The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mecha...The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from Coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the Coniacian-Maastrichtian age sequential subdivision were aligned with the chart.展开更多
We performed a meta-analysis to compare treatment with a combination of solifenacin plus tamsulosin oral controlled absorption system （TOCAS） with placebo or TOCAS monotherapy. The aim of the meta-analysis was to cl...We performed a meta-analysis to compare treatment with a combination of solifenacin plus tamsulosin oral controlled absorption system （TOCAS） with placebo or TOCAS monotherapy. The aim of the meta-analysis was to clarify the efficacy and safety of the combination treatments method for lower urinary tract symptoms （LUTS）. We searched for trials of men with LUTS that were randomized to combination treatment compared with TOCAS monotherapy or placebo. We pooled data from three placebo-controlled trials meeting inclusion criteria. Primary outcomes of interest included changes in International Prostate Symptom Score （IPSS） and urinary frequency. We also assessed postvoid residual, maximum urinary flow rate, incidence of urinary retention （UR）, adverse events. Data were pooled using random or fixed effect models for continuous outcomes and the ManteI-Haenszel method to generate risk ratio. Reductions in IPSS storage subscore and total urgency and frequency score （TUFS） were observed with solifenacin 6 mg plus TOCAS compared with placebo （P 〈 0.0001 and P 〈 0.0001, respectively）. Reductions in IPSS storage subscore and TUFS were observed with solifenacin 9 mg plus TOCAS compared with placebo （P= 0.003 and P = 0.0006, respectively）. Reductions in TUFS was observed with solifenacin 6 mg plus TOCAS compared with TOCAS （P = 0.01）. Both combination treatments were well tolerated, with low incidence of UR. Solifenacin 6 mg plus TOCAS significantly improved total IPSS, storage and voiding symptoms compared with placebo. Solifenacin 6 mg plus TOCAS also improved storage symptoms compared with TOCAS alone. There was no additional benefit of solifenacin 9 mg compared with 6 mg when used in combination with TOCAS.展开更多
Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mu...Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mud diapirs/mud volcanos,bottom-water methane anomalies and so on.In this study,six key stratigraphic interfaces including T_0(seafloor),T_1(LGM,23 kyr B.P.),T_2(2.58 Myr),T_3(5.33 Myr),T_4(11.02 Myr)and T_5(16.12 Myr)were identified,and then five third-order sequences of SQIII1 to SQIII5 were divided.However,T5 in southern continental slope is not found,which shows that the middle-northern Okinawa Trough had begun to rift in the early Miocene,earlier than the southern segment.Four system tracts including lowstand systems tract(LST),transgressive systems tract(TST),highstand systems tract(HST)and falling stage systems tract(FSST)are further divided.The marine erosion interface of 11.02 Myr and regressive unconformity interface of 23 kyr B.P.indicate two large-scale sea level drop events in the research area.Seven typical seismic facies identified in the continental slope are continental shelf-edge deltas,littoral fluvial-delta plains,incised channels or submarine canyons,slope fans,submarine fans or coastal sandbars,littoral-neritic finegrained sediments,mud volcanos and some other geological bodies respectively.The minimum water depth for hydrate occurrence in the Okinawa Trough is 630 m,and the thickness of gas hydrate stability zone in continental slope is between 0 and 590 m.The calculated bottom boundary of hydrate stability zone is slightly deeper than BSRs on the seismic sections.The re-depositional turbidite sand bodies,such as canyon channels,slope fans and submarine fans developed in Quaternary strata,are the predominant hydrate reservoirs.According to developing process,the dynamic accumulation of hydrate systems can be divided into three evolutionary stages including canyon erosion and hydrate stability zone migration stage,sediments destabilizing and methane leakage stage,and channel filling and hydrate re-occurrence stage.展开更多
Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness.Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality;however,the gast...Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness.Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality;however,the gastrointestinal tract is the most commonly damaged system.Virtually all parts of the gastrointestinal(GI)tract can be involved,although the esophagus is the most frequently reported.The mechanisms that cause such extensive damage are generally unclear,but vascular changes,immunological abnormalities,excessive accumulation of collagen in the submucosa,smooth muscle atrophy and neuropathy may participate because these are the most common histological findings in biopsies and autopsies.Most patients with GI tract involvement complain about dyspepsia,nausea,vomiting,abdominal bloating/distension,and fecal incontinence.These symptoms are generally mild during the early stage of the disease and are likely ignored by physicians.As the disease becomes more advanced,however,patient quality of life is markedly influenced,whereby malnutrition and shortened survival are the usual consequences.The diagnosis for systemic sclerosis is based on manometry measurements and an endoscopy examination.Supportive and symptomatic treatment is the main therapeutic strategy;however,an early diagnosis is critical for successful management.展开更多
In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary...In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary tract pressure was increased.It was found that both the blood pressure and cardiac output evidently decreased (P<0.05) parallelly, and the systolic pressure decreased more markedly than diastolic pressure. At the same time there was fluctuation in heart rate and in central venous pressure; but there was no significant difference between them (P>0. 05), suggesting that in the absence of infective agents,the increased biliary tract pressure can bring about a decrease in cardiac output, which is an important factor contributing to an early blood pressure decrease in acute cholangitis of severe type (ACST).展开更多
Bangladesh is a country with limited sources of energy and since 1990 natural gas has been its main source of energy. Most of the exploration approaches had been conducted onshore especially in the central and eastern...Bangladesh is a country with limited sources of energy and since 1990 natural gas has been its main source of energy. Most of the exploration approaches had been conducted onshore especially in the central and eastern part of Bangladesh, particularly in northeastern Sylhet basin. Among the hydrocarbon provinces, the East Delta Hill Tract province is an under explored petroleum province in Bangladesh. An exploratory well drilled in Sitakund anticline was found dry but no reasonable cause was perceived why that well went dry. Although many works had been carried out in Chittagong Hill Tracts but none of them was cumulative and descriptive. In this study, the overall hydrocarbon prospect of the Chittagong Hill Tracts was analyzed by mapping of potential zones on the basis of the evaluation of regional structure and construction of lithocolumn of the prospective zones. The five elements of the petroleum system discussed thoroughly to find overall petroleum prospect of the study area. Source rocks of Chittagong Hill Tracts are mainly Bhuban shale, reservoir rock is sandstone from Bhuban-Bokabil formation, the way of migration path is both through longitudinal and cross fault. The data of source rock and seal is collected from previous researches. Multiple types of traps have been found there. Conventional anticlinal traps which are highly disturbed due to tectonic instability & the core part are shale diapirism. Most of the anticlines are plunging and the nose or plunge area might be prospective to HC for being comparatively less faulted. Broad synclinal areas between tight narrow anticlines are another prospective area for HC. These similar types of synclines are also found in Tripura, India which is a highly prospective area for petroleum and their small anticlinal hums within syncline are also prospective. Some stratigraphic traps have also been found in Tripura from where production has been started already. Both Chittagong Hill Tracts and Tripura Fold Belts are parts of great Arakan Fold Belts, so similar type of structures might be prospective here. Apart from these, Bangladesh is a deltaic country. So stratigraphic trapment like channel sand, pinch-outs is possible. Considering all the elements of petroleum prospectivity of the area and factors discussed above, it is quite clear that Chittagong hill tracts might be the next target for HC exploration program.展开更多
Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstru...Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstruct the remaining neural network. In the motor system, such neural network remodeling is observed as a motor map reorganization. Because of its significant correlation with functional recovery, motor map reorganization has been regarded as a key phenomenon for functional recovery after stroke. Although the mechanism underlying motor map reorganization remains unclear, increasing evidence has shown a critical role for axonal remodeling in the corticospinal tract. In this study, we review previous studies investigating axonal remodeling in the corticospinal tract after stroke and discuss which mechanisms may underlie the stimulatory effect of rehabilitative training. Axonal remodeling in the corticospinal tract can be classified into three types based on the location and the original targets of corticospinal neurons, and it seems that all the surviving corticospinal neurons in both ipsilesional and contralesional hemisphere can participate in axonal remodeling and motor map reorganization. Through axonal remodeling, corticospinal neurons alter their output selectivity from a single to multiple areas to compensate for the lost function. The remodeling of the corticospinal axon is influenced by the extent of tissue destruction and promoted by various therapeutic interventions, including rehabilitative training. Although the precise molecular mechanism underlying rehabilitation-promoted axonal remodeling remains elusive, previous data suggest that rehabilitative training promotes axonal remodeling by upregulating growth-promoting and downregulating growth-inhibiting signals.展开更多
文摘The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from Coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the Coniacian-Maastrichtian age sequential subdivision were aligned with the chart.
文摘We performed a meta-analysis to compare treatment with a combination of solifenacin plus tamsulosin oral controlled absorption system （TOCAS） with placebo or TOCAS monotherapy. The aim of the meta-analysis was to clarify the efficacy and safety of the combination treatments method for lower urinary tract symptoms （LUTS）. We searched for trials of men with LUTS that were randomized to combination treatment compared with TOCAS monotherapy or placebo. We pooled data from three placebo-controlled trials meeting inclusion criteria. Primary outcomes of interest included changes in International Prostate Symptom Score （IPSS） and urinary frequency. We also assessed postvoid residual, maximum urinary flow rate, incidence of urinary retention （UR）, adverse events. Data were pooled using random or fixed effect models for continuous outcomes and the ManteI-Haenszel method to generate risk ratio. Reductions in IPSS storage subscore and total urgency and frequency score （TUFS） were observed with solifenacin 6 mg plus TOCAS compared with placebo （P 〈 0.0001 and P 〈 0.0001, respectively）. Reductions in IPSS storage subscore and TUFS were observed with solifenacin 9 mg plus TOCAS compared with placebo （P= 0.003 and P = 0.0006, respectively）. Reductions in TUFS was observed with solifenacin 6 mg plus TOCAS compared with TOCAS （P = 0.01）. Both combination treatments were well tolerated, with low incidence of UR. Solifenacin 6 mg plus TOCAS significantly improved total IPSS, storage and voiding symptoms compared with placebo. Solifenacin 6 mg plus TOCAS also improved storage symptoms compared with TOCAS alone. There was no additional benefit of solifenacin 9 mg compared with 6 mg when used in combination with TOCAS.
基金supported by the National Natural Science Foundation of China (Nos. 41806073, 41530963)the Natural Science Foundation of Shandong Province (No. ZR 2017BD014)+1 种基金the Shandong Provincial Key Laboratory of Depositional Mineralization & Sedimentary Minerals, Shandong University of Science and Technology (No. DMSM 2017042)the Fundamental Research Funds for the Central Universities (Nos. 201964016, 201851023)
文摘Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mud diapirs/mud volcanos,bottom-water methane anomalies and so on.In this study,six key stratigraphic interfaces including T_0(seafloor),T_1(LGM,23 kyr B.P.),T_2(2.58 Myr),T_3(5.33 Myr),T_4(11.02 Myr)and T_5(16.12 Myr)were identified,and then five third-order sequences of SQIII1 to SQIII5 were divided.However,T5 in southern continental slope is not found,which shows that the middle-northern Okinawa Trough had begun to rift in the early Miocene,earlier than the southern segment.Four system tracts including lowstand systems tract(LST),transgressive systems tract(TST),highstand systems tract(HST)and falling stage systems tract(FSST)are further divided.The marine erosion interface of 11.02 Myr and regressive unconformity interface of 23 kyr B.P.indicate two large-scale sea level drop events in the research area.Seven typical seismic facies identified in the continental slope are continental shelf-edge deltas,littoral fluvial-delta plains,incised channels or submarine canyons,slope fans,submarine fans or coastal sandbars,littoral-neritic finegrained sediments,mud volcanos and some other geological bodies respectively.The minimum water depth for hydrate occurrence in the Okinawa Trough is 630 m,and the thickness of gas hydrate stability zone in continental slope is between 0 and 590 m.The calculated bottom boundary of hydrate stability zone is slightly deeper than BSRs on the seismic sections.The re-depositional turbidite sand bodies,such as canyon channels,slope fans and submarine fans developed in Quaternary strata,are the predominant hydrate reservoirs.According to developing process,the dynamic accumulation of hydrate systems can be divided into three evolutionary stages including canyon erosion and hydrate stability zone migration stage,sediments destabilizing and methane leakage stage,and channel filling and hydrate re-occurrence stage.
文摘Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness.Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality;however,the gastrointestinal tract is the most commonly damaged system.Virtually all parts of the gastrointestinal(GI)tract can be involved,although the esophagus is the most frequently reported.The mechanisms that cause such extensive damage are generally unclear,but vascular changes,immunological abnormalities,excessive accumulation of collagen in the submucosa,smooth muscle atrophy and neuropathy may participate because these are the most common histological findings in biopsies and autopsies.Most patients with GI tract involvement complain about dyspepsia,nausea,vomiting,abdominal bloating/distension,and fecal incontinence.These symptoms are generally mild during the early stage of the disease and are likely ignored by physicians.As the disease becomes more advanced,however,patient quality of life is markedly influenced,whereby malnutrition and shortened survival are the usual consequences.The diagnosis for systemic sclerosis is based on manometry measurements and an endoscopy examination.Supportive and symptomatic treatment is the main therapeutic strategy;however,an early diagnosis is critical for successful management.
文摘In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary tract pressure was increased.It was found that both the blood pressure and cardiac output evidently decreased (P<0.05) parallelly, and the systolic pressure decreased more markedly than diastolic pressure. At the same time there was fluctuation in heart rate and in central venous pressure; but there was no significant difference between them (P>0. 05), suggesting that in the absence of infective agents,the increased biliary tract pressure can bring about a decrease in cardiac output, which is an important factor contributing to an early blood pressure decrease in acute cholangitis of severe type (ACST).
文摘Bangladesh is a country with limited sources of energy and since 1990 natural gas has been its main source of energy. Most of the exploration approaches had been conducted onshore especially in the central and eastern part of Bangladesh, particularly in northeastern Sylhet basin. Among the hydrocarbon provinces, the East Delta Hill Tract province is an under explored petroleum province in Bangladesh. An exploratory well drilled in Sitakund anticline was found dry but no reasonable cause was perceived why that well went dry. Although many works had been carried out in Chittagong Hill Tracts but none of them was cumulative and descriptive. In this study, the overall hydrocarbon prospect of the Chittagong Hill Tracts was analyzed by mapping of potential zones on the basis of the evaluation of regional structure and construction of lithocolumn of the prospective zones. The five elements of the petroleum system discussed thoroughly to find overall petroleum prospect of the study area. Source rocks of Chittagong Hill Tracts are mainly Bhuban shale, reservoir rock is sandstone from Bhuban-Bokabil formation, the way of migration path is both through longitudinal and cross fault. The data of source rock and seal is collected from previous researches. Multiple types of traps have been found there. Conventional anticlinal traps which are highly disturbed due to tectonic instability & the core part are shale diapirism. Most of the anticlines are plunging and the nose or plunge area might be prospective to HC for being comparatively less faulted. Broad synclinal areas between tight narrow anticlines are another prospective area for HC. These similar types of synclines are also found in Tripura, India which is a highly prospective area for petroleum and their small anticlinal hums within syncline are also prospective. Some stratigraphic traps have also been found in Tripura from where production has been started already. Both Chittagong Hill Tracts and Tripura Fold Belts are parts of great Arakan Fold Belts, so similar type of structures might be prospective here. Apart from these, Bangladesh is a deltaic country. So stratigraphic trapment like channel sand, pinch-outs is possible. Considering all the elements of petroleum prospectivity of the area and factors discussed above, it is quite clear that Chittagong hill tracts might be the next target for HC exploration program.
基金supported by the JSPSKAKENHI Grant-in-Aid for Scientific Research(B),Grant Numbers24700572 and 30614276
文摘Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstruct the remaining neural network. In the motor system, such neural network remodeling is observed as a motor map reorganization. Because of its significant correlation with functional recovery, motor map reorganization has been regarded as a key phenomenon for functional recovery after stroke. Although the mechanism underlying motor map reorganization remains unclear, increasing evidence has shown a critical role for axonal remodeling in the corticospinal tract. In this study, we review previous studies investigating axonal remodeling in the corticospinal tract after stroke and discuss which mechanisms may underlie the stimulatory effect of rehabilitative training. Axonal remodeling in the corticospinal tract can be classified into three types based on the location and the original targets of corticospinal neurons, and it seems that all the surviving corticospinal neurons in both ipsilesional and contralesional hemisphere can participate in axonal remodeling and motor map reorganization. Through axonal remodeling, corticospinal neurons alter their output selectivity from a single to multiple areas to compensate for the lost function. The remodeling of the corticospinal axon is influenced by the extent of tissue destruction and promoted by various therapeutic interventions, including rehabilitative training. Although the precise molecular mechanism underlying rehabilitation-promoted axonal remodeling remains elusive, previous data suggest that rehabilitative training promotes axonal remodeling by upregulating growth-promoting and downregulating growth-inhibiting signals.
