Increasing access to locally produced, safe, nutritious and affordable complementary foods is essential to combat micronutrient deficiencies in young children in low- and middle-income countries. Two formulations of s...Increasing access to locally produced, safe, nutritious and affordable complementary foods is essential to combat micronutrient deficiencies in young children in low- and middle-income countries. Two formulations of sweets based on jujube, baobab fruit powder and sweet potato puree were produced, and their nutritional values and sensory properties such as taste, smell, color and acceptability were assessed. The formulation containing the most jujube powder, baobab fruit and sweet potato puree gave the best nutritional value. The sweets are rich in calcium (259.80 mg/100 g), magnesium (67.98 mg/100 g), potassium (782.04 mg/100 g), vitamin C (32.37 mg/100 g), iron (6.45 g mg/100 g) and zinc (0.97 mg/100 g). Sensory tests on the two formulations showed acceptability scores ranging from 81.26% to 84.58%, well above the minimum acceptable threshold. Candies with jujube, baobab fruit powder and sweet potato puree could be an alternative for preventing micronutrient deficiencies.展开更多
SWEET (sugars will eventually be exported transporters)是植物中新发现的一类编码糖转运蛋白的基因,它在植物生长发育及糖代谢过程中发挥重要作用。该基因家族在木薯(Manihot esculenta)中尚未有详细的报道。本研究从Phytozome数据...SWEET (sugars will eventually be exported transporters)是植物中新发现的一类编码糖转运蛋白的基因,它在植物生长发育及糖代谢过程中发挥重要作用。该基因家族在木薯(Manihot esculenta)中尚未有详细的报道。本研究从Phytozome数据库获得了28个木薯SWEET候选基因并对其进行生物信息学分析,在华南124的木薯苗中通过荧光定量实验检测SWEET基因在旱胁迫下的表达水平。结果发现木薯SWEET基因被分为4簇,主要分布在第6条和第14条染色体上,编码234 aa与302 aa之间的氨基酸序列;木薯SWEET基因家族的表达在旱胁迫条件下发生了变化,其中明显上调的基因有9个,包括MeSWEET1b、MeSWEET2a、MeSWEET6、MeSWEET9a、MeSWEET9b、MeSWEET12、MeSWEET15a、MeSWEET15b和MeSWEET16c;而表达量明显下调的基因也有9个,为MeSWEET2b、MeSWEET3b、MeSWEET4、MeSWEET7、MeSWEET11、MeSWEET16a、MeSWEET16b、MeSWEET17a和MeSWEET17c。这些结果为进一步阐明SWEET基因家族在木薯中的功能提供理论依据。展开更多
If we were to say,“I am giving something sweet to someone who is verysweet,”then I think the meaning of this expression would become immedi-ately clear.We say it when giving something sweet to a person-usually tochi...If we were to say,“I am giving something sweet to someone who is verysweet,”then I think the meaning of this expression would become immedi-ately clear.We say it when giving something sweet to a person-usually tochildren or someone considered very wonderful.“I’ve been saving this展开更多
SWEET(sugars will eventually be exported transporters)蛋白是近年来鉴定的新型糖转运蛋白,在植物生长发育和果实品质形成过程中有重要作用。为探究金柑SWEET基因家族特点及其在果实发育过程中的表达,从金柑基因组数据库中鉴定出17个...SWEET(sugars will eventually be exported transporters)蛋白是近年来鉴定的新型糖转运蛋白,在植物生长发育和果实品质形成过程中有重要作用。为探究金柑SWEET基因家族特点及其在果实发育过程中的表达,从金柑基因组数据库中鉴定出17个SWEET成员,生物信息学分析表明金柑SWEET基因家族多数成员具有典型的7次跨膜螺旋结构,属于疏水碱性蛋白,在基序和结构域上相对保守。进化分析表明金柑SWEET成员可以分为4类。蛋白质互作网络分析发现FhSWEET16b是重要的核心家族成员。基因表达分析发现FhSWEET1、FhSWEET2b、FhSWEET15和FhSWEET16a在果实发育过程中表达量较高,可能在金柑果实糖分积累中起关键作用。本研究结果为进一步分析柑橘SWEET基因调控果实糖积累的分子机制提供基础。展开更多
Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sw...Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity.展开更多
目的分析尼拉帕利所致药物不良反应(ADR)的发生情况及其临床特点。方法检索中国知网、万方、维普、PubMed、Web of Science数据库中收录的尼拉帕利致ADR个案报道,并对ADR的类型、发生时间、合并用药情况进行分析。结果共筛选出有效文献8...目的分析尼拉帕利所致药物不良反应(ADR)的发生情况及其临床特点。方法检索中国知网、万方、维普、PubMed、Web of Science数据库中收录的尼拉帕利致ADR个案报道,并对ADR的类型、发生时间、合并用药情况进行分析。结果共筛选出有效文献8篇,涉及研究对象共计13例。13例患者年龄43~82岁。其中3例患者合并使用其他药物,其他患者不详。12例患者用药剂量在常规范围内,1例患者的相关信息缺失。在不良反应发生时间已知的患者中,多数患者在用药后1个月内出现ADR。13例患者中,11例患者出现血液系统疾病(10例为血小板减少,1例为全血细胞减少),另有1例出现皮肤Sweet综合征,1例出现间质性肺病。结论尼拉帕利引起的ADR需引起临床高度重视,应加强用药监测,以减少潜在致命性ADR的发生。展开更多
Sweet cherry(Prunus avium)represents a significant stone fruit crop in temperate regions worldwide.While molecular breeding has progressed substantially following the initial sweet cherry genome release,existing genom...Sweet cherry(Prunus avium)represents a significant stone fruit crop in temperate regions worldwide.While molecular breeding has progressed substantially following the initial sweet cherry genome release,existing genome assemblies contain unresolved gaps and comprise consensus chimeric sequences that fail to differentiate haplotype alleles,significantly constraining research on important agronomic trait inheritance.This study presents a phased-resolved telomere-to-telomere reference genome of sweet cherry‘Tieton’.The assembly anchors 653.03 Mb of sequence onto 16 pseudochromosomes representing two haplotypes,with 67,012 coding genes identified(33,777 in hapA and 33,235 in hapB).The genome demonstrates superior quality metrics,including a consensus accuracy exceeding QV44,contig N50 above 17.94 Mb,Benchmarking Universal Single-Copy Orthologs completeness of 98.7%,and a long terminal repeat(LTR)assembly index exceeding 20.This genome provides phased and annotated chromosome pairs,offering a comprehensive view of sweet cherry’s diploid genome organization.Utilizing this reference genome,we identified a large fragment deletion associated with yellow-skinned fruit in sweet cherry‘13-33’.This resource will significantly enhance breeding efforts and genetic research in sweet cherries.展开更多
Conversation A(in the break room)Sara:Do I see a picture of a pie?Greg:Youdo.I'm looking at achart of people'sfavoritefall sweettreats.Sara:Yummy!Applepie ismyfavorite.Greg:It'salsothefavoriteof 30percento...Conversation A(in the break room)Sara:Do I see a picture of a pie?Greg:Youdo.I'm looking at achart of people'sfavoritefall sweettreats.Sara:Yummy!Applepie ismyfavorite.Greg:It'salsothefavoriteof 30percentofpeople.This chartsays that.Sara:Well,apple pie is great.展开更多
Bud endodormancy represents an ecological adaptation mechanism in perennial deciduous fruit trees to endure winter cold conditions.Sucrose serves a crucial role in bud endodormancy as both an energy metabolizer and si...Bud endodormancy represents an ecological adaptation mechanism in perennial deciduous fruit trees to endure winter cold conditions.Sucrose serves a crucial role in bud endodormancy as both an energy metabolizer and signaling molecule.Sugars Will Eventually be Exported Transporters(SWEETs)function as sugar-efflux transporters that respond to environmental stimuli and contribute to plant growth and development.While SWEET gene families have been identified in various plant species for sugar transport regulation,their mechanism in regulating peach bud endodormancy remains undefined.In this study,we identified 15 SWEET genes in peach.The nomenclature was established through homologous alignment with the Arabidopsis SWEET gene family,resulting in four distinct clades through phylogenetic analysis.Covariance correlation analysis revealed 6 and 12 collinear SWEET genes in peach and Arabidopsis,respectively,forming 13 collinear gene pairs.Real-time quantitative polymerase chain reaction(RT-qPCR)analysis demonstrated significantly elevated expression of PpSWEET6 during peach bud endodormancy release,correlating positively with sucrose content.Transient overexpression of PpSWEET6 enhanced peach bud endodormancy release,while overexpressing PpSWEET6 in Arabidopsis enhanced seed germination and flowering.Y2H and luciferase complementation imaging(LCI)assays confirmed PpSWEET6 interacted with PpABF2.Additionally,dual luciferase reporter(DLR)assays showed that PpSWEET6 significantly decreased the activation of PpDAM6(key dormancy-inducing gene)through PpABF2,thereby modulating peach bud endodormancy release.These findings advance our understanding of SWEET genes in peach bud endodormancy regulation.展开更多
Located in the heart of southern China’s Jiangnan region,Wuxi is a famous city rich in history and culture during the Spring Festival,showing a unique charm.One of the most interesting features of Wuxi’s New Year ce...Located in the heart of southern China’s Jiangnan region,Wuxi is a famous city rich in history and culture during the Spring Festival,showing a unique charm.One of the most interesting features of Wuxi’s New Year celebrations lies in its sweet taste.Unlike many other parts of China where spicy(辛辣)or savory delicacies dominate the feast,Wuxi boasts a tradition of sweet foods during the Spring Festival.展开更多
文摘Increasing access to locally produced, safe, nutritious and affordable complementary foods is essential to combat micronutrient deficiencies in young children in low- and middle-income countries. Two formulations of sweets based on jujube, baobab fruit powder and sweet potato puree were produced, and their nutritional values and sensory properties such as taste, smell, color and acceptability were assessed. The formulation containing the most jujube powder, baobab fruit and sweet potato puree gave the best nutritional value. The sweets are rich in calcium (259.80 mg/100 g), magnesium (67.98 mg/100 g), potassium (782.04 mg/100 g), vitamin C (32.37 mg/100 g), iron (6.45 g mg/100 g) and zinc (0.97 mg/100 g). Sensory tests on the two formulations showed acceptability scores ranging from 81.26% to 84.58%, well above the minimum acceptable threshold. Candies with jujube, baobab fruit powder and sweet potato puree could be an alternative for preventing micronutrient deficiencies.
文摘SWEET (sugars will eventually be exported transporters)是植物中新发现的一类编码糖转运蛋白的基因,它在植物生长发育及糖代谢过程中发挥重要作用。该基因家族在木薯(Manihot esculenta)中尚未有详细的报道。本研究从Phytozome数据库获得了28个木薯SWEET候选基因并对其进行生物信息学分析,在华南124的木薯苗中通过荧光定量实验检测SWEET基因在旱胁迫下的表达水平。结果发现木薯SWEET基因被分为4簇,主要分布在第6条和第14条染色体上,编码234 aa与302 aa之间的氨基酸序列;木薯SWEET基因家族的表达在旱胁迫条件下发生了变化,其中明显上调的基因有9个,包括MeSWEET1b、MeSWEET2a、MeSWEET6、MeSWEET9a、MeSWEET9b、MeSWEET12、MeSWEET15a、MeSWEET15b和MeSWEET16c;而表达量明显下调的基因也有9个,为MeSWEET2b、MeSWEET3b、MeSWEET4、MeSWEET7、MeSWEET11、MeSWEET16a、MeSWEET16b、MeSWEET17a和MeSWEET17c。这些结果为进一步阐明SWEET基因家族在木薯中的功能提供理论依据。
文摘If we were to say,“I am giving something sweet to someone who is verysweet,”then I think the meaning of this expression would become immedi-ately clear.We say it when giving something sweet to a person-usually tochildren or someone considered very wonderful.“I’ve been saving this
文摘SWEET(sugars will eventually be exported transporters)蛋白是近年来鉴定的新型糖转运蛋白,在植物生长发育和果实品质形成过程中有重要作用。为探究金柑SWEET基因家族特点及其在果实发育过程中的表达,从金柑基因组数据库中鉴定出17个SWEET成员,生物信息学分析表明金柑SWEET基因家族多数成员具有典型的7次跨膜螺旋结构,属于疏水碱性蛋白,在基序和结构域上相对保守。进化分析表明金柑SWEET成员可以分为4类。蛋白质互作网络分析发现FhSWEET16b是重要的核心家族成员。基因表达分析发现FhSWEET1、FhSWEET2b、FhSWEET15和FhSWEET16a在果实发育过程中表达量较高,可能在金柑果实糖分积累中起关键作用。本研究结果为进一步分析柑橘SWEET基因调控果实糖积累的分子机制提供基础。
文摘Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity.
文摘目的分析尼拉帕利所致药物不良反应(ADR)的发生情况及其临床特点。方法检索中国知网、万方、维普、PubMed、Web of Science数据库中收录的尼拉帕利致ADR个案报道,并对ADR的类型、发生时间、合并用药情况进行分析。结果共筛选出有效文献8篇,涉及研究对象共计13例。13例患者年龄43~82岁。其中3例患者合并使用其他药物,其他患者不详。12例患者用药剂量在常规范围内,1例患者的相关信息缺失。在不良反应发生时间已知的患者中,多数患者在用药后1个月内出现ADR。13例患者中,11例患者出现血液系统疾病(10例为血小板减少,1例为全血细胞减少),另有1例出现皮肤Sweet综合征,1例出现间质性肺病。结论尼拉帕利引起的ADR需引起临床高度重视,应加强用药监测,以减少潜在致命性ADR的发生。
基金supported by the Shandong Provincial Natural Science Foundation,China(ZR2021MC117)the Key R&D Program of Shandong Province,China(2022TZXD006).
文摘Sweet cherry(Prunus avium)represents a significant stone fruit crop in temperate regions worldwide.While molecular breeding has progressed substantially following the initial sweet cherry genome release,existing genome assemblies contain unresolved gaps and comprise consensus chimeric sequences that fail to differentiate haplotype alleles,significantly constraining research on important agronomic trait inheritance.This study presents a phased-resolved telomere-to-telomere reference genome of sweet cherry‘Tieton’.The assembly anchors 653.03 Mb of sequence onto 16 pseudochromosomes representing two haplotypes,with 67,012 coding genes identified(33,777 in hapA and 33,235 in hapB).The genome demonstrates superior quality metrics,including a consensus accuracy exceeding QV44,contig N50 above 17.94 Mb,Benchmarking Universal Single-Copy Orthologs completeness of 98.7%,and a long terminal repeat(LTR)assembly index exceeding 20.This genome provides phased and annotated chromosome pairs,offering a comprehensive view of sweet cherry’s diploid genome organization.Utilizing this reference genome,we identified a large fragment deletion associated with yellow-skinned fruit in sweet cherry‘13-33’.This resource will significantly enhance breeding efforts and genetic research in sweet cherries.
文摘Conversation A(in the break room)Sara:Do I see a picture of a pie?Greg:Youdo.I'm looking at achart of people'sfavoritefall sweettreats.Sara:Yummy!Applepie ismyfavorite.Greg:It'salsothefavoriteof 30percentofpeople.This chartsays that.Sara:Well,apple pie is great.
基金funded by the National Key Research and Development Program of China(2018YFD1000104)the Shandong Provincial Fruit Industry Technology System Cultivation and Soil Fertilization Post,China(SDAIT-06-04)the Key R&D Program of Shandong Province(Competitive Innovation Platform),China(2022CXPT017).
文摘Bud endodormancy represents an ecological adaptation mechanism in perennial deciduous fruit trees to endure winter cold conditions.Sucrose serves a crucial role in bud endodormancy as both an energy metabolizer and signaling molecule.Sugars Will Eventually be Exported Transporters(SWEETs)function as sugar-efflux transporters that respond to environmental stimuli and contribute to plant growth and development.While SWEET gene families have been identified in various plant species for sugar transport regulation,their mechanism in regulating peach bud endodormancy remains undefined.In this study,we identified 15 SWEET genes in peach.The nomenclature was established through homologous alignment with the Arabidopsis SWEET gene family,resulting in four distinct clades through phylogenetic analysis.Covariance correlation analysis revealed 6 and 12 collinear SWEET genes in peach and Arabidopsis,respectively,forming 13 collinear gene pairs.Real-time quantitative polymerase chain reaction(RT-qPCR)analysis demonstrated significantly elevated expression of PpSWEET6 during peach bud endodormancy release,correlating positively with sucrose content.Transient overexpression of PpSWEET6 enhanced peach bud endodormancy release,while overexpressing PpSWEET6 in Arabidopsis enhanced seed germination and flowering.Y2H and luciferase complementation imaging(LCI)assays confirmed PpSWEET6 interacted with PpABF2.Additionally,dual luciferase reporter(DLR)assays showed that PpSWEET6 significantly decreased the activation of PpDAM6(key dormancy-inducing gene)through PpABF2,thereby modulating peach bud endodormancy release.These findings advance our understanding of SWEET genes in peach bud endodormancy regulation.
文摘Located in the heart of southern China’s Jiangnan region,Wuxi is a famous city rich in history and culture during the Spring Festival,showing a unique charm.One of the most interesting features of Wuxi’s New Year celebrations lies in its sweet taste.Unlike many other parts of China where spicy(辛辣)or savory delicacies dominate the feast,Wuxi boasts a tradition of sweet foods during the Spring Festival.
