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Incidence Law and Disease Symptom of Rice Blast and Its Control Technique 被引量:1
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作者 罗守进 《Plant Diseases and Pests》 CAS 2010年第3期1-5,18,共6页
The article systematically summarizes the pathogen, incidence law and disease symptom of rice blast, and raises the integrated control technique for the disease, which will provide the certain theoretical basis for th... The article systematically summarizes the pathogen, incidence law and disease symptom of rice blast, and raises the integrated control technique for the disease, which will provide the certain theoretical basis for the control of the disease, being benefit for the actual production of rice in field. 展开更多
关键词 RICE Rice blast Incidence law symptom control
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Efficacy and safety of solifenacin plus tamsulosin oral controlled absorption system in men with lower urinary tract symptoms: a meta-analysis 被引量:1
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作者 Ming-Chao Li Zheng-Yun Wang +5 位作者 Jun Yang Xiao-Lin Guo Tao Wang Shao-Gang Wang Ji-Hong Liu Zhang-Qun Ye 《Asian Journal of Andrology》 SCIE CAS CSCD 2015年第1期124-134,I0011,共12页
We performed a meta-analysis to compare treatment with a combination of solifenacin plus tamsulosin oral controlled absorption system (TOCAS) with placebo or TOCAS monotherapy. The aim of the meta-analysis was to cl... We performed a meta-analysis to compare treatment with a combination of solifenacin plus tamsulosin oral controlled absorption system (TOCAS) with placebo or TOCAS monotherapy. The aim of the meta-analysis was to clarify the efficacy and safety of the combination treatments method for lower urinary tract symptoms (LUTS). We searched for trials of men with LUTS that were randomized to combination treatment compared with TOCAS monotherapy or placebo. We pooled data from three placebo-controlled trials meeting inclusion criteria. Primary outcomes of interest included changes in International Prostate Symptom Score (IPSS) and urinary frequency. We also assessed postvoid residual, maximum urinary flow rate, incidence of urinary retention (UR), adverse events. Data were pooled using random or fixed effect models for continuous outcomes and the ManteI-Haenszel method to generate risk ratio. Reductions in IPSS storage subscore and total urgency and frequency score (TUFS) were observed with solifenacin 6 mg plus TOCAS compared with placebo (P 〈 0.0001 and P 〈 0.0001, respectively). Reductions in IPSS storage subscore and TUFS were observed with solifenacin 9 mg plus TOCAS compared with placebo (P= 0.003 and P = 0.0006, respectively). Reductions in TUFS was observed with solifenacin 6 mg plus TOCAS compared with TOCAS (P = 0.01). Both combination treatments were well tolerated, with low incidence of UR. Solifenacin 6 mg plus TOCAS significantly improved total IPSS, storage and voiding symptoms compared with placebo. Solifenacin 6 mg plus TOCAS also improved storage symptoms compared with TOCAS alone. There was no additional benefit of solifenacin 9 mg compared with 6 mg when used in combination with TOCAS. 展开更多
关键词 combination therapy lower urinary tract symptoms SOLIFENACIN tamsulosin oral controlled absorption system
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Investigating the Effectiveness of Dialectical Behavior Therapy in Clinical Symptoms, Anger Control and Emotional Regulation of Bully Children
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作者 Fereshteh Partoiy Ziraki Toozandehjani Hassan 《International Journal of Clinical Medicine》 2017年第4期277-292,共16页
The present study aims to investigate the effectiveness of dialectical behavior therapy in clinical symptoms, anger control and emotional regulation of bully children. This research is a pretest-posttest quasi-experim... The present study aims to investigate the effectiveness of dialectical behavior therapy in clinical symptoms, anger control and emotional regulation of bully children. This research is a pretest-posttest quasi-experimental study design with a nonequivalent control group. The research sample comprises 24 bully children who were purposefully selected from among the students who had responded positively to the researcher’s call. The participants were randomly assigned into two experimental and control groups. Group therapy intervention was conducted on the experimental group during ten sessions. The tools applied in this study consisted of Cognitive Emotion Regulation Questionnaire by Garnefski et al., State-Trait Anger Expression Inventory by Spielberger and Bullying Scale by Illinois, Espelage and Holt and the subjects answered to their questions in the stage of pretest and posttest. In this research, the data was analyzed based on the analysis of covariance test and with the aid of SPSS software. The findings demonstrated that dialectical behavior therapy has a significant impact on clinical symptoms, anger control and its components and emotional regulation and its components (P < 0.01). 展开更多
关键词 DIALECTICAL Behavior Therapy Clinical symptomS of BULLYING ANGER control Emotional Regulation
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Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus 被引量:3
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作者 Francisco Baldaque-Silva Michael Vieth +8 位作者 Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall 《World Journal of Gastroenterology》 SCIE CAS 2017年第17期3174-3183,共10页
AIM To determine the impact of upwards titration of proton pump inhibition(PPI)on acid reflux,symptom scores and histology,compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett&#... AIM To determine the impact of upwards titration of proton pump inhibition(PPI)on acid reflux,symptom scores and histology,compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE)patients were studied.In group 1(n=24),increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization.At each assessment,ambulatory 24 h p H recording,endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire,GERD/HRLQ)were performed.Group 2(n=30)consisted of patients with a previous fundoplication.RESULTS In group 1,acid reflux normalized in 23 of 24 patients,resulting in improved GERD/HRQL scores(P=0.001),which were most pronounced after the starting dose of PPI(P<0.001).PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P=0.5).Normalization of acid reflux in both groups was associated with reduction in papillary length,basal cell layer thickness,intercellular space dilatation,and acute and chronic inflammation of squamous epithelium.CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients,especially after the first dose of PPI,reaching the same level as after a successful fundoplication.Minor changes were found among GERD markers at the morphological level. 展开更多
关键词 Barrett’s esophagus Acid reflux Proton pump inhibitors Health related quality of life Gastroesophageal reflux symptom control Antireflux surgery
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Identification and Control of Persimmon anthracnose 被引量:1
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作者 杜社妮 白岗栓 +1 位作者 张树军 张蕊 《Plant Diseases and Pests》 CAS 2010年第1期40-42,共3页
[ Objective] The study aimed to research the identification of Persimmon anthracnose and its controlling methods.[ Method ] The pathogen and characteristics, infection and occurrence law, damage symptoms of persimmon ... [ Objective] The study aimed to research the identification of Persimmon anthracnose and its controlling methods.[ Method ] The pathogen and characteristics, infection and occurrence law, damage symptoms of persimmon anthracnose were stated simply and the methods for con- trolling the disease were summed up. [ Result] The pathogen of Persimmon anthracnose was Gloeospor/um kaki Hod, belonging to Deuteromycotina. Germination and invasion of the conidia, sporulation and growth of mycelium all required high temperature, with the optimum temperature of 25 ℃ and the lethal temperature of 50 ℃ (10 min). The occurrence strength of Persimmon anthracnose related with the factors including host, environment, culture circumstances, mainly doing harm to the fruits and branches. The occurrence of the disease could be controlled by such agricultur- al measures as cleaning the orchard, using the resistant varieties and planting the disease-free seedlings, adopting the balanced fertilization, improving the irrigation and drainage systems, conducting the dense planting and thin branches, building garden using the seedling that grafting on planted stock and raising the grafted parts of the stock. When the incidence was heavy, it needed to spray the fungicides or protective agent for the control of the Persimmon anthracnose. The fungicides should be mainly sprayed on the lesion of shoot, fruit surface and branches. [ Conclusion] The study provided the reference for the control of the Persimmon anthracnose. 展开更多
关键词 Persimmon anthracnose Damage symptoms Occurrence law controlling measure
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Acupuncture treatment of lung-spleen Qi deficiency in stable chronic obstructive pulmonary disease: a randomized, open-label, controlled trial 被引量:16
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作者 Li Yu Xiong Chan +8 位作者 Zeng Yan Wei Hua Zhuang Guangtong Zhao Lihong Li Chenyi Li Lin Qin Erqi Chen Xiaoqin Fu Juanjuan 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2019年第6期885-891,共7页
OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,ope... OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,open-controlled trial in which the acupuncturist and the participants were not blinded,but the outcome evalu-ators and data analysts were blinded.One-hundred-and-two patients with stable COPD were randomly divided into two groups in a 1∶1 ratio.The acupuncture group received 30-minute sessions of acupuncture therapy at the same acupoints three times weekly for 6 weeks in addition to routine conventional Western Medicine treatment;the control group received routine conventional Western Medicine treatment alone.The primary outcome was the Borg scale score,which was assessed immediately after the 6-minute walk test.The secondary outcomes were the 6-minute walk distance,lung function,and oxygen saturation.Measurements were obtained at baseline and after 6 weeks of treatment.RESULTS:After 6 weeks of treatment,the Borg scale score in the acupuncture group was significantly better than that in the control group(2.02±0.71 versus 5.01±0.34,P<0.05).Furthermore,the post-treatment improvements in the 6-minute walk distance,lung function,and oxygen saturation were significantly greater in the acupuncture group than in the control group,showing that the acupuncture group had better exercise tolerance.CONCLUSION:The findings suggest that acupuncture that aims to reinforce the spleen to strengthen the lung is a safe and effective adjuvant therapy that effectively improves the exercise capacity of patients with stable COPD. 展开更多
关键词 ACUPUNCTURE Pulmonary disease chronic obstructive Randomized controlled trial symptoms and signs
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Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial 被引量:19
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作者 Ya-ru Huangfu Wei Peng +5 位作者 Bao-jun Guo Zhi-fu Shen Li Li Shi-wei Liu Hui Zheng You-ping Hu 《Journal of Integrative Medicine》 SCIE CAS CSCD 2019年第3期161-166,共6页
Background: Insomnia is a common complaint that is closely related to gastrointestinal symptoms, which is consistent with the traditional Chinese medicine classical theory of ‘‘stomach disharmony leading to restless... Background: Insomnia is a common complaint that is closely related to gastrointestinal symptoms, which is consistent with the traditional Chinese medicine classical theory of ‘‘stomach disharmony leading to restless sleep." Acupuncture is an effective complementary and alternative medicine therapy to improve gastrointestinal function and restore the normal sleep-wake cycle. However, studies on the effectiveness of acupuncture for insomnia due to spleen-stomach disharmony syndrome are limited to case reports and few randomized controlled trials; deeper research on its mechanism is still lacking. This randomized controlled trial aims to assess the treatment efficacy of ‘‘harmonizing stomach to tranquilize mind"acupuncture for insomnia and its influence on the intestinal microbiome.Methods/design: This is a randomized, single-blind, parallel-group study. Sixty eligible patients with insomnia due to spleen-stomach disharmony syndrome will be randomly divided into two groups(1:1 allocation ratio). The intervention group will use ‘‘harmonizing stomach to tranquilize mind"acupuncture, and the control group will receive sham acupuncture. Participants will receive 5 acupuncture treatment sessions per week for 4 consecutive weeks. The Pittsburgh Sleep Quality Index will be used to evaluate the clinical efficacy of acupuncture treatment by making assessments at baseline, the end of treatment and the end of the follow-up. High-throughput 16 S ribosomal ribonucleic acid gene sequencing will be performed to detect changes in the intestinal microbial composition before and after treatment.Discussion: The results of this trial are expected to confirm that ‘‘harmonizing stomach to tranquilize mind" acupuncture can effectively relieve insomnia and alter the intestinal microbiome. 展开更多
关键词 INSOMNIA Gastrointestinal symptomS ACUPUNCTURE INTESTINAL MICROBIOME Randomized controlled trial Study protocol
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Control tactics of poplar diseases in China
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作者 项存悌 朱虹 《Journal of Forestry Research》 SCIE CAS CSCD 2000年第4期252-254,共3页
Based on the present studies and literatures about the poplar diseases in China, the present study situation of poplar disease was introduced in this paper. 31 kinds of poplar diseases were collected of which there we... Based on the present studies and literatures about the poplar diseases in China, the present study situation of poplar disease was introduced in this paper. 31 kinds of poplar diseases were collected of which there were 14 kinds of leaves disease, 11 kinds of branch disease, 4 kinds of root disease, 2 kinds of stand rot. Each poplar species was studied on the harm, distribution, symptom, pathogens, occurrence regulation and control measures. According to previously studies, the sustained control tactics of poplar disease were summarized in this paper. 展开更多
关键词 Poplar diseases symptom Present situation control tactics
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Identification and Prevention and Control of Scab-anthracnoge of Landscape Plant Fatsia japonica
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作者 Ruan Lingxuan 《Plant Diseases and Pests》 CAS 2019年第4期7-9,共3页
The pathogenic characteristics of scab-anthracnoge of Fatsia japonica was introduced,and the infection cycle,occurrence regularity and main harmful symptoms of the disease were elaborated.Prevention is the main method... The pathogenic characteristics of scab-anthracnoge of Fatsia japonica was introduced,and the infection cycle,occurrence regularity and main harmful symptoms of the disease were elaborated.Prevention is the main method to prevent scab-anthracnoge of F.japonica,and disease-free seedlings should be cultivated.Meantime,cultivation management should be strengthened to improve disease resistance of plant,and chemical agents must be timely sprayed in the early incidence stage,in order to achieve the purpose of comprehensive control. 展开更多
关键词 Scab-anthracnoge Fatsia JAPONICA DAMAGE symptomS PREVENTION and control
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Occurrence of Rice Dry Straight Head Disease and Its Control
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作者 黄自安 刘小林 +2 位作者 倪春耕 胡宏云 王振荣 《Plant Diseases and Pests》 CAS 2010年第2期1-4,9,共5页
[Objective] Cause of disease and control measures of rice dry straight head disease in Chuzhou area was discussed. [Method] Field investigation and comprehensive analysis of the literature were conducted to study the ... [Objective] Cause of disease and control measures of rice dry straight head disease in Chuzhou area was discussed. [Method] Field investigation and comprehensive analysis of the literature were conducted to study the reason of dry straight head disease in Chuzhou area, some common control measures were summarized. [Result] The characteristic of main symptoms included incidence of single plant, incidence of cluster, inclusive incidence between clusters. Sporadic normal rice grains existed in diseased spikes under the incidence of grains. The main pathogenic factors of dry straight head disease were concentration of arsenic or lack of elements, belonging to physiological disease, while the effect of other pathogenic factors could not be excluded. Heavy application of organic fertilizer and crop rotation should be conducted, white soil field should be paid more attention about the changes of disease condition with more wet and dry roasting over fields. Application time of micro fertilizer should be chosen properly, while tillering final stage and pollen formation stage must be adjusted to avoid high temperature, irrigation management should also be improved. [Conclusion] The study could provide reference for preventing rice dry straight head disease. 展开更多
关键词 Rice dry straight head disease Research symptom Cause of disease Arsenic concentration Prevention and control measure
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鞘内注射万古霉素对颅内感染患者脑脊液生化指标及外周血感染指标的影响 被引量:1
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作者 陈颖 马星海 王衍刚 《中华医院感染学杂志》 北大核心 2025年第1期80-85,共6页
目的基于症状控制、脑脊液生化指标及外周血感染指标等分析鞘内注射万古霉素在颅内感染治疗中的应用效果,为临床优化治疗方案提供参考。方法回顾性分析焦作市人民医院2021年1月-2023年10月收治的颅内感染患者的临床资料,按照患者的治疗... 目的基于症状控制、脑脊液生化指标及外周血感染指标等分析鞘内注射万古霉素在颅内感染治疗中的应用效果,为临床优化治疗方案提供参考。方法回顾性分析焦作市人民医院2021年1月-2023年10月收治的颅内感染患者的临床资料,按照患者的治疗方案不同分别纳入对照组和研究组,每组40例,对照组常规给予注射用盐酸万古霉素和美罗培南静脉滴注治疗,研究组在对照组的基础上给予万古霉素鞘内注射治疗,两组均治疗1周,比较两组治疗后的临床疗效、症状控制情况、住院时间;分析两组治疗前后脑脊液常规及生化指标水平、神经功能缺损情况、外周血感染指标水平;观察两组治疗期间不良反应发生情况。结果80例患者脑脊液细菌培养阳性率为17.50%,共检出菌株15株,以表皮葡萄球菌检出最多(4株,占26.67%);治疗1周后研究组总有效率(95.00%)较对照组(77.50%)更高(χ^(2)=5.165,P=0.023);与对照组比较,研究组体温恢复正常及住院时间更短[(2.87±0.25)d、(31.25±3.25)d](P<0.05)。两组治疗1周后的脑脊液中有核细胞数、脑脊液蛋白、外周血白细胞介素-6(IL-6)、白细胞(WBC)、C-反应蛋白(CRP)水平及美国国立卫生研究院卒中量表(NIHSS)评分较治疗前降低(P<0.05),研究组[(12.75±2.12)×10^(6)/L、(304.65±26.12)mg/L、(8.71±0.65)pg/ml、(3.97±0.22)×10^(9)/L、(6.21±0.37)mg/L、(7.56±1.22)分]低于对照组(P<0.05);脑脊液中葡萄糖水平升高(P<0.05),研究组[(4.40±0.72)mmol/L]高于对照组(P<0.05)。治疗期间两组总不良反应发生率比较,差异无统计学意义。结论鞘内注射万古霉素可有效调节颅内感染患者脑脊液生化指标及外周血感染指标水平,减轻炎症及神经功能缺损程度,控制症状,疗效显著,安全性良好。 展开更多
关键词 颅内感染 万古霉素 鞘内注射 症状控制 感染指标 神经功能 疗效
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基于“肠–脑轴”针刺疗法配合感统训练治疗孤独症谱系障碍患儿的疗效及对胃肠症状的影响 被引量:1
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作者 王楠 王国琴 陈栋 《中国针灸》 北大核心 2025年第1期36-40,60,共6页
目的:探讨基于“肠-脑轴”针刺疗法配合感统训练治疗孤独症谱系障碍(简称孤独症)患儿的疗效及对胃肠症状的影响。方法:将96例孤独症患儿随机分为观察组和对照组,每组48例,各脱落3例。对照组采用感统训练,观察组在对照组的基础上采用基... 目的:探讨基于“肠-脑轴”针刺疗法配合感统训练治疗孤独症谱系障碍(简称孤独症)患儿的疗效及对胃肠症状的影响。方法:将96例孤独症患儿随机分为观察组和对照组,每组48例,各脱落3例。对照组采用感统训练,观察组在对照组的基础上采用基于“肠-脑轴”的针刺治疗,头针选取额五针(双侧头维、头临泣和神庭)、四神聪,体针穴取中枢及双侧天枢、脾俞、心俞、足三里、合谷、太冲,隔日1次,每周3次。两组均治疗12周。比较两组患儿治疗前后孤独症行为量表(ABC)、儿童孤独症评定量表(CARS)、孤独症治疗评估量表(ATEC)、胃肠中医症状评分及肠道菌群相对丰度,评估两组的临床疗效。结果:治疗后,两组患儿ABC、CARS评分较治疗前降低(P<0.001,P<0.05),且观察组ABC、CARS评分低于对照组(P<0.01)。治疗后,观察组患儿ATEC语言、感知觉、社交、行为评分及总分较治疗前降低(P<0.001,P<0.01),对照组患儿ATEC语言、社交、行为评分及总分较治疗前降低(P<0.01,P<0.001,P<0.05);观察组ATEC各项评分及总分均低于对照组(P<0.05)。治疗后,两组患儿大便稀溏、胃脘疼痛、胃脘痞满、食欲减退评分及总分均较治疗前降低(P<0.001),且观察组低于对照组(P<0.001)。治疗后,两组患儿大肠埃希菌、肠球菌相对丰度较治疗前降低(P<0.001),且观察组低于对照组(P<0.001);双歧杆菌、乳酸杆菌相对丰度较治疗前升高(P<0.001),且观察组高于对照组(P<0.001)。观察组总有效率为88.9%(40/45),高于对照组的66.7%(30/45,P<0.05)。结论:在感统训练基础上行基于“肠-脑轴”针刺疗法可改善孤独症患儿行为状态和胃肠症状,纠正肠道菌群失调。 展开更多
关键词 孤独症谱系障碍 针刺 肠-脑轴 感统训练 胃肠症状 肠道菌群 随机对照试验
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FeNO对COPD稳定期患者吸入药物选择的指导作用
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作者 金其武 徐玲玲 +1 位作者 邹俊辉 李军 《首都食品与医药》 2025年第18期44-47,共4页
目的探讨FeNO在指导COPD稳定期患者吸入药物治疗中的作用。方法纳入九江市第一人民医院呼吸科COPD稳定期患者90例,随机分为FeNO组与对照组各45例。两组均按GOLD2023指南进行综合评估,FeNO组额外结合FeNO值制定吸入方案:A型予LAMA;B/E型... 目的探讨FeNO在指导COPD稳定期患者吸入药物治疗中的作用。方法纳入九江市第一人民医院呼吸科COPD稳定期患者90例,随机分为FeNO组与对照组各45例。两组均按GOLD2023指南进行综合评估,FeNO组额外结合FeNO值制定吸入方案:A型予LAMA;B/E型予LAMA/LABA;当FeNO≥25ppb和/或EOS≥300个/μL时,升级为LAMA/LABA/ICS三联疗法。对照组用药:A型予LAMA;B/E型予LAMA/LABA;仅当EOS≥300个/μL时对E型患者启用三联疗法。均为每日1次,口吸入。随访12个月,每月记录CAT评分和AE次数,前3个月每月、之后每3个月检测EOS,第12个月检测肺功能。FeNO组于相同时间节点进行FeNO检测,并结合FeNO值调整方案,对照组按指南推荐调整。观察两组初始LAMA/LABA/ICS使用率、年度CAT评分变化、方案调整频次、AE次数及末次肺功能(FEV_(1)、FVC、PEF)。结果初始治疗中,FeNO组三联药物使用率显著高于对照组(33.3%vs9.0%,P=0.006)。随访期间,FeNO组CAT评分较基线改善幅度优于对照组(P=0.047),年度AE次数显著更低[(0.91±0.70)次vs(1.22±0.74)次,P=0.043],药物方案调整频次更高(P=0.005)。两组末次肺功能指标差异无统计学意义(P均>0.05)。结论联合FeNO与GOLD2023评估体系,可优化COPD稳定期患者吸入药物选择,提高三联治疗早期使用率,有效改善症状控制并减少AE。 展开更多
关键词 呼出气一氧化氮 慢性阻塞性肺疾病 吸入药物 症状控制 随访管理
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玉米白斑病研究进展
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作者 薛春生 贾嘉琦 +2 位作者 李星来 李文玲 肖淑芹 《植物病理学报》 北大核心 2025年第5期1001-1012,共12页
玉米作为全球广泛种植的重要农作物,兼具粮食、饲料及工业原料等多重功能,是具有重要战略价值的农业资源,在国民经济中占据重要地位。然而在实际生产中,玉米常受到多种病虫害的威胁,其中玉米白斑病是近年来在我国西南地区危害最严重的... 玉米作为全球广泛种植的重要农作物,兼具粮食、饲料及工业原料等多重功能,是具有重要战略价值的农业资源,在国民经济中占据重要地位。然而在实际生产中,玉米常受到多种病虫害的威胁,其中玉米白斑病是近年来在我国西南地区危害最严重的玉米叶部病害之一,目前已扩散至我国北方地区如山东、辽宁等地。该病害发生区域呈现快速扩张趋势,对玉米安全生产构成严重威胁。本文系统综述了玉米白斑病的发生危害、田间症状、病原菌种类、发生规律、品种抗病性以及综合防控措施等方面的研究进展,以期为该病害的科学防控提供参考。 展开更多
关键词 玉米 白斑病 症状特点 病原菌 防治策略
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Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study 被引量:9
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作者 Takayoshi Suzuki Masashi Matsushima +9 位作者 Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine 《World Journal of Gastroenterology》 SCIE CAS 2015年第16期5023-5031,共9页
AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized t... AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N. 展开更多
关键词 Irsogladine MALEATE RABEPRAZOLE Nonerosivereflux DISEASE Randomized controlled trial Frequency scale for the symptomS of GASTROESOPHAGEALREFLUX DISEASE Quality of life
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Clinical Trial Protocol: Randomized Controlled Trial of Cancer Pain Monitoring System (CAPAMOS) in Patients with Advanced Cancer
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作者 Shiori Yoshida Fumiko Sato +1 位作者 Keita Tagami Shin Takahashi 《Open Journal of Nursing》 2022年第2期113-124,共12页
Purpose: This randomized controlled trial (RCT) protocol was designed to evaluate the effectiveness of the Cancer Pain Monitoring System (CAPAMOS), a telenursing system designed to alleviate pain in ambulatory patient... Purpose: This randomized controlled trial (RCT) protocol was designed to evaluate the effectiveness of the Cancer Pain Monitoring System (CAPAMOS), a telenursing system designed to alleviate pain in ambulatory patients with advanced cancer. Methods: The study design involved a randomized controlled trial consisting of an intervention group using CAPAMOS and a control group that received usual care. At the time of enrollment, both groups will be given a questionnaire regarding issues, such as concerns related to cancer pain and self-management of opioid medication. Patients will then receive pain relief education based on the results of the questionnaire. Subjects in the control group will receive a pain diary and pain-relief pamphlet that acts as an educational tool. They could also call the outpatient clinic if they wanted to ask for a nursing consultation. The intervention group will be able to use CAPAMOS to manage their pain and receive video consultation with a telenurse, who is an oncology nursing specialist. Educational tools will be built into CAPAMOS. The study will be conducted for one month. The primary endpoint of this study was to calculate the Japanese Brief Pain Inventory score. The secondary endpoints were to assess the opioid medication self-management, Barriers Questionnaire, Japanese EuroQol 5-dimensions 5-level, and economic evaluation. Assessment items will be evaluated at registration and 2 and 4 weeks after registration. Conclusions: A RCT based on this protocol is expected to validate the efficacy of telenursing using CAPAMOS in patients with advanced cancer and pain. 展开更多
关键词 TELENURSING Cancer Pain Advanced Cancer Patients symptom Management Patient Care Randomized controlled Trial
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呼吸-营养整合干预模式对COPD患者症状控制及血气优化的影响研究
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作者 王红兰 《科技与健康》 2025年第20期141-144,共4页
探讨呼吸-营养整合干预模式对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者症状控制及血气优化的影响。选取东台市人民医院2020年1月—2024年12月接诊的60例COPD住院患者为研究对象,按照随机数字表法将其分为对照... 探讨呼吸-营养整合干预模式对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者症状控制及血气优化的影响。选取东台市人民医院2020年1月—2024年12月接诊的60例COPD住院患者为研究对象,按照随机数字表法将其分为对照组(n=30,实施常规治疗方案)和观察组(n=30,实施呼吸-营养整合干预),比较组间治疗效果,评估两组患者治疗前后的症状变化,对比两组患者的营养指标、血气指标、生活质量情况。结果显示,治疗后,观察组患者的治疗总有效率高于对照组(P<0.05);症状评估得分低于对照组(P<0.05);营养指标检测结果优于对照组(P<0.05);血气指标检测结果中氧分压高于对照组,二氧化碳分压低于对照组(P<0.05)。治疗后,观察组患者的生活质量评分高于对照组(P<0.05)。研究发现,针对COPD患者实施呼吸-营养整合干预模式能够有效控制症状,改善机体营养状态,优化血气指标,提升生活质量,值得推广。 展开更多
关键词 呼吸-营养整合干预模式 COPD 症状控制 血气指标
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耳部铜砭刮痧联合耳穴压豆在注意缺陷多动障碍患儿中的应用效果
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作者 张萌 师晓敏 +1 位作者 李维佳 白青云 《临床心身疾病杂志》 2025年第4期66-69,75,共5页
目的探讨耳部铜砭刮痧联合耳穴压豆在注意缺陷多动障碍(ADHD)患儿中的应用效果。方法将90例ADHD患儿随机分为观察组和对照组,各45例。对照组患儿给予引导式训练,观察组患儿在对照组基础上给予耳部铜砭刮痧联合耳穴压豆。两组患儿均干预... 目的探讨耳部铜砭刮痧联合耳穴压豆在注意缺陷多动障碍(ADHD)患儿中的应用效果。方法将90例ADHD患儿随机分为观察组和对照组,各45例。对照组患儿给予引导式训练,观察组患儿在对照组基础上给予耳部铜砭刮痧联合耳穴压豆。两组患儿均干预1个月。比较两组患儿症状好转所用时间、临床症状[注意缺陷多动障碍评定量表(SNAP-Ⅳ)评分]、综合反应控制能力[综合反应控制商数(FRCQ)评分]及智力水平[韦氏儿童智力量表第4版(WISC-Ⅳ)评分]。结果干预后,观察组患儿活动过度、注意力涣散及情绪不稳定好转所用时间短于对照组(P<0.01)。干预后,两组患儿SNAP-IV评分较干预前降低,FRCQ、WISC-Ⅳ评分较干预前升高,且观察组优于对照组(P<0.01)。结论耳部铜砭刮痧联合耳穴压豆应用于ADHD患儿,可有效缩短症状好转所用时间,改善患儿注意力、控制力,提高智力水平,值得推广应用。 展开更多
关键词 耳部铜砭刮痧 耳穴压豆 注意缺陷多动障碍 临床症状 反应控制能力 智力水平
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玫烟色虫草IF-1106菌株对小菜蛾致病力及时间-剂量-死亡率模型分析
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作者 田晶 孟豪 马瑞燕 《西北农业学报》 北大核心 2025年第4期726-732,共7页
为获得对小菜蛾(Plutella xylostella)具有高毒力的虫生真菌并将其应用于生产,采用喷雾法测定玫烟色虫草(Cordyceps fumosorosea)对小菜蛾幼虫的致病力,观察小菜蛾3龄幼虫的感病症状,并运用时间-剂量-死亡率模型分析玫烟色虫草IF-1106... 为获得对小菜蛾(Plutella xylostella)具有高毒力的虫生真菌并将其应用于生产,采用喷雾法测定玫烟色虫草(Cordyceps fumosorosea)对小菜蛾幼虫的致病力,观察小菜蛾3龄幼虫的感病症状,并运用时间-剂量-死亡率模型分析玫烟色虫草IF-1106菌株对小菜蛾幼虫的时间效应和剂量效应。结果表明:小菜蛾3龄幼虫接种玫烟色虫草IF-1106菌株5~7d后,虫体全身被菌丝包被,并缩小且变得干瘪,体色呈黑褐色。不同浓度的玫烟色虫草孢子悬浮液处理小菜蛾2~4龄幼虫后,所有龄期都会感染而发病死亡。在孢子浓度为1.0×10^(8)cfu/mL时,2、3、4龄幼虫处理7d后的累计校正死亡率分别为94.12%、88.89%、78.95%。运用时间-剂量-死亡率模型对生物测定数据进行拟合,通过Hosmer-Lemeshow拟合异质性检验,并估计该菌株对小菜蛾的致死剂量与致死时间。随着接种天数的增加,相应的LD50和LD90随之降低,剂量效应逐渐增强,致死时间与剂量对数有关,2龄幼虫的LT50在1.0×10^(6)~1.0×10^(8)孢子/mL范围内由4.77d降到2.89d。由此可见,玫烟色虫草IF-1106菌株对小菜蛾的生物防治具有较好的应用潜力。 展开更多
关键词 玫烟色虫草 小菜蛾 致病力 感病症状 时间-剂量-死亡率模型 生物防治
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