High silica zeolite Y has been positively evaluated to clean-up water polluted with sulfonamides, an antibiotic family which is known to be involved in the antibiotic resistance evolution. To define possible strategie...High silica zeolite Y has been positively evaluated to clean-up water polluted with sulfonamides, an antibiotic family which is known to be involved in the antibiotic resistance evolution. To define possible strategies for the exhausted zeolite regeneration,the efficacy of some chemico-physical treatments on the zeolite loaded with four different sulfonamides was evaluated. The evolution of photolysis, Fenton-like reaction, thermal treatments, and solvent extractions and the occurrence in the zeolite pores of organic residues eventually entrapped was elucidated by a combined thermogravimetric（TGA–DTA）, diffractometric（XRPD）, and spectroscopic（FT-IR） approach. The chemical processes were not able to remove the organic vip from zeolite pores and a limited transformation on embedded molecules was observed. On the contrary, both thermal treatment and solvent extraction succeeded in the regeneration of the zeolite loaded from deionized and natural fresh water. The recyclability of regenerated zeolite was evaluated over several adsorption/regeneration cycles, due to the treatment efficacy and its stability as well as the ability to regain the structural features of the unloaded material.展开更多
Modification of sulfonamid drug using different principles of chemical reactions was investigated. These reactions involve the condensation of an amino group with triethyl orthoformate and dimethylformamide dimethyl a...Modification of sulfonamid drug using different principles of chemical reactions was investigated. These reactions involve the condensation of an amino group with triethyl orthoformate and dimethylformamide dimethyl acetal. Ability of sulfa to condense with active keto compounds, like ethyl pyruvate and piprazine carboxyaldehye was studied. Alkyation of sulfa with different chloro derivatives was also reported. The structure of the isolated compound was elucidated and confirmed using elemental analysis and spectral data. The bioactivity of the ob-tained compounds was investigated against different gram positive and gram negative bacteria. The study reveals that most of the modified drugs show high to moderate antibacterial activity.展开更多
Objective: To observe the effect of treatment of Mailuoning Injection (MI) for pregnancy induced hypertension (PIH). Methods: Forty six PIH patients in the treated group were treated with intravenous dripping of MI an...Objective: To observe the effect of treatment of Mailuoning Injection (MI) for pregnancy induced hypertension (PIH). Methods: Forty six PIH patients in the treated group were treated with intravenous dripping of MI and 40 patients in the control group treated with intravenous dripping of 25% magnesium sulfas. Results: Headache and edema were ameliorated significantly in the MI treated group in comparison with the control （P＜ 0.05）. Both methods could the decrease levels of mean arterial pressure, improve hemorheologic change, and lower the hematocrit, but the effects of the former was better than those of the latter. No difference was found in albuminuria, delivery pattern, postpartum bleeding and neonatal Apgar Score between the two groups. Conclusion: MI could prevent the progress of pathological process of the PIH. The therapeutic mechanism of MI might be relevant to the dilatation of the arteriospasm, improvement of the abnormal microcirculation and hemorheologic character of the patients.展开更多
基金co-funded by the Italian Ministry of Education, University, and Research (No. PRIN 2008 BL2NWK: Zeolites as nano-reactors for the environment: efficiency, selectivity and stability in the adsorption of drugs from contaminated waters)
文摘High silica zeolite Y has been positively evaluated to clean-up water polluted with sulfonamides, an antibiotic family which is known to be involved in the antibiotic resistance evolution. To define possible strategies for the exhausted zeolite regeneration,the efficacy of some chemico-physical treatments on the zeolite loaded with four different sulfonamides was evaluated. The evolution of photolysis, Fenton-like reaction, thermal treatments, and solvent extractions and the occurrence in the zeolite pores of organic residues eventually entrapped was elucidated by a combined thermogravimetric（TGA–DTA）, diffractometric（XRPD）, and spectroscopic（FT-IR） approach. The chemical processes were not able to remove the organic vip from zeolite pores and a limited transformation on embedded molecules was observed. On the contrary, both thermal treatment and solvent extraction succeeded in the regeneration of the zeolite loaded from deionized and natural fresh water. The recyclability of regenerated zeolite was evaluated over several adsorption/regeneration cycles, due to the treatment efficacy and its stability as well as the ability to regain the structural features of the unloaded material.
文摘Modification of sulfonamid drug using different principles of chemical reactions was investigated. These reactions involve the condensation of an amino group with triethyl orthoformate and dimethylformamide dimethyl acetal. Ability of sulfa to condense with active keto compounds, like ethyl pyruvate and piprazine carboxyaldehye was studied. Alkyation of sulfa with different chloro derivatives was also reported. The structure of the isolated compound was elucidated and confirmed using elemental analysis and spectral data. The bioactivity of the ob-tained compounds was investigated against different gram positive and gram negative bacteria. The study reveals that most of the modified drugs show high to moderate antibacterial activity.
文摘Objective: To observe the effect of treatment of Mailuoning Injection (MI) for pregnancy induced hypertension (PIH). Methods: Forty six PIH patients in the treated group were treated with intravenous dripping of MI and 40 patients in the control group treated with intravenous dripping of 25% magnesium sulfas. Results: Headache and edema were ameliorated significantly in the MI treated group in comparison with the control （P＜ 0.05）. Both methods could the decrease levels of mean arterial pressure, improve hemorheologic change, and lower the hematocrit, but the effects of the former was better than those of the latter. No difference was found in albuminuria, delivery pattern, postpartum bleeding and neonatal Apgar Score between the two groups. Conclusion: MI could prevent the progress of pathological process of the PIH. The therapeutic mechanism of MI might be relevant to the dilatation of the arteriospasm, improvement of the abnormal microcirculation and hemorheologic character of the patients.
