Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has...Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics.展开更多
Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely us...Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems.展开更多
BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognit...BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.展开更多
This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanis...This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.展开更多
As artificial intelligence and big data become increasingly prevalent, resistive random-access memory (RRAM) has become one of the most promising alternatives for storing massive amounts of data. In this study, we emp...As artificial intelligence and big data become increasingly prevalent, resistive random-access memory (RRAM) has become one of the most promising alternatives for storing massive amounts of data. In this study, we employed high-quality crystalline TiN/Al_(2)O_(3)/BaTiO_(3)/Pt RRAM with an optimized thin Al_(2)O_(3) interlayer around 12 nm thick prepared using atomic layer deposition since the thickness of the interlayer affects the memory window size. After insertion of the Al_(2)O_(3) interlayer, the novel RRAM exhibited outstanding uniform resistive switching voltage and the ON/OFF memory window drastically increased from 10 to 103 without any discernible decline in performance. Moreover, the low-resistance state and high-resistance state operating current values decreased by almost one order and three orders of magnitude, respectively, thereby decreasing the power consumption for the RESET and SET processes by more than three and almost one order of magnitude, respectively. The device also exhibits multilevel resistive switching behavior when varying the applied voltage. Finally, we also developed a 6 6 crossbar array which demonstrated consistent and reliable resistive switching behavior with minimal variation. Hence, our approach holds great promise for producing state-of-the-art non-volatile resistive switching devices.展开更多
Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,th...Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization algorithm.The proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop control.Then,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control strategy.Precise pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid voltage.Additionally,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee algorithm.These operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load transients.This strategy effectively mitigated transient voltage and current surges during mode transitions.Consequently,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid inverter.The enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.展开更多
Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present so...Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.展开更多
The phenomena of thermal runaway and accidental deformation due to external stresses in lithium batteries or film capacitors consti-tute their primary failure mechanisms.Therefore,monitoring and early warning of overh...The phenomena of thermal runaway and accidental deformation due to external stresses in lithium batteries or film capacitors consti-tute their primary failure mechanisms.Therefore,monitoring and early warning of overheating or localized strain are of great value for the safe use of lithium batteries or film capacitors;however,this function usually requires a system of multiple complex sensors.The realization of the above multiple hazards using a single sensor for monitoring and alarm functions has not been reported.Here,we exploit the thermally induced conductivity and modulus change during solid-liquid conversion of low melting point polyalloys to modulate the electronic relaxation polariza-tion and interfacial polarization in the composites for dielectric switching,and the reduction of alloy particle spacing during bending/compres-sive strain can be used to generate switchable tunneling effects for insulator-conductor transition.By synergizing dielectric switching and insula-tor-conductor transition,the final flexible thermoplastic polyurethane elastomer/low-melting-point polyalloy composite film achieves the func-tional integration of multi-level overheating warning and small deformation monitoring.展开更多
To enable distributed PV to adapt to variations in power grid strength and achieve stable grid connection while enhancing operational flexibility,it is essential to configure grid-connected inverters with an integrate...To enable distributed PV to adapt to variations in power grid strength and achieve stable grid connection while enhancing operational flexibility,it is essential to configure grid-connected inverters with an integrated grid-following control mode,allowing smooth switching between GFL and GFM modes.First,impedance models of GFL and GFM PV energy storage VSG systems were established,and grid stability was analyzed.Second,an online impedance identification method based on voltage fluctuation data screening was proposed to enhance the accuracy of impedance identification.Additionally,a PV energy storage GFM/GFL VSG smooth switching method based on current inner loop compensation was introduced to achieve stable grid-connected operation of distributed photovoltaics under changes in strong and weak power grids.Finally,a grid stability analysis was conducted on the multi-machine parallel PV ESS,and a simulation model of a multi-machine parallel PV ESS based on current inner loop compensation was established for testing.Results showed that,compared to using a single GFM or single GFL control for the PV VSG system,the smooth switching method of multi-machine parallel PV ESS effectively suppresses system resonance under variations in power grid strength,enabling adaptive and stable grid-connected operations of distributed PV.展开更多
The efficiency of energy conversion from mechanical to electrical in AC generators is not entirely optimal,as power losses are converted into heat.Accurate thermal modeling and temperature measurement of advanced elec...The efficiency of energy conversion from mechanical to electrical in AC generators is not entirely optimal,as power losses are converted into heat.Accurate thermal modeling and temperature measurement of advanced electric machines with complex structures are mandatory to confirm their reliability and safe operation.In a unique axial transverse flux switching permanent magnet(ATFSPM)generator,due to its high power density,large stray loss from leakage flux,compact topology,and totally enclosed structure,thermal analysis is of paramount significance.In this paper,thermal modeling and analysis of ATFSPM are carried out in detail using a three-dimensional(3D)finite element analysis(FEA)to evaluate the thermal condition for a precise performance improvement.To begin,all loss sources are accurately derived using 3-D FEA and analytical methods,taking into account the temperature dependence of material properties,and then losses are coupled to the thermal model as heat sources.Afterward,aiming for realistic thermal modelling,the convection heat transfer in the different regions of internal and external areas as well as thin layers of interface gaps between components are all considered.In addition,the prototype of ATFSPM is supplied to validate the accuracy of 3-D FEA temperature prediction.Furthermore,a novel technique is carried out to effectively improve thermal performance,enhance the efficiency,and limit hot-spot temperatures.The steady-state and transient temperature results demonstrate the high accuracy of the thermal modeling,enhance the secure operation of the ATFSPM,and facilitate increased loading utilizing the proposed technique.(1)展开更多
The solenoid switching valve(SSV)is the key control component of heavy equipment such as continuous casting machines.However,the incompatibility of structural parameters increases the opening and closing time of the S...The solenoid switching valve(SSV)is the key control component of heavy equipment such as continuous casting machines.However,the incompatibility of structural parameters increases the opening and closing time of the SSV.Therefore,this study proposes an optimized design method for an SSV to improve its dynamic performance.First,a multi-physics field-coupling model of the SSV is built,and the effects of different structural parameters on the electromagnetic characteristics are analyzed.After identifying the key influencing parameters,second-order response surface models are established to efficiently predict the opening and closing time.Subsequently,based on the nondominated sorting genetic algorithmⅡ(NSGA-Ⅱ),multi-objective optimization is applied to obtain the Pareto optimal solution of the structural parameters under the double-voltage driving strategy.The structure of the solenoid and valve as well as the dynamic characteristics of the valve are improved.Compared with those before optimization,the optimization results show that the opening and closing time of the optimized SSV are reduced by 24.38%and 51.8%,respectively,and the volume is reduced by 19.7%.The research results and the influence of the solenoid structural parameters on the electromagnetic force provide significant guidance for the design of this type of valve.展开更多
Objective:Cold exposure may impair vascular function and promote cardiovascular diseases(CVDs)by causing vasoconstriction,hemodynamic changes,and sympathetic activation.Vascular aging,a key factor in CVDs,is linked to...Objective:Cold exposure may impair vascular function and promote cardiovascular diseases(CVDs)by causing vasoconstriction,hemodynamic changes,and sympathetic activation.Vascular aging,a key factor in CVDs,is linked to phenotypic switching of vascular smooth muscle cells(VSMCs),but its regulatory mechanisms are not fully understood.Materials and methods:We used aged C57BL/6 mice and D-galactose-induced senescent VSMCs to investigate the role of the E3 ligase RLIM in arterial aging.RLIM knockdown and overexpression in vivo were achieved using adeno-associated virus(AAV)vectors.Vascular aging and stiffness were assessed usingβ-galactosidase staining,pulse wave velocity(PWV)measurements,and histological staining.Proteomic profiling was conducted to identify key protein alterations associated with vascular dysfunction and to elucidate underlying mechanisms.Results:RLIM expression was significantly upregulated in the aortae of aged mice and D-galactose-induced senescent VSMCs.AAV-mediated RLIM knockdown significantly attenuated vascular aging,as evidenced by vascular ultrasound and histological assessments.Conversely,RLIM overexpression exacerbated vascular damage.Proteomic analysis revealed that RLIM knockdown in VSMCs from aged mice resulted in increased expression of smooth muscle contractile proteins and decreased levels of inflammatory markers,indicating a phenotypic shift toward a more contractile state.Conclusion:These findings identify RLIM as a key regulator of arterial aging and a promising therapeutic target for age-related cardiovascular diseases.展开更多
BACKGROUND Glucagon-like peptide-1 receptor agonists(GLP-1RAs)play a key role in managing type 2 diabetes mellitus(T2DM).Transitioning between different GLP-1RA has been proposed as a treatment strategy.AIM To investi...BACKGROUND Glucagon-like peptide-1 receptor agonists(GLP-1RAs)play a key role in managing type 2 diabetes mellitus(T2DM).Transitioning between different GLP-1RA has been proposed as a treatment strategy.AIM To investigate switching patterns between GLP-1RA and their impact on glycemic control.METHODS A retrospective study involving patients with T2DM who initiated GLP-1RA therapy between 2009 and 2021 and transitioned to another GLP-1RA.Baseline glycated hemoglobin(HbA1c)was defined as the most recent measurement within 1 year prior to switching,and follow-up HbA1c was the first measurement recorded 4-15 months post-switch.RESULTS Among 70654 patients initiating GLP-1RA therapy,18047(25.5%)switched regimens.In the 13970 patients with available HbA1c,levels decreased from 8.5%±1.6%to 7.6%±1.4%(P<0.001).HbA1c decreased in 78.3%(10943/13970)of these patients,with the most frequent improvement observed in those switching from daily to weekly GLP-1RA(81%,5582/6890).CONCLUSION Switching between GLP-1RAs can serve as a practical alternative to treatment intensification for effectively managing T2DM.展开更多
Background : SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. Methods : In vascular smooth ...Background : SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. Methods : In vascular smooth muscle cells(VSMCs), we employed gain-and loss-offunction approaches combined with RNA sequencing, autophagy flux assessment, and phenotype characterization. Additionally, we established a mouse model with Sox6 overexpression via adeno-associated virus 2(AAV2) to validate the findings in vivo. Results : We validated the increased expression of SOX6 in hypertension both in vitro and in vivo. Genetic silencing of Sox6 in VSMCs attenuated the phenotypic switching induced by angiotensin Ⅱ. Conversely, in vivo overexpression of Sox6 led to a significant elevation in blood pressure and promoted vascular remodeling. Mechanistically, SOX6 was shown to regulate phenotypic switching via an autophagydependent pathway. Specifically, Sox6 overexpression augmented VSMC autophagy and facilitated phenotypic switching, whereas Sox6 knockdown yielded opposite outcomes. Modulation of autophagy using 3-MA or RAPA could effectively counteract the effect mediated by SOX6. Conclusions : Our findings revealed that SOX6 regulates VSMC plasticity and elevates blood pressure by activating autophagy. Therefore, SOX6 inhibition potentially represents a novel strategy for treating hypertension and vascular remodeling.展开更多
With the advancement of more electric aircraft(MEA)technology,the application of electro-hydrostatic actuators(EHAs)in aircraft actuation systems has become increasingly prevalent.This paper focuses on the modeling an...With the advancement of more electric aircraft(MEA)technology,the application of electro-hydrostatic actuators(EHAs)in aircraft actuation systems has become increasingly prevalent.This paper focuses on the modeling and mode switching analysis of EHA used in the primary flight control actuation systems of large aircraft,addressing the challenges associated with mode switching.First,we analyze the functional architecture and operational characteristics of multi-mode EHA,and sumarize the operating modes and implementation methods.Based on the EHA system architecture,we then develop a theoretical mathematical model and a simulation model.Using the simulation model,we analyze the performance of the EHA during normal operation.Finally,the performance of the EHA during mode switching under various functional switching scenarios is investigated.The results indicate that the EHA meets the performance requirements in terms of accuracy,bandwidth,and load capacity.Additionally,the hydraulic cylinder operates smoothly during the EHA mode switching,and the response time for switching between different modes is less than the specified threshold.These findings validate the system performance of multi-mode EHA,which helps to improve the reliability of EHA and the safety of aircraft flight control systems.展开更多
Cropland is persistently affected by soil loss by water erosion in China,which causes economic loss and threatens soil health.Integrating crop switching and improved management provides a promising strategy for contro...Cropland is persistently affected by soil loss by water erosion in China,which causes economic loss and threatens soil health.Integrating crop switching and improved management provides a promising strategy for controlling soil loss by water erosion in cropland and promoting sustainable agriculture.However,optimizing crop composition with fewer inputs involves balancing agricultural resource use with environmental costs.Aiming to explore the potential of crop switching as a strategy for mitigating soil erosion in cropland,we develop a spatial optimization model that redistributes the sown areas of different crops in each prefecture-level city based on existing resource availability.Our findings gained from our simulations show that crop switching in China alone can reduce total soil erosion in cropland by an estimated 13%.Furthermore,combining crop switching with improved agricultural management practices can further reduce soil erosion in cropland by an estimated 25%.Cereals including maize,wheat,and rice demonstrate significant potential for reducing soil erosion in cropland.Shifting major maize-producing areas northward could result in a substantial decrease in soil erosion,ranging from 10% to 19% of historical soil erosion in cropland.These results offer implications for formulating regional strategy in mitigating soil erosion challenges in China while maximizing the benefits from existing agricultural resource.展开更多
Dear Editor,This letter introduces an innovative event-triggered secondary control strategy for Microgrid(MG)to address challenges of low inertia and renewable energy integration.Utilizing semi-Markov switching topolo...Dear Editor,This letter introduces an innovative event-triggered secondary control strategy for Microgrid(MG)to address challenges of low inertia and renewable energy integration.Utilizing semi-Markov switching topologies,this method employs semi-Markov jump processes for accurate load forecasting,facilitating adaptive adjustments of distributed generators(DGs)in response to load changes.展开更多
The thermal switch plays a crucial role in regulating system temperature,protecting devices from overheating,and improving energy efficiency.Achieving a high thermal switching ratio is essential for its practical appl...The thermal switch plays a crucial role in regulating system temperature,protecting devices from overheating,and improving energy efficiency.Achieving a high thermal switching ratio is essential for its practical application.In this study,by utilizing first-principles calculations and semi-classical Boltzmann transport theory,it is found that hole doping with an experimentally achievable concentration of 1.83×10^(14)cm^(-2)can reduce the lattice thermal conductivity of monolayer MoS_(2) from 151.79 W·m^(-1)·K^(-1)to 12.19 W·m^(-1)·K^(-1),achieving a high thermal switching ratio of 12.5.The achieved switching ratio significantly surpasses previously reported values,including those achieved by extreme strain methods.This phenomenon mainly arises from the enhanced lattice anharmonicity,which is primarily contributed by the S atoms.These results indicate that hole doping is an effective method for tuning the lattice thermal conductivity of materials,and demonstrate that monolayer MoS_(2) is a potential candidate material for thermal switches.展开更多
This article investigates the time-varying output group formation tracking control(GFTC)problem for heterogeneous multi-agent systems(HMASs)under switching topologies.The objective is to design a distributed control s...This article investigates the time-varying output group formation tracking control(GFTC)problem for heterogeneous multi-agent systems(HMASs)under switching topologies.The objective is to design a distributed control strategy that enables the outputs of the followers to form the desired sub-formations and track the outputs of the leader in each subgroup.Firstly,novel distributed observers are developed to estimate the states of the leaders under switching topologies.Then,GFTC protocols are designed based on the proposed observers.It is shown that with the distributed protocol,the GFTC problem for HMASs under switching topologies is solved if the average dwell time associated with the switching topologies is larger than a fixed threshold.Finally,an example is provided to illustrate the effectiveness of the proposed control strategy.展开更多
The event-triggered mechanism serves as an effective discontinuous control strategy for addressing the consensus tracking problem in multiagent systems(MASs).This approach optimizes energy consumption by updating the ...The event-triggered mechanism serves as an effective discontinuous control strategy for addressing the consensus tracking problem in multiagent systems(MASs).This approach optimizes energy consumption by updating the controller only when some observed errors exceed a predefined threshold.Considering the influence of noise on agent dynamics in complex control environments,this study investigates an event-triggered control scheme for stochastic MASs,where noise is modeled as Brownian motion.Furthermore,the communication topology of the stochastic MASs is assumed to exhibit a Markovian switching mechanism.Analytical criteria are derived to guarantee consensus tracking in the mean square sense,and a numerical example is provided to validate the effectiveness of the proposed control methods.展开更多
基金supported by the Natural Science Foundation of Guangdong Province,China (No.2025A1515011654)the National Natural Science Foundation of China (No.22090053)+3 种基金the Fundamental Research Funds for National Universities,China University of Geosciences (Wuhan)support from the program of China Scholarships Council (No.202406410155)Young Elite Scientists Sponsorship Program by CAST-Doctoral Student Special Plansupport from the S&T Special Program of Huzhou (No.2024GZ07)。
文摘Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics.
基金support from the Beijing Natural Science Foundation-Xiaomi Innovation Joint Fund(No.L233009)National Natural Science Foundation of China(NSFC Nos.62422409,62174152,and 62374159)from the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2020115).
文摘Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems.
基金Supported by Wuxi Taihu Talent Project,No.WXTTP 2021the General Scientific Research Program of Wuxi Municipal Health Commission,No.M202447.
文摘BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.
基金supported by the National Natural Science Foundation under Grant 62273189the Shandong Province Natural Science Foundation under Grant ZR2021MF005Systems Science Plus Joint Research Program of Qingdao University under Grant XT2024201 of China supporting this research work.
文摘This article investigates the anti-disturbance and stabilization problems for the nonlinear uncertain permanent magnet synchronous motor(PMSM)with stator voltage saturation and unknown load.A smooth switching mechanism is presented to structure the adaptive integral terminal sliding mode control(SMC)strategy.The control design consists of compensation control and nominal control,which improves the rapidity and accuracy of trajectory tracking.The smooth saturation model based on the error function is applied to approximate the voltage saturation phenomenon.Additionally,to deal with the adverse effects of various unknown disturbances,including model parameter uncertainties and unknown external load disturbances,an improved disturbance observer(DO)is proposed.This observer effectively suppresses the fluctuations caused by fixed gain during the starting period of the system.Finally,the experimental results under different conditions show that the proposed strategy has good tracking and disturbance suppression performances.
基金supported by the National Research Foundation of Korea funded by the Korean Government(grant No.RS-2023-00208801).
文摘As artificial intelligence and big data become increasingly prevalent, resistive random-access memory (RRAM) has become one of the most promising alternatives for storing massive amounts of data. In this study, we employed high-quality crystalline TiN/Al_(2)O_(3)/BaTiO_(3)/Pt RRAM with an optimized thin Al_(2)O_(3) interlayer around 12 nm thick prepared using atomic layer deposition since the thickness of the interlayer affects the memory window size. After insertion of the Al_(2)O_(3) interlayer, the novel RRAM exhibited outstanding uniform resistive switching voltage and the ON/OFF memory window drastically increased from 10 to 103 without any discernible decline in performance. Moreover, the low-resistance state and high-resistance state operating current values decreased by almost one order and three orders of magnitude, respectively, thereby decreasing the power consumption for the RESET and SET processes by more than three and almost one order of magnitude, respectively. The device also exhibits multilevel resistive switching behavior when varying the applied voltage. Finally, we also developed a 6 6 crossbar array which demonstrated consistent and reliable resistive switching behavior with minimal variation. Hence, our approach holds great promise for producing state-of-the-art non-volatile resistive switching devices.
基金received funding from the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX23_1633)2023 University Student Innovation and Entrepreneurship Training Program(202311463009Z)+1 种基金Changzhou Science and Technology Support Project(CE20235045)Open Project of Jiangsu Key Laboratory of Power Transmission&Distribution Equipment Technology(2021JSSPD12).
文摘Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization algorithm.The proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop control.Then,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control strategy.Precise pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid voltage.Additionally,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee algorithm.These operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load transients.This strategy effectively mitigated transient voltage and current surges during mode transitions.Consequently,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid inverter.The enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.
基金supported in part by the National Natural Science Foundation of China(62273255,62350003,62088101)the Shanghai Science and Technology Cooperation Project(22510712000,21550760900)+1 种基金the Shanghai Municipal Science and Technology Major Project(2021SHZDZX0100)the Fundamental Research Funds for the Central Universities
文摘Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.
基金financially supported by the National Natural Science Foundation of China (No.51503158)Key R&D Program of Hubei Province (No.2023BAB104)Open Project Program of High-Tech Organic Fibers Key Laboratory of Sichuan Province(No.PLN2024-08)
文摘The phenomena of thermal runaway and accidental deformation due to external stresses in lithium batteries or film capacitors consti-tute their primary failure mechanisms.Therefore,monitoring and early warning of overheating or localized strain are of great value for the safe use of lithium batteries or film capacitors;however,this function usually requires a system of multiple complex sensors.The realization of the above multiple hazards using a single sensor for monitoring and alarm functions has not been reported.Here,we exploit the thermally induced conductivity and modulus change during solid-liquid conversion of low melting point polyalloys to modulate the electronic relaxation polariza-tion and interfacial polarization in the composites for dielectric switching,and the reduction of alloy particle spacing during bending/compres-sive strain can be used to generate switchable tunneling effects for insulator-conductor transition.By synergizing dielectric switching and insula-tor-conductor transition,the final flexible thermoplastic polyurethane elastomer/low-melting-point polyalloy composite film achieves the func-tional integration of multi-level overheating warning and small deformation monitoring.
基金supported by National Key Research and Development Technology Project program(SQ2022YFB2400136).
文摘To enable distributed PV to adapt to variations in power grid strength and achieve stable grid connection while enhancing operational flexibility,it is essential to configure grid-connected inverters with an integrated grid-following control mode,allowing smooth switching between GFL and GFM modes.First,impedance models of GFL and GFM PV energy storage VSG systems were established,and grid stability was analyzed.Second,an online impedance identification method based on voltage fluctuation data screening was proposed to enhance the accuracy of impedance identification.Additionally,a PV energy storage GFM/GFL VSG smooth switching method based on current inner loop compensation was introduced to achieve stable grid-connected operation of distributed photovoltaics under changes in strong and weak power grids.Finally,a grid stability analysis was conducted on the multi-machine parallel PV ESS,and a simulation model of a multi-machine parallel PV ESS based on current inner loop compensation was established for testing.Results showed that,compared to using a single GFM or single GFL control for the PV VSG system,the smooth switching method of multi-machine parallel PV ESS effectively suppresses system resonance under variations in power grid strength,enabling adaptive and stable grid-connected operations of distributed PV.
基金supported by research grants of the Iran National Science Foundation(INSF)under grant No.98002866。
文摘The efficiency of energy conversion from mechanical to electrical in AC generators is not entirely optimal,as power losses are converted into heat.Accurate thermal modeling and temperature measurement of advanced electric machines with complex structures are mandatory to confirm their reliability and safe operation.In a unique axial transverse flux switching permanent magnet(ATFSPM)generator,due to its high power density,large stray loss from leakage flux,compact topology,and totally enclosed structure,thermal analysis is of paramount significance.In this paper,thermal modeling and analysis of ATFSPM are carried out in detail using a three-dimensional(3D)finite element analysis(FEA)to evaluate the thermal condition for a precise performance improvement.To begin,all loss sources are accurately derived using 3-D FEA and analytical methods,taking into account the temperature dependence of material properties,and then losses are coupled to the thermal model as heat sources.Afterward,aiming for realistic thermal modelling,the convection heat transfer in the different regions of internal and external areas as well as thin layers of interface gaps between components are all considered.In addition,the prototype of ATFSPM is supplied to validate the accuracy of 3-D FEA temperature prediction.Furthermore,a novel technique is carried out to effectively improve thermal performance,enhance the efficiency,and limit hot-spot temperatures.The steady-state and transient temperature results demonstrate the high accuracy of the thermal modeling,enhance the secure operation of the ATFSPM,and facilitate increased loading utilizing the proposed technique.(1)
基金Supported by National Natural Science Foundation of China(Grant No.2018YFB1703000)State Key Laboratory of Metal Extrusion and Forging Equipment TechnologyChina National Heavy Machinery Research Institute Co.,Ltd.(Grant No.B2408100.W19)。
文摘The solenoid switching valve(SSV)is the key control component of heavy equipment such as continuous casting machines.However,the incompatibility of structural parameters increases the opening and closing time of the SSV.Therefore,this study proposes an optimized design method for an SSV to improve its dynamic performance.First,a multi-physics field-coupling model of the SSV is built,and the effects of different structural parameters on the electromagnetic characteristics are analyzed.After identifying the key influencing parameters,second-order response surface models are established to efficiently predict the opening and closing time.Subsequently,based on the nondominated sorting genetic algorithmⅡ(NSGA-Ⅱ),multi-objective optimization is applied to obtain the Pareto optimal solution of the structural parameters under the double-voltage driving strategy.The structure of the solenoid and valve as well as the dynamic characteristics of the valve are improved.Compared with those before optimization,the optimization results show that the opening and closing time of the optimized SSV are reduced by 24.38%and 51.8%,respectively,and the volume is reduced by 19.7%.The research results and the influence of the solenoid structural parameters on the electromagnetic force provide significant guidance for the design of this type of valve.
基金the National Natural Science Foundation of China(82273919)the HMU Marshal Initiative Funding(HMUMIF-21022).
文摘Objective:Cold exposure may impair vascular function and promote cardiovascular diseases(CVDs)by causing vasoconstriction,hemodynamic changes,and sympathetic activation.Vascular aging,a key factor in CVDs,is linked to phenotypic switching of vascular smooth muscle cells(VSMCs),but its regulatory mechanisms are not fully understood.Materials and methods:We used aged C57BL/6 mice and D-galactose-induced senescent VSMCs to investigate the role of the E3 ligase RLIM in arterial aging.RLIM knockdown and overexpression in vivo were achieved using adeno-associated virus(AAV)vectors.Vascular aging and stiffness were assessed usingβ-galactosidase staining,pulse wave velocity(PWV)measurements,and histological staining.Proteomic profiling was conducted to identify key protein alterations associated with vascular dysfunction and to elucidate underlying mechanisms.Results:RLIM expression was significantly upregulated in the aortae of aged mice and D-galactose-induced senescent VSMCs.AAV-mediated RLIM knockdown significantly attenuated vascular aging,as evidenced by vascular ultrasound and histological assessments.Conversely,RLIM overexpression exacerbated vascular damage.Proteomic analysis revealed that RLIM knockdown in VSMCs from aged mice resulted in increased expression of smooth muscle contractile proteins and decreased levels of inflammatory markers,indicating a phenotypic shift toward a more contractile state.Conclusion:These findings identify RLIM as a key regulator of arterial aging and a promising therapeutic target for age-related cardiovascular diseases.
文摘BACKGROUND Glucagon-like peptide-1 receptor agonists(GLP-1RAs)play a key role in managing type 2 diabetes mellitus(T2DM).Transitioning between different GLP-1RA has been proposed as a treatment strategy.AIM To investigate switching patterns between GLP-1RA and their impact on glycemic control.METHODS A retrospective study involving patients with T2DM who initiated GLP-1RA therapy between 2009 and 2021 and transitioned to another GLP-1RA.Baseline glycated hemoglobin(HbA1c)was defined as the most recent measurement within 1 year prior to switching,and follow-up HbA1c was the first measurement recorded 4-15 months post-switch.RESULTS Among 70654 patients initiating GLP-1RA therapy,18047(25.5%)switched regimens.In the 13970 patients with available HbA1c,levels decreased from 8.5%±1.6%to 7.6%±1.4%(P<0.001).HbA1c decreased in 78.3%(10943/13970)of these patients,with the most frequent improvement observed in those switching from daily to weekly GLP-1RA(81%,5582/6890).CONCLUSION Switching between GLP-1RAs can serve as a practical alternative to treatment intensification for effectively managing T2DM.
基金Beijing Nova Program,Grant/Award Number:20230484842National Natural Science Foundation of China,Grant/Award Number:82470461。
文摘Background : SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. Methods : In vascular smooth muscle cells(VSMCs), we employed gain-and loss-offunction approaches combined with RNA sequencing, autophagy flux assessment, and phenotype characterization. Additionally, we established a mouse model with Sox6 overexpression via adeno-associated virus 2(AAV2) to validate the findings in vivo. Results : We validated the increased expression of SOX6 in hypertension both in vitro and in vivo. Genetic silencing of Sox6 in VSMCs attenuated the phenotypic switching induced by angiotensin Ⅱ. Conversely, in vivo overexpression of Sox6 led to a significant elevation in blood pressure and promoted vascular remodeling. Mechanistically, SOX6 was shown to regulate phenotypic switching via an autophagydependent pathway. Specifically, Sox6 overexpression augmented VSMC autophagy and facilitated phenotypic switching, whereas Sox6 knockdown yielded opposite outcomes. Modulation of autophagy using 3-MA or RAPA could effectively counteract the effect mediated by SOX6. Conclusions : Our findings revealed that SOX6 regulates VSMC plasticity and elevates blood pressure by activating autophagy. Therefore, SOX6 inhibition potentially represents a novel strategy for treating hypertension and vascular remodeling.
基金supported by the Chinese Civil Aircraft Project(No.MJ-2017-S49).
文摘With the advancement of more electric aircraft(MEA)technology,the application of electro-hydrostatic actuators(EHAs)in aircraft actuation systems has become increasingly prevalent.This paper focuses on the modeling and mode switching analysis of EHA used in the primary flight control actuation systems of large aircraft,addressing the challenges associated with mode switching.First,we analyze the functional architecture and operational characteristics of multi-mode EHA,and sumarize the operating modes and implementation methods.Based on the EHA system architecture,we then develop a theoretical mathematical model and a simulation model.Using the simulation model,we analyze the performance of the EHA during normal operation.Finally,the performance of the EHA during mode switching under various functional switching scenarios is investigated.The results indicate that the EHA meets the performance requirements in terms of accuracy,bandwidth,and load capacity.Additionally,the hydraulic cylinder operates smoothly during the EHA mode switching,and the response time for switching between different modes is less than the specified threshold.These findings validate the system performance of multi-mode EHA,which helps to improve the reliability of EHA and the safety of aircraft flight control systems.
基金financially supported by the National Natural Science Foundation of China(Grant No.42377321)。
文摘Cropland is persistently affected by soil loss by water erosion in China,which causes economic loss and threatens soil health.Integrating crop switching and improved management provides a promising strategy for controlling soil loss by water erosion in cropland and promoting sustainable agriculture.However,optimizing crop composition with fewer inputs involves balancing agricultural resource use with environmental costs.Aiming to explore the potential of crop switching as a strategy for mitigating soil erosion in cropland,we develop a spatial optimization model that redistributes the sown areas of different crops in each prefecture-level city based on existing resource availability.Our findings gained from our simulations show that crop switching in China alone can reduce total soil erosion in cropland by an estimated 13%.Furthermore,combining crop switching with improved agricultural management practices can further reduce soil erosion in cropland by an estimated 25%.Cereals including maize,wheat,and rice demonstrate significant potential for reducing soil erosion in cropland.Shifting major maize-producing areas northward could result in a substantial decrease in soil erosion,ranging from 10% to 19% of historical soil erosion in cropland.These results offer implications for formulating regional strategy in mitigating soil erosion challenges in China while maximizing the benefits from existing agricultural resource.
基金supported by the Shandong Provincial Natural Science Foundation(ZR2023QF092)the National Natural Science Foundation of China(62373224).
文摘Dear Editor,This letter introduces an innovative event-triggered secondary control strategy for Microgrid(MG)to address challenges of low inertia and renewable energy integration.Utilizing semi-Markov switching topologies,this method employs semi-Markov jump processes for accurate load forecasting,facilitating adaptive adjustments of distributed generators(DGs)in response to load changes.
基金supported by the National Natural Science Foundation of China(Grant Nos.12104145 and 12374040)。
文摘The thermal switch plays a crucial role in regulating system temperature,protecting devices from overheating,and improving energy efficiency.Achieving a high thermal switching ratio is essential for its practical application.In this study,by utilizing first-principles calculations and semi-classical Boltzmann transport theory,it is found that hole doping with an experimentally achievable concentration of 1.83×10^(14)cm^(-2)can reduce the lattice thermal conductivity of monolayer MoS_(2) from 151.79 W·m^(-1)·K^(-1)to 12.19 W·m^(-1)·K^(-1),achieving a high thermal switching ratio of 12.5.The achieved switching ratio significantly surpasses previously reported values,including those achieved by extreme strain methods.This phenomenon mainly arises from the enhanced lattice anharmonicity,which is primarily contributed by the S atoms.These results indicate that hole doping is an effective method for tuning the lattice thermal conductivity of materials,and demonstrate that monolayer MoS_(2) is a potential candidate material for thermal switches.
文摘This article investigates the time-varying output group formation tracking control(GFTC)problem for heterogeneous multi-agent systems(HMASs)under switching topologies.The objective is to design a distributed control strategy that enables the outputs of the followers to form the desired sub-formations and track the outputs of the leader in each subgroup.Firstly,novel distributed observers are developed to estimate the states of the leaders under switching topologies.Then,GFTC protocols are designed based on the proposed observers.It is shown that with the distributed protocol,the GFTC problem for HMASs under switching topologies is solved if the average dwell time associated with the switching topologies is larger than a fixed threshold.Finally,an example is provided to illustrate the effectiveness of the proposed control strategy.
文摘The event-triggered mechanism serves as an effective discontinuous control strategy for addressing the consensus tracking problem in multiagent systems(MASs).This approach optimizes energy consumption by updating the controller only when some observed errors exceed a predefined threshold.Considering the influence of noise on agent dynamics in complex control environments,this study investigates an event-triggered control scheme for stochastic MASs,where noise is modeled as Brownian motion.Furthermore,the communication topology of the stochastic MASs is assumed to exhibit a Markovian switching mechanism.Analytical criteria are derived to guarantee consensus tracking in the mean square sense,and a numerical example is provided to validate the effectiveness of the proposed control methods.
