When we were moved by the warmth of Korean ethic family drama,we began to fall into the feeling that these dramas were so real just as our daily life.But we tend to overlook the fact that the dramas which have been el...When we were moved by the warmth of Korean ethic family drama,we began to fall into the feeling that these dramas were so real just as our daily life.But we tend to overlook the fact that the dramas which have been elaborated by authors are just a mirror of daily life.Suspense narrative,contrast narrative,and coincidence narrative are three main narrative techniques of Korean family drama.As an important narrative technique of Korean family ethic drama,suspense is a narrative skill organizing the plot and making dramas to be more charming.So this paper will analyze the suspense of Korean family ethic drama from these three aspects:story,plot,and metronome.展开更多
Murder on the Orient Express, a masterpiece in the detective fictions, is one of the most prevailing works of Agatha Christie. It provides special modes and new ideas for the later creation of the detective stories. S...Murder on the Orient Express, a masterpiece in the detective fictions, is one of the most prevailing works of Agatha Christie. It provides special modes and new ideas for the later creation of the detective stories. Suspense is embodied largely in this book. A variety of suspense interweaves, overlaps and creates the stirring effect. This thesis first introduces the lifetime of the au?thor, the typicality of the book among the same kind of detective fictions. Then it aims at explaining and analyzing the suspense set?tings from the narrative time, the narrative point of view, clues in the book and the ending of the story by using the text analysis. Fi?nally, it states the significance of suspense settings. The study of suspense settings can not only dissect the artistic value and the charm of suspense in detective fictions but also contribute to improving readers'abilities of appreciating mystery stories. It can help them to shape a unique aesthetic perspective.展开更多
The transformation from multibody models to lumped-parameter models is a crucial aspect of vehicle dynamics research.The velocity transformation method is adopted in this research,and the suspension multibody model is...The transformation from multibody models to lumped-parameter models is a crucial aspect of vehicle dynamics research.The velocity transformation method is adopted in this research,and the suspension multibody model is described using only one degree of freedom.It is found that the equivalent mass of the system is time-dependent during the simulation process,as observed in numerical simulations.Further symbolic calculations are conducted to derive the analytical form of the equivalent mass,and the results show that once the static parameters are determined,the equivalent mass of the suspension system is determined solely by the vertical position of the suspension upright,which reveals the kinematics characteristic of the equivalent mass of the suspension system.It is found that the equivalent mass experiences smaller changes when the suspension is compressed from the middle position,but larger changes when the suspension is extended.Furthermore,by comparing the multibody model,the lumped-parameter model with static mass,and the proposed lumped-parameter model considering the kinematics characteristic of the equivalent unsprung mass,the proposed model produces simulation results that more closely match the original multibody model than the model with static mass.The improvements in accuracy can be up to 20%under certain evaluation metrics.展开更多
Main cable displacement-controlled devices(DCDs)are key components for coordinating the vertical deformation of the main cable and main girder in the side span of continuous suspension bridges.To reveal the mechanical...Main cable displacement-controlled devices(DCDs)are key components for coordinating the vertical deformation of the main cable and main girder in the side span of continuous suspension bridges.To reveal the mechanical action mechanisms of DCD on bridge structures,a three-span continuous suspension bridge was taken as the engineering background in this study.The influence of different forms of DCD on the internal force and displacement of the components in the side span of the bridge and the structural dynamic characteristics were explored through numerical simulations.The results showed that the lack of DCD caused the main cable and main girder to have large vertical displacements.The stresses of other components were redistributed,and the safety factor of the suspenders at the side span was greatly reduced.The setting of DCD improved the vertical stiffness of the structure.The rigid DCD had larger internal forces,but its control effect on the internal forces at the side span was slightly better than that of the flexible DCD.Both forms of DCD effectively coordinated the deformation of the main cable and main girder and the stress distribution of components in the side span area.The choice of DCD form depends on the topographic factors of bridge sites and the design requirements of related components at the side span.展开更多
The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restrain...The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
This article presents an adaptive optimal control method for a semi-active suspension system.The model of the suspension system is built,in which the components of uncertain parameters and exogenous disturbance are de...This article presents an adaptive optimal control method for a semi-active suspension system.The model of the suspension system is built,in which the components of uncertain parameters and exogenous disturbance are described.The adaptive optimal control law consists of the sum of the optimal control component and the adaptive control component.First,the optimal control law is designed for the model of the suspension system after ignoring the components of uncertain parameters and exogenous disturbance caused by the road surface.The optimal control law expresses the desired dynamic characteristics of the suspension system.Next,the adaptive component is designed with the purpose of compensating for the effects caused by uncertain parameters and exogenous disturbance caused by the road surface;the adaptive component has adaptive parameter rules to estimate uncertain parameters and exogenous disturbance.When exogenous disturbances are eliminated,the system responds with an optimal controller designed.By separating theoretically the dynamic of a semi-active suspension system,this solution allows the design of two separate controllers easily and has reduced the computational burden and the use of too many tools,thus allowing for more convenient hardware implementation.The simulation results also show the effectiveness of damping oscillations of the proposed solution in this article.展开更多
From complicated overpasses that defy(违抗)engineering conventions to suspended“river highways”,China is internationally recognized for its innovative infrastructure.Another example of the nation's fearless appr...From complicated overpasses that defy(违抗)engineering conventions to suspended“river highways”,China is internationally recognized for its innovative infrastructure.Another example of the nation's fearless approach to building and design is the temporary suspension bridge.展开更多
Rice callus suspension culture(RCSC)has been shown to have anticancer activity based on cytotoxic activity on human colon and lung cancer cell lines.In the present study,the effect of RCSC on the expression of protein...Rice callus suspension culture(RCSC)has been shown to have anticancer activity based on cytotoxic activity on human colon and lung cancer cell lines.In the present study,the effect of RCSC on the expression of proteins in lung(A549)and colon(HT29)cancer cell lines was examined by using proteomics analysis.The protein-protein interaction study of differentially expressed proteins was done by using the Search Tool for the Retrieval of Interacting Genes(STRING),and the results showed that the proteins interacting with each other belong to different pathways.展开更多
Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-indus...Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-industrial trials were conducted.Vanadium in raw ore mainly exists in sericite,roscoelite,and limonite,predominantly in the forms of V(Ⅲ)and V(Ⅳ).Under the conditions of a feed rate of 30 kg/h,an air flow rate of 28.0 m^(3)/h,an O_(2) flow rate of 4.0 m^(3)/h,and a temperature of 900℃ in both the suspension furnace and fluidized reactor,the vanadium-bearing mica underwent dehydroxylation and transformed into illite-montmorillonite.These changes disrupted the crystal structure of mica,facilitating vanadium extraction.Compared to direct acid leaching,curing-leaching demonstrates better performance in vanadium extraction.Under the conditions of curing temperature of 130℃,acid dosage of 40 wt.%,curing time of 6 h,and leaching time of 3 h,a V_(2)O_(5) leaching efficiency of 83.92% was achieved.展开更多
BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major...BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major blood vessels remains a substantial clinical challenge.Traditionally,these cases often require open abdominal surgery or combined organ resections,and in some instances,the tumors are considered unresectable.Currently,no reports have described the resection of such tumors via laparoscopy.CASE SUMMARY A 35-year-old woman was admitted to our hospital after the incidental discovery of a retroperitoneal space-occupying lesion.Imaging revealed a mass with the celiac axis and superior mesenteric artery passing through it.A neurogenic tumor was suspected,with ganglioneuroma being the most likely diagnosis.Following comprehensive preoperative preparation,the retroperitoneal tumor was resected using a three-dimensional laparoscopy combined with an organ suspension technique.The surgical approach involved incising the tumor along the vascular axis and conducting meticulous,vascular-preserving tumor excision.The operation lasted approximately 458 minutes,with an estimated blood loss of 50 mL.The patient was discharged on the 8th postoperative day.A transient liver injury occurred after surgery but improved rapidly.After 11 months of postoperative follow-up,no complications or tumor recurrence were observed.CONCLUSION This case illustrates the feasibility of minimally invasive laparoscopic resection for retroperitoneal ganglioneuromas encasing major blood vessels.展开更多
Coronavirus is a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused by a novel coronavirus belonging to the family Coronaviridae. The disease was first discovered in December 2019 in Wuhan City, Hubei...Coronavirus is a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused by a novel coronavirus belonging to the family Coronaviridae. The disease was first discovered in December 2019 in Wuhan City, Hubei Province, China. A few months later, the disease spread all over the world and became an epidemic. The infection for most people is mild to moderate but in Vulnerable groups, if they have the infections, they might experience severe COVID-19. Saudi Arabia initiated its response plan early, and all sectors and agencies worked in an integrated way to combat the disease. It has maintained proper communication during the pandemic and ensured community involvement, epidemiologic surveillance, and activation of rapid response teams. The COVID-19 pandemic significantly affected daily lives. Schools and daycares were closed, education was online, traveling stopped, work was suspended, gathering in social activities and practicing religious rituals, like praying or doing Umrah or Hajj, were banded. Changing lifestyles as a response to COVID-19 impacted whole communities with different categories of children, parents, and families. Women usually take the majority of daily responsibilities. The sudden change in lifestyle during COVID-19 put pressure on mothers, especially those who are working to balance work and family obligations. This study aims to identify the impact of Coronavirus disease 2019 on working mothers in Saudi Arabia. Method: Data of the study was collected through survey posted on social media and analyzed through Excel. It focuses on five aspects: health, lifestyle, social relations, work production and financial status. Our target population was working mothers in Saudi Arabia aged at least 25 years. Results: In this study, all factors affected working mothers categorized under two groups: Social Economic Status and Work suspension. For Social Economic Status factors, we find five factors which are monthly income, main breadwinner, number of children at school age, type of housing, and type of work. Almost all mothers include spiritual activities to their routine to cope with stress during this period. About half of our sample have negative impact on their mental health because they are the main breadwinner, and mothers with a smaller number of children at school age have more challenges to cope up. We found that mothers who own a house or work at governmental sector have better outcome of health. After analyzing data related to Work suspension, we found that mothers who have work support have better management for life circumstances, however their health outcomes were negatively affected. In addition, mothers working at education sector have the highest positive impact among other sectors. Our data shows that working mothers’ abilities to follow up with their children decreased. This study recommends that there is need to invest more in working mothers’ research and supportive programs and ensure collaboration globally to address working mothers’ needs and share experiences.展开更多
[Objectives]To assess the carbon sink capacity in seawater suspension cage aquaculture of shellfish in Tianjin from 2015 to 2022.[Methods]The carbon sink capacity of different shellfish species was evaluated using bot...[Objectives]To assess the carbon sink capacity in seawater suspension cage aquaculture of shellfish in Tianjin from 2015 to 2022.[Methods]The carbon sink capacity of different shellfish species was evaluated using both physical and value assessment methods.[Results]The shellfish cultivated in seawater suspension cages in Tianjin exhibited a significant capacity for carbon sinks.The amounts of carbon removed by suspension cage aquaculture of Rapana venosa,Crassostrea gigas,Scapharca subcrenata,Scapharca broughtonii and Argopectens irradias were 448.297,403.398,89.463,40.657,and 106.719 t,respectively.Furthermore,the total volume of shellfish cultivated in seawater exhibited a consistent upward trend over time,correlating with an annual increase in the amount of carbon removed.Among the shellfish cultivated in seawater suspension cages,the order of carbon sink capacity was as follows:C.gigas>R.venosa>A.irradias>S.subcrenata and S.broughtonii.In terms of the carbon sink capacity of soft tissues,the ranking was as follows:A.irradias>R.venosa>C.gigas>S.subcrenata and S.broughtonii.The structural and yield factors associated with seawater suspension cage aquaculture of shellfish significantly influenced the enhancement of the total carbon sink of cultivated shellfish.Notably,structural factors had a greater impact on the increase in the carbon sink of cultivated shellfish compared to total yield factors.[Conclusions]The findings will serve as a reference for enhancing the carbon sink potential of fisheries and achieving sustainable development in seawater aquaculture in Tianjin.展开更多
Roasting bastnaesite concentrates is a crucial process in extracting rare earths.This study explored an efficient suspension roasting technology and investigated the bastnaesite pyrolysis and cerium(Ce)oxidation.Relev...Roasting bastnaesite concentrates is a crucial process in extracting rare earths.This study explored an efficient suspension roasting technology and investigated the bastnaesite pyrolysis and cerium(Ce)oxidation.Relevant analytical tests were applied to evaluate the phase and surface property variations of bastnaesite,and isothermal kinetic analysis of bastnaesite pyrolysis and Ce oxidation was performed.The results revealed that bastnaesite decomposed rapidly and accompanied by Ce oxidation,and the gas-solid products were identified as CO_(2),Ce_(7)O_(12),La_(2)O_(3),CeF_(3) and LaF_(3),with Ce oxidation restricted by bastnaesite pyrolysis.As roasting time prolonged,cracks and pores appeared on bastnaesite surface;the BET specific surface and pore diameter increased.In later roasting period,the pore diameter continued to increase but the specific surface decreased,assigned to particle fusion agglomeration and pore consolidation.Additionally,the surface C content reduced and Ce(Ⅳ)content increased gradually as roasting progressed.The reaction kinetics all followed Avrami-Erofeev equations,the reaction orders of bastnaesite pyrolysis and Ce oxidation decreased with decreasing reaction temperature.The calculated activation energies at lower temperatures were higher than those calculated at higher temperatures.This study analyzed the bastnaesite reaction mechanism to supply a reference for the application of suspension roasting technology in bastnaesite smelting.展开更多
Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its com...Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its compliance,particularly among children.Consequently,this study aimed to devise a novel sustained-release suspension of OP employing an ion exchange resin as a carrier to address these challenges.The OP-drug resin complex(OP-DRC)was synthesized utilizing ion exchange technology,while OP-coated microcapsules(OP-CM)were fabricated via the emulsion-evaporation method.The optimization of the formulation process for the OP sustained-release suspension was achieved through a combination of single-factor experimentation and orthogonal experimental design.Furthermore,the drug release kinetics and pharmacokinetic properties of the sustained-release suspension were thoroughly evaluated both in vitro and in vivo.Scanning electron microscopy(SEM),X-ray diffraction(XRD),and attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR)analyses confirmed the formation of drug-resin complexes via ionic bonding.The in vitro cumulative release rates were found to be 16%(1 h),53%(6 h),and 84%(24 h),respectively.Notably,the self-made sustained-release suspension exhibited an extended half-life(21.518 h),delayed time to peak concentration(T_(max))(6 h),and reduced maximum plasma concentration(C_(max))(0.397μg/mL)in comparison to commercial granules(half-life=8.466 h;T_(max)=2 h;C_(max)=0.631μg/mL).Additionally,the area under the curve(AUC)indicated that the bioavailability of the self-made OP suspension surpassed that of the commercial OP granules by 101%.These findings underscored the successful development of an oral OP sustained-release suspension characterized by stability,tastelessness,ease of swallowing,convenient administration,and sustained-release properties,thereby potentially enhancing drug compliance among children.展开更多
To improve the nutritional and functional value of rice,numerous biotechnological approaches have focused on metabolic engineering to address nutritional deficiencies and produce health-beneficial compounds that are e...To improve the nutritional and functional value of rice,numerous biotechnological approaches have focused on metabolic engineering to address nutritional deficiencies and produce health-beneficial compounds that are either absent or naturally present in low amounts.A prominent example is‘Golden Rice’,which has been genetically modified to accumulateβ-carotene to combat vitamin A deficiency in regions with limited dietary intake.Scientists have been continuously biofortifying rice with various specialized metabolites,including terpenoids,flavonoids,non-flavonoid polyphenols,betalains,vitamins,and amino acids.This review explores the specific pathways and genetic modifications utilized by researchers to enhance the accumulation of targeted metabolites in rice.It comprehensively summarizes key strategies and research trends in rice metabolic engineering,demonstrating how rice can be transformed into a strategic crop for producing industrially valuable compounds beyond its traditional role as a staple food by leveraging its advantages as a versatile host system through its grains,leaves,and cells.Furthermore,we highlight the potential of intergrating metabolic engineering with synthetic biology and big data-driven computational modeling,particularly through artificial intelligence and machine learning,as promising future research directions.展开更多
To improve the accuracy of thermal response estimation and overcome the limitations of the linear regression model and Artificial Neural Network(ANN)model,this study introduces a deep learning estimation method specif...To improve the accuracy of thermal response estimation and overcome the limitations of the linear regression model and Artificial Neural Network(ANN)model,this study introduces a deep learning estimation method specifically based on the Long Short-Term Memory(LSTM)network,to predict temperature-induced girder end displacements of the Dasha Waterway Bridge,a suspension bridge in China.First,to enhance data quality and select target sensors,preprocessing based on the sigma rule and nearest neighbor interpolation is applied to the raw data.Furthermore,to eliminate the high-frequency components from the displacement signal,the wavelet transform is conducted.Subsequently,the linear regression model and ANN model are established,whose results do not meet the requirements and fail to address the time lag effect between temperature and displacements.The study proceeds to develop the LSTM network model and determine the optimal parameters through hyperparameter sensitivity analysis.Finally,the results of the LSTM network model are discussed by a comparative analysis against the linear regression model and ANN model,which indicates a higher accuracy in predicting temperatureinduced girder end displacements and the ability to mitigate the time-lag effect.To be more specific,in comparison between the linear regression model and LSTM network,the mean square error decreases from 6.5937 to 1.6808 and R^(2) increases from 0.683 to 0.930,which corresponds to a 74.51%decrease in MSE and a 36.14%improvement in R^(2).Compared to ANN,with an MSE of 4.6371 and an R^(2) of 0.807,LSTM shows a decrease in MSE of 63.75%and an increase in R^(2) of 13.23%,demonstrating a significant enhancement in predictive performance.展开更多
文摘When we were moved by the warmth of Korean ethic family drama,we began to fall into the feeling that these dramas were so real just as our daily life.But we tend to overlook the fact that the dramas which have been elaborated by authors are just a mirror of daily life.Suspense narrative,contrast narrative,and coincidence narrative are three main narrative techniques of Korean family drama.As an important narrative technique of Korean family ethic drama,suspense is a narrative skill organizing the plot and making dramas to be more charming.So this paper will analyze the suspense of Korean family ethic drama from these three aspects:story,plot,and metronome.
文摘Murder on the Orient Express, a masterpiece in the detective fictions, is one of the most prevailing works of Agatha Christie. It provides special modes and new ideas for the later creation of the detective stories. Suspense is embodied largely in this book. A variety of suspense interweaves, overlaps and creates the stirring effect. This thesis first introduces the lifetime of the au?thor, the typicality of the book among the same kind of detective fictions. Then it aims at explaining and analyzing the suspense set?tings from the narrative time, the narrative point of view, clues in the book and the ending of the story by using the text analysis. Fi?nally, it states the significance of suspense settings. The study of suspense settings can not only dissect the artistic value and the charm of suspense in detective fictions but also contribute to improving readers'abilities of appreciating mystery stories. It can help them to shape a unique aesthetic perspective.
基金This work was supported by the National Natural Science Foundation of China(Grant No.12272141)The financial support is gratefully acknowledged.
文摘The transformation from multibody models to lumped-parameter models is a crucial aspect of vehicle dynamics research.The velocity transformation method is adopted in this research,and the suspension multibody model is described using only one degree of freedom.It is found that the equivalent mass of the system is time-dependent during the simulation process,as observed in numerical simulations.Further symbolic calculations are conducted to derive the analytical form of the equivalent mass,and the results show that once the static parameters are determined,the equivalent mass of the suspension system is determined solely by the vertical position of the suspension upright,which reveals the kinematics characteristic of the equivalent mass of the suspension system.It is found that the equivalent mass experiences smaller changes when the suspension is compressed from the middle position,but larger changes when the suspension is extended.Furthermore,by comparing the multibody model,the lumped-parameter model with static mass,and the proposed lumped-parameter model considering the kinematics characteristic of the equivalent unsprung mass,the proposed model produces simulation results that more closely match the original multibody model than the model with static mass.The improvements in accuracy can be up to 20%under certain evaluation metrics.
基金The National Natural Science Foundation of China(No.52338011)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX23_0067).
文摘Main cable displacement-controlled devices(DCDs)are key components for coordinating the vertical deformation of the main cable and main girder in the side span of continuous suspension bridges.To reveal the mechanical action mechanisms of DCD on bridge structures,a three-span continuous suspension bridge was taken as the engineering background in this study.The influence of different forms of DCD on the internal force and displacement of the components in the side span of the bridge and the structural dynamic characteristics were explored through numerical simulations.The results showed that the lack of DCD caused the main cable and main girder to have large vertical displacements.The stresses of other components were redistributed,and the safety factor of the suspenders at the side span was greatly reduced.The setting of DCD improved the vertical stiffness of the structure.The rigid DCD had larger internal forces,but its control effect on the internal forces at the side span was slightly better than that of the flexible DCD.Both forms of DCD effectively coordinated the deformation of the main cable and main girder and the stress distribution of components in the side span area.The choice of DCD form depends on the topographic factors of bridge sites and the design requirements of related components at the side span.
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
基金supported in part by the Thai Nguyen University of Technology,Vietnam.
文摘This article presents an adaptive optimal control method for a semi-active suspension system.The model of the suspension system is built,in which the components of uncertain parameters and exogenous disturbance are described.The adaptive optimal control law consists of the sum of the optimal control component and the adaptive control component.First,the optimal control law is designed for the model of the suspension system after ignoring the components of uncertain parameters and exogenous disturbance caused by the road surface.The optimal control law expresses the desired dynamic characteristics of the suspension system.Next,the adaptive component is designed with the purpose of compensating for the effects caused by uncertain parameters and exogenous disturbance caused by the road surface;the adaptive component has adaptive parameter rules to estimate uncertain parameters and exogenous disturbance.When exogenous disturbances are eliminated,the system responds with an optimal controller designed.By separating theoretically the dynamic of a semi-active suspension system,this solution allows the design of two separate controllers easily and has reduced the computational burden and the use of too many tools,thus allowing for more convenient hardware implementation.The simulation results also show the effectiveness of damping oscillations of the proposed solution in this article.
文摘From complicated overpasses that defy(违抗)engineering conventions to suspended“river highways”,China is internationally recognized for its innovative infrastructure.Another example of the nation's fearless approach to building and design is the temporary suspension bridge.
文摘Rice callus suspension culture(RCSC)has been shown to have anticancer activity based on cytotoxic activity on human colon and lung cancer cell lines.In the present study,the effect of RCSC on the expression of proteins in lung(A549)and colon(HT29)cancer cell lines was examined by using proteomics analysis.The protein-protein interaction study of differentially expressed proteins was done by using the Search Tool for the Retrieval of Interacting Genes(STRING),and the results showed that the proteins interacting with each other belong to different pathways.
基金funded by the National Key Research and Development Program of China(No.2020YFC1909704)the Fundamental Research Funds for the Central Universities,China(Nos.N2301026,N2301017).
文摘Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-industrial trials were conducted.Vanadium in raw ore mainly exists in sericite,roscoelite,and limonite,predominantly in the forms of V(Ⅲ)and V(Ⅳ).Under the conditions of a feed rate of 30 kg/h,an air flow rate of 28.0 m^(3)/h,an O_(2) flow rate of 4.0 m^(3)/h,and a temperature of 900℃ in both the suspension furnace and fluidized reactor,the vanadium-bearing mica underwent dehydroxylation and transformed into illite-montmorillonite.These changes disrupted the crystal structure of mica,facilitating vanadium extraction.Compared to direct acid leaching,curing-leaching demonstrates better performance in vanadium extraction.Under the conditions of curing temperature of 130℃,acid dosage of 40 wt.%,curing time of 6 h,and leaching time of 3 h,a V_(2)O_(5) leaching efficiency of 83.92% was achieved.
基金Supported by the Zhejiang Medical Science and Technology Project,No.2022KY1325 and No.2023KY381Public Welfare Project of Jinhua Science and Technology Plan,No.2023-4-084Major Project of Jinhua Science and Technology Plan,No.2023-3-066.
文摘BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major blood vessels remains a substantial clinical challenge.Traditionally,these cases often require open abdominal surgery or combined organ resections,and in some instances,the tumors are considered unresectable.Currently,no reports have described the resection of such tumors via laparoscopy.CASE SUMMARY A 35-year-old woman was admitted to our hospital after the incidental discovery of a retroperitoneal space-occupying lesion.Imaging revealed a mass with the celiac axis and superior mesenteric artery passing through it.A neurogenic tumor was suspected,with ganglioneuroma being the most likely diagnosis.Following comprehensive preoperative preparation,the retroperitoneal tumor was resected using a three-dimensional laparoscopy combined with an organ suspension technique.The surgical approach involved incising the tumor along the vascular axis and conducting meticulous,vascular-preserving tumor excision.The operation lasted approximately 458 minutes,with an estimated blood loss of 50 mL.The patient was discharged on the 8th postoperative day.A transient liver injury occurred after surgery but improved rapidly.After 11 months of postoperative follow-up,no complications or tumor recurrence were observed.CONCLUSION This case illustrates the feasibility of minimally invasive laparoscopic resection for retroperitoneal ganglioneuromas encasing major blood vessels.
文摘Coronavirus is a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused by a novel coronavirus belonging to the family Coronaviridae. The disease was first discovered in December 2019 in Wuhan City, Hubei Province, China. A few months later, the disease spread all over the world and became an epidemic. The infection for most people is mild to moderate but in Vulnerable groups, if they have the infections, they might experience severe COVID-19. Saudi Arabia initiated its response plan early, and all sectors and agencies worked in an integrated way to combat the disease. It has maintained proper communication during the pandemic and ensured community involvement, epidemiologic surveillance, and activation of rapid response teams. The COVID-19 pandemic significantly affected daily lives. Schools and daycares were closed, education was online, traveling stopped, work was suspended, gathering in social activities and practicing religious rituals, like praying or doing Umrah or Hajj, were banded. Changing lifestyles as a response to COVID-19 impacted whole communities with different categories of children, parents, and families. Women usually take the majority of daily responsibilities. The sudden change in lifestyle during COVID-19 put pressure on mothers, especially those who are working to balance work and family obligations. This study aims to identify the impact of Coronavirus disease 2019 on working mothers in Saudi Arabia. Method: Data of the study was collected through survey posted on social media and analyzed through Excel. It focuses on five aspects: health, lifestyle, social relations, work production and financial status. Our target population was working mothers in Saudi Arabia aged at least 25 years. Results: In this study, all factors affected working mothers categorized under two groups: Social Economic Status and Work suspension. For Social Economic Status factors, we find five factors which are monthly income, main breadwinner, number of children at school age, type of housing, and type of work. Almost all mothers include spiritual activities to their routine to cope with stress during this period. About half of our sample have negative impact on their mental health because they are the main breadwinner, and mothers with a smaller number of children at school age have more challenges to cope up. We found that mothers who own a house or work at governmental sector have better outcome of health. After analyzing data related to Work suspension, we found that mothers who have work support have better management for life circumstances, however their health outcomes were negatively affected. In addition, mothers working at education sector have the highest positive impact among other sectors. Our data shows that working mothers’ abilities to follow up with their children decreased. This study recommends that there is need to invest more in working mothers’ research and supportive programs and ensure collaboration globally to address working mothers’ needs and share experiences.
基金Supported by Science and Technology Commissioner Project of Tianjin Science and Technology Bureau(22ZYCGSN00630).
文摘[Objectives]To assess the carbon sink capacity in seawater suspension cage aquaculture of shellfish in Tianjin from 2015 to 2022.[Methods]The carbon sink capacity of different shellfish species was evaluated using both physical and value assessment methods.[Results]The shellfish cultivated in seawater suspension cages in Tianjin exhibited a significant capacity for carbon sinks.The amounts of carbon removed by suspension cage aquaculture of Rapana venosa,Crassostrea gigas,Scapharca subcrenata,Scapharca broughtonii and Argopectens irradias were 448.297,403.398,89.463,40.657,and 106.719 t,respectively.Furthermore,the total volume of shellfish cultivated in seawater exhibited a consistent upward trend over time,correlating with an annual increase in the amount of carbon removed.Among the shellfish cultivated in seawater suspension cages,the order of carbon sink capacity was as follows:C.gigas>R.venosa>A.irradias>S.subcrenata and S.broughtonii.In terms of the carbon sink capacity of soft tissues,the ranking was as follows:A.irradias>R.venosa>C.gigas>S.subcrenata and S.broughtonii.The structural and yield factors associated with seawater suspension cage aquaculture of shellfish significantly influenced the enhancement of the total carbon sink of cultivated shellfish.Notably,structural factors had a greater impact on the increase in the carbon sink of cultivated shellfish compared to total yield factors.[Conclusions]The findings will serve as a reference for enhancing the carbon sink potential of fisheries and achieving sustainable development in seawater aquaculture in Tianjin.
基金Projects(2022YFC2905800,2021YFC2901000)supported by the National Key R&D Program of ChinaProject(52174242)supported by the National Science and Technology of ChinaProject(52130406)supported by the National Science and Technology Major Project of China。
文摘Roasting bastnaesite concentrates is a crucial process in extracting rare earths.This study explored an efficient suspension roasting technology and investigated the bastnaesite pyrolysis and cerium(Ce)oxidation.Relevant analytical tests were applied to evaluate the phase and surface property variations of bastnaesite,and isothermal kinetic analysis of bastnaesite pyrolysis and Ce oxidation was performed.The results revealed that bastnaesite decomposed rapidly and accompanied by Ce oxidation,and the gas-solid products were identified as CO_(2),Ce_(7)O_(12),La_(2)O_(3),CeF_(3) and LaF_(3),with Ce oxidation restricted by bastnaesite pyrolysis.As roasting time prolonged,cracks and pores appeared on bastnaesite surface;the BET specific surface and pore diameter increased.In later roasting period,the pore diameter continued to increase but the specific surface decreased,assigned to particle fusion agglomeration and pore consolidation.Additionally,the surface C content reduced and Ce(Ⅳ)content increased gradually as roasting progressed.The reaction kinetics all followed Avrami-Erofeev equations,the reaction orders of bastnaesite pyrolysis and Ce oxidation decreased with decreasing reaction temperature.The calculated activation energies at lower temperatures were higher than those calculated at higher temperatures.This study analyzed the bastnaesite reaction mechanism to supply a reference for the application of suspension roasting technology in bastnaesite smelting.
基金2023 Nantong Jianghai Talents Project2023 Nantong Social Livelihood Science and Technology Plan+4 种基金2021 Jurong Social Development Science&Technology Program(Grant No.ZA42109)2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research InstituteChina Postdoctoral Science Foundation(Grant No.2020M681532)Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.2020Z209)Natural Science Research Projects of Universities in Jiangsu Province(Grant No.20KJD350001)。
文摘Oseltamivir phosphate(OP),renowned as one of the most effective drugs for influenza treatment,encounters several challenges,including poor stability,difficulty in swallowing,and a bitter taste,thereby limiting its compliance,particularly among children.Consequently,this study aimed to devise a novel sustained-release suspension of OP employing an ion exchange resin as a carrier to address these challenges.The OP-drug resin complex(OP-DRC)was synthesized utilizing ion exchange technology,while OP-coated microcapsules(OP-CM)were fabricated via the emulsion-evaporation method.The optimization of the formulation process for the OP sustained-release suspension was achieved through a combination of single-factor experimentation and orthogonal experimental design.Furthermore,the drug release kinetics and pharmacokinetic properties of the sustained-release suspension were thoroughly evaluated both in vitro and in vivo.Scanning electron microscopy(SEM),X-ray diffraction(XRD),and attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR)analyses confirmed the formation of drug-resin complexes via ionic bonding.The in vitro cumulative release rates were found to be 16%(1 h),53%(6 h),and 84%(24 h),respectively.Notably,the self-made sustained-release suspension exhibited an extended half-life(21.518 h),delayed time to peak concentration(T_(max))(6 h),and reduced maximum plasma concentration(C_(max))(0.397μg/mL)in comparison to commercial granules(half-life=8.466 h;T_(max)=2 h;C_(max)=0.631μg/mL).Additionally,the area under the curve(AUC)indicated that the bioavailability of the self-made OP suspension surpassed that of the commercial OP granules by 101%.These findings underscored the successful development of an oral OP sustained-release suspension characterized by stability,tastelessness,ease of swallowing,convenient administration,and sustained-release properties,thereby potentially enhancing drug compliance among children.
基金supported by the Bio&Medical Technology Development Program of the National Research Foundation(NRF)funded by the Korean government(MSIT)(Grant No.RS-2024-00440478)to Sun-Hwa HAthe NRF by MSIT(Grant Nos.RS-2024-00347806 and RS-2024-00407469)to Sun-Hwa HAthe New Plant Breed Technology Program funded by the Rural Development Administration,Republic of Korea(Grant No.RS-2024-00322447)to Sun-Hwa HA.
文摘To improve the nutritional and functional value of rice,numerous biotechnological approaches have focused on metabolic engineering to address nutritional deficiencies and produce health-beneficial compounds that are either absent or naturally present in low amounts.A prominent example is‘Golden Rice’,which has been genetically modified to accumulateβ-carotene to combat vitamin A deficiency in regions with limited dietary intake.Scientists have been continuously biofortifying rice with various specialized metabolites,including terpenoids,flavonoids,non-flavonoid polyphenols,betalains,vitamins,and amino acids.This review explores the specific pathways and genetic modifications utilized by researchers to enhance the accumulation of targeted metabolites in rice.It comprehensively summarizes key strategies and research trends in rice metabolic engineering,demonstrating how rice can be transformed into a strategic crop for producing industrially valuable compounds beyond its traditional role as a staple food by leveraging its advantages as a versatile host system through its grains,leaves,and cells.Furthermore,we highlight the potential of intergrating metabolic engineering with synthetic biology and big data-driven computational modeling,particularly through artificial intelligence and machine learning,as promising future research directions.
基金The National Key Research and Development Program of China grant No.2022YFB3706704 received by Yuan Renthe National Natural and Science Foundation of China grant No.52308150 received by Xiang Xu.
文摘To improve the accuracy of thermal response estimation and overcome the limitations of the linear regression model and Artificial Neural Network(ANN)model,this study introduces a deep learning estimation method specifically based on the Long Short-Term Memory(LSTM)network,to predict temperature-induced girder end displacements of the Dasha Waterway Bridge,a suspension bridge in China.First,to enhance data quality and select target sensors,preprocessing based on the sigma rule and nearest neighbor interpolation is applied to the raw data.Furthermore,to eliminate the high-frequency components from the displacement signal,the wavelet transform is conducted.Subsequently,the linear regression model and ANN model are established,whose results do not meet the requirements and fail to address the time lag effect between temperature and displacements.The study proceeds to develop the LSTM network model and determine the optimal parameters through hyperparameter sensitivity analysis.Finally,the results of the LSTM network model are discussed by a comparative analysis against the linear regression model and ANN model,which indicates a higher accuracy in predicting temperatureinduced girder end displacements and the ability to mitigate the time-lag effect.To be more specific,in comparison between the linear regression model and LSTM network,the mean square error decreases from 6.5937 to 1.6808 and R^(2) increases from 0.683 to 0.930,which corresponds to a 74.51%decrease in MSE and a 36.14%improvement in R^(2).Compared to ANN,with an MSE of 4.6371 and an R^(2) of 0.807,LSTM shows a decrease in MSE of 63.75%and an increase in R^(2) of 13.23%,demonstrating a significant enhancement in predictive performance.
