The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of ...The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of β-asarone and eugenol, components of the Chinese herb grassleaf sweetflag rhizome, on PC12 cells. First, PC12 cells were cultured with different concentrations（between 1 × 10–10 M and 1 × 10–5 M） of β-asarone and eugenol. Survival rates of PC12 cells were not significantly affected. Second, PC12 cells incubated with amyloid-beta42, which reduced cell survival, were cultured under the same conditions（1 × 10–6 M β-asarone and eugenol）. The survival rates of PC12 cells significantly increased, while expression levels of the m RNAs for the pro-apoptotic protein Bax decreased, and those for the anti-apoptotic protein Bcl m RNA increased. In addition, the combination of β-asarone with eugenol achieved better results than either component alone. Our experimental findings indicate that both β-asarone and eugenol protect PC12 cells through inhibiting apoptosis, and that the combination of the two is better than either alone.展开更多
Grass leaved Sweetflag (Shi chang pu),a traditional Chinese drug, is dried rhizome of Acorus tatarinowii Schott. and the main active components are αand β asarone.In order to control the interior quality of the Gras...Grass leaved Sweetflag (Shi chang pu),a traditional Chinese drug, is dried rhizome of Acorus tatarinowii Schott. and the main active components are αand β asarone.In order to control the interior quality of the Grass leaved Sweetflag, the HPLC method was built to determine the Contents ofαand β asarone in Grass leaved Sweetflag. The method was superior to the GS/MS method.展开更多
This article examines the presence and uses of plants attested in the Chinese medical tradition in the materia medica literature of classical antiquity.It is based on the consultation of the major ancient compilations...This article examines the presence and uses of plants attested in the Chinese medical tradition in the materia medica literature of classical antiquity.It is based on the consultation of the major ancient compilations on materia medica of Chinese medicine and classical antiquity,specifically Bencao Gangmu by Li Shizhen(16th cent.)and De materia medica by Dioscorides(1st cent.A.D.).The article is divided in three major parts:the identification of plants used in the Chinese medical tradition in the medicine of the Mediterranean World in Antiquity;the analysis of the knowledge of these plants and their origin in classical antiquity;a comparison of the uses of these plants in the Bencao Gangmu and De materia medica.It traces the presence of plants of the Chinese medical tradition in Classical antiquity.Although their exact origin was not known,they were reputed at that time to be native to either India or the Black Sea,two areas that correspond to the ending points of the Silk Road.As for their uses in both traditions,they correspond for some plants,whereas they do not for others because either the uses attested in the Chinese tradition were not preserved on the Mediterranean or different uses appeared in the Mediterranean tradition.These differentiated uses hint at both continuities and ruptures,with the latter resulting from the long journey of the plants from the Chinese World to the Mediterranean and,at the same time,attempts aimed to diversify and optimize the applications of non-native medicinal substances.展开更多
基金financially supported by a grant from Guangdong Provincial Science and Technology Plan Program of China,No.2010B060900085
文摘The major ingredients of grassleaf sweetflag rhizome are β-asarone and eugenol, which can cross the blood-brain barrier and protect neurons. This study aimed to observe the neuroprotective effects and mechanisms of β-asarone and eugenol, components of the Chinese herb grassleaf sweetflag rhizome, on PC12 cells. First, PC12 cells were cultured with different concentrations（between 1 × 10–10 M and 1 × 10–5 M） of β-asarone and eugenol. Survival rates of PC12 cells were not significantly affected. Second, PC12 cells incubated with amyloid-beta42, which reduced cell survival, were cultured under the same conditions（1 × 10–6 M β-asarone and eugenol）. The survival rates of PC12 cells significantly increased, while expression levels of the m RNAs for the pro-apoptotic protein Bax decreased, and those for the anti-apoptotic protein Bcl m RNA increased. In addition, the combination of β-asarone with eugenol achieved better results than either component alone. Our experimental findings indicate that both β-asarone and eugenol protect PC12 cells through inhibiting apoptosis, and that the combination of the two is better than either alone.
文摘Grass leaved Sweetflag (Shi chang pu),a traditional Chinese drug, is dried rhizome of Acorus tatarinowii Schott. and the main active components are αand β asarone.In order to control the interior quality of the Grass leaved Sweetflag, the HPLC method was built to determine the Contents ofαand β asarone in Grass leaved Sweetflag. The method was superior to the GS/MS method.
文摘This article examines the presence and uses of plants attested in the Chinese medical tradition in the materia medica literature of classical antiquity.It is based on the consultation of the major ancient compilations on materia medica of Chinese medicine and classical antiquity,specifically Bencao Gangmu by Li Shizhen(16th cent.)and De materia medica by Dioscorides(1st cent.A.D.).The article is divided in three major parts:the identification of plants used in the Chinese medical tradition in the medicine of the Mediterranean World in Antiquity;the analysis of the knowledge of these plants and their origin in classical antiquity;a comparison of the uses of these plants in the Bencao Gangmu and De materia medica.It traces the presence of plants of the Chinese medical tradition in Classical antiquity.Although their exact origin was not known,they were reputed at that time to be native to either India or the Black Sea,two areas that correspond to the ending points of the Silk Road.As for their uses in both traditions,they correspond for some plants,whereas they do not for others because either the uses attested in the Chinese tradition were not preserved on the Mediterranean or different uses appeared in the Mediterranean tradition.These differentiated uses hint at both continuities and ruptures,with the latter resulting from the long journey of the plants from the Chinese World to the Mediterranean and,at the same time,attempts aimed to diversify and optimize the applications of non-native medicinal substances.
