Lignocellulosic feedstocks,which are currently under-exploited,can be used for the production of biofuels,such as ethanol,and for biorefinery applications to produce a variety of value-added products.Although bioconve...Lignocellulosic feedstocks,which are currently under-exploited,can be used for the production of biofuels,such as ethanol,and for biorefinery applications to produce a variety of value-added products.Although bioconversion of lignocellulose by microbial or yeast fermentation have been reported,efficient and economical lignocellulosic fermentation process is still a challenge due to multiple process parameters involved for bioprocess design,optimization and scale-up.Bioprocess modelling strategies have been proven effective for achieving high-production process*efficiency in yield,productivity or titer of desired product.Several types of bioprocess modelling for lignocellulosic application have been developed and successfully validated as a promising alternative for rapid design,optimization and scaling up of biomass-based process.This review aims to summarize the important development of bioprocess modelling for lignocellulosic bioprocess applications towards the success of biorefineries and bio-based economy.In particular,we discuss modelling relevant to lignocellulosic bioprocess including cell modelling based on kinetics,stoichiometry and integrative approaches and fermentation kinetic modelling for process performance assessment.An overview of these modelling approaches and their application for systematic design of efficient and economical lignocellulose-based bioprocesses are given.展开更多
Natural products(NPs)continue to play a pivotal role in drug discovery programs.The rapid development of synthetic biology has conferred the strategies of NPs production.Synthetic biology is a new engineering discipli...Natural products(NPs)continue to play a pivotal role in drug discovery programs.The rapid development of synthetic biology has conferred the strategies of NPs production.Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways.However,there is still a challenge for integrating a heterologous pathway in chassis cells for overproduction purpose due to the limited characterized parts,modules incompatibility,and cell tolerance towards product.Enormous endeavors have been taken for mentioned issues.Herein,in this review,the progresses in naturally discovering novel biological parts and rational design of synthetic biological parts are reviewed,combining with the advanced assembly technologies,pathway engineering,and pathway optimization in global network guidance.The future perspectives are also presented.展开更多
基金Fund(Grant no.P-15-51025)National Center for Genetic Engineering and Biotechnology,Thailand(Grant no.P-15-50042),for funding support.
文摘Lignocellulosic feedstocks,which are currently under-exploited,can be used for the production of biofuels,such as ethanol,and for biorefinery applications to produce a variety of value-added products.Although bioconversion of lignocellulose by microbial or yeast fermentation have been reported,efficient and economical lignocellulosic fermentation process is still a challenge due to multiple process parameters involved for bioprocess design,optimization and scale-up.Bioprocess modelling strategies have been proven effective for achieving high-production process*efficiency in yield,productivity or titer of desired product.Several types of bioprocess modelling for lignocellulosic application have been developed and successfully validated as a promising alternative for rapid design,optimization and scaling up of biomass-based process.This review aims to summarize the important development of bioprocess modelling for lignocellulosic bioprocess applications towards the success of biorefineries and bio-based economy.In particular,we discuss modelling relevant to lignocellulosic bioprocess including cell modelling based on kinetics,stoichiometry and integrative approaches and fermentation kinetic modelling for process performance assessment.An overview of these modelling approaches and their application for systematic design of efficient and economical lignocellulose-based bioprocesses are given.
基金the National Basic Research Program of China(“973”Program,grant No.2012CB721104)the National Natural Science Foundation of China(grant No.31170101).
文摘Natural products(NPs)continue to play a pivotal role in drug discovery programs.The rapid development of synthetic biology has conferred the strategies of NPs production.Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways.However,there is still a challenge for integrating a heterologous pathway in chassis cells for overproduction purpose due to the limited characterized parts,modules incompatibility,and cell tolerance towards product.Enormous endeavors have been taken for mentioned issues.Herein,in this review,the progresses in naturally discovering novel biological parts and rational design of synthetic biological parts are reviewed,combining with the advanced assembly technologies,pathway engineering,and pathway optimization in global network guidance.The future perspectives are also presented.
