In the present study,cefditoren sodium(CT-Na),the sodium salt form of cefditoren(CT),was selected as the model compound,and cholestyramine resin was employed as the drug carrier to formulate CT-Na-resin complexes.The ...In the present study,cefditoren sodium(CT-Na),the sodium salt form of cefditoren(CT),was selected as the model compound,and cholestyramine resin was employed as the drug carrier to formulate CT-Na-resin complexes.The interaction mechanism between CT-Na and cholestyramine resin was elucidated using scanning electron microscopy(SEM),fourier-transform infrared spectroscopy(FTIR),and differential scanning calorimetry(DSC).Bioadhesive,sustained-release microcapsules were subsequently developed via an emulsification—solvent evaporation technique.Comprehensive characterization of the formulation was conducted,with key quality indices systematically evaluated.Notably,the formulation exhibited minimal leakage(0.07%)after 7 d of storage and retained 94.59%of its drug content over a 6-month period.Pharmacokinetic studies comparing the CT-Na active pharmaceutical ingredient(APl)solution and the self-developed dry suspension revealed a marked extension in drug release for the latter.The dry suspension displayed a delayed T_(max)(3 h vs.2 h),an extended half-life(t_(1/2))(12.44 h vs.4 h),and a moderately reduced peak concentration(C_(max))(3.99μg/mL vs.4.82μg/mL),while achieving a significantly higher overall drug exposure(AUC_(0-24h):50.868μg·h/mL vs.30.281μg·h/mL).These findings indicated that relative to the API solution,the optimized dry suspension provided sustained drug release with improved bioavailability.展开更多
Different dosage forms can significantly impact pharmacokinetics in vivo,leading to varied effects and potential adverse reactions.This study aimed to evaluate the efficacy,safety,and cost-effectiveness of isosorbide ...Different dosage forms can significantly impact pharmacokinetics in vivo,leading to varied effects and potential adverse reactions.This study aimed to evaluate the efficacy,safety,and cost-effectiveness of isosorbide mononitrate sustained-release capsules(IMSRC)combined with conventional treatments,compared to isosorbide mononitrate tablets(IMT)combined with conventional treatments,for managing angina pectoris in patients with coronary heart diseases.A network meta-analysis(NMA)was conducted to assess the efficacy and safety of IMSRC and IMT.Relevant literature was sourced from databases,including PubMed,Embase,Cochrane Library,ScienceDirect,Web of Science,CNKI,Wanfang,and VIP,covering publications up to July 2023.The cost-effectiveness analysis(CEA)was performed from the perspective of China’s healthcare system,utilizing inputs derived from the NMA.The analysis included 15 studies.The NMA results revealed no significant difference in efficacy and safety between IMSRC plus conventional treatments and IMT plus conventional treatments.However,both combinations were more effective than conventional treatments without isosorbide mononitrate.No differences in safety were observed among the three groups.The surface under the cumulative ranking(SUCRA)of the NMA indicated that IMT had a slight edge over IMSRC in the total effective rate of angina pectoris,whereas IMSRC showed higher probabilities for markedly effective rate and ECG effective rate compared to IMT.The incidence of adverse events was ranked as IMT>conventional preparation>IMSRC.The CEA results highlighted that the incremental cost-effectiveness ratios(ICERs)for the markedly effective and total effective rates of angina pectoris were-133.41 and-260.20,respectively.The ICERs for ECG effective rates were-83.34 and-234.24,respectively.In conclusion,while IMSRC combined with conventional treatments and IMT combined with conventional treatments were similar in efficacy and safety,IMSRC proved to be more economical.展开更多
Spinal cord injury is accompanied by a substantial loss of neurons.Cell replacement therapy improves motor and sensory dysfunction by replacing dead neurons,and endogenous neurogenesis is an important cell replacement...Spinal cord injury is accompanied by a substantial loss of neurons.Cell replacement therapy improves motor and sensory dysfunction by replacing dead neurons,and endogenous neurogenesis is an important cell replacement source.Stimulating endogenous neurogenesis is therefore a viable approach for treating spinal cord injury.Given that basic fibroblast growth factor is a potent inducer of neurogenesis,we developed a sustained-release system of basic fibroblast growth factor-chitosan to enhance tissue repair in spinal cord injury.In the present study,we isolated neural stem cells from the spinal cords of neonatal rats and used single-cell RNA sequencing to trace the complete process of neurogenesis under ex vivo culture conditions.Under the influence of basic fibroblast growth factor-chitosan,neural stem cells were able to transition from a quiescent state to an activated state and subsequently differentiate into neuronal precursor cells and immature neurons.Additionally,basic fibroblast growth factor-chitosan significantly enhanced neural stem cell proliferation in vitro and promoted neuronal generation.Subsequent in vivo experiments confirmed the therapeutic efficacy of basic fibroblast growth factor-chitosan in spinal cord injury,demonstrating enhanced neurogenesis and tissue repair.展开更多
Allelochemicals sustained-release microspheres(ACs-SMs)exhibited great inhibition effect on algae,however,few studies have focused on ACs-SMs toxicity on invertebrate.In this study,the effects of single high-concentra...Allelochemicals sustained-release microspheres(ACs-SMs)exhibited great inhibition effect on algae,however,few studies have focused on ACs-SMs toxicity on invertebrate.In this study,the effects of single high-concentration ACs(15 mg/L,SH-ACs),repeated lowconcentration ACs(3×5 mg/L,RL-ACs)and ACs-SMs containing 15 mg/L ACs exposure on the ingestion,incorporation,and digestion of Daphniamagna Straus(DS)were investigated by stable isotope 15N labeling method.Meanwhile,the diversity and abundance of microflora in DS guts were determined by 16S rRNA genes and cloning methods.The results showed that SH-ACs exposure caused 50%and 33.3%death rates for newborn and adult DS,while RL-ACs exposure caused 10%death rate for newborn DS and no obvious effect on the activity of adult DS.And ACs-SMs exposure did not diminish the motility of both newborn and adult DS,indicating the lower acute toxicity of ACs-SMs.Furthermore,SH-ACs inhibited the ingestion(-6.45%),incorporation(-47.1%)and digestion(-53.8%)abilities of DS and reduced the microbial abundance(-27.7%)in DS guts.Compared with SH-ACs,RL-ACs showed relatively low impact on the ingestion(-3.23%),incorporation(-5.89%)and digestion(-23.9%)abilities of DS.Interestingly,ACs-SMs enhanced the ingestion(+9.68%),incorporation(+52.9%)and digestion(+51.3%)abilities of DS and increased the microbial abundance(+10.7%)in DS guts.Overall ACs and ACs-SMs reduced the diversity of microflora in DS guts.In conclusion,ACs-SMs can release ACs sustainably and prolong the sustained release time,which not only effectively reduce the toxicity of ACs,but also had positive effects on DS.展开更多
[Objective]The paper was to screen a new ideal sustained-release,long-lasting and low-toxic pesticide and convenient and efficient pesticide application technology for controlling Ceratovacuna lanigera and Baliathrips...[Objective]The paper was to screen a new ideal sustained-release,long-lasting and low-toxic pesticide and convenient and efficient pesticide application technology for controlling Ceratovacuna lanigera and Baliathrips serratus. [Method]2% Imidacloprid GR were selected and applied in the soil for field efficacy trial. [Result] The optimum dosage of 2% imidacloprid GR was 30 kg/hm^2（ active ingredient 600 g）,which can be mixed with fertilizer（ 30 kg pesticide and 40-80 kg fertilizer per hm^2） once combined with sugarcane planting management or big ridging during February and June. The control effects against C. lanigera and B. serratus could be more than 98. 2% and 81. 1%,respectively. The actual yield and sugar content in various pesticide treatments were increased by 33 390 kg/hm^2 and 6. 6% respectively compared to blank control. [Conclusion]2% imidacloprid GR has good control effects on C. lanigera and B. serratus. It is a new pesticide with ideal sustained-release,long-lasting and low-toxin effects against C. lanigera and B. serratus. Therefore,it could be used alternatively with other pesticides,to delay production and development of drug resistance.展开更多
Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its com...Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its compliance,particularly among children.Consequently,this study aimed to devise a novel sustained-release suspension of OP employing an ion exchange resin as a carrier to address these challenges.The OP-drug resin complex(OP-DRC)was synthesized utilizing ion exchange technology,while OP-coated microcapsules(OP-CM)were fabricated via the emulsion-evaporation method.The optimization of the formulation process for the OP sustained-release suspension was achieved through a combination of single-factor experimentation and orthogonal experimental design.Furthermore,the drug release kinetics and pharmacokinetic properties of the sustained-release suspension were thoroughly evaluated both in vitro and in vivo.Scanning electron microscopy(SEM),X-ray diffraction(XRD),and attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR)analyses confirmed the formation of drug-resin complexes via ionic bonding.The in vitro cumulative release rates were found to be 16%(1 h),53%(6 h),and 84%(24 h),respectively.Notably,the self-made sustained-release suspension exhibited an extended half-life(21.518 h),delayed time to peak concentration(T_(max))(6 h),and reduced maximum plasma concentration(C_(max))(0.397μg/mL)in comparison to commercial granules(half-life=8.466 h;T_(max)=2 h;C_(max)=0.631μg/mL).Additionally,the area under the curve(AUC)indicated that the bioavailability of the self-made OP suspension surpassed that of the commercial OP granules by 101%.These findings underscored the successful development of an oral OP sustained-release suspension characterized by stability,tastelessness,ease of swallowing,convenient administration,and sustained-release properties,thereby potentially enhancing drug compliance among children.展开更多
Rabbits with the body weight of （2.0 ± 0.5 ） kg were chosen, to study the effects of sustained-release calcium hydroxide and sustained-release hydro- chloric acid on nutrient digestion and absorption of rabbits...Rabbits with the body weight of （2.0 ± 0.5 ） kg were chosen, to study the effects of sustained-release calcium hydroxide and sustained-release hydro- chloric acid on nutrient digestion and absorption of rabbits. The results showed that sustained-release calcium hydroxide promoted digestion and absorption of nutri- ents, especially calcium and crude protein. The digestibility of calcium and crude protein was increased from 89.8% and 93.8% to 41.0% and 65.2%, respec- tively. Sustained-release hydrochloric acid was adverse to digestion and absorption of nutrients, especially calcium and crude protein. The digestibility of calcium and crude protein were decreased from 55.5% and 84.9% to 28.4% and 68.7%, respectively. The promotion effects of sustained-release hydrochloride on diges- tion lasted for 3 -4 d. Therefore, sustained-release calcium hydroxide promoted digestion and absorption of calcium and protein, while digestion and absorption of fat remained at a high level no matter what the condition was. Consequently, increasing the intake of fat would cause over nutrition. However, taking sustained-re- lease hydrochloric acid would reduce nutrient digestion and absorption.展开更多
Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms lig...Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms ligand bonds or hydrogen bonds with sulfur ions in lithium polysulfides(LiPSs),thus inhibiting the shuttle effect.Electrochemical analyses demonstrated that lithium‑sulfur(Li‑S)batteries employing the NH2‑SS interlayer exhibited discharge specific capacities of 1048 and 789 mAh·g^(-1) at 0.2C and 2C,respectively,and even at 4C,the initial discharge specific capacity remained at 590 mAh·g^(-1),outperforming the Li‑S battery with unmodified SS as the interlayer.展开更多
The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF...The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result.展开更多
Agglomeration supports the high-quality development of the manufacturing industry,and its associated resource and environmental effects play a crucial role in driving green economic development.Based on data from pref...Agglomeration supports the high-quality development of the manufacturing industry,and its associated resource and environmental effects play a crucial role in driving green economic development.Based on data from prefecture-level cities in China from 2005 to 2019,this study employs the inverse distance weighting method,the bivariate local indicator of spatial association model,the spatial Durbin model,and other techniques to explore the relationship between manufacturing agglomeration and PM_(2.5)concentrations,and to assess the impact of its manufacturing agglomeration.Four correlation patterns are observed:high-high,low-low,high-low,and low-high.Among these,high-high and low-low patterns dominate in terms of number of cities.These correlation patterns demonstrate strong temporal stability,with a clear“Matthew effect”.The effect of manufacturing agglomeration on PM_(2.5)levels is significantly negative and helps reduce concentrations regionally,indicating the need to further enhance agglomeration levels regionally.However,it can increase PM_(2.5)levels in neighboring areas due to a siphon effect,and the impact of varies across regions.Compared with levels in 2005-2013,the significance of the relationship between manufacturing agglomeration and PM_(2.5)weakened in the 2013-2019 period.Accordingly,this study proposes countermeasures and policy recommendations aimed at strengthening regional collaborative governance and inspiring differentiated agglomeration strategies to support sustainable economic development in China.展开更多
Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticle...Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.展开更多
Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electro...Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.展开更多
The efficient electrocatalytic oxidation of glycerol(GLY)is one of the most promising routes for the valorization of GLY.Doping has emerged as a powerful strategy to tailor the electrocatalytic performance of silver n...The efficient electrocatalytic oxidation of glycerol(GLY)is one of the most promising routes for the valorization of GLY.Doping has emerged as a powerful strategy to tailor the electrocatalytic performance of silver nanoclusters(Ag NCs),yet the effects of doping mode(surface vs.core)and the interface environment(e.g.,electrolyte concentration)on the electrocatalytic performance for Ag NCs toward GLY oxidation remain understood.In this work,surface-doped Ag_(4)M_(2)(SR)_(8) and core-doped Ag_(24)M(SR)_(18)(M=Ni,Pd,Pt;SR=SPhMe_(2))NCs were synthesized for electrocatalytic GLY oxidation.The results revealed a strong dependence of selectivity on doping mode and electrolyte concentration:under low KOH concentration,Pd-and Pt-doped Ag_(4)M_(2) NCs exhibited 100%selectivity toward oxalic acid(OA),whereas Pd-and Pt-doped Ag_(24)M NCs delivered>95%selectivity for formic acid(FA).In contrast,under high KOH concentration,Pd-and Pt-doped Ag_(4)M_(2) NCs gave rise to>80%FA,while Pd-and Pt-doped Ag_(24)M NCs produced>45%FA.Mechanism studies indicated that Ni doping predominantly enhanced catalytic activity via lowering the activation barrier of the initial reaction step(GLY→glyceraldehyde),whereas Pd and Pt doping modulated selectivity through reducing the energy barrier of the selective branch step(glyceric acid→OA,OA→FA).High KOH concentration promoted the oxidation by increasing the electrochemical active surface area and facilitating electron transfer of Ag NCs.This study provides clear guidance for designing high-performance Ag-based electrocatalysts for biomass valorization.展开更多
Objective: To explore the therapeutic effect of nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients whose age above 60 years old with coronary heart disease and hypertensi...Objective: To explore the therapeutic effect of nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients whose age above 60 years old with coronary heart disease and hypertension. Methods: 260 elderly patients whose age above 60 years old with coronary heart disease and hypertension were selected and analyzed. The research time span was from August 2019 to April 2020. The patients were randomly divided into control group and observation group with 130 cases in each group. There was no significant difference in general data after statistical analysis. The treatment intervention program formulated by the control group was nifedipine sustained-release tablets, while the treatment intervention program formulated by the observation group was combined with enalapril on the basis of control group. The clinical value of nifedipine sustained-release tablets combined with enalapril was compared in the evaluation of condition control and safety of the two treatment regimens. Results: after the intervention of the two treatment schemes, the total effective rate of disease control treatment evaluation of elderly patients with coronary heart disease and hypertension was higher than that of the control group, and there were significant differences between groups, and statistical significance was indicated after analysis and calculation, (P < 0.05). There were no serious adverse reactions in the two groups during the treatment, there was no significant difference in the data between the groups, and there was no statistical significance after calculation and analysis, (P > 0.05). Conclusion: nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients with coronary heart disease and hypertension can achieve better clinical efficacy than use nifedipine sustained-release tablets alone, and will not increase the probability of adverse reactions, can improve the quality of life of patients, has the value of popularization and application.展开更多
The UV-2600 ultraviolet(UV)spectrophotometer and the UV sunscreen index analyzer SolarLight Model 601 were used to test the UV absorption capacity and the UV damage alleviating effect of commonly used raw materials,an...The UV-2600 ultraviolet(UV)spectrophotometer and the UV sunscreen index analyzer SolarLight Model 601 were used to test the UV absorption capacity and the UV damage alleviating effect of commonly used raw materials,and the Hen’s Egg Test-Chorioallantoic Membrane were also processed to assess the mildness.As a result,bisabolol,pongamia pinnata seed extract,pterocarpus marsupium bark extract and other materials were screened as the effective and gentle sunscreen synergistic ingredients.展开更多
The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,rem...The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,remove toxins,clear heat,and alleviate wind-heat syndromes.It also has hepatoprotective,anti-inflammatory,antiviral,antibacterial,anticancer,antioxidant,antiaging,and anti-obesity effects,as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy.It is used to treat scrofula,mastitis,wind-heat common cold,and other ailments.The review summarizes the chemical constituents and pharmacological effects of F.suspensa,aiming to provide a scientific foundation for its future development,research,and clinical utilization.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
The Zeeman effect,a fundamental quantum phenomenon,demonstrates the interaction between magnetic fields and atomic systems.While precise spectroscopic measurements of this effect have advanced significantly,there rema...The Zeeman effect,a fundamental quantum phenomenon,demonstrates the interaction between magnetic fields and atomic systems.While precise spectroscopic measurements of this effect have advanced significantly,there remains a lack of simple,visually accessible demonstration for educational purposes.Here,we present a low-cost experiment that allows for direct visual observation of the Zeeman effect.Our setup involves a flame containing sodium(from table salt)placed in front of a sodium vapor lamp.When a magnetic field is applied to the flame,the shadow cast by the flame noticeably lightens,providing a clear,naked-eye demonstration of the Zeeman effect.Furthermore,we conduct two quantitative experiments using this setup,examining the effects of varying magnetic field strength and sodium concentration.This innovative approach not only enriches the experimental demonstration for teaching atomic physics at undergraduate and high school levels but also provides an open platform for students to explore the Zeeman effect through hands-on experience.展开更多
Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which...Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which has a Curie temperature of~290 K and an in-plane easy magnetization axis.Magnetotransport measurements show a positive magnetoresistance(MR)below 50 K,which becomes negative at higher temperatures.An intrinsic anomalous Hall conductivity of 114 S·cm^(-1)is observed in MgMn_(6)Sn_(6) single crystals,consistent with ab initio calculations.Moreover,theoretical predictions indicate that shifting the Fermi level(EF)upward by~70 meV could enhance the AHE to~528 S·cm^(-1).These results position MgMn_(6)Sn_(6) as a promising and tunable platform for exploring topological magnetism and related electronic phenomena.展开更多
Preferential magnesium(Mg)electrodeposition on separators is a ubiquitous yet poorly understood phenomenon in rechargeable Mg-metal batteries,posing a fundamental challenge to their development.In this work,the synerg...Preferential magnesium(Mg)electrodeposition on separators is a ubiquitous yet poorly understood phenomenon in rechargeable Mg-metal batteries,posing a fundamental challenge to their development.In this work,the synergy effects of interface-accelerating desolvation and spatial confinement have been demonstrated as the essential causation of this counterintuitive experimental phenomenon.At the molecular level,the imide ring(-CO-NR-CO-,in which R represents the phenyl)groups in an artificially introduced polyimide(PI)interlayer facilitate the strong electrostatic affinity towards Mg^(2+),which accelerates the desolvation process for Mg^(2+)solvation structures at the inner Helmholtz plane.At the nucleation scale,the wedge-like concave geometry formed at the PI/current collector interface provides energetically favorable sites for Mg nucleation.This unique architecture reduces the critical nucleus size,thereby significantly lowering nucleation energy barriers.As a result,the satisfactory Coulombic efficiency for Mg plating/stripping(98.22%)and cycle lifespan(1200 cycles,above 100 days)have been achieved,outperforming most of the previous results.This work pioneers a molecular-level understanding of separator-directed Mg deposition and resolves a long-standing confusion in Mg-metal batteries.展开更多
基金The 2023 Nantong Jianghai Talents Project2023 Nantong Social Livelihood Science and Technology Plan+2 种基金2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research InstituteWuyi University Scientific Research Project (Grant No.2023AL001)the Innovation and Entrepreneurship Project for Returned Overseas Students in Jiangmen。
文摘In the present study,cefditoren sodium(CT-Na),the sodium salt form of cefditoren(CT),was selected as the model compound,and cholestyramine resin was employed as the drug carrier to formulate CT-Na-resin complexes.The interaction mechanism between CT-Na and cholestyramine resin was elucidated using scanning electron microscopy(SEM),fourier-transform infrared spectroscopy(FTIR),and differential scanning calorimetry(DSC).Bioadhesive,sustained-release microcapsules were subsequently developed via an emulsification—solvent evaporation technique.Comprehensive characterization of the formulation was conducted,with key quality indices systematically evaluated.Notably,the formulation exhibited minimal leakage(0.07%)after 7 d of storage and retained 94.59%of its drug content over a 6-month period.Pharmacokinetic studies comparing the CT-Na active pharmaceutical ingredient(APl)solution and the self-developed dry suspension revealed a marked extension in drug release for the latter.The dry suspension displayed a delayed T_(max)(3 h vs.2 h),an extended half-life(t_(1/2))(12.44 h vs.4 h),and a moderately reduced peak concentration(C_(max))(3.99μg/mL vs.4.82μg/mL),while achieving a significantly higher overall drug exposure(AUC_(0-24h):50.868μg·h/mL vs.30.281μg·h/mL).These findings indicated that relative to the API solution,the optimized dry suspension provided sustained drug release with improved bioavailability.
基金The 2022 Ministry of Education General Project for Humanities and Social Sciences Research(Grant No.22YJAZH147)the General Subject of Guangzhou Philosophy and Social Science Development“14th Five-Year Plan”in 2023(Grant No.2023GZYB68)+2 种基金China University Industry-Academia-Research Innovation Fund-Huatong Guokang Medical Research Special Project(Grant No.2023HT017)2024 Guangdong Province General Project for the Planning of Philosophy and Social Sciences(Grant No.GD24CGL29)the Innovation Team Project of Colleges and Universities in Guangdong Province(Grant No.2022WCXTD011).
文摘Different dosage forms can significantly impact pharmacokinetics in vivo,leading to varied effects and potential adverse reactions.This study aimed to evaluate the efficacy,safety,and cost-effectiveness of isosorbide mononitrate sustained-release capsules(IMSRC)combined with conventional treatments,compared to isosorbide mononitrate tablets(IMT)combined with conventional treatments,for managing angina pectoris in patients with coronary heart diseases.A network meta-analysis(NMA)was conducted to assess the efficacy and safety of IMSRC and IMT.Relevant literature was sourced from databases,including PubMed,Embase,Cochrane Library,ScienceDirect,Web of Science,CNKI,Wanfang,and VIP,covering publications up to July 2023.The cost-effectiveness analysis(CEA)was performed from the perspective of China’s healthcare system,utilizing inputs derived from the NMA.The analysis included 15 studies.The NMA results revealed no significant difference in efficacy and safety between IMSRC plus conventional treatments and IMT plus conventional treatments.However,both combinations were more effective than conventional treatments without isosorbide mononitrate.No differences in safety were observed among the three groups.The surface under the cumulative ranking(SUCRA)of the NMA indicated that IMT had a slight edge over IMSRC in the total effective rate of angina pectoris,whereas IMSRC showed higher probabilities for markedly effective rate and ECG effective rate compared to IMT.The incidence of adverse events was ranked as IMT>conventional preparation>IMSRC.The CEA results highlighted that the incremental cost-effectiveness ratios(ICERs)for the markedly effective and total effective rates of angina pectoris were-133.41 and-260.20,respectively.The ICERs for ECG effective rates were-83.34 and-234.24,respectively.In conclusion,while IMSRC combined with conventional treatments and IMT combined with conventional treatments were similar in efficacy and safety,IMSRC proved to be more economical.
基金supported by the National Natural Science Foundation of China,Nos.82271403(to XL),82272171(to ZY),31730030(to XL),81941011(to XL),31971279(to ZY)the Natural Science Foundation of Beijing,No.7222004(to HD).
文摘Spinal cord injury is accompanied by a substantial loss of neurons.Cell replacement therapy improves motor and sensory dysfunction by replacing dead neurons,and endogenous neurogenesis is an important cell replacement source.Stimulating endogenous neurogenesis is therefore a viable approach for treating spinal cord injury.Given that basic fibroblast growth factor is a potent inducer of neurogenesis,we developed a sustained-release system of basic fibroblast growth factor-chitosan to enhance tissue repair in spinal cord injury.In the present study,we isolated neural stem cells from the spinal cords of neonatal rats and used single-cell RNA sequencing to trace the complete process of neurogenesis under ex vivo culture conditions.Under the influence of basic fibroblast growth factor-chitosan,neural stem cells were able to transition from a quiescent state to an activated state and subsequently differentiate into neuronal precursor cells and immature neurons.Additionally,basic fibroblast growth factor-chitosan significantly enhanced neural stem cell proliferation in vitro and promoted neuronal generation.Subsequent in vivo experiments confirmed the therapeutic efficacy of basic fibroblast growth factor-chitosan in spinal cord injury,demonstrating enhanced neurogenesis and tissue repair.
基金supported by National Natural Science Foundation of China (Nos. 41977317, 42177051)Beijing Natural Science Foundation (No. 8182037)
文摘Allelochemicals sustained-release microspheres(ACs-SMs)exhibited great inhibition effect on algae,however,few studies have focused on ACs-SMs toxicity on invertebrate.In this study,the effects of single high-concentration ACs(15 mg/L,SH-ACs),repeated lowconcentration ACs(3×5 mg/L,RL-ACs)and ACs-SMs containing 15 mg/L ACs exposure on the ingestion,incorporation,and digestion of Daphniamagna Straus(DS)were investigated by stable isotope 15N labeling method.Meanwhile,the diversity and abundance of microflora in DS guts were determined by 16S rRNA genes and cloning methods.The results showed that SH-ACs exposure caused 50%and 33.3%death rates for newborn and adult DS,while RL-ACs exposure caused 10%death rate for newborn DS and no obvious effect on the activity of adult DS.And ACs-SMs exposure did not diminish the motility of both newborn and adult DS,indicating the lower acute toxicity of ACs-SMs.Furthermore,SH-ACs inhibited the ingestion(-6.45%),incorporation(-47.1%)and digestion(-53.8%)abilities of DS and reduced the microbial abundance(-27.7%)in DS guts.Compared with SH-ACs,RL-ACs showed relatively low impact on the ingestion(-3.23%),incorporation(-5.89%)and digestion(-23.9%)abilities of DS.Interestingly,ACs-SMs enhanced the ingestion(+9.68%),incorporation(+52.9%)and digestion(+51.3%)abilities of DS and increased the microbial abundance(+10.7%)in DS guts.Overall ACs and ACs-SMs reduced the diversity of microflora in DS guts.In conclusion,ACs-SMs can release ACs sustainably and prolong the sustained release time,which not only effectively reduce the toxicity of ACs,but also had positive effects on DS.
基金Supported by Special Fund for China Agricultural Industry Research System(CARS-20-2-2)Special Fund for Agricultural Industry Research System of Yunnan Province(YNGZTX-4-92)
文摘[Objective]The paper was to screen a new ideal sustained-release,long-lasting and low-toxic pesticide and convenient and efficient pesticide application technology for controlling Ceratovacuna lanigera and Baliathrips serratus. [Method]2% Imidacloprid GR were selected and applied in the soil for field efficacy trial. [Result] The optimum dosage of 2% imidacloprid GR was 30 kg/hm^2（ active ingredient 600 g）,which can be mixed with fertilizer（ 30 kg pesticide and 40-80 kg fertilizer per hm^2） once combined with sugarcane planting management or big ridging during February and June. The control effects against C. lanigera and B. serratus could be more than 98. 2% and 81. 1%,respectively. The actual yield and sugar content in various pesticide treatments were increased by 33 390 kg/hm^2 and 6. 6% respectively compared to blank control. [Conclusion]2% imidacloprid GR has good control effects on C. lanigera and B. serratus. It is a new pesticide with ideal sustained-release,long-lasting and low-toxin effects against C. lanigera and B. serratus. Therefore,it could be used alternatively with other pesticides,to delay production and development of drug resistance.
基金2023 Nantong Jianghai Talents Project2023 Nantong Social Livelihood Science and Technology Plan+4 种基金2021 Jurong Social Development Science&Technology Program(Grant No.ZA42109)2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research InstituteChina Postdoctoral Science Foundation(Grant No.2020M681532)Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.2020Z209)Natural Science Research Projects of Universities in Jiangsu Province(Grant No.20KJD350001)。
文摘Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its compliance,particularly among children.Consequently,this study aimed to devise a novel sustained-release suspension of OP employing an ion exchange resin as a carrier to address these challenges.The OP-drug resin complex(OP-DRC)was synthesized utilizing ion exchange technology,while OP-coated microcapsules(OP-CM)were fabricated via the emulsion-evaporation method.The optimization of the formulation process for the OP sustained-release suspension was achieved through a combination of single-factor experimentation and orthogonal experimental design.Furthermore,the drug release kinetics and pharmacokinetic properties of the sustained-release suspension were thoroughly evaluated both in vitro and in vivo.Scanning electron microscopy(SEM),X-ray diffraction(XRD),and attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR)analyses confirmed the formation of drug-resin complexes via ionic bonding.The in vitro cumulative release rates were found to be 16%(1 h),53%(6 h),and 84%(24 h),respectively.Notably,the self-made sustained-release suspension exhibited an extended half-life(21.518 h),delayed time to peak concentration(T_(max))(6 h),and reduced maximum plasma concentration(C_(max))(0.397μg/mL)in comparison to commercial granules(half-life=8.466 h;T_(max)=2 h;C_(max)=0.631μg/mL).Additionally,the area under the curve(AUC)indicated that the bioavailability of the self-made OP suspension surpassed that of the commercial OP granules by 101%.These findings underscored the successful development of an oral OP sustained-release suspension characterized by stability,tastelessness,ease of swallowing,convenient administration,and sustained-release properties,thereby potentially enhancing drug compliance among children.
基金Supported by National Natural Science Foundation of China(21576055)
文摘Rabbits with the body weight of （2.0 ± 0.5 ） kg were chosen, to study the effects of sustained-release calcium hydroxide and sustained-release hydro- chloric acid on nutrient digestion and absorption of rabbits. The results showed that sustained-release calcium hydroxide promoted digestion and absorption of nutri- ents, especially calcium and crude protein. The digestibility of calcium and crude protein was increased from 89.8% and 93.8% to 41.0% and 65.2%, respec- tively. Sustained-release hydrochloric acid was adverse to digestion and absorption of nutrients, especially calcium and crude protein. The digestibility of calcium and crude protein were decreased from 55.5% and 84.9% to 28.4% and 68.7%, respectively. The promotion effects of sustained-release hydrochloride on diges- tion lasted for 3 -4 d. Therefore, sustained-release calcium hydroxide promoted digestion and absorption of calcium and protein, while digestion and absorption of fat remained at a high level no matter what the condition was. Consequently, increasing the intake of fat would cause over nutrition. However, taking sustained-re- lease hydrochloric acid would reduce nutrient digestion and absorption.
文摘Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms ligand bonds or hydrogen bonds with sulfur ions in lithium polysulfides(LiPSs),thus inhibiting the shuttle effect.Electrochemical analyses demonstrated that lithium‑sulfur(Li‑S)batteries employing the NH2‑SS interlayer exhibited discharge specific capacities of 1048 and 789 mAh·g^(-1) at 0.2C and 2C,respectively,and even at 4C,the initial discharge specific capacity remained at 590 mAh·g^(-1),outperforming the Li‑S battery with unmodified SS as the interlayer.
基金National Natural Science Foundation of China(11875039)Shanxi Scholarship Council of China(2023-033)+2 种基金Fundamental Research Program of Shanxi Province(202303021221071)China Baowu Low Carbon Metallurgical Innovation Foundation(2022)2023 Anhui Major Industrial Innovation Plan Project。
文摘The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result.
基金supported by the National Natural Science Foundation of China“Research on the Multi-scale Regional Industrial Spatial Evolution Mechanism,Resource and Environmental Effects,and Green Transformation in the Yellow River Basin”[Grant No.42371194]Taishan Scholar Foundation of Shandong Province[Grant Nos.tsqn202408148 and tstp20240821].
文摘Agglomeration supports the high-quality development of the manufacturing industry,and its associated resource and environmental effects play a crucial role in driving green economic development.Based on data from prefecture-level cities in China from 2005 to 2019,this study employs the inverse distance weighting method,the bivariate local indicator of spatial association model,the spatial Durbin model,and other techniques to explore the relationship between manufacturing agglomeration and PM_(2.5)concentrations,and to assess the impact of its manufacturing agglomeration.Four correlation patterns are observed:high-high,low-low,high-low,and low-high.Among these,high-high and low-low patterns dominate in terms of number of cities.These correlation patterns demonstrate strong temporal stability,with a clear“Matthew effect”.The effect of manufacturing agglomeration on PM_(2.5)levels is significantly negative and helps reduce concentrations regionally,indicating the need to further enhance agglomeration levels regionally.However,it can increase PM_(2.5)levels in neighboring areas due to a siphon effect,and the impact of varies across regions.Compared with levels in 2005-2013,the significance of the relationship between manufacturing agglomeration and PM_(2.5)weakened in the 2013-2019 period.Accordingly,this study proposes countermeasures and policy recommendations aimed at strengthening regional collaborative governance and inspiring differentiated agglomeration strategies to support sustainable economic development in China.
文摘Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.
基金supported by the National Natural Science Foundation of China(No.62464010)Spring City Plan-Special Program for Young Talents(K202005007)+2 种基金Yunnan Talents Support Plan for Young Talents(XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects(202101BA070001-138)Frontier Research Team of Kunming University 2023.
文摘Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.
基金support from the Jiangsu Natural Science Foundation of China(BK20230329)the National Natural Science Foundation of China(22401147,22361132540,and 22178161)the Russian Science Foundation(23-73-30007).
文摘The efficient electrocatalytic oxidation of glycerol(GLY)is one of the most promising routes for the valorization of GLY.Doping has emerged as a powerful strategy to tailor the electrocatalytic performance of silver nanoclusters(Ag NCs),yet the effects of doping mode(surface vs.core)and the interface environment(e.g.,electrolyte concentration)on the electrocatalytic performance for Ag NCs toward GLY oxidation remain understood.In this work,surface-doped Ag_(4)M_(2)(SR)_(8) and core-doped Ag_(24)M(SR)_(18)(M=Ni,Pd,Pt;SR=SPhMe_(2))NCs were synthesized for electrocatalytic GLY oxidation.The results revealed a strong dependence of selectivity on doping mode and electrolyte concentration:under low KOH concentration,Pd-and Pt-doped Ag_(4)M_(2) NCs exhibited 100%selectivity toward oxalic acid(OA),whereas Pd-and Pt-doped Ag_(24)M NCs delivered>95%selectivity for formic acid(FA).In contrast,under high KOH concentration,Pd-and Pt-doped Ag_(4)M_(2) NCs gave rise to>80%FA,while Pd-and Pt-doped Ag_(24)M NCs produced>45%FA.Mechanism studies indicated that Ni doping predominantly enhanced catalytic activity via lowering the activation barrier of the initial reaction step(GLY→glyceraldehyde),whereas Pd and Pt doping modulated selectivity through reducing the energy barrier of the selective branch step(glyceric acid→OA,OA→FA).High KOH concentration promoted the oxidation by increasing the electrochemical active surface area and facilitating electron transfer of Ag NCs.This study provides clear guidance for designing high-performance Ag-based electrocatalysts for biomass valorization.
文摘Objective: To explore the therapeutic effect of nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients whose age above 60 years old with coronary heart disease and hypertension. Methods: 260 elderly patients whose age above 60 years old with coronary heart disease and hypertension were selected and analyzed. The research time span was from August 2019 to April 2020. The patients were randomly divided into control group and observation group with 130 cases in each group. There was no significant difference in general data after statistical analysis. The treatment intervention program formulated by the control group was nifedipine sustained-release tablets, while the treatment intervention program formulated by the observation group was combined with enalapril on the basis of control group. The clinical value of nifedipine sustained-release tablets combined with enalapril was compared in the evaluation of condition control and safety of the two treatment regimens. Results: after the intervention of the two treatment schemes, the total effective rate of disease control treatment evaluation of elderly patients with coronary heart disease and hypertension was higher than that of the control group, and there were significant differences between groups, and statistical significance was indicated after analysis and calculation, (P < 0.05). There were no serious adverse reactions in the two groups during the treatment, there was no significant difference in the data between the groups, and there was no statistical significance after calculation and analysis, (P > 0.05). Conclusion: nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients with coronary heart disease and hypertension can achieve better clinical efficacy than use nifedipine sustained-release tablets alone, and will not increase the probability of adverse reactions, can improve the quality of life of patients, has the value of popularization and application.
文摘The UV-2600 ultraviolet(UV)spectrophotometer and the UV sunscreen index analyzer SolarLight Model 601 were used to test the UV absorption capacity and the UV damage alleviating effect of commonly used raw materials,and the Hen’s Egg Test-Chorioallantoic Membrane were also processed to assess the mildness.As a result,bisabolol,pongamia pinnata seed extract,pterocarpus marsupium bark extract and other materials were screened as the effective and gentle sunscreen synergistic ingredients.
文摘The dried fruit of Forsythia suspensa(Oleaceae),also known as Forsythia,is a traditional Chinese medicinal herb known for its heat-clearing and detoxifying properties.It is used to disperse nodules,reduce swelling,remove toxins,clear heat,and alleviate wind-heat syndromes.It also has hepatoprotective,anti-inflammatory,antiviral,antibacterial,anticancer,antioxidant,antiaging,and anti-obesity effects,as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy.It is used to treat scrofula,mastitis,wind-heat common cold,and other ailments.The review summarizes the chemical constituents and pharmacological effects of F.suspensa,aiming to provide a scientific foundation for its future development,research,and clinical utilization.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
基金the National Natural Science Foundation of China for support under grant No.12305037the Fundamental Research Funds for the Central Universities under grant No.2023NTST017。
文摘The Zeeman effect,a fundamental quantum phenomenon,demonstrates the interaction between magnetic fields and atomic systems.While precise spectroscopic measurements of this effect have advanced significantly,there remains a lack of simple,visually accessible demonstration for educational purposes.Here,we present a low-cost experiment that allows for direct visual observation of the Zeeman effect.Our setup involves a flame containing sodium(from table salt)placed in front of a sodium vapor lamp.When a magnetic field is applied to the flame,the shadow cast by the flame noticeably lightens,providing a clear,naked-eye demonstration of the Zeeman effect.Furthermore,we conduct two quantitative experiments using this setup,examining the effects of varying magnetic field strength and sodium concentration.This innovative approach not only enriches the experimental demonstration for teaching atomic physics at undergraduate and high school levels but also provides an open platform for students to explore the Zeeman effect through hands-on experience.
基金Project supported by the National Natural Science Foundation of China(Grant No.12204347)National Key Research and Development Program of China(Grant No.2022YFA1402600)the Fund from Beijing National Laboratory for Condensed Matter Physics(Grant No.2023BNLCMPKF011)。
文摘Kagome magnets are of growing interest due to their topological electronic structures and unconventional magnetic behavior.Here,we report on the anomalous Hall effect(AHE)in the kagome ferromagnet MgMn_(6)Sn_(6),which has a Curie temperature of~290 K and an in-plane easy magnetization axis.Magnetotransport measurements show a positive magnetoresistance(MR)below 50 K,which becomes negative at higher temperatures.An intrinsic anomalous Hall conductivity of 114 S·cm^(-1)is observed in MgMn_(6)Sn_(6) single crystals,consistent with ab initio calculations.Moreover,theoretical predictions indicate that shifting the Fermi level(EF)upward by~70 meV could enhance the AHE to~528 S·cm^(-1).These results position MgMn_(6)Sn_(6) as a promising and tunable platform for exploring topological magnetism and related electronic phenomena.
基金supported by the National Natural Science Foundation of China(22279068,52374306)the Taishan Scholars of Shandong Province(tsqn202408202)the Qingdao New Energy Shandong Laboratory Open Project(QNESL OP202312)。
文摘Preferential magnesium(Mg)electrodeposition on separators is a ubiquitous yet poorly understood phenomenon in rechargeable Mg-metal batteries,posing a fundamental challenge to their development.In this work,the synergy effects of interface-accelerating desolvation and spatial confinement have been demonstrated as the essential causation of this counterintuitive experimental phenomenon.At the molecular level,the imide ring(-CO-NR-CO-,in which R represents the phenyl)groups in an artificially introduced polyimide(PI)interlayer facilitate the strong electrostatic affinity towards Mg^(2+),which accelerates the desolvation process for Mg^(2+)solvation structures at the inner Helmholtz plane.At the nucleation scale,the wedge-like concave geometry formed at the PI/current collector interface provides energetically favorable sites for Mg nucleation.This unique architecture reduces the critical nucleus size,thereby significantly lowering nucleation energy barriers.As a result,the satisfactory Coulombic efficiency for Mg plating/stripping(98.22%)and cycle lifespan(1200 cycles,above 100 days)have been achieved,outperforming most of the previous results.This work pioneers a molecular-level understanding of separator-directed Mg deposition and resolves a long-standing confusion in Mg-metal batteries.
