The importance of continuous healthcare management has significantly accelerated the development of wearable devices for monitoring health-related physical and biochemical markers. Despite extensive research on wearab...The importance of continuous healthcare management has significantly accelerated the development of wearable devices for monitoring health-related physical and biochemical markers. Despite extensive research on wearable devices for physiological and biochemical monitoring, critical issues of power management and device/skin interfacial properties restrict the advancement of personalized healthcare and early disease detection. Here, we report a multimodal sweat monitoring device featuring a real-time display and long-term data analysis based on self-powered format of sweat-activated batteries (SABs). The polyvinyl alcohol-sucrose (PVA-Suc) hydrogel serves as the key component for the SAB, offering not only great long-term adhesive properties for conformable wearability but also significant power generation capabilities. A maximum current density of 44.06 mA cm^(−2) and a maximum power density of 21.89 mW cm^(−2) can be realized for the hydrogel based SAB. The resulting device integrates an advanced colorimetric and electrochemical sensor array to measure pH levels, glucose concentrations, and chloride ion levels in human sweat, with data wirelessly transmitted by Near Field Communication. The self-powering features and multiple mode sensing function offer sufficient power to support real-time monitoring of metabolic biomarkers in sweat, with the ability to visually observe changes in the colorimetric sensors for long-term data monitoring.展开更多
Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications.These two measurements are always done simultaneously in wearable sweat se...Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications.These two measurements are always done simultaneously in wearable sweat sensing platforms.However,concentration measurements of biomarkers are always delayed on the timeline compared with their production,whereas there is no such delay for sweating rate.Thus,a timeline mismatch exists between these two measurements.This means that the concentration vs rate correlation constructed on the basis of such measurements will deviate from the actual correlation.This study demonstrates the existence of this mismatch and explains its cause using sweat Na^(+)measurements.It also proposes an effective approach that applies a point-by-point compensation for the delay between Na+measurements and the real-time sweating rates,such that the data on the repositioned concentration vs time curve correspond to exactly the same point on the timeline as their production.A vison sensor is developed to measure the sweating rate with high accuracy at a frequency of more than 0.1 Hz.Off-body and on-body measurements of sweating rate and Na^(+)concentration are carried out,and concentration–rate correlations are constructed using both measured and repositioned concentration curves.The least squares and random forest methods are employed to fit the constructed correlations and evaluate the reliability of the proposed approach.The use of the repositioned concentration curve gives a constructed correlation that is much closer to the actual one.This study indicates the necessity to rearrange sensor-measured biomarker concentration vs time curves when correlations of concentration with sweating rate need to be constructed and proposes a practical point-by-point data repositioning strategy for doing so.The results presented here will benefit the study of sweat biomarkers with unclear correlations with sweating rate,as well as providing a basis for the development of more reliable sweat-based diagnostic methods.展开更多
The rapid advancement of personalized healthcare brings forth a myriad of self-powered integrated sweat fabric systems.However,challenges such as alkaline by-products,low open-circuit voltage and output power have mad...The rapid advancement of personalized healthcare brings forth a myriad of self-powered integrated sweat fabric systems.However,challenges such as alkaline by-products,low open-circuit voltage and output power have made them unsuit-able for the continuously powering biosensors.Here,we have designed a sweat-activated polyaniline/single-wall carbon nanotube||Zinc(PANI/SWCNTs||Zn)battery fabric featuring multiple redox states.This innovative battery achieves a high open-circuit voltage of 1.2 V within 1.0 s and boasts an impressive power density of 2.5 mW cm^(-2)due to the rapid solid–liquid two-phase electronic/ionic transfer interface.In-depth characterization reveals that the discharge mechanism involves the reduction of emeraldine salt to leucoemeraldine without oxygen reduction.By integrating this system seamlessly,the sweat-activated batteries can directly power a patterned light-emitting diode and a multiplexed sweat biosensor,while wire-lessly transmitting data to a user interface via Bluetooth.This strategic design offers safety warnings and continuous real-time health monitoring for night walking or running.This work paves the way for the development of an efficient and sustainable energy-autonomous electronic fabric system tailored for individual health monitoring.展开更多
Monitoring of sweat pH plays important roles in physiological health,nutritional balance,psychological stress,and sports performance.However,the combination of functional MOFs with phosphorescent material to acquire t...Monitoring of sweat pH plays important roles in physiological health,nutritional balance,psychological stress,and sports performance.However,the combination of functional MOFs with phosphorescent material to acquire the real-time physiological information,as well as the application of dual mode anti-counterfeiting,has seldom been reported.Herein,we developed multifunctional gel films based on MOFs and phosphorescent dyes which responded to H+ions and the related mechanism was studied in detail.Upon exposure to H+,the composite gel film exhibited decreased fluorescent signal but enhanced room temperature phosphorescence(RTP),which could be utilized for sweat pH sensing through a dual-mode.Moreover,multifunctional gel films exhibited a potential application in information encryption and anti-counterfeiting by designing of stimulus responsive multiple patterns.This research provided a new avenue for portable and non-invasive sweat pH monitoring methods while also offering insights into stimulus-responsive multifunctional materials.展开更多
基金Research Grants Council,University Grants Committee,Grant/Award Numbers:11211523,11213721,11215722,RFS2324-1S03National Natural Science Foundation of China,Grant/Award Number:62122002City University of Hong Kong,Grant/Award Numbers:9667199,9667221,9667246,9680322。
文摘The importance of continuous healthcare management has significantly accelerated the development of wearable devices for monitoring health-related physical and biochemical markers. Despite extensive research on wearable devices for physiological and biochemical monitoring, critical issues of power management and device/skin interfacial properties restrict the advancement of personalized healthcare and early disease detection. Here, we report a multimodal sweat monitoring device featuring a real-time display and long-term data analysis based on self-powered format of sweat-activated batteries (SABs). The polyvinyl alcohol-sucrose (PVA-Suc) hydrogel serves as the key component for the SAB, offering not only great long-term adhesive properties for conformable wearability but also significant power generation capabilities. A maximum current density of 44.06 mA cm^(−2) and a maximum power density of 21.89 mW cm^(−2) can be realized for the hydrogel based SAB. The resulting device integrates an advanced colorimetric and electrochemical sensor array to measure pH levels, glucose concentrations, and chloride ion levels in human sweat, with data wirelessly transmitted by Near Field Communication. The self-powering features and multiple mode sensing function offer sufficient power to support real-time monitoring of metabolic biomarkers in sweat, with the ability to visually observe changes in the colorimetric sensors for long-term data monitoring.
基金support from the National Natural Science Foundation of China(Grant No.61901295)the Nanchang Microsystem Institute of Tianjin University.
文摘Accurately correlating the sweating rate and the concentration of biomarkers in sweat is essential in many sweat-based diagnostic applications.These two measurements are always done simultaneously in wearable sweat sensing platforms.However,concentration measurements of biomarkers are always delayed on the timeline compared with their production,whereas there is no such delay for sweating rate.Thus,a timeline mismatch exists between these two measurements.This means that the concentration vs rate correlation constructed on the basis of such measurements will deviate from the actual correlation.This study demonstrates the existence of this mismatch and explains its cause using sweat Na^(+)measurements.It also proposes an effective approach that applies a point-by-point compensation for the delay between Na+measurements and the real-time sweating rates,such that the data on the repositioned concentration vs time curve correspond to exactly the same point on the timeline as their production.A vison sensor is developed to measure the sweating rate with high accuracy at a frequency of more than 0.1 Hz.Off-body and on-body measurements of sweating rate and Na^(+)concentration are carried out,and concentration–rate correlations are constructed using both measured and repositioned concentration curves.The least squares and random forest methods are employed to fit the constructed correlations and evaluate the reliability of the proposed approach.The use of the repositioned concentration curve gives a constructed correlation that is much closer to the actual one.This study indicates the necessity to rearrange sensor-measured biomarker concentration vs time curves when correlations of concentration with sweating rate need to be constructed and proposes a practical point-by-point data repositioning strategy for doing so.The results presented here will benefit the study of sweat biomarkers with unclear correlations with sweating rate,as well as providing a basis for the development of more reliable sweat-based diagnostic methods.
基金supported by the National Natural Science Foundation of China no.T2188101,Gusu’s young leading talent(ZXL2021449)Key industry technology innovation project of Suzhou(SYG202108).
文摘The rapid advancement of personalized healthcare brings forth a myriad of self-powered integrated sweat fabric systems.However,challenges such as alkaline by-products,low open-circuit voltage and output power have made them unsuit-able for the continuously powering biosensors.Here,we have designed a sweat-activated polyaniline/single-wall carbon nanotube||Zinc(PANI/SWCNTs||Zn)battery fabric featuring multiple redox states.This innovative battery achieves a high open-circuit voltage of 1.2 V within 1.0 s and boasts an impressive power density of 2.5 mW cm^(-2)due to the rapid solid–liquid two-phase electronic/ionic transfer interface.In-depth characterization reveals that the discharge mechanism involves the reduction of emeraldine salt to leucoemeraldine without oxygen reduction.By integrating this system seamlessly,the sweat-activated batteries can directly power a patterned light-emitting diode and a multiplexed sweat biosensor,while wire-lessly transmitting data to a user interface via Bluetooth.This strategic design offers safety warnings and continuous real-time health monitoring for night walking or running.This work paves the way for the development of an efficient and sustainable energy-autonomous electronic fabric system tailored for individual health monitoring.
基金supported by the Basic Research Fund for the Central Universities(WK3450000006)the National Natural Science Foundation of China(52373122).
文摘Monitoring of sweat pH plays important roles in physiological health,nutritional balance,psychological stress,and sports performance.However,the combination of functional MOFs with phosphorescent material to acquire the real-time physiological information,as well as the application of dual mode anti-counterfeiting,has seldom been reported.Herein,we developed multifunctional gel films based on MOFs and phosphorescent dyes which responded to H+ions and the related mechanism was studied in detail.Upon exposure to H+,the composite gel film exhibited decreased fluorescent signal but enhanced room temperature phosphorescence(RTP),which could be utilized for sweat pH sensing through a dual-mode.Moreover,multifunctional gel films exhibited a potential application in information encryption and anti-counterfeiting by designing of stimulus responsive multiple patterns.This research provided a new avenue for portable and non-invasive sweat pH monitoring methods while also offering insights into stimulus-responsive multifunctional materials.
