Schizophrenia(SCZ)is a severe mental illness that affects several brain domains with relation to cognition and behaviour.SCZ symptoms are typically classified into three categories,namely,positive,negative,and cogniti...Schizophrenia(SCZ)is a severe mental illness that affects several brain domains with relation to cognition and behaviour.SCZ symptoms are typically classified into three categories,namely,positive,negative,and cognitive.The etiology of SCZ is thought to be multifactorial and poorly understood.Accumulating evidence has indicated abnormal synaptic plasticity and cognitive impairments in SCZ.Synaptic plasticity is thought to be induced at appropriate synapses during memory formation and has a critical role in the cognitive symptoms of SCZ.Many factors,including synaptic structure changes,aberrant expression of plasticityrelated genes,and abnormal synaptic transmission,may influence synaptic plasticity and play vital roles in SCZ.In this article,we briefly summarize the morphology of the synapse,the neurobiology of synaptic plasticity,and the role of synaptic plasticity,and review potential mechanisms underlying abnormal synaptic plasticity in SCZ.These abnormalities involve dendritic spines,postsynaptic density,and long-term potentiation-like plasticity.We also focus on cognitive dysfunction,which reflects impaired connectivity in SCZ.Additionally,the potential targets for the treatment of SCZ are discussed in this article.Therefore,understanding abnormal synaptic plasticity and impaired cognition in SCZ has an essential role in drug therapy.展开更多
From a neuroscience perspective,cancer neuroscience has emerged as a subfield of cancer research.Presumable mechanisms underlying cancer-related neuronal activity(termed neurosciences)include the induction and modulat...From a neuroscience perspective,cancer neuroscience has emerged as a subfield of cancer research.Presumable mechanisms underlying cancer-related neuronal activity(termed neurosciences)include the induction and modulation of signaling pathways that govern cell fate determination and emotional responses(anxiety and stress),such as structural molecules(synaptic structures and current transduction)and secretory substances(neurotransmitters,cytokines,hormones and neuropeptides).In the past 3 years,these neuronal activities,which can either promote cancer growth or be hijacked by cancer cells to support tumor survival and invasion,have been widely demonstrated to be closely related to cancer progression.The molecular mechanisms are also being refined.Despite their great promise,translating neuroscientific discoveries into clinically actionable strategies for cancer diagnosis,prognosis,and treatment remains a formidable task.In this comprehensive review,we attempt to provide a full account of the intersection between neuroscience and cancer research.From the perspective of cancer neuroscience,we fully discuss the potential signaling molecules and their regulatory mechanisms,as well as targets and emerging therapeutic strategies that control tumor progression via multiomics approaches.Overall,cancer neuroscience may have unprecedented potential for understanding neuronal functions and cancer development,ultimately offering the significantly improved cancer treatment.展开更多
基金Supported by National Natural Science Foundation of China,No. 81971943, No. 81772196, No. 31470264, No. 81271820, No. 30870789 and No. 30300117Stanley Foundation from the Stanley Medical Research Institute (SMRI),United States,No. 06R-1366 (to Dr. Zhu F)Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University,No. TFJC 2018002
文摘Schizophrenia(SCZ)is a severe mental illness that affects several brain domains with relation to cognition and behaviour.SCZ symptoms are typically classified into three categories,namely,positive,negative,and cognitive.The etiology of SCZ is thought to be multifactorial and poorly understood.Accumulating evidence has indicated abnormal synaptic plasticity and cognitive impairments in SCZ.Synaptic plasticity is thought to be induced at appropriate synapses during memory formation and has a critical role in the cognitive symptoms of SCZ.Many factors,including synaptic structure changes,aberrant expression of plasticityrelated genes,and abnormal synaptic transmission,may influence synaptic plasticity and play vital roles in SCZ.In this article,we briefly summarize the morphology of the synapse,the neurobiology of synaptic plasticity,and the role of synaptic plasticity,and review potential mechanisms underlying abnormal synaptic plasticity in SCZ.These abnormalities involve dendritic spines,postsynaptic density,and long-term potentiation-like plasticity.We also focus on cognitive dysfunction,which reflects impaired connectivity in SCZ.Additionally,the potential targets for the treatment of SCZ are discussed in this article.Therefore,understanding abnormal synaptic plasticity and impaired cognition in SCZ has an essential role in drug therapy.
基金funded by the National Natural Science Foundation of China(Nos.82201594,81502582)National Key Research Project of MOST(2023YFA0915000)+5 种基金Fund of the Affiliated Xiangshan Hospital of Wenzhou Medical University,and Wenzhou Institute University of Chinese Academy of SciencesFunding was also provided by the Fundamental Research Funds for the Central Universities(N182004002,N2220002)Natural Science Foundation of Liaoning Province(2021-MS-104,2022-YGJC-39,2022-MS-228)Fundamental Scientific Research Fund of Liaoning Provincial Education Department(LJKQZ2021002)supported by the Open project of State Key Laboratory of Animal Biotech Breeding(No.2025SKLAB6-13)Construction Project of Liaoning Provincial Key Laboratory,China(2022JH13/10200026).
文摘From a neuroscience perspective,cancer neuroscience has emerged as a subfield of cancer research.Presumable mechanisms underlying cancer-related neuronal activity(termed neurosciences)include the induction and modulation of signaling pathways that govern cell fate determination and emotional responses(anxiety and stress),such as structural molecules(synaptic structures and current transduction)and secretory substances(neurotransmitters,cytokines,hormones and neuropeptides).In the past 3 years,these neuronal activities,which can either promote cancer growth or be hijacked by cancer cells to support tumor survival and invasion,have been widely demonstrated to be closely related to cancer progression.The molecular mechanisms are also being refined.Despite their great promise,translating neuroscientific discoveries into clinically actionable strategies for cancer diagnosis,prognosis,and treatment remains a formidable task.In this comprehensive review,we attempt to provide a full account of the intersection between neuroscience and cancer research.From the perspective of cancer neuroscience,we fully discuss the potential signaling molecules and their regulatory mechanisms,as well as targets and emerging therapeutic strategies that control tumor progression via multiomics approaches.Overall,cancer neuroscience may have unprecedented potential for understanding neuronal functions and cancer development,ultimately offering the significantly improved cancer treatment.
