Introduction:In 2025,a patient with leukemia in Haizhu District,Guangdong Province,China,tested positive for dengue virus.The local Center for Disease Control and Prevention immediately initiated an investigation and ...Introduction:In 2025,a patient with leukemia in Haizhu District,Guangdong Province,China,tested positive for dengue virus.The local Center for Disease Control and Prevention immediately initiated an investigation and response.Methods:This investigation included epidemiological surveys,vector mosquito surveillance,case findings,and blood sample collection for laboratory testing.The laboratory analyses comprised dengue virus nucleic acid detection,antigen detection,specific antibody detection,viral isolation,and genetic sequencing.Results:The patient was diagnosed with dengue virus serotype 1(DENV-1)infection 6 months prior to undergoing chemotherapy and targeted therapy for leukemia.Six months later,during high-intensity immunosuppressive therapy following allogeneic hematopoietic stem cell transplantation,the patient tested positive again for DENV-1.Genetic sequencing revealed 99.99%identity between the viral sequences obtained during initial infection and subsequent detection.Viral culture confirmed the presence of a replication-competent live virus.Conclusions:This is the first documented case of persistent dengue virus infection lasting six months in a patient with leukemia in China.This highlights that for patients undergoing hematopoietic stem cell transplantation and immunosuppressive therapy,particularly in dengue-endemic regions,there should be heightened vigilance regarding the possibility of persistent dengue infection.Implementation of continuous serological monitoring is warranted in high-risk populations.展开更多
基金Supported by Guangzhou Municipal General Guidance Program for Health Technology(20251A011105).
文摘Introduction:In 2025,a patient with leukemia in Haizhu District,Guangdong Province,China,tested positive for dengue virus.The local Center for Disease Control and Prevention immediately initiated an investigation and response.Methods:This investigation included epidemiological surveys,vector mosquito surveillance,case findings,and blood sample collection for laboratory testing.The laboratory analyses comprised dengue virus nucleic acid detection,antigen detection,specific antibody detection,viral isolation,and genetic sequencing.Results:The patient was diagnosed with dengue virus serotype 1(DENV-1)infection 6 months prior to undergoing chemotherapy and targeted therapy for leukemia.Six months later,during high-intensity immunosuppressive therapy following allogeneic hematopoietic stem cell transplantation,the patient tested positive again for DENV-1.Genetic sequencing revealed 99.99%identity between the viral sequences obtained during initial infection and subsequent detection.Viral culture confirmed the presence of a replication-competent live virus.Conclusions:This is the first documented case of persistent dengue virus infection lasting six months in a patient with leukemia in China.This highlights that for patients undergoing hematopoietic stem cell transplantation and immunosuppressive therapy,particularly in dengue-endemic regions,there should be heightened vigilance regarding the possibility of persistent dengue infection.Implementation of continuous serological monitoring is warranted in high-risk populations.
