Parkinson's disease(PD)is the second most common neurodegenerative disorder.The clinical manifestations of PD include motor symptoms,such as bradykinesia,resting tremor,rigidity,and nonmotor symptoms,which include...Parkinson's disease(PD)is the second most common neurodegenerative disorder.The clinical manifestations of PD include motor symptoms,such as bradykinesia,resting tremor,rigidity,and nonmotor symptoms,which include disturbances in sleep,gastrointestinal function,and olfaction.PD misdiagnosis rates have been reported to reach approximately 30%,partly owing to the heterogeneity of parkinsonism with non-PD pathologies,and the differential diagnosis of PD from neurodegenerative diseases such as multiple systemic atrophy(MSA)and progressive supranuclear palsy poses another unmet need.展开更多
Alpha-synuclein and Parkinson's disease:Neuronal damage and inflammation caused by the aggregation of alpha-synuclein(α-syn)are central to a group of disorders known as synucleopathies,which includes Parkinson...Alpha-synuclein and Parkinson's disease:Neuronal damage and inflammation caused by the aggregation of alpha-synuclein(α-syn)are central to a group of disorders known as synucleopathies,which includes Parkinson's disease(PD),dementia with Lewy bodies,and multiple system atrophy,among others.PD,the most common synucleinopathy,is the second most prevalent neurodegenerative disease after Alzheimer's disease,and it is the fastest growing.Its primary hallmark is the degeneration of dopaminergic neurons in the substantia nigra pars compacta,disrupting the communication with the striatum.展开更多
Parkinson's disease(PD)is a neurodegenerative disorder characterized byα-Synuclein(α-Syn)aggregation and dopaminergic neuron degeneration[1].While traditionally considered a central nervous system(CNS)disorder,g...Parkinson's disease(PD)is a neurodegenerative disorder characterized byα-Synuclein(α-Syn)aggregation and dopaminergic neuron degeneration[1].While traditionally considered a central nervous system(CNS)disorder,growing evidence suggestsα-Syn pathology in the peripheral organs such as skin,minor salivary glands,submandibular glands,and so on[1].Recent studies have primarily focused on the gastrointestinal tract,supporting the hypothesis thatα-Syn may propagate from the gut to the brain in a prion-like manner[2,3].However,in a groundbreaking study published in Nature Neuroscience,Xin Yuan et al.have provided a novel perspective on the peripheral origins of PD,revealing for the first time the critical role of the kidney in the pathological transmission and initiation ofα-Syn(Fig.1)[4].展开更多
基金supported by Swiss Center for Applied Human Toxicology(SCAHT AP22-01)(to RN)。
文摘Parkinson's disease(PD)is the second most common neurodegenerative disorder.The clinical manifestations of PD include motor symptoms,such as bradykinesia,resting tremor,rigidity,and nonmotor symptoms,which include disturbances in sleep,gastrointestinal function,and olfaction.PD misdiagnosis rates have been reported to reach approximately 30%,partly owing to the heterogeneity of parkinsonism with non-PD pathologies,and the differential diagnosis of PD from neurodegenerative diseases such as multiple systemic atrophy(MSA)and progressive supranuclear palsy poses another unmet need.
基金supported by the Spanish Ministry of Science and Innovation via a doctoral grant[FPU22/03656].supported by the Spanish Ministry of Science and Innovation(PID2022-137963OB-I00)Generalitat de Catalunya(2021-SGR-00635 AGAUR)+1 种基金CERCA Programme(Generalitat de Catalunya)by ICREA,ICREA-Academia 2020(to SV)。
文摘Alpha-synuclein and Parkinson's disease:Neuronal damage and inflammation caused by the aggregation of alpha-synuclein(α-syn)are central to a group of disorders known as synucleopathies,which includes Parkinson's disease(PD),dementia with Lewy bodies,and multiple system atrophy,among others.PD,the most common synucleinopathy,is the second most prevalent neurodegenerative disease after Alzheimer's disease,and it is the fastest growing.Its primary hallmark is the degeneration of dopaminergic neurons in the substantia nigra pars compacta,disrupting the communication with the striatum.
基金supported by the Science,Technology,and Development Foundation of Wuxi City(Y20222026)Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(SJCX25_0136).
文摘Parkinson's disease(PD)is a neurodegenerative disorder characterized byα-Synuclein(α-Syn)aggregation and dopaminergic neuron degeneration[1].While traditionally considered a central nervous system(CNS)disorder,growing evidence suggestsα-Syn pathology in the peripheral organs such as skin,minor salivary glands,submandibular glands,and so on[1].Recent studies have primarily focused on the gastrointestinal tract,supporting the hypothesis thatα-Syn may propagate from the gut to the brain in a prion-like manner[2,3].However,in a groundbreaking study published in Nature Neuroscience,Xin Yuan et al.have provided a novel perspective on the peripheral origins of PD,revealing for the first time the critical role of the kidney in the pathological transmission and initiation ofα-Syn(Fig.1)[4].
