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SCS创客教学法下3D打印课程的实践创新研究
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作者 张晖 《中小学信息技术教育》 2026年第1期84-85,共2页
在新一轮基础教育课程改革的背景下,3D打印成为中小学创客教育的一大热潮。本文从创客教育的教学模式入手,探究在小学3D打印课程的教学应用中通过有效的SCS创客教学法,培养学生的空间想象、创意物化、创新思维能力,从而提升学生的整体... 在新一轮基础教育课程改革的背景下,3D打印成为中小学创客教育的一大热潮。本文从创客教育的教学模式入手,探究在小学3D打印课程的教学应用中通过有效的SCS创客教学法,培养学生的空间想象、创意物化、创新思维能力,从而提升学生的整体综合素质。 展开更多
关键词 创客教育 3D打印 scs创客教学法
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动态系统理论的SCS创客教学法对护生临床实践能力的影响
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作者 张立元 周丽娟 +3 位作者 邹莉 王琪 张文珺 韩银风 《泰州职业技术学院学报》 2025年第6期109-112,共4页
目的探索创客教学法对护理实习生临床实践能力的影响。方法采用随机数字表法将2023年8月至2024年8月在我院护理实习生随机分为干预组和对照组,每组80人。干预组使用SCS创客教学法进行授课,对照组采用传统教学方法。收集的数据使用SPSS 2... 目的探索创客教学法对护理实习生临床实践能力的影响。方法采用随机数字表法将2023年8月至2024年8月在我院护理实习生随机分为干预组和对照组,每组80人。干预组使用SCS创客教学法进行授课,对照组采用传统教学方法。收集的数据使用SPSS 26.0软件进行统计分析,符合正态分布的定量资料,使用均数±标准差(x±s)进行描述。干预措施的综合效应比较采用重复测量方差分析方法。结果重复测量方差分析结果显示,两组护生在评判性思维、职业认同感等方面具有显著的统计学差异(P<0.05)。结论基于动态系统理论的SCS创客教学法有助于提升专科及以上护理实习生专业能力、创新能力、自主学习能力、评判性思维能力、职业认同感。 展开更多
关键词 动态系统理论 scs创客教学法 护理实习生
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基于SCS模型绿色屋顶径流系数变化模拟
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作者 张启照 申红彬 《中国农村水利水电》 北大核心 2025年第3期8-13,共6页
绿色屋顶作为城市低影响开发与海绵城市建设的重要基础设施之一,如何建立一种简单实用的降雨径流计算方法,并以径流系数为重要指标,进而评价其降雨径流削减效应是一个重要的问题。根据绿色屋顶不同场次降雨径流实测数据,在SCS模型降雨... 绿色屋顶作为城市低影响开发与海绵城市建设的重要基础设施之一,如何建立一种简单实用的降雨径流计算方法,并以径流系数为重要指标,进而评价其降雨径流削减效应是一个重要的问题。根据绿色屋顶不同场次降雨径流实测数据,在SCS模型降雨径流深计算公式的基础上,进一步推导建立了径流系数的计算表达式,并采用事件分析法,通过合理确定初损量以反推计算当时可能最大滞留量,分析当时可能最大滞留量随时间的变化规律。结果表明,初损量与当时可能最大滞留量基本呈线性关系,平均初损率约为0.28;当时可能最大滞留量在降雨期受雨水截留作用会有所减小,随后在非降雨期逐步得到恢复,且总体呈现出初始恢复速率较快、随后逐渐降低、最后趋近于0的变化趋势,据此推导建立了当时可能最大滞留量随时间(包括降雨期与非降雨期)变化的计算表达式。基于SCS模型径流深与径流系数计算公式,结合绿色屋顶当时可能最大滞留量随时间变化的计算表达式,对绿色屋顶不同场次降雨径流深与径流系数进行连续演算模拟,并分别采用确定性系数R2与Nash-Sutcliffe效率系数NSE对模型效果进行评价。结果表明,不同场次降雨径流深与径流系数计算值与实测值的变化趋势基本吻合,相应R2值分别为0.93、0.85,NSE值分别为0.94、0.85,具有良好的模拟效果。 展开更多
关键词 绿色屋顶 scs模型 事件分析法 当时可能最大滞留量 径流系数
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基于不同SCS模型的植草沟径流模拟应用与比较
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作者 张启照 张勤 《水资源与水工程学报》 北大核心 2025年第6期52-59,共8页
植草沟作为一种重要的城市低影响开发与海绵城市基础设施,如何简化、高效地对其开展径流模拟是一个重要问题。基于SCS模型,通过将植草沟进、出口径流过程转化为径流深,并视进口流量为等效降雨量,以出口径流量与进口径流量比值为径流系数... 植草沟作为一种重要的城市低影响开发与海绵城市基础设施,如何简化、高效地对其开展径流模拟是一个重要问题。基于SCS模型,通过将植草沟进、出口径流过程转化为径流深,并视进口流量为等效降雨量,以出口径流量与进口径流量比值为径流系数,则可实现对植草沟径流量、径流系数等的简化高效模拟。结合植草沟径流削减试验监测数据,分别采用SCS标准及两种改进模型(SCS-RILR模型和SCS-REP模型)开展植草沟径流模拟。结果表明:径流量、径流系数的模拟值与实测值均符合较好,3种模型模拟的径流量确定性系数分别为0.98、0.97、0.99,Nash-Sutcliffe效率系数分别为0.95、0.96、0.96;相应径流系数确定性系数分别为0.92、0.90、0.96,Nash-Sutcliffe效率系数分别为0.89、0.86、0.94。综合比较来看,SCS-REP模型的模拟效果最优,特别是对径流系数的模拟优化效果更为明显,反映出静态下渗与等效雨强变化对植草沟径流系数的影响。 展开更多
关键词 植草沟 径流模拟 scs模型 径流系数 等效降雨 静态下渗
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基于UVM的PCIe交换芯片Switch子系统验证平台的设计 被引量:1
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作者 郑锐 沈剑良 +2 位作者 刘冬培 李智超 曹睿 《计算机应用研究》 北大核心 2025年第5期1480-1489,共10页
PCIe是一种高速串行计算机扩展总线标准,据此设计的PCIe交换芯片可将CPU提供的PCIe通道扩展出更多的PCIe接口。然而,随着PCIe交换芯片设计复杂度和验证向量剧增,传统基于Verilog搭建的验证平台难以实现对逻辑复杂的Switch子系统高效地验... PCIe是一种高速串行计算机扩展总线标准,据此设计的PCIe交换芯片可将CPU提供的PCIe通道扩展出更多的PCIe接口。然而,随着PCIe交换芯片设计复杂度和验证向量剧增,传统基于Verilog搭建的验证平台难以实现对逻辑复杂的Switch子系统高效地验证,且缺乏功能覆盖率模型。为解决上述问题,采用UVM通用验证方法学,搭建了针对PCIe交换芯片中Switch子系统的验证平台,采用层次划分设计,支持覆盖率驱动,且较于一般UVM验证平台作出效率优化。具体而言,首先,对平台组件Reference Model建立通信对象和通信方式进行优化设计;其次,对平台组件ScoreBoard的比对方式和接收报文端口进行改进;最后,依据PCIe协议及交换芯片特点,对功能点进行梳理分类后针对性地设计了测试用例,对Switch子系统进行全面验证。经信号波形及覆盖率数据的分析表明,改进后的验证平台在没有人为过滤的情况下实现了96.8%的代码覆盖率和100%的功能覆盖率,仿真时间平均减少了约10%。该平台显著提升了验证效率,高效地支撑了PCIe交换芯片的验证工作,为相关UVM验证平台的搭建提供了参考。 展开更多
关键词 PCIe交换芯片 switch子系统 UVM验证平台 reference model ScoreBoard 覆盖率
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Electropolymerized dopamine-based memristors using threshold switching behaviors for artificial current-activated spiking neurons 被引量:1
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作者 Bowen Zhong Xiaokun Qin +4 位作者 Zhexin Li Yiqiang Zheng Lingchen Liu Zheng Lou Lili Wang 《Journal of Semiconductors》 2025年第2期98-103,共6页
Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely us... Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems. 展开更多
关键词 ELECTROPOLYMERIZATION POLYDOPAMINE MEMRISTOR threshold switching spiking voltage artificial neuron
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A Comprehensive Review of Torque and Speed Control Strategies for Switched Reluctance Motor Drives 被引量:1
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作者 Sreeram K Preetha P K +1 位作者 Javier Rodríguez-García Carlosálvarez-Bel 《CES Transactions on Electrical Machines and Systems》 2025年第1期46-75,共30页
Switched Reluctance Motors(SRMs),outfitted with rugged construction,good speed range,high torque density,and rare earth-free nature that outweigh induction motors(IM)and permanent magnet synchronous motor(PMSM),afford... Switched Reluctance Motors(SRMs),outfitted with rugged construction,good speed range,high torque density,and rare earth-free nature that outweigh induction motors(IM)and permanent magnet synchronous motor(PMSM),afford a broad range of applications in the domain of electric vehicles(EVs).Standard copper magnetic wire and low-carbon steel laminations are used to construct SRMs,which give them high efficiency in the range of 85-95%.Despite SRM's desirable features over traditional motor-speed drives,high torque ripples and radial distortions constrain their deployment in EVs.Precise rotor position is imperative for effective management of the speed and torque of SRMs.This paper provides an illustrative compendium on review of the torque-speed control and ripple mitigation techniques using design enhancements and control methods for SRM drives for EV applications.The various schemes were evaluated on their performance metricsoperational speed range,control complexity,practical realization,need for pre-stored parameters(look-up tables of current,inductance and torque profiles)and motor controller memory requirements.The findings provide valuable insights into balancing the gains and trade-offs associated with EV applications.Furthermore,they pinpoint opportunities for enhancement by analyzing the cost and technical aspects of different SRM controllers. 展开更多
关键词 Electric vehicles switched reluctance motor Speed control Torque control Traction motor Torque ripple
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Grid-Connected/Islanded Switching Control Strategy for Photovoltaic Storage Hybrid Inverters Based on Modified Chimpanzee Optimization Algorithm
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作者 Chao Zhou Narisu Wang +1 位作者 Fuyin Ni Wenchao Zhang 《Energy Engineering》 EI 2025年第1期265-284,共20页
Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,th... Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization algorithm.The proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop control.Then,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control strategy.Precise pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid voltage.Additionally,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee algorithm.These operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load transients.This strategy effectively mitigated transient voltage and current surges during mode transitions.Consequently,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid inverter.The enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability. 展开更多
关键词 Photovoltaic storage hybrid inverters modified chimpanzee optimization algorithm droop control seamless switching
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SCS创客教学法在中职Web前端开发课程中的应用研究
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作者 孟艳梅 余秋冬 《电脑与电信》 2025年第7期69-73,79,共6页
为提升中职Web前端开发课程的教学效果,满足行业对创新型技术技能人才的需求,本研究将SCS创客教学法引入教学实践。研究方法上,采用对比实验法,选取两个初始水平相当的中职班级,实验班实施基于SCS创客教学法的教学设计,对照班沿用传统... 为提升中职Web前端开发课程的教学效果,满足行业对创新型技术技能人才的需求,本研究将SCS创客教学法引入教学实践。研究方法上,采用对比实验法,选取两个初始水平相当的中职班级,实验班实施基于SCS创客教学法的教学设计,对照班沿用传统教学法。研究结果发现,实验班学生在课堂参与率、自主开发创新交互功能的比例以及项目代码完整度方面均显著优于对照班。结论表明,SCS创客教学法能有效激发中职学生学习兴趣,显著提升其实践能力与创新能力,并强化团队协作精神与职业素养,为中职Web前端开发课程改革提供了有效的实践路径。 展开更多
关键词 scs创客教学法 Web前端开发 中职教育
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New Controllability Criteria for Linear Switched and Impulsive Systems
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作者 Jiayuan Yan Bin Hu +2 位作者 Zhi-Hong Guan Yandong Hou Lei Shi 《IEEE/CAA Journal of Automatica Sinica》 2025年第4期830-832,共3页
Dear Editor,In this letter,several novel controllability results for a class of linear switched and impulsive systems are established.Different from the developed controllability conditions in most existing literature... Dear Editor,In this letter,several novel controllability results for a class of linear switched and impulsive systems are established.Different from the developed controllability conditions in most existing literature,the important role of switched and impulsive time sequence is considered.Applying the relevant geometric theory of matrix,a necessary and sufficient criterion for the controllability is firstly developed to judge when the controllability of such systems is affected by switched and impulsive time sequence.Furthermore,we further obtain a sufficient controllability condition that can be used to verify the controllability of such systems regardless of the switched and impulsive time sequence.Finally,a numerical example is given to verify the obtained theoretical results. 展开更多
关键词 switched systems CONTROLLABILITY linear switched impulsive systems switched impulsive time sequence impulsive systems linear systems developed controllability conditions switched impulsive time
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基于SCS模型的区域尺度内涝风险格局构建及应用——以山西运城为例
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作者 王敏 《福建理工大学学报》 2025年第6期607-612,共6页
全球气候变化使得极端天气增加,加剧了城市内涝风险。以山西运城为案例,基于“无源淹没”理论,将宏观尺度低数据需求的SCS-CN与ArcGIS模型融合,通过识别易涝区内建设用地和农业用地的分布与占比定义流域内涝风险指数,识别不同程度的雨... 全球气候变化使得极端天气增加,加剧了城市内涝风险。以山西运城为案例,基于“无源淹没”理论,将宏观尺度低数据需求的SCS-CN与ArcGIS模型融合,通过识别易涝区内建设用地和农业用地的分布与占比定义流域内涝风险指数,识别不同程度的雨洪灾害风险区。提出“识别内涝风险区域、疏通雨洪径流廊道、控制生态战略点”的规划策略,重构“面-线-点”城市防涝减灾格局,为提前规划布局相应的基础设施,增强抵御暴雨的能力奠定基础。 展开更多
关键词 无源淹没 scs模型 运城市 “面-线-点”策略
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面向“网页设计与制作”课程的SCS创客教学法研究
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作者 余思怡 《计算机应用文摘》 2025年第18期17-19,共3页
针对“网页设计与制作”课程中学生实践能力不足、创新意识不强等问题,文章提出一种基于SCS创客教学法的教学策略。首先应用层次分析法(AHP)对教学目标进行权重评估,突出课程重点;其次采用模糊综合评价法对学生的学习过程与成果进行多... 针对“网页设计与制作”课程中学生实践能力不足、创新意识不强等问题,文章提出一种基于SCS创客教学法的教学策略。首先应用层次分析法(AHP)对教学目标进行权重评估,突出课程重点;其次采用模糊综合评价法对学生的学习过程与成果进行多维度评价,实现教学反馈优化;最后利用数据挖掘技术分析学生的学习行为与学习效果的关联,构建教学改进模型。实验结果表明,应用该方法后,实验班学生的网页作品完成度平均提升18.7%,创新设计得分提升22.5%,其实践能力与创新意识显著增强。 展开更多
关键词 scs创客教学法 网页设计与制作 实践能力培养 教学效果评价
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Finite-Time Stability of Impulsive and Switched Hybrid Systems With Delay-Dependent Impulses
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作者 Taixiang Zhang Jinde Cao +1 位作者 Mahmoud Abdel-Aty Ardak Kashkynbayev 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期466-468,共3页
Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimati... Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimating settling-time function (STF) of the hybrid systems.When switching dynamics are FTS and impulsive dynamics involve destabilizing delay-dependent impulses, the FTS is retained if the impulses occur infrequently. 展开更多
关键词 finite time stability delay dependent impulses hybrid systemswhen switching dynamics impulsive dynamics impulsive switched hybrid systems switched systems lyapunov method
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Enantiomeric organic amine-borane adduct crystals with room-temperature multi-channel switches
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作者 Zi-Yi Yu Gen-Feng Li +4 位作者 Zhe-Kun Xu Lipeng Long Yan Qin Zi-Yi Du Zhong-Xia Wang 《Chinese Journal of Structural Chemistry》 2025年第11期46-52,共7页
Stimuli-responsive materials offer significant potential for high-security encryption,smart sensors,and optoelectronic switching due to their reversible state transitions triggered by external stimuli(temperature,ligh... Stimuli-responsive materials offer significant potential for high-security encryption,smart sensors,and optoelectronic switching due to their reversible state transitions triggered by external stimuli(temperature,light,or electric fields).Combining quasi-spherical molecular design with chiral engineering,we designed enantiomeric organic amine-borane adduct crystals exhibiting multi-channel switching behavior at room temperature.The strategic introduction of intramolecular hydrogen bonding and chirality in engineered R/S-HQNB crystals successfully enables room-temperature structural phase transitions.This transition is coupled with pronounced onoff switching in dielectric,SHG,and SHG-CD responses,demonstrating practical application potential through ambient-temperature operation,which is rarely documented in pure small molecule organic crystals.This advance establishes a pathway for functional organic materials design and enables chiral optical applications with integrated stimuli-responsive capabilities. 展开更多
关键词 Enantiomeric amine-borane adduct Structural phase transition Dielectric switching SHG switching SHG-CD
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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr_(2)TiAlC_(2) saturable absorber
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作者 Ahmed Shakir AL-HITI Hiba HASSAN 《Optoelectronics Letters》 2025年第1期7-12,共6页
We demonstrated a new type of MAX phase material,chromium titanium aluminum carbide(Cr_(2)TiAlC_(2)) polymer film,to generate a passively Q-switched erbium-doped fiber laser(EDFL).The film thickness was measured to be... We demonstrated a new type of MAX phase material,chromium titanium aluminum carbide(Cr_(2)TiAlC_(2)) polymer film,to generate a passively Q-switched erbium-doped fiber laser(EDFL).The film thickness was measured to be around 45 μm,which was fabricated using the embedding method with polyvinyl alcohol(PVA) polymer as hoster.The saturable absorber(SA) film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm,respectively.The Q-switching pulse duration could be varied from 2.46 μs to 770 ns,while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW.The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW,respectively. 展开更多
关键词 switchED pulse fiber
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Time-Varying Formation Tracking Control of Heterogeneous Multi-Agent Systems With Intermittent Communications and Directed Switching Networks
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作者 Yuhan Wang Zhuping Wang +1 位作者 Hao Zhang Huaicheng Yan 《IEEE/CAA Journal of Automatica Sinica》 2025年第1期294-296,共3页
Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present so... Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems. 展开更多
关键词 switched systems time varying formation tracking directed switching networks heterogeneous multi agent systems intermittent communications exponential stability
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Stability,Control and Fault Diagnosis of Switched Linear Parameter Varying Systems:A Survey
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作者 Yanzheng Zhu Junxing Che +3 位作者 Fen Wu Xinkai Chen Weixing Zheng Donghua Zhou 《IEEE/CAA Journal of Automatica Sinica》 2025年第9期1745-1761,共17页
Switched linear parameter varying(LPV)systems have,in recent years,inspired a great number of research endeavors owing to their excellent ability to approximate nonlinear systems and handle complex hybrid dynamics in ... Switched linear parameter varying(LPV)systems have,in recent years,inspired a great number of research endeavors owing to their excellent ability to approximate nonlinear systems and handle complex hybrid dynamics in system analysis and synthesis.Nevertheless,numerous difficulties and challenges are also encountered due to the reciprocal effects of switching signals and scheduling parameters in the analysis and synthesis of switched LPV systems.In this paper,the standard description and specific characteristics of switched LPV systems are first introduced.Then,the main methodologies are proposed in the literature to cope with stability and performance analysis,control synthesis,as well as fault diagnosis and fault-tolerant control issues,and the typical applications in various fields are surveyed.Finally,several key open problems and current research activities are also discussed to elucidate the potential research directions in the future. 展开更多
关键词 Control synthesis fault diagnosis Lyapunov method STABILITY switched linear parameter varying(LPV)systems switching LPV control
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SCS模型CN值优化方法研究——以丹江流域为例
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作者 卓静 胡皓 +1 位作者 王智 马楠 《水土保持研究》 北大核心 2025年第6期290-296,共7页
[目的]探寻SCS模型在秦岭流域地表径流模拟中的适用性,为秦岭流域地表径流估算提供技术支撑。[方法]基于2011年103场降雨径流观测数据,分别通过观测值公式模拟和多元回归模型两种方法对CN进行优化,并分析优化后CN反演的地表径流精度。[... [目的]探寻SCS模型在秦岭流域地表径流模拟中的适用性,为秦岭流域地表径流估算提供技术支撑。[方法]基于2011年103场降雨径流观测数据,分别通过观测值公式模拟和多元回归模型两种方法对CN进行优化,并分析优化后CN反演的地表径流精度。[结果](1)研究区水文土壤类型为壤土;土地利用以落叶阔叶林为主,占整个研究区面积的61.85%;全年土壤湿润程度以干旱为主,占比高达76.70%;CN值与降雨量和前5日降雨量存在显著正相关性。(2)利用观测数据公式模拟的CN值模拟精度明显高于直接查表和多元回归模型的模拟精度,且数据误差均在可利用范围之内。(3)降雨径流较大时的样本模拟精度低于降雨地表径流较小时的样本模拟精度。[结论] SCS模型应用到秦岭地区的地表径流估算中是可行的,优化后的CN值,可为SCS模型在丹江流域地表径流的估算提供支撑。 展开更多
关键词 scs-CN模型 丹江流域 优化方法
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Dual-responsive Flexible Dielectric Switching Composites for Overheating Warning and Small Deformation Monitoring
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作者 Chuan-Yu Jiang Hai-Rong Li +6 位作者 Yu Peng Liu-Yang Zhang Wu-Hou Fan Luo-Xin Wang Ming Jiang Zi-Qing Cai Li-Jie Dong 《Chinese Journal of Polymer Science》 2025年第10期1885-1893,共9页
The phenomena of thermal runaway and accidental deformation due to external stresses in lithium batteries or film capacitors consti-tute their primary failure mechanisms.Therefore,monitoring and early warning of overh... The phenomena of thermal runaway and accidental deformation due to external stresses in lithium batteries or film capacitors consti-tute their primary failure mechanisms.Therefore,monitoring and early warning of overheating or localized strain are of great value for the safe use of lithium batteries or film capacitors;however,this function usually requires a system of multiple complex sensors.The realization of the above multiple hazards using a single sensor for monitoring and alarm functions has not been reported.Here,we exploit the thermally induced conductivity and modulus change during solid-liquid conversion of low melting point polyalloys to modulate the electronic relaxation polariza-tion and interfacial polarization in the composites for dielectric switching,and the reduction of alloy particle spacing during bending/compres-sive strain can be used to generate switchable tunneling effects for insulator-conductor transition.By synergizing dielectric switching and insula-tor-conductor transition,the final flexible thermoplastic polyurethane elastomer/low-melting-point polyalloy composite film achieves the func-tional integration of multi-level overheating warning and small deformation monitoring. 展开更多
关键词 Dielectric switching Insulator-conductor transition Polarization OVERHEATING DEFORMATION
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SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy
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作者 Qianhui Ling Xilan Dong +5 位作者 Liyan Mao Chengjun Huang Linjing Cong Haizeng Zhang Jun Cai Zhenzhen Chen 《Animal Models and Experimental Medicine》 2025年第8期1400-1415,共16页
Background : SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. Methods : In vascular smooth ... Background : SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. Methods : In vascular smooth muscle cells(VSMCs), we employed gain-and loss-offunction approaches combined with RNA sequencing, autophagy flux assessment, and phenotype characterization. Additionally, we established a mouse model with Sox6 overexpression via adeno-associated virus 2(AAV2) to validate the findings in vivo. Results : We validated the increased expression of SOX6 in hypertension both in vitro and in vivo. Genetic silencing of Sox6 in VSMCs attenuated the phenotypic switching induced by angiotensin Ⅱ. Conversely, in vivo overexpression of Sox6 led to a significant elevation in blood pressure and promoted vascular remodeling. Mechanistically, SOX6 was shown to regulate phenotypic switching via an autophagydependent pathway. Specifically, Sox6 overexpression augmented VSMC autophagy and facilitated phenotypic switching, whereas Sox6 knockdown yielded opposite outcomes. Modulation of autophagy using 3-MA or RAPA could effectively counteract the effect mediated by SOX6. Conclusions : Our findings revealed that SOX6 regulates VSMC plasticity and elevates blood pressure by activating autophagy. Therefore, SOX6 inhibition potentially represents a novel strategy for treating hypertension and vascular remodeling. 展开更多
关键词 AUTOPHAGY HYPERTENSION SOX6 VSMC phenotypic switching
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