Neuropathic pain is a complex and debilitating condition caused by lesions or dysfunction within the somatosensory nervous system.Affecting an estimated 7%-10%of the global population,it presents with spontaneous pain...Neuropathic pain is a complex and debilitating condition caused by lesions or dysfunction within the somatosensory nervous system.Affecting an estimated 7%-10%of the global population,it presents with spontaneous pain,hyperalgesia,and allodynia,often accompanied by long-term emotional and cognitive consequences,such as depression and anxiety,which result in a reduced quality of life.Despite extensive research efforts,effective treatments remain limited.This limited efficacy likely stems,in part,from the heterogeneous nature of neuropathic pain,which varies widely across individuals in both clinical presentation and treatment responsiveness.展开更多
基金Institute for Basic Science(IBS)Center for Cognition and Sociality(IBS-R001-D2 to BL).
文摘Neuropathic pain is a complex and debilitating condition caused by lesions or dysfunction within the somatosensory nervous system.Affecting an estimated 7%-10%of the global population,it presents with spontaneous pain,hyperalgesia,and allodynia,often accompanied by long-term emotional and cognitive consequences,such as depression and anxiety,which result in a reduced quality of life.Despite extensive research efforts,effective treatments remain limited.This limited efficacy likely stems,in part,from the heterogeneous nature of neuropathic pain,which varies widely across individuals in both clinical presentation and treatment responsiveness.
