the cell subtypes and identify specific markers in the TS retina including CA10 for bipolar cells,MEGF11 for H1 horizontal cells,and SLIT2,RUNX1,FOXP2,and SPP1 for retinal ganglion cell subpopulations.The cross-species analysis elucidates the cell type-specific transcriptional programs,different cell compositions,and cell communications.The comparisons also reveal that TS cones and subclasses of bipolar and amacrine cells exhibit the closest relationship with humans and macaques.Our results suggests that TS could be used as a better disease model to understand age-dependent cellular and genetic mechanisms of the retina,particularly for the retinal diseases associated with cones.
