This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized ...This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized via the esterification of phytosterol and oleic acid,whose structure was characterized using Fourier-transform infrared spectroscopy(FTIR)and mass spectrometry(MS).Its liquid crystalline behavior was confirmed via the polarized optical microscopy(POM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),wide-angle X-ray scattering(WAXS),and small-angle X-ray scattering(SAXS).UV absorption tests were conducted to assess the UV-blocking performance of the oleic acid sterol ester liquid crystals.To improve the stability of its liquid crystalline structure,the oleic acid sterol ester was encapsulated into microcapsules through the emulsion polymerization.SPF measurements were performed on the sunscreen formulations containing liquid crystal microcapsules.The oleic acid sterol ester displayed cholesteric liquid crystalline behavior and strong UVA absorption,which indicates its suitability as a natural UV absorber.Microencapsulation further enhanced its stability and UV-blocking properties.SPF testing showed that the formulations with microcapsules achieved an SPF value of 7.01,which surpasses the nano titanium dioxide(SPF=6.23)and significantly outperform the unencapsulated liquid crystal formulations(SPF=2.65).This study highlights the potential of microencapsulated oleic acid sterol ester as a novel UV absorber in the sunscreen formulations,offers the enhanced stability and effective UV protection,and showcases its application potential in the innovative cosmetic products.展开更多
Organic ultraviolet(UV)filters play a crucial role in reducing sunburn,photoaging,and the risk of skin cancer induced by UV radiation.However,the challenges posed by photodegradation,potential phototoxicity,and poor d...Organic ultraviolet(UV)filters play a crucial role in reducing sunburn,photoaging,and the risk of skin cancer induced by UV radiation.However,the challenges posed by photodegradation,potential phototoxicity,and poor dispersion characteristics of organic UV filters significantly hinder their practical applications.This study aims to encapsulate avobenzone,a widely used UV filter,in mesoporous silica(MPS)to form AB@MPS particles via an in-situ sol-gel process,and to research their sunscreen performance as stabilizers in Pickering emulsion.The UV absorption capability of AB@MPS particles is stronger than free avobenzone.The in vitro skin penetration study reveals a greatly reduced permeability(73.9%)for avobenzone from AB@MPS compared to its free form.Furthermore,the photostability of AB@MPS particles increases 14.3 times compared to that of free avobenzone.In UV protection tests,the Pickering emulsion’s anti-UVA efficacy is 2.28 times greater than that of 20%PG solution,4.41 times greater than Carbomer hydrogel,and 3.59 times greater than the cream formulation.The SPF value of the Pickering emulsion is 2.41 times greater than the 20%PG solution,2 times greater than the Carbomer hydrogel,and 6.77 times greater than the cream formulation.This study presents a promising strategy for the application of Pickering emulsions in the cosmetic and pharmaceutical sectors,providing a safe and efficient formulation for sunscreens.展开更多
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsu...Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.展开更多
Titanium dioxide(TiO_(2))has been an important protective ingredient in mineral-based sunscreens since the 1990s.However,traditional TiO_(2)nanoparticle formulations have seen little improvement over the past decades ...Titanium dioxide(TiO_(2))has been an important protective ingredient in mineral-based sunscreens since the 1990s.However,traditional TiO_(2)nanoparticle formulations have seen little improvement over the past decades and continue to face persistent challenges related to light transmission,biosafety,and visual appearance.Here,we report the discovery of two-dimensional(2D)TiO_(2),characterized by a micro-sized lateral dimension(~1.6μm)and atomic-scale thickness,which fundamentally resolves these long-standing issues.The 2D structure enables exceptional light management,achieving 80%visible light transparency—rendering it nearly invisible on the skin—while maintaining UV-blocking performance comparable to unmodified rutile TiO_(2)nanoparticles.Its larger lateral size results in a two-orders-of-magnitude reduction in skin penetration(0.96 w/w%),significantly enhancing biosafety.Moreover,the unique layered architecture inherently suppresses the generation of reactive oxygen species(ROS)under sunlight exposure,reducing the ROS generation rate by 50-fold compared to traditional TiO_(2)nanoparticles.Through precise metal element modulation,we further developed the first customizable sunscreen material capable of tuning UV protection ranges and automatically matching diverse skin tones.The 2D TiO_(2)offers a potentially transformative approach to modern sunscreen formulation,combining superior UV protection,enhanced safety and a natural appearance.展开更多
Sunscreen agents derived from plants have been regarded as promising alternatives to artificial compounds.In this work,carbon dots(CDs)were prepared from carrot juice via a continuous microflowbased approach,where the...Sunscreen agents derived from plants have been regarded as promising alternatives to artificial compounds.In this work,carbon dots(CDs)were prepared from carrot juice via a continuous microflowbased approach,where the influence of process parameters was studied and optimized.Complimentary characterization revealed the CDs not only have small size,narrow size distribution,and good water solubility,but also have abundant functional groups as well as excellent UV absorption performance.Relying on these properties,the CDs were used as UV absorbers,suggesting they have strong long-term UV absorption ability over a broad pH range.The UV-absorption properties of the CDs were confirmed by incorporating the CDs in polyvinyl alcohol(PVA)to get C-CDs@PVA films of different thickness,in which significantly enhanced UV absorption performance was observed.Besides,the sun protection performance is also related to the film thickness.Afterwards,the practical application of the CDs was evaluated by adding them in a typical skin cream.With the addition of the CDs,the cream has drastically reduced UV transmittance in both UVA and UVB regions,and exhibits better UV absorption performance than commercial sunscreen agents.The CDs also demonstrated low cytotoxicity and high DPPH radical scavenging activity,making them promising as green sunscreen absorbers.This work is expected to provide a guidance for the development of green and effective natural sunscreen agents via microflowbased method.展开更多
Background:Long-term exposure to sunlight can lead to inflammatory responses,skin photoaging and cancers.Plant extracts can serve as effective biological UV(ultraviolet)filters for their UV absorption capacity.Red ric...Background:Long-term exposure to sunlight can lead to inflammatory responses,skin photoaging and cancers.Plant extracts can serve as effective biological UV(ultraviolet)filters for their UV absorption capacity.Red rice extract is rich in phenolic acids,flavonoids,anthocyanins and procyanins has the potential as a biological UV filter.Aims:This study aims to evaluate the potential of red rice extract as a biological UV filter.Forthurmore,exploring the ability of red rice extract to enhance SPF performance and serve as a potential substitute for chemical UV filters.Methods:Using UV absorption spectroscopy,the UV absorption performance of red rice extract was compared with that of three known UV filters.Additionally,using the Folin-Ciocalteu reagent to test the total phenolic acids content of red rice extract and the antioxidant capacity of red rice extract was verified through a 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical clearance assay,confirming its potential as a biological UV filter.Subsequently,the photoprotective enhancement effects of red rice extract in sunscreen formulations were explored by testing the SPF value with UV2000S.Results:Experiments conducted by adding different concentrations of red rice extract to sunscreen formulations demonstrated that its photoprotective enhancement effects were positively correlated with its concentration.The addition of 1%red rice extract to both oil-in-water(O/W)and water-in-oil(W/O)sunscreen formulations demonstrated good photoprotective enhancement effects,with SPF values increasing by over 10%.Further experiments showed that 1%,3%,and 5%red rice extract could replace approximately 12.82%,19.05%,and 26.09%of traditional UV filters in sunscreen formulations,achieving similar SPF values.Conclusions:These findings suggest that red rice extract is a promising biological UV filter,capable of enhancing SPF values and serving as a viable alternative for traditional UV filters.Red rice extract can be used in sunscreen products and provide photoprotection benefit.展开更多
Based on liquid crystal emulsification technology,a combination of macromolecular organic sunscreens and physical sunscreens was used to study and develop the formula of sunscreen lotion.The performance of the sunscre...Based on liquid crystal emulsification technology,a combination of macromolecular organic sunscreens and physical sunscreens was used to study and develop the formula of sunscreen lotion.The performance of the sunscreen lotion formula was analyzed by observing the liquid crystal structure of the lotion,investigating the stability of the formula,and using human sun protection index test and chemical skin absorption in vitro test.The study showed that in this sunscreen formula system,the combination of alkyl glycoside emulsifiers and polyglycerol emulsifiers is easier to form a liquid crystal structure than lecithin emulsifiers.The physical sunscreen zinc oxide is not conducive to the formation of the liquid crystal structure of the formula and the stability of the formula.The liquid crystal emulsification system helps to improve the sun protection index of the formula system to a certain extent.The liquid crystal structure has a certain sustained release effect on the active ingredients in the sunscreen cosmetic formula.展开更多
Farmers are frequently exposed to ultraviolet（UV） radiation which causes various diseases by inducing oxidative stress.This study aimed to assess the effects of sunblock on oxidative stress in the body.Eighty-seven ...Farmers are frequently exposed to ultraviolet（UV） radiation which causes various diseases by inducing oxidative stress.This study aimed to assess the effects of sunblock on oxidative stress in the body.Eighty-seven farmers were divided into two groups：those who wore sunblock for five days and those who did not.The total antioxidant capacity（TAC） in urine,which is an antioxidant indicator,and 8-hydroxy-2-deoxyguanosine（8-OHdG） levels in urine,an oxidative stress indicator,were measured.The urinary TAC of sunblock users was significantly higher than that of non-users,but urinary 8-OHdG levels were not significantly different.Even after adjustment for potential confounders,urinary TAC was found to be markedly increased with sunblock usage.These results suggest that sunblock is effective in preventing oxidative stress among farmers.In addition,they show that urinary TAC can be used as a good effect marker of oxidative stress caused by UV exposure.展开更多
The current study presents the characterization of three types of materials after exposure to solar UV radiation. The selection of the materials is related to socio-economic aspects and rural activities in the northwe...The current study presents the characterization of three types of materials after exposure to solar UV radiation. The selection of the materials is related to socio-economic aspects and rural activities in the northwest of Argentina (a.k.a. NOA). The objective was to establish a time parameter that allows estimating the durability of the materials according to their use. One of the materials is used as a protective cover (polyethylene film) of greenhouses, which are used for crop cultivation in the area. Another material is used in photovoltaic modules (PVMs), which are used to supply energy in isolated areas and the third material is sunscreen used by people that are exposed to UV radiation during rural activities. Degradation or deterioration of the materials was monitored using different spectroscopic assays: infrared was used to detect any structural changes in the material, X-rays were used for possible changes in the crystalline structure of the material, and spectral transmittance as this property is likely to be affected by changes in the structure of the material. The results showed that degradation of polyethylene seems to be related to the diminution in transparency and the loss of mechanical resistance with increasing exposure time. The decrease in transparency of one of the layers of a PVM caused a considerable decrease in the energy generated, whereas the sunscreens with a low sun protection factor (SPF) rapidly lost their protective properties and changed their photostability properties. Our results revealed a relationship between relative transmittance loss and exposure timse, which allows estimating the stability of different materials.展开更多
The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and m...The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600℃. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM);the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.展开更多
1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione(known as Avobenzone/AVB),widely used throughout the world as a highly effective UVA absorber,can prevent the progression of photoaging in skin,and i...1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione(known as Avobenzone/AVB),widely used throughout the world as a highly effective UVA absorber,can prevent the progression of photoaging in skin,and is also known for the disadvantage of having a reduced capability to absorb UVA when exposed to sunlight for long periods.To address this challenge,ZnTi-CO_(3)-LDH with a twodimensional layered structure was used to improve stability and synergistically enhance UV absorption of AVB.A novel AVB loaded ZnTi-CO_(3)-LDH(AVB@ZnTi-LDH)material was synthesized by reconstruction method and the loading content(LC)was about 46.8%investigated by high-performance liquid chromatography(HPLC).A possible mechanism for the binding of AVB with the ZnTi-LDH surface was proposed.X-ray photoelectron spectroscopy(XPS)and density functional theory(DFT)calculations were used to confirm further the coordination between Zn on the layer and the oxygen atom of the carbonyl group of AVB.UV absorption and critical wavelength of AVB@ZnTi-LDH were superior to those of AVB and ZnTiLDH precursors.Compared with pure AVB,the photodegradation rate was reduced from 15.06%to 4.06%.Especially in titanium dioxide,the decomposition rate was reduced from 29.75%to 7.92%.Furthermore,pure AVB often reacts with multivalent metal ions to induce an unpleasant color(light yellow to reddish brown),which is greatly mitigated with AVB@ZnTi-LDH.In this study,avobenzone was combined with hydrotalcite to prepare an organic-inorganic composite with excellent UV resistance and better stability,the composite has great promise for application in sunscreen cosmetics.展开更多
UV-B(280-320 nm)sunscreening is crucial for lives on Earth.Examining the role of surrounding of UV-B ter understand UV-B absorption.screening molecules can help us better is ubiquitous in cells as the solvent,but its ...UV-B(280-320 nm)sunscreening is crucial for lives on Earth.Examining the role of surrounding of UV-B ter understand UV-B absorption.screening molecules can help us better is ubiquitous in cells as the solvent,but its impacts on UV-B absorption of sunscreen agents are underexplored.Herein,we report a firstprinciple study on UV-B absorption of sinapate malate(SM)and rele vant molecular species,with a focus on the solvent effect of water.The capability of UV-B screening by anions of SM,the proposed species for actual sunscreening,is shaped by water.Both the implicit water providing the dielectric environment of solvation and the explicit water molecules forming hydrogen bonding to SM anion can appreciably alter the nature of transition orbitals responsible to the UV-B absorption of the anion.Finally,we find the molecular dipole moment of an organic UV-B screening agent can be an indicator of its UV-B screening sensitivity to the surrounding water.Our work may serve as a starting point of developing new water-soluble UV-B screening agent.展开更多
Dual fluorescence and UV absorption of 2′-ethylhexyl 4-（N,N-dimethylamino）benzoate （EHDMAB） were investigated in cationic, non-ionic and anionic micelles. When EHDMAB was solubilized in different micelles, the UV...Dual fluorescence and UV absorption of 2′-ethylhexyl 4-（N,N-dimethylamino）benzoate （EHDMAB） were investigated in cationic, non-ionic and anionic micelles. When EHDMAB was solubilized in different micelles, the UV absorption of EHDMAB was enhanced. Twisted intramolecular charge transfer （TICT） emission with longer wavelength was observed in ionic micelles, whereas TICT emission with shorter wavelength was obtained in non-ionic micelles. In particular, dual fluorescence of EHDMAB was significantly quenched by the positively charged pyridinium ions arranged in the Stern layer of cationic micelles. UV radiation absorbed mainly decays via TICT emission and radiationless deactivation. The dimethylamino group of EHDMAB experiences different polar environments in ionic and non-ionic micelles according to the polarity dependence of TICT emission of EHDMAB in organic solvents. In terms of the molecular structures and sizes of EHDMAB and surfactants, each individual EHDMAB molecule should be buried in micelles with its dimethylamino group toward the polar head groups of different micelles and with its 2′-ethylhexyl chain toward the hydrophobic micellar core. Dynamic fluorescence quenching measurements of EHDMAB provide further support for the location of EHDMAB in different micelles.展开更多
The impacts of Ultraviolet (UV) radiation on the human body have received increased attention in previous years. The impacts are comprised of a series of illnesses, burns, and modifications in the genetic structures. ...The impacts of Ultraviolet (UV) radiation on the human body have received increased attention in previous years. The impacts are comprised of a series of illnesses, burns, and modifications in the genetic structures. Therefore, the current study aimed to identify the effect of sunscreens on yeast to prevent ultraviolet damage. The study uses two sunscreens with different sun protection factors to show how they differently protect the cells from the wrath of UV light. The experiment involves the use of yeast as the test organism since yeast has DNA that is used for reproduction by budding. UV light affects the growth of the bacteria and the limiting factor with the sunscreens. Six Petri dishes with agar were inoculated with yeast solution and put under different conditions and the growth results will be obtained. The experiment also showed how different clothes protect human from the UV radiations.展开更多
Chloasma, or melasma, is a commonly acquired pigmentary disorder among Asian women. It may be considered as a physiological change during pregnancy. The incidence in Asian women is higher than that in other ethnic gro...Chloasma, or melasma, is a commonly acquired pigmentary disorder among Asian women. It may be considered as a physiological change during pregnancy. The incidence in Asian women is higher than that in other ethnic groups but further epidemiologic data are needed. There are very few studies related to the benefits of sunscreens to prevent this dermatosis. The aim of this study was to assess the effectiveness of a broad-spectrum sunscreen in the prevention of melasma in Korean pregnant women. We tested the effectiveness and tolerance of a sunscreen product (SPF 50+, UVA-PF 30) during a 12-month clinical trial including 220 Korean parturients with skin type III and IV. 217 women completed the study. Only 3 (1%) of the study population developed melasma, which was mild (MASI grade between 1.2 and 2.7). In addition, the clinical effectiveness of the evaluated sunscreen was judged “good to excellent” by the majority of study participants and by the research dermatologists. The “excellent” tolerance of the sunscreen under evaluation was confirmed “good” to “excellent” in 95% and 97% of cases. This study clearly demonstrates that this broad-spectrum sunscreen is well tolerated and effective in the prevention of melasma in Korean pregnant women. Although treatment remains elusive, prevention is possible.展开更多
Objective: To test the hypothesis that usage of foundation makeup (FM) and sunscreen lotion (SS), used individually or in combination, is associated with significant changes in the likelihood of lupus symptom exacerba...Objective: To test the hypothesis that usage of foundation makeup (FM) and sunscreen lotion (SS), used individually or in combination, is associated with significant changes in the likelihood of lupus symptom exacerbation. Methods: Self-reported flare days (SRF) and use of FM and SS products, were retrospectively examined in 80 Caucasian Australian women with ACR classified SLE for a year. Negative binomial regression modelled SRF days (outcome) against independent FMSS variable and covariates: age;diagnosis years;outdoor hours;BMI;stress;immune therapy medication (ITM) use. Results: Statistically significant inverse associations between SRF days and FMSS use were found. Protective effects were statistically significant (p < 0.05) for combined FMSS exposure days (OR 0.998, CI 0.997 - 1.0) and FM alone (OR 0.603, CI 0.363 - 1.0). Significant associations consistent with increased SRF risk were seen in sub-analysis models for participants taking ITM: univariate model (OR 1.968, p = 0.03);multivariate model for FMSS (OR 2.11, CI 1.161 - 3.835);FM days (OR 1.855, CI 1.023 - 3.364). Results show SRF day reduction of 0.15% for each day of product exposure. Conclusion: Study results highlight protective effects of wearing FM with or without SS. This reduction in flare days ultimately has potential to improve quality of life in SLE patients.展开更多
Background: Over the last few years sunscreen products have been suspected to be harmful to corals, especially because of their putative negative impact on symbiotic microalgae housed by these cnidarians. Previous pub...Background: Over the last few years sunscreen products have been suspected to be harmful to corals, especially because of their putative negative impact on symbiotic microalgae housed by these cnidarians. Previous publications reported that minerals or chemical UV filters could induce the release of microalgae from corals inducing their bleaching. The study of the ecotoxicity of finished cosmetic products containing these filters is important. Objectives: We sought to assess ex vivo the toxicity of five emulsions containing UV-filters on coral cuttings of Seriatopora hystrix. Materials and Methods: Coral cuttings were put in contact with 5 different emulsions containing UV-filters. The toxicity readout was the ability to induce polyp retraction and/or fragment bleaching of the coral cuttings of Seriatopora hystrix. Results: In our experimental conditions, none of the five tested formulas neither induced any significant polyp retraction nor triggered fragment bleaching of the coral. Conclusions: The five tested emulsions containing UV-filters did not modify coral cuttings. In vivo, larger tests are necessary to verify the results of this ex vivo pilot study.展开更多
The harm of ultraviolet radiation to human skin and the mechanism of traditional sunscreen agents and natural sunscreen agents were reviewed.Sunscreen agents were usually encapsulated with delivery systems due to the ...The harm of ultraviolet radiation to human skin and the mechanism of traditional sunscreen agents and natural sunscreen agents were reviewed.Sunscreen agents were usually encapsulated with delivery systems due to the instability and skin permeability.The research progress of several common sunscreen delivery systems was introduced,the future research direction of sunscreen agents was also prospected.展开更多
This article summarized and compared the requirements of UV filters in EU, US, Canada, Australia, ASEAN, China Taiwan and China, helping companies using the UV filters correctly and compling with the requirements in a...This article summarized and compared the requirements of UV filters in EU, US, Canada, Australia, ASEAN, China Taiwan and China, helping companies using the UV filters correctly and compling with the requirements in above countries and areas.展开更多
文摘This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized via the esterification of phytosterol and oleic acid,whose structure was characterized using Fourier-transform infrared spectroscopy(FTIR)and mass spectrometry(MS).Its liquid crystalline behavior was confirmed via the polarized optical microscopy(POM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),wide-angle X-ray scattering(WAXS),and small-angle X-ray scattering(SAXS).UV absorption tests were conducted to assess the UV-blocking performance of the oleic acid sterol ester liquid crystals.To improve the stability of its liquid crystalline structure,the oleic acid sterol ester was encapsulated into microcapsules through the emulsion polymerization.SPF measurements were performed on the sunscreen formulations containing liquid crystal microcapsules.The oleic acid sterol ester displayed cholesteric liquid crystalline behavior and strong UVA absorption,which indicates its suitability as a natural UV absorber.Microencapsulation further enhanced its stability and UV-blocking properties.SPF testing showed that the formulations with microcapsules achieved an SPF value of 7.01,which surpasses the nano titanium dioxide(SPF=6.23)and significantly outperform the unencapsulated liquid crystal formulations(SPF=2.65).This study highlights the potential of microencapsulated oleic acid sterol ester as a novel UV absorber in the sunscreen formulations,offers the enhanced stability and effective UV protection,and showcases its application potential in the innovative cosmetic products.
文摘Organic ultraviolet(UV)filters play a crucial role in reducing sunburn,photoaging,and the risk of skin cancer induced by UV radiation.However,the challenges posed by photodegradation,potential phototoxicity,and poor dispersion characteristics of organic UV filters significantly hinder their practical applications.This study aims to encapsulate avobenzone,a widely used UV filter,in mesoporous silica(MPS)to form AB@MPS particles via an in-situ sol-gel process,and to research their sunscreen performance as stabilizers in Pickering emulsion.The UV absorption capability of AB@MPS particles is stronger than free avobenzone.The in vitro skin penetration study reveals a greatly reduced permeability(73.9%)for avobenzone from AB@MPS compared to its free form.Furthermore,the photostability of AB@MPS particles increases 14.3 times compared to that of free avobenzone.In UV protection tests,the Pickering emulsion’s anti-UVA efficacy is 2.28 times greater than that of 20%PG solution,4.41 times greater than Carbomer hydrogel,and 3.59 times greater than the cream formulation.The SPF value of the Pickering emulsion is 2.41 times greater than the 20%PG solution,2 times greater than the Carbomer hydrogel,and 6.77 times greater than the cream formulation.This study presents a promising strategy for the application of Pickering emulsions in the cosmetic and pharmaceutical sectors,providing a safe and efficient formulation for sunscreens.
文摘Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.
基金supported by the National Key Research and Development Project(No.2019YFA0705403)the National Natural Science Foundation of China(No.T2293693,52273311)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2020B0301030002)and the Shenzhen Basic Research Project(Nos.WDZC20200824091903001,JSGG20220831105402004,JCYJ20220818100806014)Shenzhen Major Science and Technology Projects(Nos.KCXFZ20240903094013018,KCXFZ20240903094203005)。
文摘Titanium dioxide(TiO_(2))has been an important protective ingredient in mineral-based sunscreens since the 1990s.However,traditional TiO_(2)nanoparticle formulations have seen little improvement over the past decades and continue to face persistent challenges related to light transmission,biosafety,and visual appearance.Here,we report the discovery of two-dimensional(2D)TiO_(2),characterized by a micro-sized lateral dimension(~1.6μm)and atomic-scale thickness,which fundamentally resolves these long-standing issues.The 2D structure enables exceptional light management,achieving 80%visible light transparency—rendering it nearly invisible on the skin—while maintaining UV-blocking performance comparable to unmodified rutile TiO_(2)nanoparticles.Its larger lateral size results in a two-orders-of-magnitude reduction in skin penetration(0.96 w/w%),significantly enhancing biosafety.Moreover,the unique layered architecture inherently suppresses the generation of reactive oxygen species(ROS)under sunlight exposure,reducing the ROS generation rate by 50-fold compared to traditional TiO_(2)nanoparticles.Through precise metal element modulation,we further developed the first customizable sunscreen material capable of tuning UV protection ranges and automatically matching diverse skin tones.The 2D TiO_(2)offers a potentially transformative approach to modern sunscreen formulation,combining superior UV protection,enhanced safety and a natural appearance.
基金National Natural Science Foundation of China(22078125)Postdoctoral Science Foundation of China(2023M741472)Fundamental Research Funds for the Central Universities(JUSRP622038).
文摘Sunscreen agents derived from plants have been regarded as promising alternatives to artificial compounds.In this work,carbon dots(CDs)were prepared from carrot juice via a continuous microflowbased approach,where the influence of process parameters was studied and optimized.Complimentary characterization revealed the CDs not only have small size,narrow size distribution,and good water solubility,but also have abundant functional groups as well as excellent UV absorption performance.Relying on these properties,the CDs were used as UV absorbers,suggesting they have strong long-term UV absorption ability over a broad pH range.The UV-absorption properties of the CDs were confirmed by incorporating the CDs in polyvinyl alcohol(PVA)to get C-CDs@PVA films of different thickness,in which significantly enhanced UV absorption performance was observed.Besides,the sun protection performance is also related to the film thickness.Afterwards,the practical application of the CDs was evaluated by adding them in a typical skin cream.With the addition of the CDs,the cream has drastically reduced UV transmittance in both UVA and UVB regions,and exhibits better UV absorption performance than commercial sunscreen agents.The CDs also demonstrated low cytotoxicity and high DPPH radical scavenging activity,making them promising as green sunscreen absorbers.This work is expected to provide a guidance for the development of green and effective natural sunscreen agents via microflowbased method.
基金support from Guangdong S&T programme[2024A0505050001].
文摘Background:Long-term exposure to sunlight can lead to inflammatory responses,skin photoaging and cancers.Plant extracts can serve as effective biological UV(ultraviolet)filters for their UV absorption capacity.Red rice extract is rich in phenolic acids,flavonoids,anthocyanins and procyanins has the potential as a biological UV filter.Aims:This study aims to evaluate the potential of red rice extract as a biological UV filter.Forthurmore,exploring the ability of red rice extract to enhance SPF performance and serve as a potential substitute for chemical UV filters.Methods:Using UV absorption spectroscopy,the UV absorption performance of red rice extract was compared with that of three known UV filters.Additionally,using the Folin-Ciocalteu reagent to test the total phenolic acids content of red rice extract and the antioxidant capacity of red rice extract was verified through a 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical clearance assay,confirming its potential as a biological UV filter.Subsequently,the photoprotective enhancement effects of red rice extract in sunscreen formulations were explored by testing the SPF value with UV2000S.Results:Experiments conducted by adding different concentrations of red rice extract to sunscreen formulations demonstrated that its photoprotective enhancement effects were positively correlated with its concentration.The addition of 1%red rice extract to both oil-in-water(O/W)and water-in-oil(W/O)sunscreen formulations demonstrated good photoprotective enhancement effects,with SPF values increasing by over 10%.Further experiments showed that 1%,3%,and 5%red rice extract could replace approximately 12.82%,19.05%,and 26.09%of traditional UV filters in sunscreen formulations,achieving similar SPF values.Conclusions:These findings suggest that red rice extract is a promising biological UV filter,capable of enhancing SPF values and serving as a viable alternative for traditional UV filters.Red rice extract can be used in sunscreen products and provide photoprotection benefit.
文摘Based on liquid crystal emulsification technology,a combination of macromolecular organic sunscreens and physical sunscreens was used to study and develop the formula of sunscreen lotion.The performance of the sunscreen lotion formula was analyzed by observing the liquid crystal structure of the lotion,investigating the stability of the formula,and using human sun protection index test and chemical skin absorption in vitro test.The study showed that in this sunscreen formula system,the combination of alkyl glycoside emulsifiers and polyglycerol emulsifiers is easier to form a liquid crystal structure than lecithin emulsifiers.The physical sunscreen zinc oxide is not conducive to the formation of the liquid crystal structure of the formula and the stability of the formula.The liquid crystal emulsification system helps to improve the sun protection index of the formula system to a certain extent.The liquid crystal structure has a certain sustained release effect on the active ingredients in the sunscreen cosmetic formula.
基金supported by Ministry of Agriculture,Food and Rural Affairs,Republic of Korea
文摘Farmers are frequently exposed to ultraviolet（UV） radiation which causes various diseases by inducing oxidative stress.This study aimed to assess the effects of sunblock on oxidative stress in the body.Eighty-seven farmers were divided into two groups：those who wore sunblock for five days and those who did not.The total antioxidant capacity（TAC） in urine,which is an antioxidant indicator,and 8-hydroxy-2-deoxyguanosine（8-OHdG） levels in urine,an oxidative stress indicator,were measured.The urinary TAC of sunblock users was significantly higher than that of non-users,but urinary 8-OHdG levels were not significantly different.Even after adjustment for potential confounders,urinary TAC was found to be markedly increased with sunblock usage.These results suggest that sunblock is effective in preventing oxidative stress among farmers.In addition,they show that urinary TAC can be used as a good effect marker of oxidative stress caused by UV exposure.
文摘The current study presents the characterization of three types of materials after exposure to solar UV radiation. The selection of the materials is related to socio-economic aspects and rural activities in the northwest of Argentina (a.k.a. NOA). The objective was to establish a time parameter that allows estimating the durability of the materials according to their use. One of the materials is used as a protective cover (polyethylene film) of greenhouses, which are used for crop cultivation in the area. Another material is used in photovoltaic modules (PVMs), which are used to supply energy in isolated areas and the third material is sunscreen used by people that are exposed to UV radiation during rural activities. Degradation or deterioration of the materials was monitored using different spectroscopic assays: infrared was used to detect any structural changes in the material, X-rays were used for possible changes in the crystalline structure of the material, and spectral transmittance as this property is likely to be affected by changes in the structure of the material. The results showed that degradation of polyethylene seems to be related to the diminution in transparency and the loss of mechanical resistance with increasing exposure time. The decrease in transparency of one of the layers of a PVM caused a considerable decrease in the energy generated, whereas the sunscreens with a low sun protection factor (SPF) rapidly lost their protective properties and changed their photostability properties. Our results revealed a relationship between relative transmittance loss and exposure timse, which allows estimating the stability of different materials.
文摘The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600℃. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM);the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.
基金supported by the China Scholarship Council(No.202308110152)。
文摘1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione(known as Avobenzone/AVB),widely used throughout the world as a highly effective UVA absorber,can prevent the progression of photoaging in skin,and is also known for the disadvantage of having a reduced capability to absorb UVA when exposed to sunlight for long periods.To address this challenge,ZnTi-CO_(3)-LDH with a twodimensional layered structure was used to improve stability and synergistically enhance UV absorption of AVB.A novel AVB loaded ZnTi-CO_(3)-LDH(AVB@ZnTi-LDH)material was synthesized by reconstruction method and the loading content(LC)was about 46.8%investigated by high-performance liquid chromatography(HPLC).A possible mechanism for the binding of AVB with the ZnTi-LDH surface was proposed.X-ray photoelectron spectroscopy(XPS)and density functional theory(DFT)calculations were used to confirm further the coordination between Zn on the layer and the oxygen atom of the carbonyl group of AVB.UV absorption and critical wavelength of AVB@ZnTi-LDH were superior to those of AVB and ZnTiLDH precursors.Compared with pure AVB,the photodegradation rate was reduced from 15.06%to 4.06%.Especially in titanium dioxide,the decomposition rate was reduced from 29.75%to 7.92%.Furthermore,pure AVB often reacts with multivalent metal ions to induce an unpleasant color(light yellow to reddish brown),which is greatly mitigated with AVB@ZnTi-LDH.In this study,avobenzone was combined with hydrotalcite to prepare an organic-inorganic composite with excellent UV resistance and better stability,the composite has great promise for application in sunscreen cosmetics.
基金supported by the National Key Research and Development Program of China(2018YFA0208702)the National Natural Science Foundation of China(No.22025304 and No.22033007)Guozhen Zhang is grateful for the start-up funding of University of Science and Technology of China.The numerical calculations in this work have been done in the Supercomputing Center of University of Science and Technology of China.
文摘UV-B(280-320 nm)sunscreening is crucial for lives on Earth.Examining the role of surrounding of UV-B ter understand UV-B absorption.screening molecules can help us better is ubiquitous in cells as the solvent,but its impacts on UV-B absorption of sunscreen agents are underexplored.Herein,we report a firstprinciple study on UV-B absorption of sinapate malate(SM)and rele vant molecular species,with a focus on the solvent effect of water.The capability of UV-B screening by anions of SM,the proposed species for actual sunscreening,is shaped by water.Both the implicit water providing the dielectric environment of solvation and the explicit water molecules forming hydrogen bonding to SM anion can appreciably alter the nature of transition orbitals responsible to the UV-B absorption of the anion.Finally,we find the molecular dipole moment of an organic UV-B screening agent can be an indicator of its UV-B screening sensitivity to the surrounding water.Our work may serve as a starting point of developing new water-soluble UV-B screening agent.
基金This work was supported by the National Natural Science Foundation of China （No.20335030） and the Innovation Foundation of Science and Technology （No.NWNU-KJCXGC-02-09）.
文摘Dual fluorescence and UV absorption of 2′-ethylhexyl 4-（N,N-dimethylamino）benzoate （EHDMAB） were investigated in cationic, non-ionic and anionic micelles. When EHDMAB was solubilized in different micelles, the UV absorption of EHDMAB was enhanced. Twisted intramolecular charge transfer （TICT） emission with longer wavelength was observed in ionic micelles, whereas TICT emission with shorter wavelength was obtained in non-ionic micelles. In particular, dual fluorescence of EHDMAB was significantly quenched by the positively charged pyridinium ions arranged in the Stern layer of cationic micelles. UV radiation absorbed mainly decays via TICT emission and radiationless deactivation. The dimethylamino group of EHDMAB experiences different polar environments in ionic and non-ionic micelles according to the polarity dependence of TICT emission of EHDMAB in organic solvents. In terms of the molecular structures and sizes of EHDMAB and surfactants, each individual EHDMAB molecule should be buried in micelles with its dimethylamino group toward the polar head groups of different micelles and with its 2′-ethylhexyl chain toward the hydrophobic micellar core. Dynamic fluorescence quenching measurements of EHDMAB provide further support for the location of EHDMAB in different micelles.
文摘The impacts of Ultraviolet (UV) radiation on the human body have received increased attention in previous years. The impacts are comprised of a series of illnesses, burns, and modifications in the genetic structures. Therefore, the current study aimed to identify the effect of sunscreens on yeast to prevent ultraviolet damage. The study uses two sunscreens with different sun protection factors to show how they differently protect the cells from the wrath of UV light. The experiment involves the use of yeast as the test organism since yeast has DNA that is used for reproduction by budding. UV light affects the growth of the bacteria and the limiting factor with the sunscreens. Six Petri dishes with agar were inoculated with yeast solution and put under different conditions and the growth results will be obtained. The experiment also showed how different clothes protect human from the UV radiations.
文摘Chloasma, or melasma, is a commonly acquired pigmentary disorder among Asian women. It may be considered as a physiological change during pregnancy. The incidence in Asian women is higher than that in other ethnic groups but further epidemiologic data are needed. There are very few studies related to the benefits of sunscreens to prevent this dermatosis. The aim of this study was to assess the effectiveness of a broad-spectrum sunscreen in the prevention of melasma in Korean pregnant women. We tested the effectiveness and tolerance of a sunscreen product (SPF 50+, UVA-PF 30) during a 12-month clinical trial including 220 Korean parturients with skin type III and IV. 217 women completed the study. Only 3 (1%) of the study population developed melasma, which was mild (MASI grade between 1.2 and 2.7). In addition, the clinical effectiveness of the evaluated sunscreen was judged “good to excellent” by the majority of study participants and by the research dermatologists. The “excellent” tolerance of the sunscreen under evaluation was confirmed “good” to “excellent” in 95% and 97% of cases. This study clearly demonstrates that this broad-spectrum sunscreen is well tolerated and effective in the prevention of melasma in Korean pregnant women. Although treatment remains elusive, prevention is possible.
文摘Objective: To test the hypothesis that usage of foundation makeup (FM) and sunscreen lotion (SS), used individually or in combination, is associated with significant changes in the likelihood of lupus symptom exacerbation. Methods: Self-reported flare days (SRF) and use of FM and SS products, were retrospectively examined in 80 Caucasian Australian women with ACR classified SLE for a year. Negative binomial regression modelled SRF days (outcome) against independent FMSS variable and covariates: age;diagnosis years;outdoor hours;BMI;stress;immune therapy medication (ITM) use. Results: Statistically significant inverse associations between SRF days and FMSS use were found. Protective effects were statistically significant (p < 0.05) for combined FMSS exposure days (OR 0.998, CI 0.997 - 1.0) and FM alone (OR 0.603, CI 0.363 - 1.0). Significant associations consistent with increased SRF risk were seen in sub-analysis models for participants taking ITM: univariate model (OR 1.968, p = 0.03);multivariate model for FMSS (OR 2.11, CI 1.161 - 3.835);FM days (OR 1.855, CI 1.023 - 3.364). Results show SRF day reduction of 0.15% for each day of product exposure. Conclusion: Study results highlight protective effects of wearing FM with or without SS. This reduction in flare days ultimately has potential to improve quality of life in SLE patients.
文摘Background: Over the last few years sunscreen products have been suspected to be harmful to corals, especially because of their putative negative impact on symbiotic microalgae housed by these cnidarians. Previous publications reported that minerals or chemical UV filters could induce the release of microalgae from corals inducing their bleaching. The study of the ecotoxicity of finished cosmetic products containing these filters is important. Objectives: We sought to assess ex vivo the toxicity of five emulsions containing UV-filters on coral cuttings of Seriatopora hystrix. Materials and Methods: Coral cuttings were put in contact with 5 different emulsions containing UV-filters. The toxicity readout was the ability to induce polyp retraction and/or fragment bleaching of the coral cuttings of Seriatopora hystrix. Results: In our experimental conditions, none of the five tested formulas neither induced any significant polyp retraction nor triggered fragment bleaching of the coral. Conclusions: The five tested emulsions containing UV-filters did not modify coral cuttings. In vivo, larger tests are necessary to verify the results of this ex vivo pilot study.
文摘The harm of ultraviolet radiation to human skin and the mechanism of traditional sunscreen agents and natural sunscreen agents were reviewed.Sunscreen agents were usually encapsulated with delivery systems due to the instability and skin permeability.The research progress of several common sunscreen delivery systems was introduced,the future research direction of sunscreen agents was also prospected.
文摘This article summarized and compared the requirements of UV filters in EU, US, Canada, Australia, ASEAN, China Taiwan and China, helping companies using the UV filters correctly and compling with the requirements in above countries and areas.
